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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 1
2001 1
2002 1
2009 1
2010 3
2012 3
2013 1
2015 1
2016 1
2018 1
2019 1
2020 1
2021 4
2022 6
2023 4
2024 4

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30 results

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Page 1
Efficacy and Safety of Fenfluramine in Epilepsy: A Systematic Review and Meta-analysis.
Tabaee Damavandi P, Fabin N, Giossi R, Matricardi S, Del Giovane C, Striano P, Meletti S, Brigo F, Trinka E, Lattanzi S. Tabaee Damavandi P, et al. Neurol Ther. 2023 Apr;12(2):669-686. doi: 10.1007/s40120-023-00452-1. Epub 2023 Feb 28. Neurol Ther. 2023. PMID: 36853503 Free PMC article.
INTRODUCTION: Fenfluramine (FFA) is an amphetamine derivative that promotes the release and blocks the neuronal reuptake of serotonin. ...Decreased appetite, diarrhoea, fatigue, and weight loss were AEs associated with FFA treatment. CONCLUSION: Fenfluramine reduces …
INTRODUCTION: Fenfluramine (FFA) is an amphetamine derivative that promotes the release and blocks the neuronal reuptake of serotonin …
Pharmacotherapy for Dravet Syndrome: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.
Lattanzi S, Trinka E, Russo E, Del Giovane C, Matricardi S, Meletti S, Striano P, Damavandi PT, Silvestrini M, Brigo F. Lattanzi S, et al. Drugs. 2023 Oct;83(15):1409-1424. doi: 10.1007/s40265-023-01936-y. Epub 2023 Sep 11. Drugs. 2023. PMID: 37695433 Free PMC article.
RESULTS: Eight placebo-controlled trials were included, and the active add-on treatments were stiripentol (n = 2), pharmaceutical-grade cannabidiol (n = 3), fenfluramine hydrochloride (n = 2), and soticlestat (n = 1). The studies recruited 680 participants, of whom 409 wer …
RESULTS: Eight placebo-controlled trials were included, and the active add-on treatments were stiripentol (n = 2), pharmaceutical-grade cann …
Pharmacological Treatments for Cocaine Craving: What Is the Way Forward? A Systematic Review.
Lassi DLS, Malbergier A, Negrão AB, Florio L, De Aquino JP, Castaldelli-Maia JM. Lassi DLS, et al. Brain Sci. 2022 Nov 14;12(11):1546. doi: 10.3390/brainsci12111546. Brain Sci. 2022. PMID: 36421870 Free PMC article. Review.
In the short-term treatment, acute phenylalanine-tyrosine depletion, clonidine, fenfluramine, meta-chlorophenylpiperazine (m-CPP) and mecamylamine presented promising effects. ...CONCLUSIONS: There is a direct association between craving and cocaine use, underscoring cravi …
In the short-term treatment, acute phenylalanine-tyrosine depletion, clonidine, fenfluramine, meta-chlorophenylpiperazine (m-CPP) and …
Efficacy and tolerability of fenfluramine in patients with Dravet syndrome: A systematic review and meta-analysis.
Sharawat IK, Panda PK, Kasinathan A, Panda P, Dawman L, Joshi K. Sharawat IK, et al. Seizure. 2021 Feb;85:119-126. doi: 10.1016/j.seizure.2020.12.016. Epub 2021 Jan 11. Seizure. 2021. PMID: 33461030 Free article.
The primary outcome for the efficacy of fenfluramine was reduction in monthly convulsive seizure frequency. We carried out a random effect meta-analysis focusing on efficacy and safety variables. ...The incidence of serious adverse events was not greater in the fenflura …
The primary outcome for the efficacy of fenfluramine was reduction in monthly convulsive seizure frequency. We carried out a random e …
Efficacy of pharmacotherapies for bulimia nervosa: a systematic review and meta-analysis.
Yu S, Zhang Y, Shen C, Shao F. Yu S, et al. BMC Pharmacol Toxicol. 2023 Dec 2;24(1):72. doi: 10.1186/s40360-023-00713-7. BMC Pharmacol Toxicol. 2023. PMID: 38042827 Free PMC article.
