PubMed

Diabetes induces neural degeneration in nucleus ambiguus (NA) and attenuates heart rate control in OVE26 mice.

Yan B, Li L, Harden SW, Epstein PN, Wurster RD, Cheng ZJ.

Exp Neurol. 2009 Nov;220(1):34-43. Epub 2009 Jul 15.PMID: 19615367 [PubMed - indexed for MEDLINE]Related articles

Diabetic albuminuria is due to a small fraction of nephrons distinguished by albumin-stained tubules and glomerular adhesions.

Kralik PM, Long Y, Song Y, Yang L, Wei H, Coventry S, Zheng S, Epstein PN.

Am J Pathol. 2009 Aug;175(2):500-9. Epub 2009 Jul 2.PMID: 19574429 [PubMed - indexed for MEDLINE]Related articles

Steroidogenic acute regulatory-related lipid transfer domain protein 5 localization and regulation in renal tubules.

Chen YC, Meier RK, Zheng S, Khundmiri SJ, Tseng MT, Lederer ED, Epstein PN, Clark BJ.

Am J Physiol Renal Physiol. 2009 Aug;297(2):F380-8. Epub 2009 May 27.PMID: 19474188 [PubMed - indexed for MEDLINE]Related articles

Transgenic overexpression of aldehyde dehydrogenase-2 rescues chronic alcohol intake-induced myocardial hypertrophy and contractile dysfunction.

Doser TA, Turdi S, Thomas DP, Epstein PN, Li SY, Ren J.

Circulation. 2009 Apr 14;119(14):1941-9. Epub 2009 Mar 30.PMID: 19332462 [PubMed - indexed for MEDLINE]Related articles

Impaired baroreflex control of renal sympathetic nerve activity in type 1 diabetic mice (OVE26).

Gu H, Zhang ZH, Epstein PN, Li L, Harden SW, Wurster RD, Cheng ZJ.

Neuroscience. 2009 Jun 16;161(1):78-85. Epub 2009 Mar 19.PMID: 19303918 [PubMed - indexed for MEDLINE]Related articles

Transgenic expression of insulin-response element binding protein-1 in beta-cells reproduces type 2 diabetes.

Villafuerte BC, Barati MT, Song Y, Moore JP, Epstein PN, Portillo J.

Endocrinology. 2009 Jun;150(6):2611-7. Epub 2009 Feb 12.PMID: 19213832 [PubMed - indexed for MEDLINE]Related articles

Metallothionein over-expression in podocytes reduces adriamycin nephrotoxicity.

Yang L, Zheng S, Epstein PN.

Free Radic Res. 2009 Feb;43(2):174-82.PMID: 19204870 [PubMed - indexed for MEDLINE]Related articles

Beta-cell death and proliferation after intermittent hypoxia: role of oxidative stress.

Xu J, Long YS, Gozal D, Epstein PN.

Free Radic Biol Med. 2009 Mar 15;46(6):783-90. Epub 2008 Dec 14.PMID: 19133326 [PubMed - in process]Related articles

Renal tubulointerstitial fibrosis in OVE26 type 1 diabetic mice.

Powell DW, Bertram CC, Cummins TD, Barati MT, Zheng S, Epstein PN, Klein JB.

Nephron Exp Nephrol. 2009;111(1):e11-9. Epub 2008 Dec 2.PMID: 19052473 [PubMed - indexed for MEDLINE]Related articles

Malic enzyme is present in mouse islets and modulates insulin secretion.

Xu J, Han J, Long YS, Lock J, Weir GC, Epstein PN, Liu YQ.

Diabetologia. 2008 Dec;51(12):2281-9. Epub 2008 Sep 19.PMID: 18802677 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of pyruvate carboxylase in insulin secretion and proliferation in rat pancreatic beta cells.

Xu J, Han J, Long YS, Epstein PN, Liu YQ.

Diabetologia. 2008 Nov;51(11):2022-30. Epub 2008 Sep 4.PMID: 18769905 [PubMed - indexed for MEDLINE]Related articlesFree article

Podocyte-specific overexpression of the antioxidant metallothionein reduces diabetic nephropathy.

Zheng S, Carlson EC, Yang L, Kralik PM, Huang Y, Epstein PN.

J Am Soc Nephrol. 2008 Nov;19(11):2077-85. Epub 2008 Jul 16.PMID: 18632844 [PubMed - indexed for MEDLINE]Related articlesFree article

Cardiac phosphatase-deficient 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase increases glycolysis, hypertrophy, and myocyte resistance to hypoxia.

