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    Results: 1 to 50 of 91

    1.

    Prevalence of loss of function FTO mutations in lean and obese individuals.

    Meyre D, Proulx K, Kawagoe-Takaki H, Vatin V, Gutiérrez-Aguilar R, Lyon D, Ma M, Choquet H, Horber F, Van Hul W, Van Gaal L, Balkau B, Visvikis-Siest S, Pattou F, Farooqi IS, Saudek V, O'Rahilly S, Froguel P, Sedgwick B, Yeo GS.

    Diabetes. 2009 Oct 15. [Epub ahead of print]PMID: 19833892 [PubMed - as supplied by publisher]Related articles

    2.

    Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations.

    Boissel S, Reish O, Proulx K, Kawagoe-Takaki H, Sedgwick B, Yeo GS, Meyre D, Golzio C, Molinari F, Kadhom N, Etchevers HC, Saudek V, Farooqi IS, Froguel P, Lindahl T, O'Rahilly S, Munnich A, Colleaux L.

    Am J Hum Genet. 2009 Jul;85(1):106-11. Epub 2009 Jun 25.PMID: 19559399 [PubMed - indexed for MEDLINE]Related articles

    3.

    A deletion of the HBII-85 class of small nucleolar RNAs (snoRNAs) is associated with hyperphagia, obesity and hypogonadism.

    de Smith AJ, Purmann C, Walters RG, Ellis RJ, Holder SE, Van Haelst MM, Brady AF, Fairbrother UL, Dattani M, Keogh JM, Henning E, Yeo GS, O'Rahilly S, Froguel P, Farooqi IS, Blakemore AI.

    Hum Mol Genet. 2009 Sep 1;18(17):3257-65. Epub 2009 Jun 4.PMID: 19498035 [PubMed - indexed for MEDLINE]Related articles

    4.

    Leptin: a pivotal regulator of human energy homeostasis.

    Farooqi IS, O'Rahilly S.

    Am J Clin Nutr. 2009 Mar;89(3):980S-984S. Epub 2009 Feb 11. Review.PMID: 19211814 [PubMed - indexed for MEDLINE]Related articles

    5.

    Human obesity as a heritable disorder of the central control of energy balance.

    O'Rahilly S, Farooqi IS.

    Int J Obes (Lond). 2008 Dec;32 Suppl 7:S55-61. Review.PMID: 19136992 [PubMed - indexed for MEDLINE]Related articles

    6.

    Modulation of blood pressure by central melanocortinergic pathways.

    Greenfield JR, Miller JW, Keogh JM, Henning E, Satterwhite JH, Cameron GS, Astruc B, Mayer JP, Brage S, See TC, Lomas DJ, O'Rahilly S, Farooqi IS.

    N Engl J Med. 2009 Jan 1;360(1):44-52. Epub 2008 Dec 17.PMID: 19092146 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.

    Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM, Berndt SI, Elliott AL, Jackson AU, Lamina C, Lettre G, Lim N, Lyon HN, McCarroll SA, Papadakis K, Qi L, Randall JC, Roccasecca RM, Sanna S, Scheet P, Weedon MN, Wheeler E, Zhao JH, Jacobs LC, Prokopenko I, Soranzo N, Tanaka T, Timpson NJ, Almgren P, Bennett A, Bergman RN, Bingham SA, Bonnycastle LL, Brown M, Burtt NP, Chines P, Coin L, Collins FS, Connell JM, Cooper C, Smith GD, Dennison EM, Deodhar P, Elliott P, Erdos MR, Estrada K, Evans DM, Gianniny L, Gieger C, Gillson CJ, Guiducci C, Hackett R, Hadley D, Hall AS, Havulinna AS, Hebebrand J, Hofman A, Isomaa B, Jacobs KB, Johnson T, Jousilahti P, Jovanovic Z, Khaw KT, Kraft P, Kuokkanen M, Kuusisto J, Laitinen J, Lakatta EG, Luan J, Luben RN, Mangino M, McArdle WL, Meitinger T, Mulas A, Munroe PB, Narisu N, Ness AR, Northstone K, O'Rahilly S, Purmann C, Rees MG, Ridderstråle M, Ring SM, Rivadeneira F, Ruokonen A, Sandhu MS, Saramies J, Scott LJ, Scuteri A, Silander K, Sims MA, Song K, Stephens J, Stevens S, Stringham HM, Tung YC, Valle TT, Van Duijn CM, Vimaleswaran KS, Vollenweider P, Waeber G, Wallace C, Watanabe RM, Waterworth DM, Watkins N; Wellcome Trust Case Control Consortium, Witteman JC, Zeggini E, Zhai G, Zillikens MC, Altshuler D, Caulfield MJ, Chanock SJ, Farooqi IS, Ferrucci L, Guralnik JM, Hattersley AT, Hu FB, Jarvelin MR, Laakso M, Mooser V, Ong KK, Ouwehand WH, Salomaa V, Samani NJ, Spector TD, Tuomi T, Tuomilehto J, Uda M, Uitterlinden AG, Wareham NJ, Deloukas P, Frayling TM, Groop LC, Hayes RB, Hunter DJ, Mohlke KL, Peltonen L, Schlessinger D, Strachan DP, Wichmann HE, McCarthy MI, Boehnke M, Barroso I, Abecasis GR, Hirschhorn JN; Genetic Investigation of ANthropometric Traits Consortium.

