PubMed

From the Cover: CD39 deletion exacerbates experimental murine colitis and human polymorphisms increase susceptibility to inflammatory bowel disease.

Friedman DJ, Künzli BM, A-Rahim YI, Sevigny J, Berberat PO, Enjyoji K, Csizmadia E, Friess H, Robson SC.

Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16788-93. Epub 2009 Sep 28.PMID: 19805374 [PubMed - in process]Related articles

Isolated CD39 expression on CD4+ T cells denotes both regulatory and memory populations.

Zhou Q, Yan J, Putheti P, Wu Y, Sun X, Toxavidis V, Tigges J, Kassam N, Enjyoji K, Robson SC, Strom TB, Gao W.

Am J Transplant. 2009 Oct;9(10):2303-11. Epub 2009 Jul 28.PMID: 19656134 [PubMed - in process]Related articles

Vascular stasis, intestinal hemorrhage, and heightened vascular permeability complicate acute portal hypertension in cd39-null mice.

Sun X, Cárdenas A, Wu Y, Enjyoji K, Robson SC.

Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G306-11. Epub 2009 Jun 11.PMID: 19520738 [PubMed - indexed for MEDLINE]Related articles

Preservation of cochlear function in Cd39 deficient mice.

Vlajkovic SM, Housley GD, Thorne PR, Gupta R, Enjyoji K, Cowan PJ, Charles Liberman M, Robson SC.

Hear Res. 2009 Jul;253(1-2):77-82. Epub 2009 Mar 25.PMID: 19327391 [PubMed - indexed for MEDLINE]Related articles

Vascular smooth muscle cell expression of ectonucleotidase CD39 (ENTPD1) is required for neointimal formation in mice.

Behdad A, Sun X, Khalpey Z, Enjyoji K, Wink M, Wu Y, Usheva A, Robson SC.

Purinergic Signal. 2009 Sep;5(3):335-42. Epub 2009 Mar 24.PMID: 19308674 [PubMed - in process]Related articlesFree article

Functional ENTPD1 polymorphisms in African Americans with diabetes and end-stage renal disease.

Friedman DJ, Talbert ME, Bowden DW, Freedman BI, Mukanya Y, Enjyoji K, Robson SC.

Diabetes. 2009 Apr;58(4):999-1006. Epub 2008 Dec 18.PMID: 19095759 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulated catalysis of extracellular nucleotides by vascular CD39/ENTPD1 is required for liver regeneration.

Beldi G, Wu Y, Sun X, Imai M, Enjyoji K, Csizmadia E, Candinas D, Erb L, Robson SC.

Gastroenterology. 2008 Nov;135(5):1751-60. Epub 2008 Jul 31.PMID: 18804472 [PubMed - indexed for MEDLINE]Related articles

Natural killer T cell dysfunction in CD39-null mice protects against concanavalin A-induced hepatitis.

Beldi G, Wu Y, Banz Y, Nowak M, Miller L, Enjyoji K, Haschemi A, Yegutkin GG, Candinas D, Exley M, Robson SC.

Hepatology. 2008 Sep;48(3):841-52. Erratum in: Hepatology. 2009 Jul;50(1):331. PMID: 18752325 [PubMed - indexed for MEDLINE]Related articles

HVJ-AVE liposome-mediated Tissue Factor Pathway Inhibitor (TFPI) gene transfer with recombinant TFPI (rTFPI) irrigation attenuates restenosis in atherosclerotic arteries.

Yin X, Fu Y, Yutani C, Ikeda Y, Enjyoji K, Kato H.

Int J Cardiol. 2009 Jun 26;135(2):245-8. Epub 2008 Jun 30.PMID: 18590936 [PubMed - indexed for MEDLINE]Related articles

Deletion of cd39/entpd1 results in hepatic insulin resistance.

Enjyoji K, Kotani K, Thukral C, Blumel B, Sun X, Wu Y, Imai M, Friedman D, Csizmadia E, Bleibel W, Kahn BB, Robson SC.