Wang Q, Donthi RV, Wang J, Lange AJ, Watson LJ, Jones SP, Epstein PN.

Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2889-97. Epub 2008 May 2.PMID: 18456722 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional changes in baroreceptor afferent, central and efferent components of the baroreflex circuitry in type 1 diabetic mice (OVE26).

Gu H, Epstein PN, Li L, Wurster RD, Cheng ZJ.

Neuroscience. 2008 Mar 27;152(3):741-52. Epub 2007 Dec 4.PMID: 18328631 [PubMed - indexed for MEDLINE]Related articles

Altering and analyzing glucose metabolism in perfused hearts of transgenic mice.

Donthi RV, Epstein PN.

Methods Mol Med. 2007;139:151-61.PMID: 18287670 [PubMed - indexed for MEDLINE]Related articles

Podocyte loss in aging OVE26 diabetic mice.

Teiken JM, Audettey JL, Laturnus DI, Zheng S, Epstein PN, Carlson EC.

Anat Rec (Hoboken). 2008 Jan;291(1):114-21.PMID: 18085629 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetic Cardiomyopathy in OVE26 Mice Shows Mitochondrial ROS Production and Divergence Between In Vivo and In Vitro Contractility.

Song Y, Du Y, Prabhu SD, Epstein PN.

Rev Diabet Stud. 2007 Fall;4(3):159-68. Epub 2007 Nov 10.PMID: 18084673 [PubMed - in process]Related articlesFree article

Morphology and topography of nucleus ambiguus projections to cardiac ganglia in rats and mice.

Ai J, Epstein PN, Gozal D, Yang B, Wurster R, Cheng ZJ.

Neuroscience. 2007 Nov 23;149(4):845-60. Epub 2007 Sep 11.PMID: 17942236 [PubMed - indexed for MEDLINE]Related articles

Proteomic identification and immunolocalization of increased renal calbindin-D28k expression in OVE26 diabetic mice.

Thongboonkerd V, Zheng S, McLeish KR, Epstein PN, Klein JB.

Rev Diabet Stud. 2005 Spring;2(1):19-26. Epub 2005 May 10.PMID: 17491655 [PubMed]Related articlesFree article

Causes and characteristics of diabetic cardiomyopathy.

Wang J, Song Y, Wang Q, Kralik PM, Epstein PN.

Rev Diabet Stud. 2006 Fall;3(3):108-17. Epub 2006 Nov 10.PMID: 17487334 [PubMed - in process]Related articlesFree article

Hyperglycemia alters enzyme activity and cell number in spinal sensory ganglia.

Zaruba RA, Epstein PN, Carr PA.

J Brachial Plex Peripher Nerve Inj. 2007 Apr 25;2:11.PMID: 17459160 [PubMed]Related articlesFree article

Rat maternal diabetes impairs pancreatic beta-cell function in the offspring.

Han J, Xu J, Long YS, Epstein PN, Liu YQ.

Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E228-36. Epub 2007 Mar 27.PMID: 17389712 [PubMed - indexed for MEDLINE]Related articlesFree article

Metallothionein and catalase sensitize to diabetes in nonobese diabetic mice: reactive oxygen species may have a protective role in pancreatic beta-cells.

Li X, Chen H, Epstein PN.

Diabetes. 2006 Jun;55(6):1592-604.PMID: 16731821 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of PDK mRNA by high fatty acid and glucose in pancreatic islets.

Xu J, Han J, Epstein PN, Liu YQ.

Biochem Biophys Res Commun. 2006 Jun 9;344(3):827-33. Epub 2006 Apr 19.PMID: 16631612 [PubMed - indexed for MEDLINE]Related articles

Protection of cardiac mitochondria by overexpression of MnSOD reduces diabetic cardiomyopathy.

Shen X, Zheng S, Metreveli NS, Epstein PN.

Diabetes. 2006 Mar;55(3):798-805.PMID: 16505246 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of hexokinase protects hypoxic and diabetic cardiomyocytes by increasing ATP generation.

Ye G, Donthi RV, Metreveli NS, Epstein PN.

Cardiovasc Toxicol. 2005;5(3):293-300.PMID: 16244374 [PubMed - indexed for MEDLINE]Related articles

Cardiomyocyte dysfunction in models of type 1 and type 2 diabetes.

Kralik PM, Ye G, Metreveli NS, Shem X, Epstein PN.

