PubMed

Functional magnetic resonance imaging of the spinal cord during sensory stimulation in diabetic rats.

Malisza KL, Jones C, Gruwel ML, Foreman D, Fernyhough P, Calcutt NA.

J Magn Reson Imaging. 2009 Aug;30(2):271-6.PMID: 19629995 [PubMed - indexed for MEDLINE]Related articles

4-Hydroxy-2-Nonenal Induces Mitochondrial Dysfunction and Aberrant Axonal Outgrowth in Adult Sensory Neurons that Mimics Features of Diabetic Neuropathy.

Akude E, Zherebitskaya E, Roy Chowdhury SK, Girling K, Fernyhough P.

Neurotox Res. 2009 Jun 26. [Epub ahead of print]PMID: 19557324 [PubMed - as supplied by publisher]Related articles

Nuclear factor-kappaB activation in axons and Schwann cells in experimental sciatic nerve injury and its role in modulating axon regeneration: studies with etanercept.

Smith D, Tweed C, Fernyhough P, Glazner GW.

J Neuropathol Exp Neurol. 2009 Jun;68(6):691-700.PMID: 19458540 [PubMed - indexed for MEDLINE]Related articles

Development of selective axonopathy in adult sensory neurons isolated from diabetic rats: role of glucose-induced oxidative stress.

Zherebitskaya E, Akude E, Smith DR, Fernyhough P.

Diabetes. 2009 Jun;58(6):1356-64. Epub 2009 Feb 27.PMID: 19252136 [PubMed - indexed for MEDLINE]Related articlesFree article

Distal degenerative sensory neuropathy in a long-term type 2 diabetes rat model.

Brussee V, Guo G, Dong Y, Cheng C, Martinez JA, Smith D, Glazner GW, Fernyhough P, Zochodne DW.

Diabetes. 2008 Jun;57(6):1664-73. Epub 2008 Mar 10.PMID: 18332094 [PubMed - indexed for MEDLINE]Related articlesFree article

Blockade of hexokinase activity and binding to mitochondria inhibits neurite outgrowth in cultured adult rat sensory neurons.

Wang Z, Gardiner NJ, Fernyhough P.

Neurosci Lett. 2008 Mar 21;434(1):6-11. Epub 2008 Jan 31.PMID: 18308470 [PubMed - indexed for MEDLINE]Related articles

Growth factors as therapeutics for diabetic neuropathy.

Calcutt NA, Jolivalt CG, Fernyhough P.

Curr Drug Targets. 2008 Jan;9(1):47-59. Review.PMID: 18220712 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial malfunction and Ca2+ dyshomeostasis drive neuronal pathology in diabetes.

Verkhratsky A, Fernyhough P.

Cell Calcium. 2008 Jul;44(1):112-22. Epub 2008 Jan 11. Review.PMID: 18191198 [PubMed - indexed for MEDLINE]Related articles

Expression of hexokinase isoforms in the dorsal root ganglion of the adult rat and effect of experimental diabetes.

Gardiner NJ, Wang Z, Luke C, Gott A, Price SA, Fernyhough P.

Brain Res. 2007 Oct 17;1175:143-54. Epub 2007 Aug 14.PMID: 17803972 [PubMed - indexed for MEDLINE]Related articles

Insulin-like growth factor-1-dependent maintenance of neuronal metabolism through the phosphatidylinositol 3-kinase-Akt pathway is inhibited by C2-ceramide in CAD cells.

Arboleda G, Huang TJ, Waters C, Verkhratsky A, Fernyhough P, Gibson RM.

Eur J Neurosci. 2007 May;25(10):3030-8.PMID: 17561816 [PubMed - indexed for MEDLINE]Related articles

Preconditioning injury-induced neurite outgrowth of adult rat sensory neurons on fibronectin is mediated by mobilisation of axonal alpha5 integrin.

Gardiner NJ, Moffatt S, Fernyhough P, Humphries MJ, Streuli CH, Tomlinson DR.

Mol Cell Neurosci. 2007 Jun;35(2):249-60. Epub 2007 Mar 6.PMID: 17433878 [PubMed - indexed for MEDLINE]Related articles

Neurotrophin-3 prevents mitochondrial dysfunction in sensory neurons of streptozotocin-diabetic rats.

Huang TJ, Sayers NM, Verkhratsky A, Fernyhough P.