Diabetes. 2008 Sep;57(9):2311-20. Epub 2008 Jun 20.PMID: 18567823 [PubMed - indexed for MEDLINE]Related articlesFree article

Tubuloglomerular feedback and renin secretion in NTPDase1/CD39-deficient mice.

Oppermann M, Friedman DJ, Faulhaber-Walter R, Mizel D, Castrop H, Enjyoji K, Robson SC, Schnermann J.

Am J Physiol Renal Physiol. 2008 Apr;294(4):F965-70. Epub 2008 Feb 6.PMID: 18256308 [PubMed - indexed for MEDLINE]Related articlesFree article

The ectonucleotidase cd39/ENTPDase1 modulates purinergic-mediated microglial migration.

Färber K, Markworth S, Pannasch U, Nolte C, Prinz V, Kronenberg G, Gertz K, Endres M, Bechmann I, Enjyoji K, Robson SC, Kettenmann H.

Glia. 2008 Feb;56(3):331-41.PMID: 18098126 [PubMed - indexed for MEDLINE]Related articles

Disordered pancreatic inflammatory responses and inhibition of fibrosis in CD39-null mice.

Künzli BM, Nuhn P, Enjyoji K, Banz Y, Smith RN, Csizmadia E, Schuppan D, Berberat PO, Friess H, Robson SC.

Gastroenterology. 2008 Jan;134(1):292-305. Epub 2007 Oct 25.PMID: 18036594 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of purinergic signaling in the liver and in transplantation: effects of extracellular nucleotides on hepatic graft vascular injury, rejection and metabolism.

Beldi G, Enjyoji K, Wu Y, Miller L, Banz Y, Sun X, Robson SC.

Front Biosci. 2008 Jan 1;13:2588-603. Review.PMID: 17981736 [PubMed - indexed for MEDLINE]Related articles

Disordered purinergic signaling inhibits pathological angiogenesis in cd39/Entpd1-null mice.

Jackson SW, Hoshi T, Wu Y, Sun X, Enjyoji K, Cszimadia E, Sundberg C, Robson SC.

Am J Pathol. 2007 Oct;171(4):1395-404. Epub 2007 Sep 6.PMID: 17823293 [PubMed - indexed for MEDLINE]Related articlesFree article

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression.

Deaglio S, Dwyer KM, Gao W, Friedman D, Usheva A, Erat A, Chen JF, Enjyoji K, Linden J, Oukka M, Kuchroo VK, Strom TB, Robson SC.

J Exp Med. 2007 Jun 11;204(6):1257-65. Epub 2007 May 14.PMID: 17502665 [PubMed - indexed for MEDLINE]Related articlesFree article

The vascular ectonucleotidase ENTPD1 is a novel renoprotective factor in diabetic nephropathy.

Friedman DJ, Rennke HG, Csizmadia E, Enjyoji K, Robson SC.

Diabetes. 2007 Sep;56(9):2371-9. Epub 2007 May 1.PMID: 17473221 [PubMed - indexed for MEDLINE]Related articlesFree article

Ecto-nucleotidases of the CD39/NTPDase family modulate platelet activation and thrombus formation: Potential as therapeutic targets.

Atkinson B, Dwyer K, Enjyoji K, Robson SC.

Blood Cells Mol Dis. 2006 Mar-Apr;36(2):217-22. Epub 2006 Feb 13. Review.PMID: 16476557 [PubMed - indexed for MEDLINE]Related articles

Ectonucleotidases of CD39 family modulate vascular inflammation and thrombosis in transplantation.

Robson SC, Wu Y, Sun X, Knosalla C, Dwyer K, Enjyoji K.

Semin Thromb Hemost. 2005 Apr;31(2):217-33. Review.PMID: 15852225 [PubMed - indexed for MEDLINE]Related articles

Beneficial effects of CD39/ecto-nucleoside triphosphate diphosphohydrolase-1 in murine intestinal ischemia-reperfusion injury.