Cardiovasc Toxicol. 2005;5(3):285-92. Erratum in: Cardiovasc Toxicol. 2006;6(1):79. Kralik, Patricia M [added]; Donthi, Rajakumar V [removed]; Shem, Xia [added]. PMID: 16244373 [PubMed - indexed for MEDLINE]Related articles

Metallothionein alleviates cardiac contractile dysfunction induced by insulin resistance: role of Akt phosphorylation, PTB1B, PPARgamma and c-Jun.

Fang CX, Dong F, Ren BH, Epstein PN, Ren J.

Diabetologia. 2005 Nov;48(11):2412-21. Epub 2005 Sep 20.PMID: 16172869 [PubMed - indexed for MEDLINE]Related articles

Long-term effect of maternal obesity on pancreatic beta cells of offspring: reduced beta cell adaptation to high glucose and high-fat diet challenges in adult female mouse offspring.

Han J, Xu J, Epstein PN, Liu YQ.

Diabetologia. 2005 Sep;48(9):1810-8. Epub 2005 Jul 12.PMID: 16010523 [PubMed - indexed for MEDLINE]Related articles

Cardiomyocyte defects in diabetic models and protection with cardiac-targeted transgenes.

Shen X, Ye G, Metreveli NS, Epstein PN.

Methods Mol Med. 2005;112:379-88. Review.PMID: 16010031 [PubMed - indexed for MEDLINE]Related articles

MnSOD and catalase transgenes demonstrate that protection of islets from oxidative stress does not alter cytokine toxicity.

Chen H, Li X, Epstein PN.

Diabetes. 2005 May;54(5):1437-46.PMID: 15855331 [PubMed - indexed for MEDLINE]Related articlesFree article

Development of late-stage diabetic nephropathy in OVE26 diabetic mice.

Zheng S, Noonan WT, Metreveli NS, Coventry S, Kralik PM, Carlson EC, Epstein PN.

Diabetes. 2004 Dec;53(12):3248-57.PMID: 15561957 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced rat beta-cell proliferation in 60% pancreatectomized islets by increased glucose metabolic flux through pyruvate carboxylase pathway.

Liu YQ, Han J, Epstein PN, Long YS.

Am J Physiol Endocrinol Metab. 2005 Mar;288(3):E471-8. Epub 2004 Oct 26.PMID: 15507531 [PubMed - indexed for MEDLINE]Related articlesFree article

Cardiac expression of kinase-deficient 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase inhibits glycolysis, promotes hypertrophy, impairs myocyte function, and reduces insulin sensitivity.

Donthi RV, Ye G, Wu C, McClain DA, Lange AJ, Epstein PN.

J Biol Chem. 2004 Nov 12;279(46):48085-90. Epub 2004 Aug 25.PMID: 15331593 [PubMed - indexed for MEDLINE]Related articlesFree article

Cardiac mitochondrial damage and biogenesis in a chronic model of type 1 diabetes.

Shen X, Zheng S, Thongboonkerd V, Xu M, Pierce WM Jr, Klein JB, Epstein PN.

Am J Physiol Endocrinol Metab. 2004 Nov;287(5):E896-905. Epub 2004 Jul 27.PMID: 15280150 [PubMed - indexed for MEDLINE]Related articlesFree article

Catalase protects cardiomyocyte function in models of type 1 and type 2 diabetes.

Ye G, Metreveli NS, Donthi RV, Xia S, Xu M, Carlson EC, Epstein PN.

Diabetes. 2004 May;53(5):1336-43.PMID: 15111504 [PubMed - indexed for MEDLINE]Related articlesFree article

Alterations in the renal elastin-elastase system in type 1 diabetic nephropathy identified by proteomic analysis.

Thongboonkerd V, Barati MT, McLeish KR, Benarafa C, Remold-O'Donnell E, Zheng S, Rovin BH, Pierce WM, Epstein PN, Klein JB.

J Am Soc Nephrol. 2004 Mar;15(3):650-62.PMID: 14978167 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of aldehyde dehydrogenase-2 (ALDH2) transgene prevents acetaldehyde-induced cell injury in human umbilical vein endothelial cells: role of ERK and p38 mitogen-activated protein kinase.

Li SY, Gomelsky M, Duan J, Zhang Z, Gomelsky L, Zhang X, Epstein PN, Ren J.