    Nat Genet. 2009 Jan;41(1):25-34. Epub 2008 Dec 14.PMID: 19079261 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects.

    Greenfield JR, Farooqi IS, Keogh JM, Henning E, Habib AM, Blackwood A, Reimann F, Holst JJ, Gribble FM.

    Am J Clin Nutr. 2009 Jan;89(1):106-13. Epub 2008 Dec 3.PMID: 19056578 [PubMed - indexed for MEDLINE]Related articles

    9.

    SnapShot: the hormonal control of food intake.

    Coll AP, Yeo GS, Farooqi IS, O'Rahilly S.

    Cell. 2008 Oct 31;135(3):572.e1-2. No abstract available. PMID: 18984167 [PubMed - indexed for MEDLINE]Related articles

    10.

    Human obesity: a heritable neurobehavioral disorder that is highly sensitive to environmental conditions.

    O'Rahilly S, Farooqi IS.

    Diabetes. 2008 Nov;57(11):2905-10. No abstract available. PMID: 18971438 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Functional characterization and structural modeling of obesity associated mutations in the melanocortin 4 receptor.

    Tan K, Pogozheva ID, Yeo GS, Hadaschik D, Keogh JM, Haskell-Leuvano C, O'Rahilly S, Mosberg HI, Farooqi IS.

    Endocrinology. 2009 Jan;150(1):114-25. Epub 2008 Sep 18.PMID: 18801902 [PubMed - indexed for MEDLINE]Related articles

    12.

    Mutations in ligands and receptors of the leptin-melanocortin pathway that lead to obesity.

    Farooqi IS, O'Rahilly S.

    Nat Clin Pract Endocrinol Metab. 2008 Oct;4(10):569-77. Epub 2008 Sep 9. Review.PMID: 18779842 [PubMed - indexed for MEDLINE]Related articles

    13.

    Functional characterization of naturally occurring pathogenic mutations in the human leptin receptor.

    Kimber W, Peelman F, Prieur X, Wangensteen T, O'Rahilly S, Tavernier J, Farooqi IS.

    Endocrinology. 2008 Dec;149(12):6043-52. Epub 2008 Aug 14.PMID: 18703626 [PubMed - indexed for MEDLINE]Related articles

    14.

    Mutations in the amino-terminal region of proopiomelanocortin (POMC) in patients with early-onset obesity impair POMC sorting to the regulated secretory pathway.

    Creemers JW, Lee YS, Oliver RL, Bahceci M, Tuzcu A, Gokalp D, Keogh J, Herber S, White A, O'Rahilly S, Farooqi IS.

    J Clin Endocrinol Metab. 2008 Nov;93(11):4494-9. Epub 2008 Aug 12.PMID: 18697863 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Leptin regulates peripheral lipid metabolism primarily through central effects on food intake.

    Prieur X, Tung YC, Griffin JL, Farooqi IS, O'Rahilly S, Coll AP.

    Endocrinology. 2008 Nov;149(11):5432-9. Epub 2008 Jul 17.PMID: 18635658 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Obesity associated genetic variation in FTO is associated with diminished satiety.

    Wardle J, Carnell S, Haworth CM, Farooqi IS, O'Rahilly S, Plomin R.