Guckelberger O, Sun XF, Sévigny J, Imai M, Kaczmarek E, Enjyoji K, Kruskal JB, Robson SC.

Thromb Haemost. 2004 Mar;91(3):576-86.PMID: 14983235 [PubMed - indexed for MEDLINE]Related articles

Coordinated adenine nucleotide phosphohydrolysis and nucleoside signaling in posthypoxic endothelium: role of ectonucleotidases and adenosine A2B receptors.

Eltzschig HK, Ibla JC, Furuta GT, Leonard MO, Jacobson KA, Enjyoji K, Robson SC, Colgan SP.

J Exp Med. 2003 Sep 1;198(5):783-96. Epub 2003 Aug 25.PMID: 12939345 [PubMed - indexed for MEDLINE]Related articlesFree article

Normal levels of anticoagulant heparan sulfate are not essential for normal hemostasis.

HajMohammadi S, Enjyoji K, Princivalle M, Christi P, Lech M, Beeler D, Rayburn H, Schwartz JJ, Barzegar S, de Agostini AI, Post MJ, Rosenberg RD, Shworak NW.

J Clin Invest. 2003 Apr;111(7):989-99.PMID: 12671048 [PubMed - indexed for MEDLINE]Related articlesFree article

Tissue factor pathway inhibitor gene delivery using HVJ-AVE liposomes markedly reduces restenosis in atherosclerotic arteries.

Yin X, Yutani C, Ikeda Y, Enjyoji K, Ishibashi-Ueda H, Yasuda S, Tsukamoto Y, Nonogi H, Kaneda Y, Kato H.

Cardiovasc Res. 2002 Dec;56(3):454-63.PMID: 12445886 [PubMed - indexed for MEDLINE]Related articlesFree article

CD39 is the dominant Langerhans cell-associated ecto-NTPDase: modulatory roles in inflammation and immune responsiveness.

Mizumoto N, Kumamoto T, Robson SC, Sévigny J, Matsue H, Enjyoji K, Takashima A.

Nat Med. 2002 Apr;8(4):358-65.PMID: 11927941 [PubMed - indexed for MEDLINE]Related articles

Production of tissue factor pathway inhibitor in cardiomyocytes and its upregulation by interleukin-1.

Kereveur A, Enjyoji K, Masuda K, Yutani C, Kato H.

Thromb Haemost. 2001 Nov;86(5):1314-9.PMID: 11816723 [PubMed - indexed for MEDLINE]Related articles

Aggregation of beta(2)-glycoprotein I induced by sodium lauryl sulfate and lysophospholipids.

Hagihara Y, Hong DP, Hoshino M, Enjyoji K, Kato H, Goto Y.

Biochemistry. 2002 Jan 22;41(3):1020-6.PMID: 11790126 [PubMed - indexed for MEDLINE]Related articles

Disordered cellular migration and angiogenesis in cd39-null mice.

Goepfert C, Sundberg C, Sévigny J, Enjyoji K, Hoshi T, Csizmadia E, Robson S.

Circulation. 2001 Dec 18;104(25):3109-15.PMID: 11748109 [PubMed - indexed for MEDLINE]Related articlesFree article

Assignment of ecto-nucleoside triphosphate diphosphohydrolase-1/cd39 expression to microglia and vasculature of the brain.

Braun N, Sévigny J, Robson SC, Enjyoji K, Guckelberger O, Hammer K, Di Virgilio F, Zimmermann H.

Eur J Neurosci. 2000 Dec;12(12):4357-66.PMID: 11122346 [PubMed - indexed for MEDLINE]Related articles

CD39/vascular ATP diphosphohydrolase modulates xenograft survival.

Imai M, Takigami K, Guckelberger O, Lin Y, Sevigny J, Kaczmarek E, Goepfert C, Enjyoji K, Bach FH, Rosenberg RD, Robson SC.

