PubMed

The cytokines IL-1{beta} and TNF-{alpha} regulate different transcriptional and alternative splicing networks in primary beta cells.

Ortis F, Naamane N, Flamez D, Ladrière L, Moore F, Cunha DA, Colli ML, Thykjaer T, Thorsen K, Orntoft TF, Eizirik DL.

Diabetes. 2009 Nov 23. [Epub ahead of print]PMID: 19934004 [PubMed - as supplied by publisher]Related articles

Detailed transcriptome atlas of the pancreatic beta cell.

Kutlu B, Burdick D, Baxter D, Rasschaert J, Flamez D, Eizirik DL, Welsh N, Goodman N, Hood L.

BMC Med Genomics. 2009 Jan 15;2:3.PMID: 19146692 [PubMed - in process]Related articlesFree article

Role of furin in granular acidification in the endocrine pancreas: identification of the V-ATPase subunit Ac45 as a candidate substrate.

Louagie E, Taylor NA, Flamez D, Roebroek AJ, Bright NA, Meulemans S, Quintens R, Herrera PL, Schuit F, Van de Ven WJ, Creemers JW.

Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12319-24. Epub 2008 Aug 19.PMID: 18713856 [PubMed - indexed for MEDLINE]Related articlesFree article

Use of a systems biology approach to understand pancreatic beta-cell death in Type 1 diabetes.

Eizirik DL, Moore F, Flamez D, Ortis F.

Biochem Soc Trans. 2008 Jun;36(Pt 3):321-7. Review.PMID: 18481950 [PubMed - indexed for MEDLINE]Related articles

Double-stranded RNA induces pancreatic beta-cell apoptosis by activation of the toll-like receptor 3 and interferon regulatory factor 3 pathways.

Dogusan Z, García M, Flamez D, Alexopoulou L, Goldman M, Gysemans C, Mathieu C, Libert C, Eizirik DL, Rasschaert J.

Diabetes. 2008 May;57(5):1236-45. Epub 2008 Jan 25.PMID: 18223009 [PubMed - indexed for MEDLINE]Related articlesFree article

Proteomics analysis of cytokine-induced dysfunction and death in insulin-producing INS-1E cells: new insights into the pathways involved.

D'Hertog W, Overbergh L, Lage K, Ferreira GB, Maris M, Gysemans C, Flamez D, Cardozo AK, Van den Bergh G, Schoofs L, Arckens L, Moreau Y, Hansen DA, Eizirik DL, Waelkens E, Mathieu C.

Mol Cell Proteomics. 2007 Dec;6(12):2180-99. Epub 2007 Oct 5.PMID: 17921177 [PubMed - indexed for MEDLINE]Related articlesFree article

T1DBase: integration and presentation of complex data for type 1 diabetes research.

Hulbert EM, Smink LJ, Adlem EC, Allen JE, Burdick DB, Burren OS, Cassen VM, Cavnor CC, Dolman GE, Flamez D, Friery KF, Healy BC, Killcoyne SA, Kutlu B, Schuilenburg H, Walker NM, Mychaleckyj J, Eizirik DL, Wicker LS, Todd JA, Goodman N.

Nucleic Acids Res. 2007 Jan;35(Database issue):D742-6. Epub 2006 Dec 14. Erratum in: Nucleic Acids Res. 2007;35(18):6338. Cassen, Victor M [added]. PMID: 17169983 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis.

Cnop M, Ladriere L, Hekerman P, Ortis F, Cardozo AK, Dogusan Z, Flamez D, Boyce M, Yuan J, Eizirik DL.

J Biol Chem. 2007 Feb 9;282(6):3989-97. Epub 2006 Dec 8.PMID: 17158450 [PubMed - indexed for MEDLINE]Related articlesFree article

Disruption of the gamma-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of beta-cells.

Gysemans CA, Ladrière L, Callewaert H, Rasschaert J, Flamez D, Levy DE, Matthys P, Eizirik DL, Mathieu C.