    J Clin Endocrinol Metab. 2008 Sep;93(9):3640-3. Epub 2008 Jun 26.PMID: 18583465 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Prevalence of melanocortin-4 receptor deficiency in Europeans and their age-dependent penetrance in multigenerational pedigrees.

    Stutzmann F, Tan K, Vatin V, Dina C, Jouret B, Tichet J, Balkau B, Potoczna N, Horber F, O'Rahilly S, Farooqi IS, Froguel P, Meyre D.

    Diabetes. 2008 Sep;57(9):2511-8. Epub 2008 Jun 16.PMID: 18559663 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Monogenic human obesity.

    Farooqi IS.

    Front Horm Res. 2008;36:1-11. Review.PMID: 18230891 [PubMed - indexed for MEDLINE]Related articles

    19.

    The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.

    Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, Yeo GS, McDonough MA, Cunliffe S, McNeill LA, Galvanovskis J, Rorsman P, Robins P, Prieur X, Coll AP, Ma M, Jovanovic Z, Farooqi IS, Sedgwick B, Barroso I, Lindahl T, Ponting CP, Ashcroft FM, O'Rahilly S, Schofield CJ.

    Science. 2007 Nov 30;318(5855):1469-72. Epub 2007 Nov 8.PMID: 17991826 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    The central melanocortin system directly controls peripheral lipid metabolism.

    Nogueiras R, Wiedmer P, Perez-Tilve D, Veyrat-Durebex C, Keogh JM, Sutton GM, Pfluger PT, Castaneda TR, Neschen S, Hofmann SM, Howles PN, Morgan DA, Benoit SC, Szanto I, Schrott B, Schürmann A, Joost HG, Hammond C, Hui DY, Woods SC, Rahmouni K, Butler AA, Farooqi IS, O'Rahilly S, Rohner-Jeanrenaud F, Tschöp MH.

    J Clin Invest. 2007 Nov;117(11):3475-88.PMID: 17885689 [PubMed - indexed for MEDLINE]Related articlesFree article

    21.

    Leptin regulates striatal regions and human eating behavior.

    Farooqi IS, Bullmore E, Keogh J, Gillard J, O'Rahilly S, Fletcher PC.

    Science. 2007 Sep 7;317(5843):1355. Epub 2007 Aug 9.PMID: 17690262 [PubMed - indexed for MEDLINE]Related articlesFree article

    22.

    Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation presenting in childhood.

    Ize-Ludlow D, Gray JA, Sperling MA, Berry-Kravis EM, Milunsky JM, Farooqi IS, Rand CM, Weese-Mayer DE.

    Pediatrics. 2007 Jul;120(1):e179-88.PMID: 17606542 [PubMed - indexed for MEDLINE]Related articlesFree article

    23.

    Hyperphagia and early-onset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3.

    Farooqi IS, Volders K, Stanhope R, Heuschkel R, White A, Lank E, Keogh J, O'Rahilly S, Creemers JW.

    J Clin Endocrinol Metab. 2007 Sep;92(9):3369-73. Epub 2007 Jun 26.PMID: 17595246 [PubMed - indexed for MEDLINE]Related articlesFree article

    24.

    Melanocortin receptors as targets in the treatment of obesity.

    Lam DD, Farooqi IS, Heisler LK.

    Curr Top Med Chem. 2007;7(11):1085-1097.PMID: 17584129 [PubMed - indexed for MEDLINE]Related articles

    25.

    Screening the human prepro-orexin gene in a single-centre narcolepsy cohort.

    Quinnell TG, Farooqi IS, Smith IE, Shneerson JM.

    Sleep Med. 2007 Aug;8(5):498-502. Epub 2007 Jun 18.PMID: 17576097 [PubMed - indexed for MEDLINE]Related articles

    26.

    The hormonal control of food intake.

    Coll AP, Farooqi IS, O'Rahilly S.

    Cell. 2007 Apr 20;129(2):251-62. Review.PMID: 17448988 [PubMed - indexed for MEDLINE]Related articlesFree article

    27.

    Genetic factors in human obesity.

    Farooqi IS, O'Rahilly S.

    Obes Rev. 2007 Mar;8 Suppl 1:37-40. Review. No abstract available. PMID: 17316299 [PubMed - indexed for MEDLINE]Related articles

    28.

    Genetic aspects of severe childhood obesity.

    Farooqi IS.