Transplant Proc. 2000 Aug;32(5):969. No abstract available. PMID: 10936301 [PubMed - indexed for MEDLINE]Related articles

Does hypertension confer a hypercoagulable state in stroke-prone spontaneously hypertensive rats?

Abumiya T, Sakata T, Enjyoji K, Kato H, Kawai J, Suzuki T, Masuda J, Sasaguri T, Ogata J.

J Hypertens. 2000 Jul;18(7):901-9.PMID: 10930188 [PubMed - indexed for MEDLINE]Related articles

Modulation of nucleoside [correction of nucleotide] triphosphate diphosphohydrolase-1 (NTPDase-1)cd39 in xenograft rejection.

Imai M, Takigami K, Guckelberger O, Enjyoji K, Smith RN, Lin Y, Csizmadia E, Sévigny J, Rosenberg RD, Bach FH, Robson SC.

Mol Med. 1999 Nov;5(11):743-52. Erratum in: Mol Med 2000 Dec;6(12):1063. PMID: 10656876 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation.

Enjyoji K, Sévigny J, Lin Y, Frenette PS, Christie PD, Esch JS 2nd, Imai M, Edelberg JM, Rayburn H, Lech M, Beeler DL, Csizmadia E, Wagner DD, Robson SC, Rosenberg RD.

Nat Med. 1999 Sep;5(9):1010-7.PMID: 10470077 [PubMed - indexed for MEDLINE]Related articles

Monkey hepatocytes efficiently express tissue factor pathway inhibitor (TFPI), in contrast with human and rat hepatocytes.

Hine C, Enjyoji K, Kokame K, Nakamura S, Takei A, Kamikubo Y, Sueishi K, Kato H.

J Biochem. 1999 Jun;125(6):1039-47.PMID: 10348905 [PubMed - indexed for MEDLINE]Related articles

A novel degradation pathway of tissue factor pathway inhibitor: incorporation into fibrin clot and degradation by thrombin.

Ohkura N, Enjyoji K, Kamikubo Y, Kato H.

Blood. 1997 Sep 1;90(5):1883-92.PMID: 9292521 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of depolymerized holothurian glycosaminoglycan (DHG) on tissue factor pathway inhibitor: in vitro and in vivo studies.

Nagase H, Enjyoji K, Kamikubo Y, Kitazato KT, Kitazato K, Saito H, Kato H.

Thromb Haemost. 1997 Aug;78(2):864-70.PMID: 9268186 [PubMed - indexed for MEDLINE]Related articles

Structure and function of the recombinant fifth domain of human beta 2-glycoprotein I: effects of specific cleavage between Lys77 and Thr78.

Hagihara Y, Enjyoji K, Omasa T, Katakura Y, Suga K, Igarashi M, Matsuura E, Kato H, Yoshimura T, Goto Y.

J Biochem. 1997 Jan;121(1):128-37.PMID: 9058203 [PubMed - indexed for MEDLINE]Related articles

Effects of recombinant human tissue factor pathway inhibitor on thrombus formation and its in vivo distribution in a rat DIC model.

Elsayed YA, Nakagawa K, Kamikubo YI, Enjyoji KI, Kato H, Sueishi K.

Am J Clin Pathol. 1996 Nov;106(5):574-83.PMID: 8929465 [PubMed - indexed for MEDLINE]Related articles

Measurement of the free form of TFPI antigen in hyperlipidemia. Relationship between free and endothelial cell-associated forms of TFPI.

Kokawa T, Enjyoji K, Kumeda K, Kamikubo Y, Harada-Shiba M, Koh H, Tsushima M, Yamamoto A, Kato H.

Arterioscler Thromb Vasc Biol. 1996 Jun;16(6):802-8.PMID: 8640408 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of depolymerized holothurian glycosaminoglycan (DHG) on the activation of factor VIII and factor V by thrombin.

Nagase H, Enjyoji K, Shima M, Kitazato K, Yoshioka A, Saito H, Kato H.

