PubMed

Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects.

Sackmann-Sala L, Ding J, Frohman LA, Kopchick JJ.

Growth Horm IGF Res. 2009 Dec;19(6):471-7. Epub 2009 Apr 21.PMID: 19386527 [PubMed - in process]Related articles

Use of the metallothionein promoter-human growth hormone-releasing hormone (GHRH) mouse to identify regulatory pathways that suppress pituitary somatotrope hyperplasia and adenoma formation due to GHRH-receptor hyperactivation.

Luque RM, Soares BS, Peng XD, Krishnan S, Cordoba-Chacon J, Frohman LA, Kineman RD.

Endocrinology. 2009 Jul;150(7):3177-85. Epub 2009 Apr 2.PMID: 19342460 [PubMed - indexed for MEDLINE]Related articles

Treatment of pituitary-dependent Cushing's disease with the multireceptor ligand somatostatin analog pasireotide (SOM230): a multicenter, phase II trial.

Boscaro M, Ludlam WH, Atkinson B, Glusman JE, Petersenn S, Reincke M, Snyder P, Tabarin A, Biller BM, Findling J, Melmed S, Darby CH, Hu K, Wang Y, Freda PU, Grossman AB, Frohman LA, Bertherat J.

J Clin Endocrinol Metab. 2009 Jan;94(1):115-22. Epub 2008 Oct 28.PMID: 18957506 [PubMed - indexed for MEDLINE]Related articles

The role of the aryl hydrocarbon receptor-interacting protein gene in familial and sporadic pituitary adenomas.

Leontiou CA, Gueorguiev M, van der Spuy J, Quinton R, Lolli F, Hassan S, Chahal HS, Igreja SC, Jordan S, Rowe J, Stolbrink M, Christian HC, Wray J, Bishop-Bailey D, Berney DM, Wass JA, Popovic V, Ribeiro-Oliveira A Jr, Gadelha MR, Monson JP, Akker SA, Davis JR, Clayton RN, Yoshimoto K, Iwata T, Matsuno A, Eguchi K, Musat M, Flanagan D, Peters G, Bolger GB, Chapple JP, Frohman LA, Grossman AB, Korbonits M.

J Clin Endocrinol Metab. 2008 Jun;93(6):2390-401. Epub 2008 Apr 1.PMID: 18381572 [PubMed - indexed for MEDLINE]Related articlesFree article

Normal physiology of hypothalamic pituitary regulation.

Sam S, Frohman LA.

Endocrinol Metab Clin North Am. 2008 Mar;37(1):1-22, vii. Review.PMID: 18226728 [PubMed - indexed for MEDLINE]Related articles

The empty sella.

Naing S, Frohman LA.

Pediatr Endocrinol Rev. 2007 Jun;4(4):335-42. Review.PMID: 17643081 [PubMed - indexed for MEDLINE]Related articles

Pituitary tumor enlargement in two patients with acromegaly during pegvisomant therapy.

Frohman LA, Bonert V.

Pituitary. 2007;10(3):283-9.PMID: 17534717 [PubMed - indexed for MEDLINE]Related articles

Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog.

Ionescu M, Frohman LA.

J Clin Endocrinol Metab. 2006 Dec;91(12):4792-7. Epub 2006 Oct 3.PMID: 17018654 [PubMed - indexed for MEDLINE]Related articlesFree article

Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse.

Alba M, Fintini D, Sagazio A, Lawrence B, Castaigne JP, Frohman LA, Salvatori R.

Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1290-4. Epub 2006 Jul 5.PMID: 16822960 [PubMed - indexed for MEDLINE]Related articlesFree article

Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults.

Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA.

J Clin Endocrinol Metab. 2006 Mar;91(3):799-805. Epub 2005 Dec 13.PMID: 16352683 [PubMed - indexed for MEDLINE]Related articlesFree article

Consensus statement: medical management of acromegaly.

Melmed S, Casanueva F, Cavagnini F, Chanson P, Frohman LA, Gaillard R, Ghigo E, Ho K, Jaquet P, Kleinberg D, Lamberts S, Laws E, Lombardi G, Sheppard MC, Thorner M, Vance ML, Wass JA, Giustina A.

Eur J Endocrinol. 2005 Dec;153(6):737-40.PMID: 16322377 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression analysis of hypothalamic and pituitary components of the growth hormone axis in fasted and streptozotocin-treated neuropeptide Y (NPY)-intact (NPY+/+) and NPY-knockout (NPY-/-) mice.

Park S, Peng XD, Frohman LA, Kineman RD.

