PubMed

Evidence for a tumor promoting effect of high-fat diet independent of insulin resistance in HER2/Neu mammary carcinogenesis.

Khalid S, Hwang D, Babichev Y, Kolli R, Altamentova S, Koren S, Goodwin PJ, Ennis M, Pollak M, Sonenberg N, Fantus IG.

Breast Cancer Res Treat. 2009 Oct 23. [Epub ahead of print]PMID: 19851863 [PubMed - as supplied by publisher]Related articles

Triple X syndrome in a patient with partial lipodystrophy discovered using a high-density oligonucleotide microarray: a case report.

Lanktree MB, Fantus IG, Hegele RA.

J Med Case Reports. 2009 Aug 12;3:8867.PMID: 19830242 [PubMed - in process]Related articlesFree article

Free fatty acid-induced muscle insulin resistance and glucose uptake dysfunction: evidence for PKC activation and oxidative stress-activated signaling pathways.

Ragheb R, Shanab GM, Medhat AM, Seoudi DM, Adeli K, Fantus IG.

Biochem Biophys Res Commun. 2009 Nov 13;389(2):211-6. Epub 2009 Aug 23.PMID: 19706288 [PubMed - indexed for MEDLINE]Related articles

Rosiglitazone prevents high glucose-induced vascular endothelial growth factor and collagen IV expression in cultured mesangial cells.

Whiteside C, Wang H, Xia L, Munk S, Goldberg HJ, Fantus IG.

Exp Diabetes Res. 2009;2009:910783. Epub 2009 Jul 7.PMID: 19609456 [PubMed - indexed for MEDLINE]Related articlesFree article

P-21-activated protein kinase-1 functions as a linker between insulin and Wnt signaling pathways in the intestine.

Sun J, Khalid S, Rozakis-Adcock M, Fantus IG, Jin T.

Oncogene. 2009 Sep 3;28(35):3132-44. Epub 2009 Jul 6.PMID: 19581924 [PubMed - indexed for MEDLINE]Related articles

High beta-cell mass prevents streptozotocin-induced diabetes in thioredoxin-interacting protein-deficient mice.

Masson E, Koren S, Razik F, Goldberg H, Kwan EP, Sheu L, Gaisano HY, Fantus IG.

Am J Physiol Endocrinol Metab. 2009 Jun;296(6):E1251-61. Epub 2009 Feb 17.PMID: 19223654 [PubMed - indexed for MEDLINE]Related articles

Insulin-lowering effects of metformin in women with early breast cancer.

Goodwin PJ, Pritchard KI, Ennis M, Clemons M, Graham M, Fantus IG.

Clin Breast Cancer. 2008 Dec;8(6):501-5.PMID: 19073504 [PubMed - indexed for MEDLINE]Related articles

Comparative effects of N-acetyl-L-cysteine and ramipril on arterial hypertension, insulin resistance, and oxidative stress in chronically glucose-fed rats.

El Midaoui A, Ismael MA, Lu H, Fantus IG, de Champlain J, Couture R.

Can J Physiol Pharmacol. 2008 Nov;86(11):752-60.PMID: 19011670 [PubMed - indexed for MEDLINE]Related articles

High glucose activates PKC-zeta and NADPH oxidase through autocrine TGF-beta1 signaling in mesangial cells.

Xia L, Wang H, Munk S, Kwan J, Goldberg HJ, Fantus IG, Whiteside CI.

Am J Physiol Renal Physiol. 2008 Dec;295(6):F1705-14. Epub 2008 Sep 24.PMID: 18815221 [PubMed - indexed for MEDLINE]Related articles

Utility of metformin in breast cancer treatment, is neoangiogenesis a risk factor?

Stambolic V, Woodgett JR, Fantus IG, Pritchard KI, Goodwin PJ.