Exp Neurol. 2005 Jul;194(1):279-83.PMID: 15899264 [PubMed - indexed for MEDLINE]Related articles

Activation of nuclear factor-kappaB via endogenous tumor necrosis factor alpha regulates survival of axotomized adult sensory neurons.

Fernyhough P, Smith DR, Schapansky J, Van Der Ploeg R, Gardiner NJ, Tweed CW, Kontos A, Freeman L, Purves-Tyson TD, Glazner GW.

J Neurosci. 2005 Feb 16;25(7):1682-90.PMID: 15716404 [PubMed - indexed for MEDLINE]Related articlesFree article

Alpha7 integrin mediates neurite outgrowth of distinct populations of adult sensory neurons.

Gardiner NJ, Fernyhough P, Tomlinson DR, Mayer U, von der Mark H, Streuli CH.

Mol Cell Neurosci. 2005 Feb;28(2):229-40.PMID: 15691705 [PubMed - indexed for MEDLINE]Related articles

Insulin enhances mitochondrial inner membrane potential and increases ATP levels through phosphoinositide 3-kinase in adult sensory neurons.

Huang TJ, Verkhratsky A, Fernyhough P.

Mol Cell Neurosci. 2005 Jan;28(1):42-54.PMID: 15607940 [PubMed - indexed for MEDLINE]Related articles

Activation of JNK in sensory neurons protects against sensory neuron cell death in diabetes and on exposure to glucose/oxidative stress in vitro.

Price SA, Hounsom L, Purves-Tyson TD, Fernyhough P, Tomlinson DR.

Ann N Y Acad Sci. 2003 Dec;1010:95-9.PMID: 15033701 [PubMed - indexed for MEDLINE]Related articles

Mechanism of mitochondrial dysfunction in diabetic sensory neuropathy.

Fernyhough P, Huang TJ, Verkhratsky A.

J Peripher Nerv Syst. 2003 Dec;8(4):227-35.PMID: 14641647 [PubMed - indexed for MEDLINE]Related articles

Peripheral axon crush elevates transport of p75NTR in the central projection of sensory neurones of rats.

Delcroix JD, Patel J, Averill S, Tomlinson DR, Priestley JV, Fernyhough P.

Neurosci Lett. 2003 Nov 20;351(3):181-5.PMID: 14623136 [PubMed - indexed for MEDLINE]Related articles

Neurotrophin-3 prevents the proximal accumulation of neurofilament proteins in sensory neurons of streptozocin-induced diabetic rats.

Sayers NM, Beswick LJ, Middlemas A, Calcutt NA, Mizisin AP, Tomlinson DR, Fernyhough P.

Diabetes. 2003 Sep;52(9):2372-80.PMID: 12941778 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin prevents depolarization of the mitochondrial inner membrane in sensory neurons of type 1 diabetic rats in the presence of sustained hyperglycemia.

Huang TJ, Price SA, Chilton L, Calcutt NA, Tomlinson DR, Verkhratsky A, Fernyhough P.

Diabetes. 2003 Aug;52(8):2129-36.PMID: 12882932 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced activation of axonally transported stress-activated protein kinases in peripheral nerve in diabetic neuropathy is prevented by neurotrophin-3.

Middlemas A, Delcroix JD, Sayers NM, Tomlinson DR, Fernyhough P.

Brain. 2003 Jul;126(Pt 7):1671-82. Epub 2003 Apr 22.PMID: 12805110 [PubMed - indexed for MEDLINE]Related articlesFree article

Neuronal survival in the balance: are endoplasmic reticulum membrane proteins the fulcrum?

Glazner GW, Fernyhough P.

Cell Calcium. 2002 Nov-Dec;32(5-6):421-33. Review. No abstract available. PMID: 12543101 [PubMed - indexed for MEDLINE]Related articles

Neurofilaments in diabetic neuropathy.

Fernyhough P, Schmidt RE.

Int Rev Neurobiol. 2002;50:115-44. Review.PMID: 12198808 [PubMed - indexed for MEDLINE]Related articles

Xestospongin C empties the ER calcium store but does not inhibit InsP3-induced Ca2+ release in cultured dorsal root ganglia neurones.

Solovyova N, Fernyhough P, Glazner G, Verkhratsky A.

Cell Calcium. 2002 Jul;32(1):49-52.PMID: 12127062 [PubMed - indexed for MEDLINE]Related articles

Diabetes-induced alterations in calcium homeostasis in sensory neurones of streptozotocin-diabetic rats are restricted to lumbar ganglia and are prevented by neurotrophin-3.