Neuroendocrinology. 2005;81(6):360-71. Epub 2005 Oct 18.PMID: 16244497 [PubMed - indexed for MEDLINE]Related articles

Tumor deletion mapping on chromosome 11q13 in eight families with isolated familial somatotropinoma and in 15 sporadic somatotropinomas.

Soares BS, Eguchi K, Frohman LA.

J Clin Endocrinol Metab. 2005 Dec;90(12):6580-7. Epub 2005 Sep 27.PMID: 16189251 [PubMed - indexed for MEDLINE]Related articlesFree article

p130Rb2 and p27kip1 cooperate to control mobilization of angiogenic progenitors from the bone marrow.

Vidal A, Zacharoulis S, Guo W, Shaffer D, Giancotti F, Bramley AH, de la Hoz C, Jensen KK, Kato D, MacDonald DD, Knowles J, Yeh N, Frohman LA, Rafii S, Lyden D, Koff A.

Proc Natl Acad Sci U S A. 2005 May 10;102(19):6890-5. Epub 2005 May 2.PMID: 15867156 [PubMed - indexed for MEDLINE]Related articlesFree article

Isolated familial somatotropinoma.

Soares BS, Frohman LA.

Pituitary. 2004;7(2):95-101.PMID: 15761658 [PubMed - indexed for MEDLINE]Related articles

Familial acromegaly.

Frohman LA, Eguchi K.

Growth Horm IGF Res. 2004 Jun;14 Suppl A:S90-6. Review.PMID: 15135786 [PubMed - indexed for MEDLINE]Related articles

A meiotic recombination in a new isolated familial somatotropinoma kindred.

Luccio-Camelo DC, Une KN, Ferreira RE, Khoo SK, Nickolov R, Bronstein MD, Vaisman M, Teh BT, Frohman LA, Mendonça BB, Gadelha MR.

Eur J Endocrinol. 2004 May;150(5):643-8.PMID: 15132719 [PubMed - indexed for MEDLINE]Related articlesFree article

Diagnosis and treatment of acromegaly complications.

Giustina A, Casanueva FF, Cavagnini F, Chanson P, Clemmons D, Frohman LA, Gaillard R, Ho K, Jaquet P, Kleinberg DL, Lamberts SW, Lombardi G, Sheppard M, Strasburger CJ, Vance ML, Wass JA, Melmed S; Pituitary Society and the European Neuroendocrine Association.

J Endocrinol Invest. 2003 Dec;26(12):1242-7.PMID: 15055479 [PubMed - indexed for MEDLINE]Related articles

Isolated familial somatotropinomas: clinical and genetic considerations.

Frohman LA.

Trans Am Clin Climatol Assoc. 2003;114:165-77.PMID: 12813918 [PubMed - indexed for MEDLINE]Related articlesFree article

Growth hormone-releasing hormone and pituitary somatotrope proliferation.

Frohman LA, Kineman RD.

Minerva Endocrinol. 2002 Dec;27(4):277-85. Review.PMID: 12511850 [PubMed - indexed for MEDLINE]Related articles

Who needs growth hormone therapy? Growth hormone helps some, but its use as an "anti-aging" agent is dubious.

Frohman LA.

Health News. 2002 Oct;8(10):4. No abstract available. PMID: 12416482 [PubMed - indexed for MEDLINE]Related articles

Growth hormone-releasing hormone and pituitary development, hyperplasia and tumorigenesis.

Frohman LA, Kineman RD.

Trends Endocrinol Metab. 2002 Sep;13(7):299-303. Review.PMID: 12163232 [PubMed - indexed for MEDLINE]Related articles

Controversy about treatment of growth hormone-deficient adults: a commentary.

Frohman LA.

Ann Intern Med. 2002 Aug 6;137(3):202-4. No abstract available. PMID: 12160369 [PubMed - indexed for MEDLINE]Related articlesFree article

The effect of GHRH on somatotrope hyperplasia and tumor formation in the presence and absence of GH signaling.

Kineman RD, Teixeira LT, Amargo GV, Coschigano KT, Kopchick JJ, Frohman LA.

Endocrinology. 2001 Sep;142(9):3764-73.PMID: 11517152 [PubMed - indexed for MEDLINE]Related articlesFree article

The growth hormone (GH)-axis of GH receptor/binding protein gene-disrupted and metallothionein-human GH-releasing hormone transgenic mice: hypothalamic neuropeptide and pituitary receptor expression in the absence and presence of GH feedback.

Peng XD, Park S, Gadelha MR, Coschigano KT, Kopchick JJ, Frohman LA, Kineman RD.

