PubMed

Human CD133+ progenitor cells promote the healing of diabetic ischemic ulcers by paracrine stimulation of angiogenesis and activation of Wnt signaling.

Barcelos LS, Duplaa C, Kränkel N, Graiani G, Invernici G, Katare R, Siragusa M, Meloni M, Campesi I, Monica M, Simm A, Campagnolo P, Mangialardi G, Stevanato L, Alessandri G, Emanueli C, Madeddu P.

Circ Res. 2009 May 8;104(9):1095-102. Epub 2009 Apr 2.PMID: 19342601 [PubMed - indexed for MEDLINE]Related articles

Critical role of tissue kallikrein in vessel formation and maturation: implications for therapeutic revascularization.

Stone OA, Richer C, Emanueli C, van Weel V, Quax PH, Katare R, Kraenkel N, Campagnolo P, Barcelos LS, Siragusa M, Sala-Newby GB, Baldessari D, Mione M, Vincent MP, Benest AV, Al Haj Zen A, Gonzalez J, Bates DO, Alhenc-Gelas F, Madeddu P.

Arterioscler Thromb Vasc Biol. 2009 May;29(5):657-64. Epub 2009 Jan 22.PMID: 19164804 [PubMed - indexed for MEDLINE]Related articles

Cardiovascular actions of neurotrophins.

Caporali A, Emanueli C.

Physiol Rev. 2009 Jan;89(1):279-308. Review.PMID: 19126759 [PubMed - indexed for MEDLINE]Related articles

Possible novel targets for therapeutic angiogenesis.

Cristofaro B, Emanueli C.

Curr Opin Pharmacol. 2009 Apr;9(2):102-8. Epub 2008 Dec 13. Review.PMID: 19071062 [PubMed - indexed for MEDLINE]Related articlesFree article

Human fetal aorta-derived vascular progenitor cells: identification and potential application in ischemic diseases.

Invernici G, Madeddu P, Emanueli C, Parati EA, Alessandri G.

Cytotechnology. 2008 Sep;58(1):43-7. Epub 2008 Oct 18.PMID: 19002770 [PubMed - in process]Related articlesFree article

Role of kinin B2 receptor signaling in the recruitment of circulating progenitor cells with neovascularization potential.

Kränkel N, Katare RG, Siragusa M, Barcelos LS, Campagnolo P, Mangialardi G, Fortunato O, Spinetti G, Tran N, Zacharowski K, Wojakowski W, Mroz I, Herman A, Manning Fox JE, MacDonald PE, Schanstra JP, Bascands JL, Ascione R, Angelini G, Emanueli C, Madeddu P.

Circ Res. 2008 Nov 21;103(11):1335-43. Epub 2008 Oct 16.PMID: 18927465 [PubMed - indexed for MEDLINE]Related articlesFree article

Neurotrophin p75 receptor (p75NTR) promotes endothelial cell apoptosis and inhibits angiogenesis: implications for diabetes-induced impaired neovascularization in ischemic limb muscles.

Caporali A, Pani E, Horrevoets AJ, Kraenkel N, Oikawa A, Sala-Newby GB, Meloni M, Cristofaro B, Graiani G, Leroyer AS, Boulanger CM, Spinetti G, Yoon SO, Madeddu P, Emanueli C.

Circ Res. 2008 Jul 18;103(2):e15-26. Epub 2008 Jun 19.PMID: 18566344 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic and dietary control of plasma tissue kallikrein secretion and urinary kinins exretion in man.

Azizi M, Emanueli C, Peyrard S, Maddedu P, Alhenc-Gelas F, Campbell DJ.

J Hypertens. 2008 Apr;26(4):714-20.PMID: 18327081 [PubMed - indexed for MEDLINE]Related articles

Diabetes and vessel wall remodelling: from mechanistic insights to regenerative therapies.

Spinetti G, Kraenkel N, Emanueli C, Madeddu P.

Cardiovasc Res. 2008 May 1;78(2):265-73. Epub 2008 Feb 15. Review.PMID: 18281374 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of the prosurvival activity of nerve growth factor on cardiac myocytes.

Caporali A, Sala-Newby GB, Meloni M, Graiani G, Pani E, Cristofaro B, Newby AC, Madeddu P, Emanueli C.

Cell Death Differ. 2008 Feb;15(2):299-311. Epub 2007 Nov 9.PMID: 17992191 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphoinositide 3-kinase gamma gene knockout impairs postischemic neovascularization and endothelial progenitor cell functions.

