PubMed

Point: The Texas advance directives act effectively and ethically resolves disputes about medical futility.

Fine RL.

Chest. 2009 Oct;136(4):963-7. No abstract available. PMID: 19809044 [PubMed - indexed for MEDLINE]Related articles

Acute ascending aortic dissection diagnosed with transthoracic echocardiography.

Brunson JM, Fine RL, Schussler JM.

J Am Soc Echocardiogr. 2009 Sep;22(9):1086.e5-7.PMID: 19733797 [PubMed - in process]Related articles

Pancreatic Proteolytic Enzyme Therapy Compared With Gemcitabine-Based Chemotherapy for the Treatment of Pancreatic Cancer.

Chabot JA, Tsai WY, Fine RL, Chen C, Kumah CK, Antman KA, Grann VR.

J Clin Oncol. 2009 Aug 17. [Epub ahead of print]PMID: 19687327 [PubMed - as supplied by publisher]Related articles

Head and neck squamous cell carcinoma in FAMMM syndrome.

Vinarsky V, Fine RL, Assaad A, Qian Y, Chabot JA, Su GH, Frucht H.

Head Neck. 2009 Nov;31(11):1524-7.PMID: 19360740 [PubMed - in process]Related articles

Mutational analyses of multiple oncogenic pathways in intraductal papillary mucinous neoplasms of the pancreas.

Schönleben F, Allendorf JD, Qiu W, Li X, Ho DJ, Ciau NT, Fine RL, Chabot JA, Remotti HE, Su GH.

Pancreas. 2008 Mar;36(2):168-72.PMID: 18376308 [PubMed - indexed for MEDLINE]Related articles

Multi-institutional phase II study of temozolomide administered twice daily in the treatment of recurrent high-grade gliomas.

Balmaceda C, Peereboom D, Pannullo S, Cheung YK, Fisher PG, Alavi J, Sisti M, Chen J, Fine RL.

Cancer. 2008 Mar 1;112(5):1139-46.PMID: 18246536 [PubMed - indexed for MEDLINE]Related articlesFree article

Language matters: "sometimes we withdraw treatment but we never withdraw care".

Fine RL.

J Palliat Med. 2007 Dec;10(6):1239-40. No abstract available. PMID: 18095797 [PubMed - indexed for MEDLINE]Related articles

Tackling medical futility in Texas.

Fine RL.

N Engl J Med. 2007 Oct 11;357(15):1558-9; author reply 1559. No abstract available. PMID: 17928610 [PubMed - indexed for MEDLINE]Related articles

Neoadjuvant chemotherapy and radiation for patients with locally unresectable pancreatic adenocarcinoma: feasibility, efficacy, and survival.

Allendorf JD, Lauerman M, Bill A, DiGiorgi M, Goetz N, Vakiani E, Remotti H, Schrope B, Sherman W, Hall M, Fine RL, Chabot JA.

J Gastrointest Surg. 2008 Jan;12(1):91-100. Epub 2007 Sep 5.PMID: 17786524 [PubMed - indexed for MEDLINE]Related articles

Activation of targeted necrosis by a p53 peptide: a novel death pathway that circumvents apoptotic resistance.

Dinnen RD, Drew L, Petrylak DP, Mao Y, Cassai N, Szmulewicz J, Brandt-Rauf P, Fine RL.

J Biol Chem. 2007 Sep 14;282(37):26675-86. Epub 2007 Jul 18.PMID: 17636258 [PubMed - indexed for MEDLINE]Related articlesFree article

Transient cerebral hypoperfusion enhances intraarterial carmustine deposition into brain tissue.

Joshi S, Wang M, Etu JJ, Suckow RF, Cooper TB, Feinmark SJ, Bruce JN, Fine RL.

J Neurooncol. 2008 Jan;86(2):123-32. Epub 2007 Jul 17.PMID: 17634743 [PubMed - indexed for MEDLINE]Related articles

Increased permeability of the blood-brain barrier to chemotherapy in metastatic brain tumors: establishing a treatment paradigm.

Gerstner ER, Fine RL.

J Clin Oncol. 2007 Jun 1;25(16):2306-12. Review.PMID: 17538177 [PubMed - indexed for MEDLINE]Related articles

The gemcitabine, docetaxel, and capecitabine (GTX) regimen for metastatic pancreatic cancer: a retrospective analysis.

Fine RL, Fogelman DR, Schreibman SM, Desai M, Sherman W, Strauss J, Guba S, Andrade R, Chabot J.