Breast Cancer Res Treat. 2009 Mar;114(2):387-9. Epub 2008 Apr 26. Review. No abstract available. PMID: 18438706 [PubMed - indexed for MEDLINE]Related articles

High insulin levels in newly diagnosed breast cancer patients reflect underlying insulin resistance and are associated with components of the insulin resistance syndrome.

Goodwin PJ, Ennis M, Bahl M, Fantus IG, Pritchard KI, Trudeau ME, Koo J, Hood N.

Breast Cancer Res Treat. 2009 Apr;114(3):517-25. Epub 2008 Apr 25.PMID: 18437560 [PubMed - indexed for MEDLINE]Related articles

Links between enhanced fatty acid flux, protein kinase C and NFkappaB activation, and apoB-lipoprotein production in the fructose-fed hamster model of insulin resistance.

Ragheb R, Medhat AM, Shanab GM, Seoudi DM, Fantus IG.

Biochem Biophys Res Commun. 2008 May 23;370(1):134-9. Epub 2008 Mar 19.PMID: 18358236 [PubMed - indexed for MEDLINE]Related articles

Cross talk between the insulin and Wnt signaling pathways: evidence from intestinal endocrine L cells.

Yi F, Sun J, Lim GE, Fantus IG, Brubaker PL, Jin T.

Endocrinology. 2008 May;149(5):2341-51. Epub 2008 Feb 7.PMID: 18258680 [PubMed - indexed for MEDLINE]Related articlesFree article

Chlamydophila pneumoniae inhibits differentiation of progenitor adipose cells and impairs insulin signaling.

Shi Y, Liu Y, Murdin A, Raudonikiene-Mancevski A, Ayach BB, Yu Z, Fantus IG, Liu PP.

J Infect Dis. 2008 Feb 1;197(3):439-48.PMID: 18199028 [PubMed - indexed for MEDLINE]Related articles

Inhibition of the protein tyrosine phosphatase PTP1B: potential therapy for obesity, insulin resistance and type-2 diabetes mellitus.

Koren S, Fantus IG.

Best Pract Res Clin Endocrinol Metab. 2007 Dec;21(4):621-40. Review.PMID: 18054739 [PubMed - indexed for MEDLINE]Related articles

Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells.

Dowling RJ, Zakikhani M, Fantus IG, Pollak M, Sonenberg N.

Cancer Res. 2007 Nov 15;67(22):10804-12.PMID: 18006825 [PubMed - indexed for MEDLINE]Related articlesFree article

Free fatty acid-induced reduction in glucose-stimulated insulin secretion: evidence for a role of oxidative stress in vitro and in vivo.

Oprescu AI, Bikopoulos G, Naassan A, Allister EM, Tang C, Park E, Uchino H, Lewis GF, Fantus IG, Rozakis-Adcock M, Wheeler MB, Giacca A.

Diabetes. 2007 Dec;56(12):2927-37. Epub 2007 Aug 23.PMID: 17717282 [PubMed - indexed for MEDLINE]Related articlesFree article

Reactive oxygen species, PKC-beta1, and PKC-zeta mediate high-glucose-induced vascular endothelial growth factor expression in mesangial cells.

Xia L, Wang H, Munk S, Frecker H, Goldberg HJ, Fantus IG, Whiteside CI.

Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1280-8. Epub 2007 Aug 21.PMID: 17711990 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin receptor is an independent predictor of a favorable outcome in early stage breast cancer.

Mulligan AM, O'Malley FP, Ennis M, Fantus IG, Goodwin PJ.

Breast Cancer Res Treat. 2007 Nov;106(1):39-47. Epub 2007 Jan 13.PMID: 17221153 [PubMed - indexed for MEDLINE]Related articles

Pancreatin therapy in patients with insulin-treated diabetes mellitus and exocrine pancreatic insufficiency according to low fecal elastase 1 concentrations. Results of a prospective multi-centre trial.

Ewald N, Bretzel RG, Fantus IG, Hollenhorst M, Kloer HU, Hardt PD; S-2453110 Study Group.

