PubMed

AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK- , ERK- and PDK1-dependent activation of atypical PKC.

Sajan MP, Bandyopadhyay G, Miura A, Standaert M, Nimal S, Longnus SL, Van Obberghen E, Hainault I, Foufelle F, Kahn CR, Braun U, Leitges M, Farese RV.

Am J Physiol Endocrinol Metab. 2009 Nov 3. [Epub ahead of print]PMID: 19887597 [PubMed - as supplied by publisher]Related articles

Atypical protein kinase C activity in the hypothalamus is required for lipopolysaccharide-mediated sickness responses.

Thaler JP, Choi SJ, Sajan MP, Ogimoto K, Nguyen HT, Matsen M, Benoit SC, Wisse BE, Farese RV, Schwartz MW.

Endocrinology. 2009 Dec;150(12):5362-72. Epub 2009 Oct 9.PMID: 19819945 [PubMed - in process]Related articles

Angiopoietin-like 4 (ANGPTL4, fasting-induced adipose factor) is a direct glucocorticoid receptor target and participates in glucocorticoid-regulated triglyceride metabolism.

Koliwad SK, Kuo T, Shipp LE, Gray NE, Backhed F, So AY, Farese RV Jr, Wang JC.

J Biol Chem. 2009 Sep 18;284(38):25593-601. Epub 2009 Jul 23.PMID: 19628874 [PubMed - indexed for MEDLINE]Related articles

The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis.

Guo S, Copps KD, Dong X, Park S, Cheng Z, Pocai A, Rossetti L, Sajan M, Farese RV, White MF.

Mol Cell Biol. 2009 Sep;29(18):5070-83. Epub 2009 Jul 13.PMID: 19596788 [PubMed - indexed for MEDLINE]Related articles

Specific role for acyl CoA:Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids.

Villanueva CJ, Monetti M, Shih M, Zhou P, Watkins SM, Bhanot S, Farese RV Jr.

Hepatology. 2009 Aug;50(2):434-42.PMID: 19472314 [PubMed - indexed for MEDLINE]Related articles

Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFkappaB) in liver of rodents used as a model of diabetes, and relationships to hyperlipidaemia and insulin resistance.

Sajan MP, Standaert ML, Rivas J, Miura A, Kanoh Y, Soto J, Taniguchi CM, Kahn CR, Farese RV.

Diabetologia. 2009 Jun;52(6):1197-207. Epub 2009 Apr 9.PMID: 19357831 [PubMed - indexed for MEDLINE]Related articles

Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding.

Yen CL, Cheong ML, Grueter C, Zhou P, Moriwaki J, Wong JS, Hubbard B, Marmor S, Farese RV Jr.

Nat Med. 2009 Apr;15(4):442-6. Epub 2009 Mar 15.PMID: 19287392 [PubMed - indexed for MEDLINE]Related articles

Lipid droplets at a glance.

Guo Y, Cordes KR, Farese RV Jr, Walther TC.

J Cell Sci. 2009 Mar 15;122(Pt 6):749-52. No abstract available. PMID: 19261844 [PubMed - indexed for MEDLINE]Related articlesFree article

The critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFkappaB in obesity.

Sajan MP, Standaert ML, Nimal S, Varanasi U, Pastoor T, Mastorides S, Braun U, Leitges M, Farese RV.

J Lipid Res. 2009 Jun;50(6):1133-45. Epub 2009 Feb 6.PMID: 19202134 [PubMed - indexed for MEDLINE]Related articles

The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria.

Stone SJ, Levin MC, Zhou P, Han J, Walther TC, Farese RV Jr.

J Biol Chem. 2009 Feb 20;284(8):5352-61. Epub 2008 Dec 1.PMID: 19049983 [PubMed - indexed for MEDLINE]Related articles

The life of lipid droplets.

Walther TC, Farese RV Jr.

Biochim Biophys Acta. 2009 Jun;1791(6):459-66. Epub 2008 Nov 7. Review.PMID: 19041421 [PubMed - indexed for MEDLINE]Related articles

Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin.

Shih MY, Kane MA, Zhou P, Yen CL, Streeper RS, Napoli JL, Farese RV Jr.

J Biol Chem. 2009 Feb 13;284(7):4292-9. Epub 2008 Nov 20.PMID: 19028692 [PubMed - indexed for MEDLINE]Related articles

Combined thiazolidinedione-metformin treatment synergistically improves insulin signalling to insulin receptor substrate-1-dependent phosphatidylinositol 3-kinase, atypical protein kinase C and protein kinase B/Akt in human diabetic muscle.

Temofonte N, Sajan MP, Nimal S, Pastoor T, Fumero C, Casaubon L, Powe JL, Standaert ML, Farese RV.