Diabetes. 2005 Aug;54(8):2396-403.PMID: 16046307 [PubMed - indexed for MEDLINE]Related articlesFree article

Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis.

Scheuner D, Vander Mierde D, Song B, Flamez D, Creemers JW, Tsukamoto K, Ribick M, Schuit FC, Kaufman RJ.

Nat Med. 2005 Jul;11(7):757-64. Epub 2005 Jun 26.PMID: 15980866 [PubMed - indexed for MEDLINE]Related articles

Essential role of chicken ovalbumin upstream promoter-transcription factor II in insulin secretion and insulin sensitivity revealed by conditional gene knockout.

Bardoux P, Zhang P, Flamez D, Perilhou A, Lavin TA, Tanti JF, Hellemans K, Gomas E, Godard C, Andreelli F, Buccheri MA, Kahn A, Le Marchand-Brustel Y, Burcelin R, Schuit F, Vasseur-Cognet M.

Diabetes. 2005 May;54(5):1357-63.PMID: 15855320 [PubMed - indexed for MEDLINE]Related articlesFree article

T1DBase, a community web-based resource for type 1 diabetes research.

Smink LJ, Helton EM, Healy BC, Cavnor CC, Lam AC, Flamez D, Burren OS, Wang Y, Dolman GE, Burdick DB, Everett VH, Glusman G, Laneri D, Rowen L, Schuilenburg H, Walker NM, Mychaleckyj J, Wicker LS, Eizirik DL, Todd JA, Goodman N.

Nucleic Acids Res. 2005 Jan 1;33(Database issue):D544-9.PMID: 15608258 [PubMed - indexed for MEDLINE]Related articlesFree article

Prior in vitro exposure to GLP-1 with or without GIP can influence the subsequent beta cell responsiveness.

Delmeire D, Flamez D, Moens K, Hinke SA, Van Schravendijk C, Pipeleers D, Schuit F.

Biochem Pharmacol. 2004 Jul 1;68(1):33-9.PMID: 15183115 [PubMed - indexed for MEDLINE]Related articles

Hypoglycemia, defective islet glucagon secretion, but normal islet mass in mice with a disruption of the gastrin gene.

Boushey RP, Abadir A, Flamez D, Baggio LL, Li Y, Berger V, Marshall BA, Finegood D, Wang TC, Schuit F, Drucker DJ.

Gastroenterology. 2003 Oct;125(4):1164-74.PMID: 14517799 [PubMed - indexed for MEDLINE]Related articles

Type VIII adenylyl cyclase in rat beta cells: coincidence signal detector/generator for glucose and GLP-1.

Delmeire D, Flamez D, Hinke SA, Cali JJ, Pipeleers D, Schuit F.

Diabetologia. 2003 Oct;46(10):1383-93. Epub 2003 Sep 17.PMID: 13680124 [PubMed - indexed for MEDLINE]Related articles

A globin in the nucleus!

Geuens E, Brouns I, Flamez D, Dewilde S, Timmermans JP, Moens L.

J Biol Chem. 2003 Aug 15;278(33):30417-20. Epub 2003 Jun 9.PMID: 12796507 [PubMed - indexed for MEDLINE]Related articlesFree article

Physiological role of AMP-activated protein kinase (AMPK): insights from knockout mouse models.

Viollet B, Andreelli F, Jørgensen SB, Perrin C, Flamez D, Mu J, Wojtaszewski JF, Schuit FC, Birnbaum M, Richter E, Burcelin R, Vaulont S.

Biochem Soc Trans. 2003 Feb;31(Pt 1):216-9. Review.PMID: 12546688 [PubMed - indexed for MEDLINE]Related articles

The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity.