Cancer Chemother Pharmacol. 2008 Jan;61(1):167-75. Epub 2007 Apr 18. Erratum in: Cancer Chemother Pharmacol. 2008 Jan;61(1):177. PMID: 17440727 [PubMed - indexed for MEDLINE]Related articles

Strategy for reversing resistance to a single anticancer agent in human prostate and pancreatic carcinomas.

Lebedeva IV, Washington I, Sarkar D, Clark JA, Fine RL, Dent P, Curiel DT, Turro NJ, Fisher PB.

Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3484-9. Epub 2007 Feb 21.PMID: 17360670 [PubMed - indexed for MEDLINE]Related articlesFree article

Ethical and practical issues with opioids in life-limiting illness.

Fine RL.

Proc (Bayl Univ Med Cent). 2007 Jan;20(1):5-12.PMID: 17256034 [PubMed - in process]Related articlesFree article

Randomized study of paclitaxel and tamoxifen deposition into human brain tumors: implications for the treatment of metastatic brain tumors.

Fine RL, Chen J, Balmaceda C, Bruce JN, Huang M, Desai M, Sisti MB, McKhann GM, Goodman RR, Bertino JS Jr, Nafziger AN, Fetell MR.

Clin Cancer Res. 2006 Oct 1;12(19):5770-6.PMID: 17020983 [PubMed - indexed for MEDLINE]Related articlesFree article

Androgen and c-Kit receptors in desmoplastic small round cell tumors resistant to chemotherapy: novel targets for therapy.

Fine RL, Shah SS, Moulton TA, Yu IR, Fogelman DR, Richardson M, Burris HA, Samuels BL, Assanasen C, Gorroochurn P, Hibshoosh H, Orjuela M, Garvin J, Goldman FD, Dubovsky D, Walterhouse D, Halligan G.

Cancer Chemother Pharmacol. 2007 Mar;59(4):429-37. Epub 2006 Aug 3.PMID: 16896931 [PubMed - indexed for MEDLINE]Related articles

Perioperative immunomodulation with Flt3 kinase ligand or a whole tumor cell vaccine is associated with a reduction in lung metastasis formation after laparotomy in mice.

Carter JJ, Feingold DL, Oh A, Kirman I, Wildbrett P, Stapleton G, Asi Z, Fowler R, Bhagat G, Huang EH, Fine RL, Whelan RL.

Surg Innov. 2006 Mar;13(1):41-7.PMID: 16708154 [PubMed - indexed for MEDLINE]Related articles

PNC-28, a p53-derived peptide that is cytotoxic to cancer cells, blocks pancreatic cancer cell growth in vivo.

Michl J, Scharf B, Schmidt A, Huynh C, Hannan R, von Gizycki H, Friedman FK, Brandt-Rauf P, Fine RL, Pincus MR.

Int J Cancer. 2006 Oct 1;119(7):1577-85.PMID: 16688716 [PubMed - indexed for MEDLINE]Related articles

Ethical issues in artificial nutrition and hydration.

Fine RL.

Nutr Clin Pract. 2006 Apr;21(2):118-25. Review.PMID: 16556921 [PubMed - indexed for MEDLINE]Related articles

Restoration of p53 function for selective Fas-mediated apoptosis in human and rat glioma cells in vitro and in vivo by a p53 COOH-terminal peptide.

Senatus PB, Li Y, Mandigo C, Nichols G, Moise G, Mao Y, Brown MD, Anderson RC, Parsa AT, Brandt-Rauf PW, Bruce JN, Fine RL.

Mol Cancer Ther. 2006 Jan;5(1):20-8.PMID: 16432159 [PubMed - indexed for MEDLINE]Related articlesFree article

Significant reduction of laparotomy-associated lung metastases and subcutaneous tumors after perioperative immunomodulation with flt3 ligand in mice.

Carter JJ, Feingold DL, Wildbrett P, Oh A, Kirman I, Asi Z, Stapleton G, Huang E, Fine RL, Whelan RL.

Surg Innov. 2005 Dec;12(4):319-25.PMID: 16424952 [PubMed - indexed for MEDLINE]Related articles

Tamoxifen paradoxically decreases paclitaxel deposition into cerebrospinal fluid of brain tumor patients.

Chen J, Balmaceda C, Bruce JN, Sisti MB, Huang M, Cheung YK, McKhann GM, Goodman RR, Fine RL.

J Neurooncol. 2006 Jan;76(1):85-92.PMID: 16402278 [PubMed - indexed for MEDLINE]Related articles

Medical futility and the Texas Advance Directives Act of 1999.