Diabetes Metab Res Rev. 2007 Jul;23(5):386-91.PMID: 17103488 [PubMed - indexed for MEDLINE]Related articles

Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells.

Zakikhani M, Dowling R, Fantus IG, Sonenberg N, Pollak M.

Cancer Res. 2006 Nov 1;66(21):10269-73. Epub 2006 Oct 23.PMID: 17062558 [PubMed - indexed for MEDLINE]Related articlesFree article

Bradykinin augments insulin-stimulated glucose transport in rat adipocytes via endothelial nitric oxide synthase-mediated inhibition of Jun NH2-terminal kinase.

Beard KM, Lu H, Ho K, Fantus IG.

Diabetes. 2006 Oct;55(10):2678-87.PMID: 17003331 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhancement of muscle glucose uptake by the vasopeptidase inhibitor, omapatrilat, is independent of insulin signaling and the AMP kinase pathway.

Wong V, Szeto L, Uffelman K, Fantus IG, Lewis GF.

J Endocrinol. 2006 Aug;190(2):441-50.PMID: 16899577 [PubMed - indexed for MEDLINE]Related articlesFree article

Oleate-induced decrease in hepatocyte insulin binding is mediated by PKC-delta.

Chen S, Lam TK, Park E, Burdett E, Wang PY, Wiesenthal SR, Lam L, Tchipashvili V, Fantus IG, Giacca A.

Biochem Biophys Res Commun. 2006 Aug 4;346(3):931-7. Epub 2006 Jun 9.PMID: 16781675 [PubMed - indexed for MEDLINE]Related articles

Upregulation of osteopontin gene expression in diabetic rat proximal tubular cells revealed by microarray profiling.

Hsieh TJ, Chen R, Zhang SL, Liu F, Brezniceanu ML, Whiteside CI, Fantus IG, Ingelfinger JR, Hamet P, Chan JS.

Kidney Int. 2006 Mar;69(6):1005-15.PMID: 16528250 [PubMed - indexed for MEDLINE]Related articles

Effects of portal free fatty acid elevation on insulin clearance and hepatic glucose flux.

Yoshii H, Lam TK, Gupta N, Goh T, Haber CA, Uchino H, Kim TT, Chong VZ, Shah K, Fantus IG, Mari A, Kawamori R, Giacca A.

Am J Physiol Endocrinol Metab. 2006 Jun;290(6):E1089-97. Epub 2006 Jan 3.PMID: 16390863 [PubMed - indexed for MEDLINE]Related articlesFree article

Posttranslational, reversible O-glycosylation is stimulated by high glucose and mediates plasminogen activator inhibitor-1 gene expression and Sp1 transcriptional activity in glomerular mesangial cells.

Goldberg HJ, Whiteside CI, Hart GW, Fantus IG.

Endocrinology. 2006 Jan;147(1):222-31. Erratum in: Endocrinology. 2006 Nov;147(11):5490. PMID: 16365142 [PubMed - indexed for MEDLINE]Related articlesFree article

Is leptin a mediator of adverse prognostic effects of obesity in breast cancer?

Goodwin PJ, Ennis M, Fantus IG, Pritchard KI, Trudeau ME, Koo J, Hood N.

J Clin Oncol. 2005 Sep 1;23(25):6037-42.PMID: 16135472 [PubMed - indexed for MEDLINE]Related articles

Mesangial cell NADPH oxidase upregulation in high glucose is protein kinase C dependent and required for collagen IV expression.

Xia L, Wang H, Goldberg HJ, Munk S, Fantus IG, Whiteside CI.

Am J Physiol Renal Physiol. 2006 Feb;290(2):F345-56. Epub 2005 Aug 30.PMID: 16131649 [PubMed - indexed for MEDLINE]Related articlesFree article

Metformin's contraindications: needed for now.

Fantus IG.

CMAJ. 2005 Aug 30;173(5):505-7. No abstract available. PMID: 16129872 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of Cdx-2 in insulin and proglucagon gene expression: a study using the RIN-1056A cell line with an inducible gene expression system.

