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Genetic Drivers of Pancreatic Islet Function.
Keller MP, Gatti DM, Schueler KL, Rabaglia ME, Stapleton DS, Simecek P, Vincent M, Allen S, Broman AT, Bacher R, Kendziorski C, Broman KW, Yandell BS, Churchill GA, Attie AD. Keller MP, et al. Genetics. 2018 May;209(1):335-356. doi: 10.1534/genetics.118.300864. Epub 2018 Mar 22. Genetics. 2018. PMID: 29567659 Free PMC article.
These include two genes previously associated with monogenic diabetes (PDX1 and HNF4A), as well as three genes with nominal association with diabetes-related traits in humans (FAM83E, IL6ST, and SAT2). We grouped transcripts into gene modules and mapped regulatory loci for …
These include two genes previously associated with monogenic diabetes (PDX1 and HNF4A), as well as three genes with nominal association with …
Identification of Prognostic and Therapeutic Biomarkers among FAM83 Family Members for Pancreatic Ductal Adenocarcinoma.
Ma Z, Zhou Z, Zhuang H, Li Z, Ma Z, Huang B, Liu C, Gong Y, Zou Y, Zheng Z, Huang S, Zhang C, Hou B. Ma Z, et al. Dis Markers. 2021 Mar 1;2021:6682697. doi: 10.1155/2021/6682697. eCollection 2021. Dis Markers. 2021. PMID: 33747255 Free PMC article.
Besides, potential associations between differentially expressed genes (DEGs) of FAM83 family and antitumor immunity were evaluated using TIMER and TISIDB analyses. As the results show, FAM83A, FAM83D, FAM83E, and FAM83H were significantly upregulated in PDAC and were iden …
Besides, potential associations between differentially expressed genes (DEGs) of FAM83 family and antitumor immunity were evaluated using TI …
Distinct whole-blood transcriptome profile of children with metabolic healthy overweight/obesity compared to metabolic unhealthy overweight/obesity.
Plaza-Florido A, Altmäe S, Esteban FJ, Cadenas-Sanchez C, Aguilera CM, Einarsdottir E, Katayama S, Krjutškov K, Kere J, Zaldivar F, Radom-Aizik S, Ortega FB. Plaza-Florido A, et al. Pediatr Res. 2021 May;89(7):1687-1694. doi: 10.1038/s41390-020-01276-7. Epub 2020 Nov 23. Pediatr Res. 2021. PMID: 33230195
The most relevant genes in understanding the molecular basis underlying the MHO/MUO phenotypes in children could be: RREB1, FAM83E, SLC44A1, NRG1, TMC5, CYP3A5, TRIM11, and ADAMTSL2. The identified whole-blood transcriptome profile related to metabolism, mitochondrial, and …
The most relevant genes in understanding the molecular basis underlying the MHO/MUO phenotypes in children could be: RREB1, FAM83E, S …
The DUF1669 domain of FAM83 family proteins anchor casein kinase 1 isoforms.
Fulcher LJ, Bozatzi P, Tachie-Menson T, Wu KZL, Cummins TD, Bufton JC, Pinkas DM, Dunbar K, Shrestha S, Wood NT, Weidlich S, Macartney TJ, Varghese J, Gourlay R, Campbell DG, Dingwell KS, Smith JC, Bullock AN, Sapkota GP. Fulcher LJ, et al. Sci Signal. 2018 May 22;11(531):eaao2341. doi: 10.1126/scisignal.aao2341. Sci Signal. 2018. PMID: 29789297 Free PMC article.
All eight members of the FAM83 family (FAM83A to FAM83H) interacted with the alpha and alpha-like isoforms of CK1; FAM83A, FAM83B, FAM83E, and FAM83H also interacted with the delta and epsilon isoforms of CK1. ...
All eight members of the FAM83 family (FAM83A to FAM83H) interacted with the alpha and alpha-like isoforms of CK1; FAM83A, FAM83B, FAM83E …
Conserved oncogenic behavior of the FAM83 family regulates MAPK signaling in human cancer.
Cipriano R, Miskimen KL, Bryson BL, Foy CR, Bartel CA, Jackson MW. Cipriano R, et al. Mol Cancer Res. 2014 Aug;12(8):1156-65. doi: 10.1158/1541-7786.MCR-13-0289. Epub 2014 Apr 15. Mol Cancer Res. 2014. PMID: 24736947 Free PMC article.
Furthermore, modeling the observed tumor expression of FAM83A, FAM83C, FAM83D, or FAM83E promoted human mammary epithelial cell (HMEC) transformation, which correlated with the ability of each FAM83 member to bind CRAF (RAF1) and promote CRAF membrane localization. ...
Furthermore, modeling the observed tumor expression of FAM83A, FAM83C, FAM83D, or FAM83E promoted human mammary epithelial cell (HMEC …