PubMed

Feasibility of pathways for transfer of acyl groups from mitochondria to the cytosol to form short chain acyl-CoAs in the pancreatic beta cell.

MacDonald MJ, Smith AD 3rd, Hasan NM, Sabat G, Fahien LA.

J Biol Chem. 2007 Oct 19;282(42):30596-606. Epub 2007 Aug 27.PMID: 17724028 [PubMed - indexed for MEDLINE]Related articlesFree article

Perspective: emerging evidence for signaling roles of mitochondrial anaplerotic products in insulin secretion.

MacDonald MJ, Fahien LA, Brown LJ, Hasan NM, Buss JD, Kendrick MA.

Am J Physiol Endocrinol Metab. 2005 Jan;288(1):E1-15. Review.PMID: 15585595 [PubMed - indexed for MEDLINE]Related articlesFree article

Citrate oscillates in liver and pancreatic beta cell mitochondria and in INS-1 insulinoma cells.

MacDonald MJ, Fahien LA, Buss JD, Hasan NM, Fallon MJ, Kendrick MA.

J Biol Chem. 2003 Dec 19;278(51):51894-900. Epub 2003 Sep 30.PMID: 14522964 [PubMed - indexed for MEDLINE]Related articlesFree article

The succinate mechanism of insulin release.

Fahien LA, MacDonald MJ.

Diabetes. 2002 Sep;51(9):2669-76. Review.PMID: 12196457 [PubMed - indexed for MEDLINE]Related articlesFree article

Normal thyroid thermogenesis but reduced viability and adiposity in mice lacking the mitochondrial glycerol phosphate dehydrogenase.

Brown LJ, Koza RA, Everett C, Reitman ML, Marshall L, Fahien LA, Kozak LP, MacDonald MJ.

J Biol Chem. 2002 Sep 6;277(36):32892-8. Epub 2002 Jul 1.PMID: 12093799 [PubMed - indexed for MEDLINE]Related articlesFree article

Glutamate is not a messenger in insulin secretion.

MacDonald MJ, Fahien LA.

J Biol Chem. 2000 Nov 3;275(44):34025-7.PMID: 10967090 [PubMed - indexed for MEDLINE]Related articlesFree article

Ability of cytosolic malate dehydrogenase and lactate dehydrogenase to increase the ratio of NADPH to NADH oxidation by cytosolic glycerol-3-phosphate dehydrogenase.

Fahien LA, Laboy JI, Din ZZ, Prabhakar P, Budker T, Chobanian M.

Arch Biochem Biophys. 1999 Apr 15;364(2):185-94.PMID: 10190973 [PubMed - indexed for MEDLINE]Related articles

Effect of NADH-X on cytosolic glycerol-3-phosphate dehydrogenase.

Prabhakar P, Laboy JI, Wang J, Budker T, Din ZZ, Chobanian M, Fahien LA.

Arch Biochem Biophys. 1998 Dec 15;360(2):195-205.PMID: 9851831 [PubMed - indexed for MEDLINE]Related articles

Metabolic requirement for inorganic phosphate by renal proximal tubules: influence upon L-glutamine metabolism.

Chobanian MC, Fahien LA, Brazy PC.

Contrib Nephrol. 1997;121:85-92. No abstract available. PMID: 9336702 [PubMed - indexed for MEDLINE]Related articles

Role of hetero-enzyme complexes in acid-base balance.

Fahien LA, Din Z, Laboy J, Chobanian MC.

Contrib Nephrol. 1997;121:1-10. No abstract available. PMID: 9336690 [PubMed - indexed for MEDLINE]Related articles

Interactions between pyruvate carboxylase and other mitochondrial enzymes.

Fahien LA, Davis JW, Laboy J.

J Biol Chem. 1993 Aug 25;268(24):17935-42.PMID: 8349677 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional and morphological studies of mitochondria exposed to undecagold clusters: biologic surfaces labeling with gold clusters.

Valdivia E, Gabel C, Reardon JE, CaJacob CA, Yang H, Wehbi RS, Scott GL, Frey PA, Fahien LA.