J Biol Chem. 2004 Mar 19;279(12):11244-52. Epub 2004 Jan 13.PMID: 14722101 [PubMed - indexed for MEDLINE]Related articlesFree article

Proteomics and diabetic nephropathy.

Thongboonkerd V, Barati MT, McLeish KR, Pierce WM, Epstein PN, Klein JB.

Contrib Nephrol. 2004;141:142-54. Review. No abstract available. PMID: 14650230 [PubMed - indexed for MEDLINE]Related articles

Metallothionein protects islets from hypoxia and extends islet graft survival by scavenging most kinds of reactive oxygen species.

Li X, Chen H, Epstein PN.

J Biol Chem. 2004 Jan 2;279(1):765-71. Epub 2003 Oct 23.PMID: 14576162 [PubMed - indexed for MEDLINE]Related articlesFree article

Cardiac overexpression of alcohol dehydrogenase exacerbates cardiac contractile dysfunction, lipid peroxidation, and protein damage after chronic ethanol ingestion.

Hintz KK, Relling DP, Saari JT, Borgerding AJ, Duan J, Ren BH, Kato K, Epstein PN, Ren J.

Alcohol Clin Exp Res. 2003 Jul;27(7):1090-8.PMID: 12878915 [PubMed - indexed for MEDLINE]Related articles

Ultrastructural morphometry of capillary basement membrane thickness in normal and transgenic diabetic mice.

Carlson EC, Audette JL, Veitenheimer NJ, Risan JA, Laturnus DI, Epstein PN.

Anat Rec A Discov Mol Cell Evol Biol. 2003 Apr;271(2):332-41.PMID: 12629676 [PubMed - indexed for MEDLINE]Related articlesFree article

Metallothionein prevents diabetes-induced deficits in cardiomyocytes by inhibiting reactive oxygen species production.

Ye G, Metreveli NS, Ren J, Epstein PN.

Diabetes. 2003 Mar;52(3):777-83.PMID: 12606520 [PubMed - indexed for MEDLINE]Related articlesFree article

Influence of gender on ethanol-induced ventricular myocyte contractile depression in transgenic mice with cardiac overexpression of alcohol dehydrogenase.

Duan J, Esberg LB, Ye G, Borgerding AJ, Ren BH, Aberle NS, Epstein PN, Ren J.

Comp Biochem Physiol A Mol Integr Physiol. 2003 Mar;134(3):607-14.PMID: 12600669 [PubMed - indexed for MEDLINE]Related articles

Impaired cardiac function and IGF-I response in myocytes from calmodulin-diabetic mice: role of Akt and RhoA.

Duan J, Zhang HY, Adkins SD, Ren BH, Norby FL, Zhang X, Benoit JN, Epstein PN, Ren J.

Am J Physiol Endocrinol Metab. 2003 Feb;284(2):E366-76.PMID: 12531745 [PubMed - indexed for MEDLINE]Related articlesFree article

Prenatal ethanol exposure alters ventricular myocyte contractile function in the offspring of rats: influence of maternal Mg2+ supplementation.

Wold LE, Norby FL, Hintz KK, Colligan PB, Epstein PN, Ren J.

Cardiovasc Toxicol. 2001;1(3):215-24.PMID: 12213974 [PubMed - indexed for MEDLINE]Related articles

Overexpression of alcohol dehydrogenase exacerbates ethanol-induced contractile defect in cardiac myocytes.

Duan J, McFadden GE, Borgerding AJ, Norby FL, Ren BH, Ye G, Epstein PN, Ren J.

Am J Physiol Heart Circ Physiol. 2002 Apr;282(4):H1216-22.PMID: 11893554 [PubMed - indexed for MEDLINE]Related articlesFree article

Elevated hexokinase increases cardiac glycolysis in transgenic mice.

Liang Q, Donthi RV, Kralik PM, Epstein PN.

Cardiovasc Res. 2002 Feb 1;53(2):423-30.PMID: 11827693 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of metallothionein reduces diabetic cardiomyopathy.

Liang Q, Carlson EC, Donthi RV, Kralik PM, Shen X, Epstein PN.

Diabetes. 2002 Jan;51(1):174-81.PMID: 11756338 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of contractile function in diabetic hypertensive cardiomyopathy in adult rat ventricular myocytes.

Wold LE, Relling DP, Colligan PB, Scott GI, Hintz KK, Ren BH, Epstein PN, Ren J.

J Mol Cell Cardiol. 2001 Sep;33(9):1719-26.PMID: 11549350 [PubMed - indexed for MEDLINE]Related articles