Madeddu P, Kraenkel N, Barcelos LS, Siragusa M, Campagnolo P, Oikawa A, Caporali A, Herman A, Azzolino O, Barberis L, Perino A, Damilano F, Emanueli C, Hirsch E.

Arterioscler Thromb Vasc Biol. 2008 Jan;28(1):68-76. Epub 2007 Oct 25.PMID: 17962628 [PubMed - indexed for MEDLINE]Related articlesFree article

Human fetal aorta contains vascular progenitor cells capable of inducing vasculogenesis, angiogenesis, and myogenesis in vitro and in a murine model of peripheral ischemia.

Invernici G, Emanueli C, Madeddu P, Cristini S, Gadau S, Benetti A, Ciusani E, Stassi G, Siragusa M, Nicosia R, Peschle C, Fascio U, Colombo A, Rizzuti T, Parati E, Alessandri G.

Am J Pathol. 2007 Jun;170(6):1879-92.PMID: 17525256 [PubMed - indexed for MEDLINE]Related articlesFree article

Regional and global protective effects of tissue kallikrein gene delivery to the peri-infarct myocardium.

Spillmann F, Graiani G, Van Linthout S, Meloni M, Campesi I, Lagrasta C, Westermann D, Tschöpe C, Quaini F, Emanueli C, Madeddu P.

Regen Med. 2006 Mar;1(2):235-54.PMID: 17465807 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of disease: the tissue kallikrein-kinin system in hypertension and vascular remodeling.

Madeddu P, Emanueli C, El-Dahr S.

Nat Clin Pract Nephrol. 2007 Apr;3(4):208-21. Review.PMID: 17389890 [PubMed - indexed for MEDLINE]Related articles

Switching on reparative angiogenesis: essential role of the vascular erythropoietin receptor.

Madeddu P, Emanueli C.

Circ Res. 2007 Mar 16;100(5):599-601. Review. No abstract available. PMID: 17363704 [PubMed - indexed for MEDLINE]Related articlesFree article

Nitropravastatin stimulates reparative neovascularisation and improves recovery from limb Ischaemia in type-1 diabetic mice.

Emanueli C, Monopoli A, Kraenkel N, Meloni M, Gadau S, Campesi I, Ongini E, Madeddu P.

Br J Pharmacol. 2007 Apr;150(7):873-82. Epub 2007 Mar 12.PMID: 17351667 [PubMed - indexed for MEDLINE]Related articlesFree article

Type-2 diabetic Lepr(db/db) mice show a defective microvascular phenotype under basal conditions and an impaired response to angiogenesis gene therapy in the setting of limb ischemia.

Emanueli C, Caporali A, Krankel N, Cristofaro B, Van Linthout S, Madeddu P.

Front Biosci. 2007 Jan 1;12:2003-12.PMID: 17127438 [PubMed - indexed for MEDLINE]Related articles

Microfabrication of fractal polymeric structures for capillary morphogenesis: applications in therapeutic angiogenesis and in the engineering of vascularized tissue.

Bianchi F, Rosi M, Vozzi G, Emanueli C, Madeddu P, Ahluwalia A.

J Biomed Mater Res B Appl Biomater. 2007 May;81(2):462-8.PMID: 17034001 [PubMed - indexed for MEDLINE]Related articles

Murine models of myocardial and limb ischemia: diagnostic end-points and relevance to clinical problems.

Madeddu P, Emanueli C, Spillmann F, Meloni M, Bouby N, Richer C, Alhenc-Gelas F, Van Weel V, Eefting D, Quax PH, Hu Y, Xu Q, Hemdahl AL, van Golde J, Huijberts M, de Lussanet Q, Struijker Boudier H, Couffinhal T, Duplaa C, Chimenti S, Staszewsky L, Latini R, Baumans V, Levy BI.

Vascul Pharmacol. 2006 Nov;45(5):281-301. Epub 2006 Aug 22. Review.PMID: 17010676 [PubMed - indexed for MEDLINE]Related articles

Therapeutic angiogenesis: translating experimental concepts to medically relevant goals.

Emanueli C, Madeddu P.

Vascul Pharmacol. 2006 Nov;45(5):334-9. Epub 2006 Aug 23. Review.PMID: 17008132 [PubMed - indexed for MEDLINE]Related articles

Benfotiamine accelerates the healing of ischaemic diabetic limbs in mice through protein kinase B/Akt-mediated potentiation of angiogenesis and inhibition of apoptosis.

Gadau S, Emanueli C, Van Linthout S, Graiani G, Todaro M, Meloni M, Campesi I, Invernici G, Spillmann F, Ward K, Madeddu P.