Zhao Y, Liu T, Zhang N, Yi F, Wang Q, Fantus IG, Jin T.

J Endocrinol. 2005 Jul;186(1):179-92.PMID: 16002547 [PubMed - indexed for MEDLINE]Related articlesFree article

Atorvastatin induces insulin sensitization in Zucker lean and fatty rats.

Wong V, Stavar L, Szeto L, Uffelman K, Wang CH, Fantus IG, Lewis GF.

Atherosclerosis. 2006 Feb;184(2):348-55. Epub 2005 Jul 5.PMID: 15998521 [PubMed - indexed for MEDLINE]Related articles

Oral antihyperglycemic therapy for type 2 diabetes mellitus.

Cheng AY, Fantus IG.

CMAJ. 2005 Jan 18;172(2):213-26. Review.PMID: 15655244 [PubMed - indexed for MEDLINE]Related articlesFree article

Reactive oxygen species blockade and action of insulin on expression of angiotensinogen gene in proximal tubular cells.

Hsieh TJ, Fustier P, Wei CC, Zhang SL, Filep JG, Tang SS, Ingelfinger JR, Fantus IG, Hamet P, Chan JS.

J Endocrinol. 2004 Dec;183(3):535-50.PMID: 15590980 [PubMed - indexed for MEDLINE]Related articlesFree article

The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species.

Lin Y, Berg AH, Iyengar P, Lam TK, Giacca A, Combs TP, Rajala MW, Du X, Rollman B, Li W, Hawkins M, Barzilai N, Rhodes CJ, Fantus IG, Brownlee M, Scherer PE.

J Biol Chem. 2005 Feb 11;280(6):4617-26. Epub 2004 Nov 9.PMID: 15536073 [PubMed - indexed for MEDLINE]Related articlesFree article

Thiazolidinedione-induced congestive heart failure.

Cheng AY, Fantus IG.

Ann Pharmacother. 2004 May;38(5):817-20. Epub 2004 Mar 23.PMID: 15039476 [PubMed - indexed for MEDLINE]Related articles

Gene and protein kinase expression profiling of reactive oxygen species-associated lipotoxicity in the pancreatic beta-cell line MIN6.

Wang X, Li H, De Leo D, Guo W, Koshkin V, Fantus IG, Giacca A, Chan CB, Der S, Wheeler MB.

Diabetes. 2004 Jan;53(1):129-40.PMID: 14693707 [PubMed - indexed for MEDLINE]Related articlesFree article

High glucose stimulates angiotensinogen gene expression and cell hypertrophy via activation of the hexosamine biosynthesis pathway in rat kidney proximal tubular cells.

Hsieh TJ, Fustier P, Zhang SL, Filep JG, Tang SS, Ingelfinger JR, Fantus IG, Hamet P, Chan JS.

Endocrinology. 2003 Oct;144(10):4338-49. Epub 2003 Jul 10.PMID: 12960040 [PubMed - indexed for MEDLINE]Related articlesFree article

High glucose-suppressed endothelin-1 Ca2+ signaling via NADPH oxidase and diacylglycerol-sensitive protein kinase C isozymes in mesangial cells.

Hua H, Munk S, Goldberg H, Fantus IG, Whiteside CI.

J Biol Chem. 2003 Sep 5;278(36):33951-62. Epub 2003 Jun 23.PMID: 12821678 [PubMed - indexed for MEDLINE]Related articlesFree article

N-acetylcysteine and taurine prevent hyperglycemia-induced insulin resistance in vivo: possible role of oxidative stress.

Haber CA, Lam TK, Yu Z, Gupta N, Goh T, Bogdanovic E, Giacca A, Fantus IG.

Am J Physiol Endocrinol Metab. 2003 Oct;285(4):E744-53. Epub 2003 Jun 10.PMID: 12799318 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms of the free fatty acid-induced increase in hepatic glucose production.