Endocrinology. 2001 Mar;142(3):1117-23.PMID: 11181526 [PubMed - indexed for MEDLINE]Related articlesFree article

Authors' Response: Isolated Familial Somatotropinomas: Does the Disease Map to 11q13 or to 2p16?

Gadelha MR, Rhode K, Kineman RD, Frohman LA.

J Clin Endocrinol Metab. 2000 Dec;85(12):4921. No abstract available. PMID: 11134166 [PubMed - as supplied by publisher]Related articles

Secretagogues and the somatotrope: signaling and proliferation.

Frohman LA, Kineman RD, Kamegai J, Park S, Teixeira LT, Coschigano KT, Kopchic JJ.

Recent Prog Horm Res. 2000;55:269-90; discussion 290-1. Review.PMID: 11036941 [PubMed - indexed for MEDLINE]Related articles

Modulation of pituitary somatostatin receptor subtype (sst1-5) messenger ribonucleic acid levels by changes in the growth hormone axis.

Park S, Kamegai J, Johnson TA, Frohman LA, Kineman RD.

Endocrinology. 2000 Oct;141(10):3556-63.PMID: 11014208 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucocorticoids regulate pituitary growth hormone secretagogue receptor gene expression.

Tamura H, Kamegai J, Sugihara H, Kineman RD, Frohman LA, Wakabayashi I.

J Neuroendocrinol. 2000 Jun;12(6):481-5.PMID: 10844575 [PubMed - indexed for MEDLINE]Related articles

p27Kip1-deficient mice exhibit accelerated growth hormone-releasing hormone (GHRH)-induced somatotrope proliferation and adenoma formation.

Teixeira LT, Kiyokawa H, Peng XD, Christov KT, Frohman LA, Kineman RD.

Oncogene. 2000 Apr 6;19(15):1875-84.PMID: 10773877 [PubMed - indexed for MEDLINE]Related articlesFree article

Increase in mRNA concentrations of pituitary receptors for growth hormone-releasing hormone and growth hormone secretagogues after neonatal monosodium glutamate treatment.

Kovacs M, Kineman RD, Schally AV, Flerko B, Frohman LA.

J Neuroendocrinol. 2000 Apr;12(4):335-41.PMID: 10718930 [PubMed - indexed for MEDLINE]Related articles

Isolated familial somatotropinomas: establishment of linkage to chromosome 11q13.1-11q13.3 and evidence for a potential second locus at chromosome 2p16-12.

Gadelha MR, Une KN, Rohde K, Vaisman M, Kineman RD, Frohman LA.

J Clin Endocrinol Metab. 2000 Feb;85(2):707-14.PMID: 10690880 [PubMed - indexed for MEDLINE]Related articlesFree article

Growth hormone (GH)-releasing hormone (GHRH) and the GH secretagogue (GHS), L692,585, differentially modulate rat pituitary GHS receptor and GHRH receptor messenger ribonucleic acid levels.

Kineman RD, Kamegai J, Frohman LA.

Endocrinology. 1999 Aug;140(8):3581-6.PMID: 10433214 [PubMed - indexed for MEDLINE]Related articlesFree article

Growth hormone-releasing hormone receptor (GHRH-R) and growth hormone secretagogue receptor (GHS-R) mRNA levels during postnatal development in male and female rats.

Kamegai J, Wakabayashi I, Kineman RD, Frohman LA.

J Neuroendocrinol. 1999 Apr;11(4):299-306.PMID: 10223284 [PubMed - indexed for MEDLINE]Related articles

Loss of heterozygosity on chromosome 11q13 in two families with acromegaly/gigantism is independent of mutations of the multiple endocrine neoplasia type I gene.

Gadelha MR, Prezant TR, Une KN, Glick RP, Moskal SF 2nd, Vaisman M, Melmed S, Kineman RD, Frohman LA.

J Clin Endocrinol Metab. 1999 Jan;84(1):249-56.PMID: 9920092 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of growth hormone (GH)-releasing hormone and somatostatin on leptin-induced GH secretion.

Carro E, Señarís RM, Seoane LM, Frohman LA, Arimura A, Casanueva FF, Diéguez C.

Neuroendocrinology. 1999 Jan;69(1):3-10.PMID: 9892845 [PubMed - indexed for MEDLINE]Related articles

Growth hormone-dependent regulation of pituitary GH secretagogue receptor (GHS-R) mRNA levels in the spontaneous dwarf Rat.

Kamegai J, Wakabayashi I, Miyamoto K, Unterman TG, Kineman RD, Frohman LA.

Neuroendocrinology. 1998 Nov;68(5):312-8.PMID: 9822798 [PubMed - indexed for MEDLINE]Related articles

Hypothalamic/pituitary-axis of the spontaneous dwarf rat: autofeedback regulation of growth hormone (GH) includes suppression of GH releasing-hormone receptor messenger ribonucleic acid.