Diabetologia. 2009 Jan;52(1):60-4. Epub 2008 Oct 30.PMID: 18972094 [PubMed - indexed for MEDLINE]Related articles

Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis.

Yen CL, Stone SJ, Koliwad S, Harris C, Farese RV Jr.

J Lipid Res. 2008 Nov;49(11):2283-301. Epub 2008 Aug 29. Review.PMID: 18757836 [PubMed - indexed for MEDLINE]Related articlesFree article

Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice.

Minehira K, Young SG, Villanueva CJ, Yetukuri L, Oresic M, Hellerstein MK, Farese RV Jr, Horton JD, Preitner F, Thorens B, Tappy L.

J Lipid Res. 2008 Sep;49(9):2038-44. Epub 2008 Jun 1.PMID: 18515909 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional genomic screen reveals genes involved in lipid-droplet formation and utilization.

Guo Y, Walther TC, Rao M, Stuurman N, Goshima G, Terayama K, Wong JS, Vale RD, Walter P, Farese RV.

Nature. 2008 May 29;453(7195):657-61. Epub 2008 Apr 13.PMID: 18408709 [PubMed - indexed for MEDLINE]Related articlesFree article

Defective Activation of Protein Kinase C-z in Muscle by Insulin and Phosphatidylinositol-3,4,5,-(PO(4))(3) in Obesity and Polycystic Ovary Syndrome.

Beeson M, Sajan MP, Daspet JG, Luna V, Dizon M, Grebenev D, Powe JL, Lucidi S, Miura A, Kanoh Y, Bandyopadhyay G, Standaert ML, Yeko TR, Farese RV.

Metab Syndr Relat Disord. 2004 Spring;2(1):49-56.PMID: 18370676 [PubMed - in process]Related articles

Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle.

Levin MC, Monetti M, Watt MJ, Sajan MP, Stevens RD, Bain JR, Newgard CB, Farese RV Sr, Farese RV Jr.

Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1772-81. Epub 2007 Oct 16.PMID: 17940217 [PubMed - indexed for MEDLINE]Related articlesFree article

Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.

Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, Guarente LP, Farese RV Jr, Weissman S, Verdin E, Schwer B.

Mol Cell Biol. 2007 Dec;27(24):8807-14. Epub 2007 Oct 8.PMID: 17923681 [PubMed - indexed for MEDLINE]Related articlesFree article

LPA3 receptor mediates chemotaxis of immature murine dendritic cells to unsaturated lysophosphatidic acid (LPA).

Chan LC, Peters W, Xu Y, Chun J, Farese RV Jr, Cases S.

J Leukoc Biol. 2007 Nov;82(5):1193-200. Epub 2007 Aug 20.PMID: 17709403 [PubMed - indexed for MEDLINE]Related articlesFree article

Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes.

Farese RV, Sajan MP, Yang H, Li P, Mastorides S, Gower WR Jr, Nimal S, Choi CS, Kim S, Shulman GI, Kahn CR, Braun U, Leitges M.

J Clin Invest. 2007 Aug;117(8):2289-301. Erratum in: J Clin Invest. 2007 Oct;117(10):3141. PMID: 17641777 [PubMed - indexed for MEDLINE]Related articlesFree article

Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver.

Monetti M, Levin MC, Watt MJ, Sajan MP, Marmor S, Hubbard BK, Stevens RD, Bain JR, Newgard CB, Farese RV Sr, Hevener AL, Farese RV Jr.

Cell Metab. 2007 Jul;6(1):69-78.PMID: 17618857 [PubMed - indexed for MEDLINE]Related articles

Exercise improves phosphatidylinositol-3,4,5-trisphosphate responsiveness of atypical protein kinase C and interacts with insulin signalling to peptide elongation in human skeletal muscle.

Frøsig C, Sajan MP, Maarbjerg SJ, Brandt N, Roepstorff C, Wojtaszewski JF, Kiens B, Farese RV, Richter EA.

J Physiol. 2007 Aug 1;582(Pt 3):1289-301. Epub 2007 May 31.PMID: 17540697 [PubMed - indexed for MEDLINE]Related articlesFree article

Membrane topology and identification of key functional amino acid residues of murine acyl-CoA:diacylglycerol acyltransferase-2.

Stone SJ, Levin MC, Farese RV Jr.

J Biol Chem. 2006 Dec 29;281(52):40273-82. Epub 2006 Oct 10.PMID: 17035227 [PubMed - indexed for MEDLINE]Related articlesFree article

Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects.

Feldman BJ, Streeper RS, Farese RV Jr, Yamamoto KR.

Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15675-80. Epub 2006 Oct 9.PMID: 17030820 [PubMed - indexed for MEDLINE]Related articlesFree article

Contrasting insulin dose-dependent defects in activation of atypical protein kinase C and protein kinase B/Akt in muscles of obese diabetic humans.

Casaubon L, Sajan MP, Rivas J, Powe JL, Standaert ML, Farese RV.

Diabetologia. 2006 Dec;49(12):3000-8. Epub 2006 Oct 7.PMID: 17028898 [PubMed - indexed for MEDLINE]Related articles

Short-term overexpression of DGAT1 or DGAT2 increases hepatic triglyceride but not VLDL triglyceride or apoB production.

Millar JS, Stone SJ, Tietge UJ, Tow B, Billheimer JT, Wong JS, Hamilton RL, Farese RV Jr, Rader DJ.

J Lipid Res. 2006 Oct;47(10):2297-305. Epub 2006 Jul 30.PMID: 16877777 [PubMed - indexed for MEDLINE]Related articlesFree article

The nine lives of ACAT inhibitors.

Farese RV Jr.

Arterioscler Thromb Vasc Biol. 2006 Aug;26(8):1684-6. Review. No abstract available. PMID: 16857957 [PubMed - indexed for MEDLINE]Related articlesFree article

ACAT inhibition and the progression of coronary atherosclerosis.

Rudel LL, Farese RV Jr.

N Engl J Med. 2006 Jun 15;354(24):2616-7; author reply 2616-7. No abstract available. PMID: 16775245 [PubMed - indexed for MEDLINE]Related articles

Fat breakdown: a function for CGI-58 (ABHD5) provides a new piece of the puzzle.

Yen CL, Farese RV Jr.

Cell Metab. 2006 May;3(5):305-7.PMID: 16679288 [PubMed - indexed for MEDLINE]Related articles

Repletion of atypical protein kinase C following RNA interference-mediated depletion restores insulin-stimulated glucose transport.

Sajan MP, Rivas J, Li P, Standaert ML, Farese RV.

J Biol Chem. 2006 Jun 23;281(25):17466-73. Epub 2006 Apr 27.PMID: 16644736 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of DGAT1 deficiency on energy and glucose metabolism are independent of adiponectin.

Streeper RS, Koliwad SK, Villanueva CJ, Farese RV Jr.

Am J Physiol Endocrinol Metab. 2006 Aug;291(2):E388-94. Epub 2006 Apr 4.PMID: 16595853 [PubMed - indexed for MEDLINE]Related articlesFree article

FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression.

Zhang W, Patil S, Chauhan B, Guo S, Powell DR, Le J, Klotsas A, Matika R, Xiao X, Franks R, Heidenreich KA, Sajan MP, Farese RV, Stolz DB, Tso P, Koo SH, Montminy M, Unterman TG.

J Biol Chem. 2006 Apr 14;281(15):10105-17. Epub 2006 Feb 21.PMID: 16492665 [PubMed - indexed for MEDLINE]Related articlesFree article

Metformin improves atypical protein kinase C activation by insulin and phosphatidylinositol-3,4,5-(PO4)3 in muscle of diabetic subjects.

Luna V, Casauban L, Sajan MP, Gomez-Daspet J, Powe JL, Miura A, Rivas J, Standaert ML, Farese RV.

Diabetologia. 2006 Feb;49(2):375-82. Epub 2006 Jan 5.PMID: 16395615 [PubMed - indexed for MEDLINE]Related articles

Insulin signalling downstream of protein kinase B is potentiated by 5'AMP-activated protein kinase in rat hearts in vivo.

Longnus SL, Ségalen C, Giudicelli J, Sajan MP, Farese RV, Van Obberghen E.

Diabetologia. 2005 Dec;48(12):2591-601. Epub 2005 Nov 11.PMID: 16283248 [PubMed - indexed for MEDLINE]Related articles

Insulin-sensitive protein kinases (atypical protein kinase C and protein kinase B/Akt): actions and defects in obesity and type II diabetes.

Farese RV, Sajan MP, Standaert ML.

Exp Biol Med (Maywood). 2005 Oct;230(9):593-605. Review.PMID: 16179727 [PubMed - indexed for MEDLINE]Related articlesFree article

A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters.

Yen CL, Brown CH 4th, Monetti M, Farese RV Jr.

J Lipid Res. 2005 Nov;46(11):2388-97. Epub 2005 Aug 16.PMID: 16106050 [PubMed - indexed for MEDLINE]Related articlesFree article

Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer.

Lee S, Nakamura E, Yang H, Wei W, Linggi MS, Sajan MP, Farese RV, Freeman RS, Carter BD, Kaelin WG Jr, Schlisio S.