Huang TJ, Sayers NM, Fernyhough P, Verkhratsky A.

Diabetologia. 2002 Apr;45(4):560-70.PMID: 12032634 [PubMed - indexed for MEDLINE]Related articles

A role for mitogen-activated protein kinases in the etiology of diabetic neuropathy.

Purves T, Middlemas A, Agthong S, Jude EB, Boulton AJ, Fernyhough P, Tomlinson DR.

FASEB J. 2001 Nov;15(13):2508-14.PMID: 11689477 [PubMed - indexed for MEDLINE]Related articlesFree article

Nerve growth factor modulates the activation status and fast axonal transport of ERK 1/2 in adult nociceptive neurones.

Averill S, Delcroix JD, Michael GJ, Tomlinson DR, Fernyhough P, Priestley JV.

Mol Cell Neurosci. 2001 Aug;18(2):183-96.PMID: 11520179 [PubMed - indexed for MEDLINE]Related articles

Quantification of mRNA levels using northern blotting.

Fernyhough P.

Methods Mol Biol. 2001;169:53-63. No abstract available. PMID: 11142020 [PubMed - indexed for MEDLINE]Related articles

Contraction-induced muscle fiber damage is increased in soleus muscle of streptozotocin-diabetic rats and is associated with elevated expression of brain-derived neurotrophic factor mRNA in muscle fibers and activated satellite cells.

Copray S, Liem R, Brouwer N, Greenhaff P, Habens F, Fernyhough P.

Exp Neurol. 2000 Feb;161(2):597-608.PMID: 10686079 [PubMed - indexed for MEDLINE]Related articles

Neurotrophin-3 reverses nerve conduction velocity deficits in streptozotocin-diabetic rats.

Mizisin AP, Calcutt NA, Tomlinson DR, Gallagher A, Fernyhough P.

J Peripher Nerv Syst. 1999;4(3-4):211-21.PMID: 10642089 [PubMed - indexed for MEDLINE]Related articles

Transforming growth factor-beta1 and glial growth factor 2 reduce neurotrophin-3 mRNA expression in cultured Schwann cells via a cAMP-dependent pathway.

Cai F, Campana WM, Tomlinson DR, Fernyhough P.

Brain Res Mol Brain Res. 1999 Aug 25;71(2):256-64.PMID: 10521580 [PubMed - indexed for MEDLINE]Related articles

Axonal transport of activating transcription factor-2 is modulated by nerve growth factor in nociceptive neurons.

Delcroix JD, Averill S, Fernandes K, Tomlinson DR, Priestley JV, Fernyhough P.

J Neurosci. 1999 Sep 15;19(18):RC24.PMID: 10479717 [PubMed - indexed for MEDLINE]Related articlesFree article

Focally administered nerve growth factor suppresses molecular regenerative responses of axotomized peripheral afferents in rats.

Mohiuddin L, Delcroix JD, Fernyhough P, Tomlinson DR.

Neuroscience. 1999;91(1):265-71.PMID: 10336076 [PubMed - indexed for MEDLINE]Related articles

Increased nerve growth factor mRNA in lateral calf skin biopsies from diabetic patients.

Diemel LT, Cai F, Anand P, Warner G, Kopelman PG, Fernyhough P, Tomlinson DR.

Diabet Med. 1999 Feb;16(2):113-8.PMID: 10229303 [PubMed - indexed for MEDLINE]Related articles

Elevated expression of neurotrophin-3 mRNA in sensory nerve of streptozotocin-diabetic rats.

Cai F, Tomlinson DR, Fernyhough P.

Neurosci Lett. 1999 Mar 26;263(2-3):81-4.PMID: 10213140 [PubMed - indexed for MEDLINE]Related articles

Aberrant neurofilament phosphorylation in sensory neurons of rats with diabetic neuropathy.

Fernyhough P, Gallagher A, Averill SA, Priestley JV, Hounsom L, Patel J, Tomlinson DR.

Diabetes. 1999 Apr;48(4):881-9.PMID: 10102707 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of nerve growth factor treatment on p75NTR gene expression in lumbar dorsal root ganglia of streptozocin-induced diabetic rats.

Delcroix JD, Michael GJ, Priestley JV, Tomlinson DR, Fernyhough P.

Diabetes. 1998 Nov;47(11):1779-85.PMID: 9792548 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of sciatic nerve crush on local and target tissue production of neurotrophin-3 transcripts in rats.