Kamegai J, Unterman TG, Frohman LA, Kineman RD.

Endocrinology. 1998 Aug;139(8):3554-60.PMID: 9681507 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of a fusion gene consisting of the mouse growth hormone-releasing hormone gene promoter linked to the SV40 T-antigen gene in transgenic mice.

Nogues N, Magnan E, De Grandis P, Butz M, Kineman RD, Kopchick JJ, Frohman LA.

Mol Cell Endocrinol. 1998 Feb;137(2):161-8.PMID: 9605518 [PubMed - indexed for MEDLINE]Related articles

Acromegaly and Cushing's syndrome due to ectopic production of GHRH and ACTH by a thymic carcinoid tumour: in vitro responses to GHRH and GHRP-6.

Jansson JO, Svensson J, Bengtsson BA, Frohman LA, Ahlman H, Wängberg B, Nilsson O, Nilsson M.

Clin Endocrinol (Oxf). 1998 Feb;48(2):243-50.PMID: 9579239 [PubMed - indexed for MEDLINE]Related articles

Effects of antagonists of growth hormone-releasing hormone (GHRH) on GH and insulin-like growth factor I levels in transgenic mice overexpressing the human GHRH gene, an animal model of acromegaly.

Kovacs M, Kineman RD, Schally AV, Zarandi M, Groot K, Frohman LA.

Endocrinology. 1997 Nov;138(11):4536-42.PMID: 9348175 [PubMed - indexed for MEDLINE]Related articlesFree article

Homologous down-regulation of growth hormone-releasing hormone receptor messenger ribonucleic acid levels.

Aleppo G, Moskal SF 2nd, De Grandis PA, Kineman RD, Frohman LA.

Endocrinology. 1997 Mar;138(3):1058-65.PMID: 9048609 [PubMed - indexed for MEDLINE]Related articlesFree article

Suppression of growth hormone (GH) hypersecretion due to ectopic GH-releasing hormone (GHRH) by a selective GHRH antagonist.

Jaffe CA, DeMott-Friberg R, Frohman LA, Barkan AL.

J Clin Endocrinol Metab. 1997 Feb;82(2):634-7.PMID: 9024267 [PubMed - indexed for MEDLINE]Related articlesFree article

The tyrosine hydroxylase-human growth hormone (GH) transgenic mouse as a model of hypothalamic GH deficiency: growth retardation is the result of a selective reduction in somatotrope numbers despite normal somatotrope function.

Kineman RD, Aleppo G, Frohman LA.

Endocrinology. 1996 Nov;137(11):4630-6.PMID: 8895326 [PubMed - indexed for MEDLINE]Related articles

New insights into the regulation of somatotrope function using genetic and transgenic models.

Frohman LA.

Metabolism. 1996 Aug;45(8 Suppl 1):1-3. Review.PMID: 8769367 [PubMed - indexed for MEDLINE]Related articles

Growth hormone physiology in health and disease: insights using genetic and transgenic models.

Frohman LA.

J Pediatr Endocrinol Metab. 1996 Jun;9 Suppl 3:233-6. Review. No abstract available. PMID: 8887166 [PubMed - indexed for MEDLINE]Related articles

Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

Kiyokawa H, Kineman RD, Manova-Todorova KO, Soares VC, Hoffman ES, Ono M, Khanam D, Hayday AC, Frohman LA, Koff A.

Cell. 1996 May 31;85(5):721-32.PMID: 8646780 [PubMed - indexed for MEDLINE]Related articles

Acromegaly: what constitutes optimal therapy?

Frohman LA.

J Clin Endocrinol Metab. 1996 Feb;81(2):443-5. Review. No abstract available. PMID: 8636245 [PubMed - indexed for MEDLINE]Related articles

Autofeedback suppression of growth hormone (GH) secretion in transgenic mice expressing a human GH reporter targeted by tyrosine hydroxylase 5'-flanking sequences to the hypothalamus.

Szabo M, Butz MR, Banerjee SA, Chikaraishi DM, Frohman LA.

Endocrinology. 1995 Sep;136(9):4044-8.PMID: 7649113 [PubMed - indexed for MEDLINE]Related articles

Discordant effects of endogenous and exogenous somatostatin on growth hormone-releasing hormone secretion from perifused mouse hypothalami.

Pecori Giraldi F, Frohman LA.

Neuroendocrinology. 1995 May;61(5):566-72.PMID: 7617135 [PubMed - indexed for MEDLINE]Related articles