Scanning Microsc. 1992 Sep;6(3):799-814; discussion 814-5.PMID: 1439671 [PubMed - indexed for MEDLINE]Related articles

Kinetics and regulation of hepatoma mitochondrial NAD(P) malic enzyme.

Teller JK, Fahien LA, Davis JW.

J Biol Chem. 1992 May 25;267(15):10423-32.PMID: 1587826 [PubMed - indexed for MEDLINE]Related articlesFree article

Glutamate-malate metabolism in liver mitochondria. A model constructed on the basis of mitochondrial levels of enzymes, specificity, dissociation constants, and stoichiometry of hetero-enzyme complexes.

Fahien LA, Teller JK.

J Biol Chem. 1992 May 25;267(15):10411-22.PMID: 1350279 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose regulates leucine-induced insulin release and the expression of the branched chain ketoacid dehydrogenase E1 alpha subunit gene in pancreatic islets.

MacDonald MJ, McKenzie DI, Kaysen JH, Walker TM, Moran SM, Fahien LA, Towle HC.

J Biol Chem. 1991 Jan 15;266(2):1335-40.PMID: 1985951 [PubMed - indexed for MEDLINE]Related articlesFree article

Interactions among mitochondrial aspartate aminotransferase, malate dehydrogenase, and the inner mitochondrial membrane from heart, hepatoma, and liver.

Teller JK, Fahien LA, Valdivia E.

J Biol Chem. 1990 Nov 15;265(32):19486-94.PMID: 2246239 [PubMed - indexed for MEDLINE]Related articlesFree article

Purification of tumor mitochondrial malic enzyme by specific ligand affinity chromatography.

Teller JK, Fahien LA.

Protein Expr Purif. 1990 Nov;1(2):151-4.PMID: 2136236 [PubMed - indexed for MEDLINE]Related articles

Novel effects of insulin secretagogues on capacitation of insulin release and survival of cultured pancreatic islets.

MacDonald MJ, Fahien LA, McKenzie DI, Moran SM.

Am J Physiol. 1990 Oct;259(4 Pt 1):E548-54.PMID: 2221056 [PubMed - indexed for MEDLINE]Related articles

Regulation of glutamate dehydrogenase by Mg2+ and magnification of leucine activation by Mg2+.

Fahien LA, Teller JK, Macdonald MJ, Fahien CM.

Mol Pharmacol. 1990 Jun;37(6):943-9.PMID: 2359406 [PubMed - indexed for MEDLINE]Related articles

Insulin release in pancreatic islets by a glycolytic and a Krebs cycle intermediate: contrasting patterns of glyceraldehyde phosphate and succinate.

MacDonald MJ, Fahien LA.

Arch Biochem Biophys. 1990 May 15;279(1):104-8.PMID: 2186702 [PubMed - indexed for MEDLINE]Related articles

Kinetic advantages of hetero-enzyme complexes with glutamate dehydrogenase and the alpha-ketoglutarate dehydrogenase complex.

Fahien LA, MacDonald MJ, Teller JK, Fibich B, Fahien CM.

J Biol Chem. 1989 Jul 25;264(21):12303-12.PMID: 2745445 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of esters of succinic acid and other citric acid cycle intermediates on insulin release and inositol phosphate formation by pancreatic islets.

MacDonald MJ, Fahien LA, Mertz RJ, Rana RS.

Arch Biochem Biophys. 1989 Mar;269(2):400-6.PMID: 2645827 [PubMed - indexed for MEDLINE]Related articles

Regulation of insulin release by factors that also modify glutamate dehydrogenase.

Fahien LA, MacDonald MJ, Kmiotek EH, Mertz RJ, Fahien CM.

J Biol Chem. 1988 Sep 25;263(27):13610-4.PMID: 3047128 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of malate dehydrogenase activity by glutamate, citrate, alpha-ketoglutarate, and multienzyme interaction.

Fahien LA, Kmiotek EH, MacDonald MJ, Fibich B, Mandic M.