Lam TK, Carpentier A, Lewis GF, van de Werve G, Fantus IG, Giacca A.

Am J Physiol Endocrinol Metab. 2003 May;284(5):E863-73. Review.PMID: 12676648 [PubMed - indexed for MEDLINE]Related articlesFree article

The differentiation of skeletal muscle cells involves a protein-tyrosine phosphatase-alpha-mediated C-Src signaling pathway.

Lu H, Shah P, Ennis D, Shinder G, Sap J, Le-Tien H, Fantus IG.

J Biol Chem. 2002 Nov 29;277(48):46687-95. Epub 2002 Sep 25.PMID: 12351660 [PubMed - indexed for MEDLINE]Related articlesFree article

Free fatty acid-induced hepatic insulin resistance: a potential role for protein kinase C-delta.

Lam TK, Yoshii H, Haber CA, Bogdanovic E, Lam L, Fantus IG, Giacca A.

Am J Physiol Endocrinol Metab. 2002 Oct;283(4):E682-91.PMID: 12217885 [PubMed - indexed for MEDLINE]Related articlesFree article

The hexosamine pathway regulates the plasminogen activator inhibitor-1 gene promoter and Sp1 transcriptional activation through protein kinase C-beta I and -delta.

Goldberg HJ, Whiteside CI, Fantus IG.

J Biol Chem. 2002 Sep 13;277(37):33833-41. Epub 2002 Jul 8.PMID: 12105191 [PubMed - indexed for MEDLINE]Related articlesFree article

Vitamin D arrests thyroid carcinoma cell growth and induces p27 dephosphorylation and accumulation through PTEN/akt-dependent and -independent pathways.

Liu W, Asa SL, Fantus IG, Walfish PG, Ezzat S.

Am J Pathol. 2002 Feb;160(2):511-9.PMID: 11839571 [PubMed - indexed for MEDLINE]Related articlesFree article

High glucose-enhanced activation of mesangial cell p38 MAPK by ET-1, ANG II, and platelet-derived growth factor.

Tsiani E, Lekas P, Fantus IG, Dlugosz J, Whiteside C.

Am J Physiol Endocrinol Metab. 2002 Jan;282(1):E161-9.PMID: 11739097 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic very low density lipoprotein-ApoB overproduction is associated with attenuated hepatic insulin signaling and overexpression of protein-tyrosine phosphatase 1B in a fructose-fed hamster model of insulin resistance.

Taghibiglou C, Rashid-Kolvear F, Van Iderstine SC, Le-Tien H, Fantus IG, Lewis GF, Adeli K.

J Biol Chem. 2002 Jan 4;277(1):793-803. Epub 2001 Oct 11.PMID: 11598116 [PubMed - indexed for MEDLINE]Related articlesFree article

High glucose-enhanced mesangial cell extracellular signal-regulated protein kinase activation and alpha1(IV) collagen expression in response to endothelin-1: role of specific protein kinase C isozymes.

Hua H, Goldberg HJ, Fantus IG, Whiteside CI.

Diabetes. 2001 Oct;50(10):2376-83.PMID: 11574422 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced sensitivity of insulin-resistant adipocytes to vanadate is associated with oxidative stress and decreased reduction of vanadate (+5) to vanadyl (+4).

Lu B, Ennis D, Lai R, Bogdanovic E, Nikolov R, Salamon L, Fantus C, Le-Tien H, Fantus IG.

J Biol Chem. 2001 Sep 21;276(38):35589-98. Epub 2001 Jul 19.PMID: 11463798 [PubMed - indexed for MEDLINE]Related articlesFree article

Decreased in situ insulin receptor dephosphorylation in hyperglycemia-induced insulin resistance in rat adipocytes.

Tang S, Le-Tien H, Goldstein BJ, Shin P, Lai R, Fantus IG.

Diabetes. 2001 Jan;50(1):83-90.PMID: 11147799 [PubMed - indexed for MEDLINE]Related articlesFree article