Cancer Cell. 2005 Aug;8(2):155-67.PMID: 16098468 [PubMed - indexed for MEDLINE]Related articles

The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters.

Yen CL, Monetti M, Burri BJ, Farese RV Jr.

J Lipid Res. 2005 Jul;46(7):1502-11. Epub 2005 Apr 16.PMID: 15834126 [PubMed - indexed for MEDLINE]Related articlesFree article

Atypical protein kinase C in insulin action and insulin resistance.

Farese RV, Sajan MP, Standaert ML.

Biochem Soc Trans. 2005 Apr;33(Pt 2):350-3. Review.PMID: 15787604 [PubMed - indexed for MEDLINE]Related articles

Insulin substrates 1 and 2 are corequired for activation of atypical protein kinase C and Cbl-dependent phosphatidylinositol 3-kinase during insulin action in immortalized brown adipocytes.

Miura A, Sajan MP, Standaert ML, Bandyopadhyay G, Kahn CR, Farese RV.

Biochemistry. 2004 Dec 14;43(49):15503-9.PMID: 15581362 [PubMed - indexed for MEDLINE]Related articles

Requirements for pYXXM motifs in Cbl for binding to the p85 subunit of phosphatidylinositol 3-kinase and Crk, and activation of atypical protein kinase C and glucose transport during insulin action in 3T3/L1 adipocytes.

Standaert ML, Sajan MP, Miura A, Bandyopadhyay G, Farese RV.

Biochemistry. 2004 Dec 14;43(49):15494-502.PMID: 15581361 [PubMed - indexed for MEDLINE]Related articles

Inhibition of triglyceride synthesis as a treatment strategy for obesity: lessons from DGAT1-deficient mice.

Chen HC, Farese RV Jr.

Arterioscler Thromb Vasc Biol. 2005 Mar;25(3):482-6. Epub 2004 Nov 29. Review.PMID: 15569818 [PubMed - indexed for MEDLINE]Related articlesFree article

ACAT2 deficiency limits cholesterol absorption in the cholesterol-fed mouse: impact on hepatic cholesterol homeostasis.

Repa JJ, Buhman KK, Farese RV Jr, Dietschy JM, Turley SD.

Hepatology. 2004 Nov;40(5):1088-97.PMID: 15486928 [PubMed - indexed for MEDLINE]Related articles

Plasma cholesteryl esters provided by lecithin:cholesterol acyltransferase and acyl-coenzyme a:cholesterol acyltransferase 2 have opposite atherosclerotic potential.

Lee RG, Kelley KL, Sawyer JK, Farese RV Jr, Parks JS, Rudel LL.

Circ Res. 2004 Nov 12;95(10):998-1004. Epub 2004 Oct 14.PMID: 15486318 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential effect of bicycling exercise intensity on activity and phosphorylation of atypical protein kinase C and extracellular signal-regulated protein kinase in skeletal muscle.

Richter EA, Vistisen B, Maarbjerg SJ, Sajan M, Farese RV, Kiens B.

J Physiol. 2004 Nov 1;560(Pt 3):909-18. Epub 2004 Aug 5.PMID: 15297577 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5-(PO4)3 in cultured preadipocyte-derived adipocytes and myotubes of obese subjects.

Sajan MP, Standaert ML, Miura A, Bandyopadhyay G, Vollenweider P, Franklin DM, Lea-Currie R, Farese RV.

J Clin Endocrinol Metab. 2004 Aug;89(8):3994-8.PMID: 15292339 [PubMed - indexed for MEDLINE]Related articlesFree article

Tissue-specific differences in activation of atypical protein kinase C and protein kinase B in muscle, liver, and adipocytes of insulin receptor substrate-1 knockout mice.

Sajan MP, Standaert ML, Miura A, Kahn CR, Farese RV.

Mol Endocrinol. 2004 Oct;18(10):2513-21. Epub 2004 Jul 15.PMID: 15256535 [PubMed - indexed for MEDLINE]Related articlesFree article

Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues.

Cases S, Zhou P, Shillingford JM, Wiseman BS, Fish JD, Angle CS, Hennighausen L, Werb Z, Farese RV Jr.

Development. 2004 Jul;131(13):3047-55. Epub 2004 May 26.PMID: 15163627 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of adipocyte-derived factors in enhancing insulin signaling in skeletal muscle and white adipose tissue of mice lacking Acyl CoA:diacylglycerol acyltransferase 1.

Chen HC, Rao M, Sajan MP, Standaert M, Kanoh Y, Miura A, Farese RV Jr, Farese RV.

Diabetes. 2004 Jun;53(6):1445-51.PMID: 15161747 [PubMed - indexed for MEDLINE]Related articlesFree article