J Biol Chem. 1988 Aug 5;263(22):10687-97.PMID: 2899080 [PubMed - indexed for MEDLINE]Related articlesFree article

Glyceraldehyde phosphate and methyl esters of succinic acid. Two "new" potent insulin secretagogues.

MacDonald MJ, Fahien LA.

Diabetes. 1988 Jul;37(7):997-9.PMID: 3290012 [PubMed - indexed for MEDLINE]Related articles

Proteolysis as a probe of ligand-associated conformational changes in rat carbamyl phosphate synthetase I.

Marshall M, Fahien LA.

Arch Biochem Biophys. 1988 May 1;262(2):455-70.PMID: 3284464 [PubMed - indexed for MEDLINE]Related articles

Proximate sulfhydryl groups in the acetylglutamate complex of rat carbamylphosphate synthetase I: their reaction with the affinity reagent 5'-p-fluorosulfonylbenzoyladenosine.

Marshall M, Fahien LA.

Arch Biochem Biophys. 1985 Aug 15;241(1):200-14.PMID: 4026316 [PubMed - indexed for MEDLINE]Related articles

Regulation of aminotransferase-glutamate dehydrogenase interactions by carbamyl phosphate synthase-I, Mg2+ plus leucine versus citrate and malate.

Fahien LA, Kmiotek EH, Woldegiorgis G, Evenson M, Shrago E, Marshall M.

J Biol Chem. 1985 May 25;260(10):6069-79.PMID: 3997814 [PubMed - indexed for MEDLINE]Related articlesFree article

Interactions between carbamyl phosphate synthase-I-mitochondrial aspartate aminotransferase and palmitoyl-CoA.

Fahien LA, Kmiotek EH, Marshall M.

Arch Biochem Biophys. 1984 Apr;230(1):213-21.PMID: 6712233 [PubMed - indexed for MEDLINE]Related articles

Aminotransferase-glutamate dehydrogenase-carbamyl phosphate synthase-I interactions.

Fahien LA, Kmiotek EH.

Prog Clin Biol Res. 1984;144B:77-86.PMID: 6718417 [PubMed - indexed for MEDLINE]Related articles

Complexes between mitochondrial enzymes and either citrate synthase or glutamate dehydrogenase.

Fahien LA, Kmiotek E.

Arch Biochem Biophys. 1983 Feb 1;220(2):386-97.PMID: 6824331 [PubMed - indexed for MEDLINE]Related articles

Regulation of glutamate dehydrogenase by palmitoyl-coenzyme A.

Fahien LA, Kmiotek E.

Arch Biochem Biophys. 1981 Nov;212(1):247-53. No abstract available. PMID: 7305405 [PubMed - indexed for MEDLINE]Related articles

Effect of malate on glutamate dehydrogenase and complexes between glutamate dehydrogenase and mitochondrial aspartate aminotransferase.

Fahien LA, Kmiotek E, Kajiwara K.

Arch Biochem Biophys. 1981 Jun;209(1):143-51. No abstract available. PMID: 7283433 [PubMed - indexed for MEDLINE]Related articles

Precipitation of complexes between glutamate dehydrogenase and mitochondrial enzymes.

Fahien LA, Kmiotek E.

J Biol Chem. 1979 Jul 10;254(13):5983-90. No abstract available. PMID: 447689 [PubMed - indexed for MEDLINE]Related articlesFree article

The purification and properties of rat brain glutamate dehydrogenase.

Chee PY, Dahl JL, Fahien LA.

J Neurochem. 1979 Jul;33(1):53-60. No abstract available. PMID: 222884 [PubMed - indexed for MEDLINE]Related articles

Glutamate dehydrogenase--malate dehydrogenase complex.

Fahien LA, Kmiotek E, Smith L.

Arch Biochem Biophys. 1979 Jan;192(1):33-46. No abstract available. PMID: 434825 [PubMed - indexed for MEDLINE]Related articles

A study of glutamate dehydrogenase.aminotransferase complexes with a bifunctional imidate.

Fahien LA, Ruoho AE, Kmiotek E.