RESULTS: The literature search ultimately included 11 drugs, 33 studies and 6 types of drugs, 8 trials with TCAs (imipramine, desipramine), 14 with SSRIs (fluoxetine, citalopram and fluvoxamine), 6 with MAOIs (phenelzine, moclobemide and brofaromine), 3 with antiepileptic drugs ( …
RESULTS: The literature search ultimately included 11 drugs, 33 studies and 6 types of drugs, 8 trials with TCAs (imipramine, desipramine), …
Comparative efficacy and safety of stiripentol, cannabidiol and fenfluramine as first-line add-on therapies for seizures in Dravet syndrome: A network meta-analysis.
Guerrini R, Chiron C, Vandame D, Linley W, Toward T. Guerrini R, et al. Epilepsia Open. 2024 Apr;9(2):689-703. doi: 10.1002/epi4.12923. Epub 2024 Mar 1. Epilepsia Open. 2024. PMID: 38427284 Free PMC article.
OBJECTIVES: Stiripentol, fenfluramine, and cannabidiol are licensed add-on therapies to treat seizures in Dravet Syndrome (DS). ...The study found that stiripentol and fenfluramine were similarly effective in reducing seizures and both were more effective than canna …
OBJECTIVES: Stiripentol, fenfluramine, and cannabidiol are licensed add-on therapies to treat seizures in Dravet Syndrome (DS). ...Th …
Breastfeeding while on treatment with antiseizure medications: a systematic review from the ILAE Women Task Force.
Tomson T, Battino D, Bromley R, Kochen S, Meador KJ, Pennell PB, Thomas SV. Tomson T, et al. Epileptic Disord. 2022 Dec 1;24(6):1020-1032. doi: 10.1684/epd.2022.1492. Epileptic Disord. 2022. PMID: 36193017 Free article. English.
No data on ASM levels in breastmilk or in breastfed infants was identified for cannabidiol, cenobamate, clobazam, eslicarbazepine-acetate, everolimus, felbamate, fenfluramine, retigabine, rufinamide, stiripentol, tiagabine, and vigabatrin. ...
No data on ASM levels in breastmilk or in breastfed infants was identified for cannabidiol, cenobamate, clobazam, eslicarbazepine-acetate, e …
Efficacy and safety of fenfluramine in patients with Dravet syndrome: A meta-analysis.
Zhang L, Li W, Wang C. Zhang L, et al. Acta Neurol Scand. 2021 Apr;143(4):339-348. doi: 10.1111/ane.13387. Epub 2020 Dec 17. Acta Neurol Scand. 2021. PMID: 33336426
The pooled RR of 5.49 (95% CI 3.13-9.65) showed that a significantly greater proportion in the fenfluramine group achieved 50% reduction in monthly convulsive seizure frequency (MCSF). ...However, a significantly greater proportion of patients in the fenfluramine gr …
The pooled RR of 5.49 (95% CI 3.13-9.65) showed that a significantly greater proportion in the fenfluramine group achieved 50% reduct …
Efficacy and safety of adjunctive antiseizure medications for dravet syndrome: A systematic review and network meta-analysis.
Wu J, Zhang L, Zhou X, Wang J, Zheng X, Hu H, Wu D. Wu J, et al. Front Pharmacol. 2022 Aug 31;13:980937. doi: 10.3389/fphar.2022.980937. eCollection 2022. Front Pharmacol. 2022. PMID: 36120377 Free PMC article.
Results: Seven RCTs involving four antiseizure medications (stiripentol, cannabidiol, fenfluramine, and soticlestat) and a total of 634 patients were included in the analysis. ...Conclusion: According to the results of indirect comparison of efficacy and safety, cannabidio …
Results: Seven RCTs involving four antiseizure medications (stiripentol, cannabidiol, fenfluramine, and soticlestat) and a total of 6 …
Brain serotonin neurotoxicity and primary pulmonary hypertension from fenfluramine and dexfenfluramine. A systematic review of the evidence.
McCann UD, Seiden LS, Rubin LJ, Ricaurte GA. McCann UD, et al. JAMA. 1997 Aug 27;278(8):666-72. JAMA. 1997. PMID: 9272900 Review.
DATA SOURCES: Archival articles and reviews identified through a computerized search of MEDLINE from 1966 to April 1997 using "fenfluramine(s)," "serotonin," "neurotoxicity," "behavior," "anorexigens," "weight loss," and "primary pulmonary hypertension" as index ter …
DATA SOURCES: Archival articles and reviews identified through a computerized search of MEDLINE from 1966 to April 1997 using "fenflurami …
30 results