Fine RL.

Proc (Bayl Univ Med Cent). 2000 Apr;13(2):144-7. No abstract available. PMID: 16389368 [PubMed]Related articlesFree article

Depression, anxiety, and delirium in the terminally ill patient.

Fine RL.

Proc (Bayl Univ Med Cent). 2001 Apr;14(2):130-3. No abstract available. PMID: 16369601 [PubMed]Related articlesFree article

Medical futility in the neonatal intensive care unit: hope for a resolution.

Fine RL, Whitfield JM, Carr BL, Mayo TW.

Pediatrics. 2005 Nov;116(5):1219-22.PMID: 16264011 [PubMed - indexed for MEDLINE]Related articlesFree article

Robert Lee Fine, MD: a conversation with the editor. Interview by William Clifford Roberts.

Fine RL.

Proc (Bayl Univ Med Cent). 2005 Oct;18(4):379-93. No abstract available. PMID: 16252030 [PubMed]Related articlesFree article

From Quinlan to Schiavo: medical, ethical, and legal issues in severe brain injury.

Fine RL.

Proc (Bayl Univ Med Cent). 2005 Oct;18(4):303-10. No abstract available. PMID: 16252019 [PubMed]Related articlesFree article

The imperative for hospital-based palliative care: patient, institutional, and societal benefits.

Fine RL.

Proc (Bayl Univ Med Cent). 2004 Jul;17(3):259-64.PMID: 16200109 [PubMed]Related articlesFree article

The history of institutional ethics at Baylor University Medical Center.

Fine RL.

Proc (Bayl Univ Med Cent). 2004 Jan;17(1):73-82. No abstract available. PMID: 16200091 [PubMed]Related articlesFree article

Selective induction of apoptosis in mutant p53 premalignant and malignant cancer cells by PRIMA-1 through the c-Jun-NH2-kinase pathway.

Li Y, Mao Y, Brandt-Rauf PW, Williams AC, Fine RL.

Mol Cancer Ther. 2005 Jun;4(6):901-9.PMID: 15956247 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of alpha-helical structure in p53 peptides as a determinant for their mechanism of cell death: necrosis versus apoptosis.

Rosal R, Brandt-Rauf P, Pincus MR, Wang H, Mao Y, Li Y, Fine RL.

Adv Drug Deliv Rev. 2005 Feb 28;57(4):653-60. Epub 2005 Jan 8. Review.PMID: 15722169 [PubMed - indexed for MEDLINE]Related articles

Selective induction of apoptosis through the FADD/caspase-8 pathway by a p53 c-terminal peptide in human pre-malignant and malignant cells.

Li Y, Mao Y, Rosal RV, Dinnen RD, Williams AC, Brandt-Rauf PW, Fine RL.

Int J Cancer. 2005 May 20;115(1):55-64.PMID: 15645452 [PubMed - indexed for MEDLINE]Related articles

BRD-glucan exhibits potent immunochemotherapeutic activity in vitro and in vivo.

Moon SH, Heo JC, Fine RL, Kim HM, Kim SU, Yoon BD, Lee SH.

Int J Oncol. 2005 Feb;26(2):395-404.PMID: 15645124 [PubMed - indexed for MEDLINE]Related articles

Panniculitis after vaccination against CEA and MUC1 in a patient with pancreatic cancer.

Kaufman HL, Harandi A, Watson MC, Carter EL, DeRaffele G, Shahid M, Fine RL.

Lancet Oncol. 2005 Jan;6(1):62-3. No abstract available. PMID: 15629278 [PubMed - indexed for MEDLINE]Related articles

Pancreatic cancer and thromboembolic disease.

Khorana AA, Fine RL.

Lancet Oncol. 2004 Nov;5(11):655-63. Review.PMID: 15522652 [PubMed - indexed for MEDLINE]Related articles

Computational protein chemistry of p53 and p53 peptides.

Brandt-Rauf PW, Rosal RV, Fine RL, Pincus MR.

Front Biosci. 2004 Sep 1;9:2778-87. Review.PMID: 15353313 [PubMed - indexed for MEDLINE]Related articles

The evolution of adjuvant and neoadjuvant chemotherapy and radiation for advanced pancreatic cancer: from 5-fluorouracil to GTX.

Fogelman DR, Chen J, Chabot JA, Allendorf JD, Schrope BA, Ennis RD, Schreibman SM, Fine RL.