J Biol Chem. 1978 Aug 25;253(16):5745-51. No abstract available. PMID: 670225 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of aspartate on complexes between glutamate dehydrogenase and various aminotransferases.

Fahien LA, Hsu SL, Kmiotek E.

J Biol Chem. 1977 Feb 25;252(4):1250-6.PMID: 14147 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of quinolinate on aminotransferases.

Hsu SL, Fahien LA.

Arch Biochem Biophys. 1976 Nov;177(1):217-25. No abstract available. PMID: 999286 [PubMed - indexed for MEDLINE]Related articles

A study of the aminotransferase-glutamate dehydrogenase complex with anilinonaphthalene sulfonate.

Fahien LA, VanEngelen DL.

Arch Biochem Biophys. 1976 Sep;176(1):298-305. No abstract available. PMID: 987754 [PubMed - indexed for MEDLINE]Related articles

The enzyme-enzyme complex of transaminase and glutamate dehydrogenase.

Fahien LA, Smith SE.

J Biol Chem. 1974 May 10;249(9):2696-703. No abstract available. PMID: 4857194 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of tranquilizers on the glutamate dehydrogenase-glutamate-oxalacetate transaminase complex.

Shemisa OA, Fahien LA.

Mol Pharmacol. 1973 Nov;9(6):726-35. No abstract available. PMID: 4148653 [PubMed - indexed for MEDLINE]Related articles

Reaction between reduced diphosphopyridine nucleotide and glutamate oxalacetate transaminases.

Shemisa OA, Happy JM, Fahien LA.

J Biol Chem. 1972 Dec 10;247(23):7556-69. No abstract available. PMID: 4404597 [PubMed - indexed for MEDLINE]Related articlesFree article

Interactions between glutamate dehydrogenase, transaminases, and keto acids.

Fahien LA, Lin-Yu JH, Smith SE, Happy JM.

J Biol Chem. 1971 Dec 10;246(23):7241-9. No abstract available. PMID: 4399705 [PubMed - indexed for MEDLINE]Related articlesFree article

Purification and regulatory properties of beef liver D-glycerate dehydrogenase.

Rosenblum IY, Antkowiak DH, Sallach HJ, Flanders LE, Fahien LA.

Arch Biochem Biophys. 1971 May;144(1):375-83. No abstract available. PMID: 4330130 [PubMed - indexed for MEDLINE]Related articles

Modifications of glutamate dehydrogenase by various drugs which affect behavior.

Shemisa OA, Fahien LA.

Mol Pharmacol. 1971 Jan;7(1):8-25. No abstract available. PMID: 5552255 [PubMed - indexed for MEDLINE]Related articles

Effects of chlorpromazine on glutamate dehydrogenase.

Fahien LA, Shemisa O.

Mol Pharmacol. 1970 Mar;6(2):156-63. No abstract available. PMID: 4392129 [PubMed - indexed for MEDLINE]Related articles

Studies of gluconeogenic mitochondrial enzymes. V. The effect of transaminases on reactions catalyzed by glutamate dehydrogenase.

Fahien LA, Smith SE.

Arch Biochem Biophys. 1969 Dec;135(1):136-51. No abstract available. PMID: 4391338 [PubMed - indexed for MEDLINE]Related articles

Studies of gluconeogenic mitochondrial enzymes. I. A new method of preparing bovine liver glutamate dehydrogenase and effects of purification methods on properties of the enzyme.

Fahien LA, Strmecki M, Smith S.

Arch Biochem Biophys. 1969 Mar;130(1):449-55. No abstract available. PMID: 5778660 [PubMed - indexed for MEDLINE]Related articles

Studies of gluconeogenic mitochondrial enzymes. IV. The conversion of oxaloacetate to fumarate by bovine liver mitochondrial malate dehydrogenase and fumarase.

Fahien LA, Strmecki M.

Arch Biochem Biophys. 1969 Mar;130(1):478-87. No abstract available. PMID: 4305166 [PubMed - indexed for MEDLINE]Related articles