Cai F, Tomlinson DR, Fernyhough P.

Neurosci Lett. 1998 Aug 7;252(1):45-8.PMID: 9756355 [PubMed - indexed for MEDLINE]Related articles

Stimulation of nerve growth-factor and substance P expression in the iris-trigeminal axis of diabetic rats--involvement of oxidative stress and effects of aldose reductase inhibition.

Fernyhough P, Brewster WJ, Fernandes K, Diemel LT, Tomlinson DR.

Brain Res. 1998 Aug 17;802(1-2):247-53.PMID: 9748608 [PubMed - indexed for MEDLINE]Related articles

Target tissue production and axonal transport of neurotrophin-3 are reduced in streptozotocin-diabetic rats.

Fernyhough P, Diemel LT, Tomlinson DR.

Diabetologia. 1998 Mar;41(3):300-6.PMID: 9541170 [PubMed - indexed for MEDLINE]Related articles

Diabetes and axotomy-induced deficits in retrograde axonal transport of nerve growth factor correlate with decreased levels of p75LNTR protein in lumbar dorsal root ganglia.

Delcroix JD, Tomlinson DR, Fernyhough P.

Brain Res Mol Brain Res. 1997 Nov;51(1-2):82-90.PMID: 9427509 [PubMed - indexed for MEDLINE]Related articles

Role of neurotrophins in diabetic neuropathy and treatment with nerve growth factors.

Tomlinson DR, Fernyhough P, Diemel LT.

Diabetes. 1997 Sep;46 Suppl 2:S43-9.PMID: 9285498 [PubMed - indexed for MEDLINE]Related articles

Brain-derived neurotrophic factor mRNA levels are up-regulated in hindlimb skeletal muscle of diabetic rats: effect of denervation.

Fernyhough P, Maeda K, Tomlinson DR.

Exp Neurol. 1996 Oct;141(2):297-303.PMID: 8812163 [PubMed - indexed for MEDLINE]Related articles

Acidic fibroblast growth factor enhances neurite outgrowth and stimulates expression of GAP-43 and T alpha 1 alpha-tubulin in cultured neurones from adult rat dorsal root ganglia.

Mohiuddin L, Fernyhough P, Tomlinson DR.

Neurosci Lett. 1996 Sep 6;215(2):111-4.PMID: 8888008 [PubMed - indexed for MEDLINE]Related articles

Deficient neurotrophic support in the aetiology of diabetic neuropathy.

Tomlinson DR, Fernyhough P, Diemel LT, Maeda K.

Diabet Med. 1996 Jul;13(7):679-81. Review. No abstract available. PMID: 8840106 [PubMed - indexed for MEDLINE]Related articles

Regenerating sensory neurones of diabetic rats express reduced levels of mRNA for GAP-43, gamma-preprotachykinin and the nerve growth factor receptors, trkA and p75NGFR.

Maeda K, Fernyhough P, Tomlinson DR.

Brain Res Mol Brain Res. 1996 Apr;37(1-2):166-74.PMID: 8738148 [PubMed - indexed for MEDLINE]Related articles

Neurotrophins and peripheral neuropathy.

Tomlinson DR, Fernyhough P, Diemel LT.

Philos Trans R Soc Lond B Biol Sci. 1996 Mar 29;351(1338):455-62. Review.PMID: 8730785 [PubMed - indexed for MEDLINE]Related articles

Nerve growth factor treatment of adult rats selectively enhances innervation of urinogenital tract rather than vascular smooth muscle.

Milner P, Crowe R, Fernyhough P, Diemel LT, Tomlinson DR, Burnstock G.

Int J Dev Neurosci. 1995 Aug;13(5):393-401.PMID: 7484210 [PubMed - indexed for MEDLINE]Related articles

Human recombinant nerve growth factor replaces deficient neurotrophic support in the diabetic rat.

Fernyhough P, Diemel LT, Hardy J, Brewster WJ, Mohiuddin L, Tomlinson DR.

Eur J Neurosci. 1995 May 1;7(5):1107-10.PMID: 7613616 [PubMed - indexed for MEDLINE]Related articles

Altered neurotrophin mRNA levels in peripheral nerve and skeletal muscle of experimentally diabetic rats.

Fernyhough P, Diemel LT, Brewster WJ, Tomlinson DR.

J Neurochem. 1995 Mar;64(3):1231-7.PMID: 7861156 [PubMed - indexed for MEDLINE]Related articles