Surg Oncol Clin N Am. 2004 Oct;13(4):711-35, x. Review.PMID: 15350944 [PubMed - indexed for MEDLINE]Related articles

Advances in the Genetic Screening, Work-up, and Treatment of Pancreatic Cancer.

Frucht H, Stevens PD, Fogelman DR, Verna EC, Chen J, Chabot JA, Fine RL.

Curr Treat Options Gastroenterol. 2004 Oct;7(5):343-354.PMID: 15345205 [PubMed - as supplied by publisher]Related articles

NMR solution structure of a peptide from the mdm-2 binding domain of the p53 protein that is selectively cytotoxic to cancer cells.

Rosal R, Pincus MR, Brandt-Rauf PW, Fine RL, Michl J, Wang H.

Biochemistry. 2004 Feb 24;43(7):1854-61.PMID: 14967026 [PubMed - indexed for MEDLINE]Related articles

Resolution of futility by due process: early experience with the Texas Advance Directives Act.

Fine RL, Mayo TW.

Ann Intern Med. 2003 May 6;138(9):743-6.PMID: 12729429 [PubMed - indexed for MEDLINE]Related articlesFree article

Fas-mediated apoptosis is dependent on wild-type p53 status in human cancer cells expressing a temperature-sensitive p53 mutant alanine-143.

Li Y, Raffo AJ, Drew L, Mao Y, Tran A, Petrylak DP, Fine RL.

Cancer Res. 2003 Apr 1;63(7):1527-33.PMID: 12670900 [PubMed - indexed for MEDLINE]Related articlesFree article

Preferential induction of necrosis in human breast cancer cells by a p53 peptide derived from the MDM2 binding site.

Do TN, Rosal RV, Drew L, Raffo AJ, Michl J, Pincus MR, Friedman FK, Petrylak DP, Cassai N, Szmulewicz J, Sidhu G, Fine RL, Brandt-Rauf PW.

Oncogene. 2003 Mar 13;22(10):1431-44.PMID: 12629507 [PubMed - indexed for MEDLINE]Related articles

The novel antimicrotubule agent cryptophycin 52 (LY355703) induces apoptosis via multiple pathways in human prostate cancer cells.

Drew L, Fine RL, Do TN, Douglas GP, Petrylak DP.

Clin Cancer Res. 2002 Dec;8(12):3922-32.PMID: 12473608 [PubMed - indexed for MEDLINE]Related articlesFree article

Correlation between hydrophobic properties and efficiency of carrier-mediated membrane transduction and apoptosis of a p53 C-terminal peptide.

Li Y, Rosal RV, Brandt-Rauf PW, Fine RL.

Biochem Biophys Res Commun. 2002 Nov 1;298(3):439-49.PMID: 12413961 [PubMed - indexed for MEDLINE]Related articles

Treatment preferences of seriously ill patients.

Fine RL.

N Engl J Med. 2002 Aug 15;347(7):533-5; author reply 533-5. No abstract available. PMID: 12182184 [PubMed - indexed for MEDLINE]Related articles

A novel stereo-selective sulfonylurea, 1-[1-(4-aminobenzoyl)-2,3-dihydro-1H-indol-6-sulfonyl]-4-phenyl-imidazolidin-2-one, has antitumor efficacy in in vitro and in vivo tumor models.

Lee CW, Hong DH, Han SB, Jung SH, Kim HC, Fine RL, Lee SH, Kim HM.

Biochem Pharmacol. 2002 Aug 1;64(3):473-80.PMID: 12147299 [PubMed - indexed for MEDLINE]Related articles

Peptides from the amino terminal mdm-2-binding domain of p53, designed from conformational analysis, are selectively cytotoxic to transformed cells.

Kanovsky M, Raffo A, Drew L, Rosal R, Do T, Friedman FK, Rubinstein P, Visser J, Robinson R, Brandt-Rauf PW, Michl J, Fine RL, Pincus MR.

Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12438-43. Epub 2001 Oct 16.PMID: 11606716 [PubMed - indexed for MEDLINE]Related articlesFree article

Combination gemcitabine and docetaxel therapy in advanced adenocarcinoma of the pancreas.

Sherman WH, Fine RL.

Oncology. 2001;60(4):316-21.PMID: 11408799 [PubMed - indexed for MEDLINE]Related articles

The Texas Advance Directives Act of 1999: politics and reality.

Fine RL.

HEC Forum. 2001 Mar;13(1):59-81. No abstract available. PMID: 11307584 [PubMed - indexed for MEDLINE]Related articles