    Pediatr Endocrinol Rev. 2006 Dec;3 Suppl 4:528-36. Review.PMID: 17237739 [PubMed - indexed for MEDLINE]Related articles

    29.

    Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor.

    Farooqi IS, Wangensteen T, Collins S, Kimber W, Matarese G, Keogh JM, Lank E, Bottomley B, Lopez-Fernandez J, Ferraz-Amaro I, Dattani MT, Ercan O, Myhre AG, Retterstol L, Stanhope R, Edge JA, McKenzie S, Lessan N, Ghodsi M, De Rosa V, Perna F, Fontana S, Barroso I, Undlien DE, O'Rahilly S.

    N Engl J Med. 2007 Jan 18;356(3):237-47.PMID: 17229951 [PubMed - indexed for MEDLINE]Related articlesFree article

    30.

    Is leptin an important physiological regulator of CRP?

    Farooqi IS, O'Rahilly S.

    Nat Med. 2007 Jan;13(1):16-7; author reply 19-21. No abstract available. PMID: 17206122 [PubMed - indexed for MEDLINE]Related articles

    31.

    Molecular genetic analysis of normosmic hypogonadotropic hypogonadism in a Turkish population: identification and detailed functional characterization of a novel mutation in the gonadotropin-releasing hormone receptor gene.

    Topaloglu AK, Lu ZL, Farooqi IS, Mungan NO, Yuksel B, O'Rahilly S, Millar RP.

    Neuroendocrinology. 2006;84(5):301-8. Epub 2006 Dec 19.PMID: 17179725 [PubMed - indexed for MEDLINE]Related articles

    32.

    Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene.

    Gray J, Yeo GS, Cox JJ, Morton J, Adlam AL, Keogh JM, Yanovski JA, El Gharbawy A, Han JC, Tung YC, Hodges JR, Raymond FL, O'rahilly S, Farooqi IS.

    Diabetes. 2006 Dec;55(12):3366-71.PMID: 17130481 [PubMed - indexed for MEDLINE]Related articlesFree article

    33.

    A quantitative trait locus on chromosome 18q for physical activity and dietary intake in Hispanic children.

    Cai G, Cole SA, Butte N, Bacino C, Diego V, Tan K, Göring HH, O'Rahilly S, Farooqi IS, Comuzzie AG.

    Obesity (Silver Spring). 2006 Sep;14(9):1596-604.PMID: 17030971 [PubMed - indexed for MEDLINE]Related articles

    34.

    Heterozygosity for a POMC-null mutation and increased obesity risk in humans.

    Farooqi IS, Drop S, Clements A, Keogh JM, Biernacka J, Lowenbein S, Challis BG, O'Rahilly S.

    Diabetes. 2006 Sep;55(9):2549-53.PMID: 16936203 [PubMed - indexed for MEDLINE]Related articlesFree article

    35.

    The severely obese patient--a genetic work-up.

    Farooqi IS.

    Nat Clin Pract Endocrinol Metab. 2006 Mar;2(3):172-7; quiz following 177.PMID: 16932276 [PubMed - indexed for MEDLINE]Related articles

    36.

    Studies of the SIM1 gene in relation to human obesity and obesity-related traits.

    Hung CC, Luan J, Sims M, Keogh JM, Hall C, Wareham NJ, O'Rahilly S, Farooqi IS.

    Int J Obes (Lond). 2007 Mar;31(3):429-34. Epub 2006 Aug 22.PMID: 16924270 [PubMed - indexed for MEDLINE]Related articles

    37.

    Monogenic human obesity syndromes.

    Farooqi IS.

    Prog Brain Res. 2006;153:119-25. Review.PMID: 16876571 [PubMed - indexed for MEDLINE]Related articles

    38.

    Genetics of obesity.

    O'Rahilly S, Farooqi IS.

    Philos Trans R Soc Lond B Biol Sci. 2006 Jul 29;361(1471):1095-105. Review.PMID: 16815794 [PubMed - indexed for MEDLINE]Related articlesFree article

    39.

    Functional characterization of human NTRK2 mutations identified in patients with severe early-onset obesity.

    Gray J, Yeo G, Hung C, Keogh J, Clayton P, Banerjee K, McAulay A, O'Rahilly S, Farooqi IS.