J Biochem. 1996 Jan;119(1):63-9.PMID: 8907177 [PubMed - indexed for MEDLINE]Related articles

An anti-tissue factor pathway inhibitor (TFPI) monoclonal antibody recognized the third Kunitz domain (K3) of free-form TFPI but not lipoprotein-associated forms in plasma.

Abumiya T, Enjyoji K, Kokawa T, Kamikubo Y, Kato H.

J Biochem. 1995 Jul;118(1):178-82.PMID: 8537308 [PubMed - indexed for MEDLINE]Related articles

Effect of heparin on the inhibition of factor Xa by tissue factor pathway inhibitor: a segment, Gly212-Phe243, of the third Kunitz domain is a heparin-binding site.

Enjyoji K, Miyata T, Kamikubo Y, Kato H.

Biochemistry. 1995 May 2;34(17):5725-35.PMID: 7727433 [PubMed - indexed for MEDLINE]Related articles

Depolymerized holothurian glycosaminoglycan with novel anticoagulant actions: antithrombin III- and heparin cofactor II-independent inhibition of factor X activation by factor IXa-factor VIIIa complex and heparin cofactor II-dependent inhibition of thrombin.

Nagase H, Enjyoji K, Minamiguchi K, Kitazato KT, Kitazato K, Saito H, Kato H.

Blood. 1995 Mar 15;85(6):1527-34.PMID: 7888673 [PubMed - indexed for MEDLINE]Related articlesFree article

Amino acid sequence and inhibitory activity of rhesus monkey tissue factor pathway inhibitor (TFPI): comparison with human TFPI.

Kamei S, Kamikubo Y, Hamuro T, Fujimoto H, Ishihara M, Yonemura H, Miyamoto S, Funatsu A, Enjyoji K, Abumiya T, et al.

J Biochem. 1994 Apr;115(4):708-14.PMID: 8089087 [PubMed - indexed for MEDLINE]Related articles

Response of plasma tissue factor pathway inhibitor to diet-induced hypercholesterolemia in crab-eating monkeys.

Abumiya T, Nakamura S, Takenaka A, Takenaka O, Yoshikuni Y, Miyamoto S, Kimura T, Enjyoji K, Kato H.

Arterioscler Thromb. 1994 Mar;14(3):483-8.PMID: 8123656 [PubMed - indexed for MEDLINE]Related articlesFree article

Human tissue factor pathway inhibitor (TFPI) gene: complete genomic structure and localization on the genetic map of chromosome 2q.

Enjyoji K, Emi M, Mukai T, Imada M, Leppert ML, Lalouel JM, Kato H.

Genomics. 1993 Aug;17(2):423-8.PMID: 8104873 [PubMed - indexed for MEDLINE]Related articles

cDNA cloning and expression of rat tissue factor pathway inhibitor (TFPI).

Enjyoji K, Emi M, Mukai T, Kato H.

J Biochem. 1992 May;111(5):681-7.PMID: 1639767 [PubMed - indexed for MEDLINE]Related articles

Purification and characterization of two isoforms of T-kininogens from rat liver microsomes.

Enjyoji K, Kato H.

J Biochem. 1992 May;111(5):670-5.PMID: 1639765 [PubMed - indexed for MEDLINE]Related articles

Hydroxylated kininogens and kinins.

Kato H, Enjyoji K.

Agents Actions Suppl. 1992;38 ( Pt 1):217-24.PMID: 1334619 [PubMed - indexed for MEDLINE]Related articles

Amino acid sequence and location of the disulfide bonds in bovine beta 2 glycoprotein I: the presence of five Sushi domains.

Kato H, Enjyoji K.

Biochemistry. 1991 Dec 17;30(50):11687-94.PMID: 1751487 [PubMed - indexed for MEDLINE]Related articles

Characterization of rat factors X and Xa: demonstration of factor Xa in rat plasma.

Enjyoji K, Miyazaki K, Kato H.

J Biochem. 1991 Jun;109(6):890-8.PMID: 1718949 [PubMed - indexed for MEDLINE]Related articles