Viollet B, Andreelli F, Jørgensen SB, Perrin C, Geloen A, Flamez D, Mu J, Lenzner C, Baud O, Bennoun M, Gomas E, Nicolas G, Wojtaszewski JF, Kahn A, Carling D, Schuit FC, Birnbaum MJ, Richter EA, Burcelin R, Vaulont S.

J Clin Invest. 2003 Jan;111(1):91-8.PMID: 12511592 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-regulated gene expression maintaining the glucose-responsive state of beta-cells.

Schuit F, Flamez D, De Vos A, Pipeleers D.

Diabetes. 2002 Dec;51 Suppl 3:S326-32. Review.PMID: 12475771 [PubMed - indexed for MEDLINE]Related articlesFree article

Critical role for cataplerosis via citrate in glucose-regulated insulin release.

Flamez D, Berger V, Kruhøffer M, Orntoft T, Pipeleers D, Schuit FC.

Diabetes. 2002 Jul;51(7):2018-24.PMID: 12086928 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitogenic effect of gastrin and expression of gastrin receptors in duct-like cells of rat pancreas.

Rooman I, Lardon J, Flamez D, Schuit F, Bouwens L.

Gastroenterology. 2001 Oct;121(4):940-9.PMID: 11606507 [PubMed - indexed for MEDLINE]Related articles

Glucagon-like peptide 1 receptor signaling influences topography of islet cells in mice.

Ling Z, Wu D, Zambre Y, Flamez D, Drucker DJ, Pipeleers DG, Schuit FC.

Virchows Arch. 2001 Apr;438(4):382-7.PMID: 11355173 [PubMed - indexed for MEDLINE]Related articles

Altered cAMP and Ca2+ signaling in mouse pancreatic islets with glucagon-like peptide-1 receptor null phenotype.

Flamez D, Gilon P, Moens K, Van Breusegem A, Delmeire D, Scrocchi LA, Henquin JC, Drucker DJ, Schuit F.

Diabetes. 1999 Oct;48(10):1979-86.PMID: 10512362 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced glucose-dependent insulinotropic polypeptide secretion and insulinotropic action in glucagon-like peptide 1 receptor -/- mice.

Pederson RA, Satkunarajah M, McIntosh CH, Scrocchi LA, Flamez D, Schuit F, Drucker DJ, Wheeler MB.

Diabetes. 1998 Jul;47(7):1046-52.PMID: 9648827 [PubMed - indexed for MEDLINE]Related articlesFree article

Mouse pancreatic beta-cells exhibit preserved glucose competence after disruption of the glucagon-like peptide-1 receptor gene.

Flamez D, Van Breusegem A, Scrocchi LA, Quartier E, Pipeleers D, Drucker DJ, Schuit F.

Diabetes. 1998 Apr;47(4):646-52.PMID: 9568699 [PubMed - indexed for MEDLINE]Related articlesFree article

Dual glucagon recognition by pancreatic beta-cells via glucagon and glucagon-like peptide 1 receptors.

Moens K, Flamez D, Van Schravendijk C, Ling Z, Pipeleers D, Schuit F.

Diabetes. 1998 Jan;47(1):66-72.PMID: 9421376 [PubMed - indexed for MEDLINE]Related articles

Expression and functional activity of glucagon, glucagon-like peptide I, and glucose-dependent insulinotropic peptide receptors in rat pancreatic islet cells.

Moens K, Heimberg H, Flamez D, Huypens P, Quartier E, Ling Z, Pipeleers D, Gremlich S, Thorens B, Schuit F.

Diabetes. 1996 Feb;45(2):257-61.PMID: 8549871 [PubMed - indexed for MEDLINE]Related articles

Production in Escherichia coli of a functional murine and murine::human chimeric F(ab')2 fragment and mature antibody directed against human placental alkaline phosphatase.

Flamez D, Remaut E, Fiers W.

J Biotechnol. 1995 Sep 29;42(2):133-43.PMID: 7576533 [PubMed - indexed for MEDLINE]Related articles