    Int J Obes (Lond). 2007 Feb;31(2):359-64. Epub 2006 May 16.PMID: 16702999 [PubMed - indexed for MEDLINE]Related articles

    40.

    WNT10B mutations in human obesity.

    Christodoulides C, Scarda A, Granzotto M, Milan G, Dalla Nora E, Keogh J, De Pergola G, Stirling H, Pannacciulli N, Sethi JK, Federspil G, Vidal-Puig A, Farooqi IS, O'Rahilly S, Vettor R.

    Diabetologia. 2006 Apr;49(4):678-84. Epub 2006 Feb 14.PMID: 16477437 [PubMed - indexed for MEDLINE]Related articles

    41.

    A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance.

    Lee YS, Challis BG, Thompson DA, Yeo GS, Keogh JM, Madonna ME, Wraight V, Sims M, Vatin V, Meyre D, Shield J, Burren C, Ibrahim Z, Cheetham T, Swift P, Blackwood A, Hung CC, Wareham NJ, Froguel P, Millhauser GL, O'Rahilly S, Farooqi IS.

    Cell Metab. 2006 Feb;3(2):135-40.PMID: 16459314 [PubMed - indexed for MEDLINE]Related articles

    42.

    Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels.

    Bhattacharyya S, Luan J, Challis B, Keogh J, Montague C, Brennand J, Morten J, Lowenbeim S, Jenkins S, Farooqi IS, Wareham NJ, O'Rahilly S.

    J Lipid Res. 2006 Apr;47(4):761-6. Epub 2006 Jan 25.PMID: 16436372 [PubMed - indexed for MEDLINE]Related articlesFree article

    43.

    Evaluation of Prader-Willi Syndrome gene MAGEL2 in severe childhood-onset obesity.

    O'Neill MA, Farooqi IS, Wevrick R.

    Obes Res. 2005 Oct;13(10):1841-2.PMID: 16286533 [PubMed - indexed for MEDLINE]Related articles

    44.

    New advances in the genetics of early onset obesity.

    Farooqi IS, O'Rahilly S.

    Int J Obes (Lond). 2005 Oct;29(10):1149-52. No abstract available. PMID: 16155585 [PubMed - indexed for MEDLINE]Related articles

    45.

    Genetic and hereditary aspects of childhood obesity.

    Farooqi IS.

    Best Pract Res Clin Endocrinol Metab. 2005 Sep;19(3):359-74. Review.PMID: 16150380 [PubMed - indexed for MEDLINE]Related articles

    46.

    Leptin predicts a worsening of the features of the metabolic syndrome independently of obesity.

    Franks PW, Brage S, Luan J, Ekelund U, Rahman M, Farooqi IS, Halsall I, O'Rahilly S, Wareham NJ.

    Obes Res. 2005 Aug;13(8):1476-84.PMID: 16129731 [PubMed - indexed for MEDLINE]Related articles

    47.

    Monogenic obesity in humans.

    Farooqi IS, O'Rahilly S.

    Annu Rev Med. 2005;56:443-58. Review.PMID: 15660521 [PubMed - indexed for MEDLINE]Related articles

    48.

    Two novel missense mutations in g protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism.

    Semple RK, Achermann JC, Ellery J, Farooqi IS, Karet FE, Stanhope RG, O'rahilly S, Aparicio SA.

    J Clin Endocrinol Metab. 2005 Mar;90(3):1849-55. Epub 2004 Dec 14.PMID: 15598687 [PubMed - indexed for MEDLINE]Related articlesFree article

    49.

    Studies of the neuromedin U-2 receptor gene in human obesity: evidence for the existence of two ancestral forms of the receptor.

    Bhattacharyya S, Luan J, Farooqi IS, Keogh J, Montague C, Brennand J, Jorde L, Wareham NJ, O'Rahilly S.

    J Endocrinol. 2004 Oct;183(1):115-20.PMID: 15525579 [PubMed - indexed for MEDLINE]Related articlesFree article

    50.

    A de novo mutation affecting human TrkB associated with severe obesity and developmental delay.

    Yeo GS, Connie Hung CC, Rochford J, Keogh J, Gray J, Sivaramakrishnan S, O'Rahilly S, Farooqi IS.

    Nat Neurosci. 2004 Nov;7(11):1187-9. Epub 2004 Oct 24.PMID: 15494731 [PubMed - indexed for MEDLINE]Related articles

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