Diabetologia. 2006 Feb;49(2):405-20. Epub 2006 Jan 17.PMID: 16416271 [PubMed - indexed for MEDLINE]Related articles

In search of the best candidate for regeneration of ischemic tissues: are embryonic/fetal stem cells more advantageous than adult counterparts?

Emanueli C, Lako M, Stojkovic M, Madeddu P.

Thromb Haemost. 2005 Oct;94(4):738-49. Review.PMID: 16270625 [PubMed - indexed for MEDLINE]Related articles

Diagnostic tools for the study of vascular cognitive dysfunction in hypertension and antihypertensive drug research.

Semplicini A, Amodio P, Leonetti G, Cuspidi C, Umiltà C, Schiff S, Scheltens P, Barkhof F, Emanueli C, Cagnin A, Pizzolato G, Macchini L, Realdi A, Royter V, Bornstein NM, Madeddu P.

Pharmacol Ther. 2006 Jan;109(1-2):274-83. Epub 2005 Oct 3. Review.PMID: 16202453 [PubMed - indexed for MEDLINE]Related articles

Genetic deletion of the p66Shc adaptor protein protects from angiotensin II-induced myocardial damage.

Graiani G, Lagrasta C, Migliaccio E, Spillmann F, Meloni M, Madeddu P, Quaini F, Padura IM, Lanfrancone L, Pelicci P, Emanueli C.

Hypertension. 2005 Aug;46(2):433-40. Epub 2005 Jul 5.PMID: 15998704 [PubMed - indexed for MEDLINE]Related articlesFree article

Antiangiogenesis mediates cisplatin-induced peripheral neuropathy: attenuation or reversal by local vascular endothelial growth factor gene therapy without augmenting tumor growth.

Kirchmair R, Walter DH, Ii M, Rittig K, Tietz AB, Murayama T, Emanueli C, Silver M, Wecker A, Amant C, Schratzberger P, Yoon YS, Weber A, Panagiotou E, Rosen KM, Bahlmann FH, Adelman LS, Weinberg DH, Ropper AH, Isner JM, Losordo DW.

Circulation. 2005 May 24;111(20):2662-70. Epub 2005 May 16.PMID: 15897348 [PubMed - indexed for MEDLINE]Related articlesFree article

Changing the logic of therapeutic angiogenesis for ischemic disease.

Emanueli C, Madeddu P.

Trends Mol Med. 2005 May;11(5):207-16. Review.PMID: 15882608 [PubMed - indexed for MEDLINE]Related articles

Increased circulating levels of tissue kallikrein in systemic sclerosis correlate with microvascular involvement.

Del Rosso A, Distler O, Milia AF, Emanueli C, Ibba-Manneschi L, Guiducci S, Conforti ML, Generini S, Pignone A, Gay S, Madeddu P, Matucci-Cerinic M.

Ann Rheum Dis. 2005 Mar;64(3):382-7.PMID: 15708892 [PubMed - indexed for MEDLINE]Related articlesFree article

Akt/protein kinase B and endothelial nitric oxide synthase mediate muscular neovascularization induced by tissue kallikrein gene transfer.

Emanueli C, Salis MB, Van Linthout S, Meloni M, Desortes E, Silvestre JS, Clergue M, Figueroa CD, Gadau S, Condorelli G, Madeddu P.

Circulation. 2004 Sep 21;110(12):1638-44. Epub 2004 Sep 13.PMID: 15364809 [PubMed - indexed for MEDLINE]Related articlesFree article

Transplantation of low dose CD34+KDR+ cells promotes vascular and muscular regeneration in ischemic limbs.

Madeddu P, Emanueli C, Pelosi E, Salis MB, Cerio AM, Bonanno G, Patti M, Stassi G, Condorelli G, Peschle C.

FASEB J. 2004 Nov;18(14):1737-9. Epub 2004 Sep 2.PMID: 15345695 [PubMed - indexed for MEDLINE]Related articlesFree article

Nitric oxide-releasing aspirin derivative, NCX 4016, promotes reparative angiogenesis and prevents apoptosis and oxidative stress in a mouse model of peripheral ischemia.

Emanueli C, Van Linthout S, Salis MB, Monopoli A, Del Soldato P, Ongini E, Madeddu P.

Arterioscler Thromb Vasc Biol. 2004 Nov;24(11):2082-7. Epub 2004 Sep 2.PMID: 15345513 [PubMed - indexed for MEDLINE]Related articlesFree article

Angiogenesis therapy with human tissue kallikrein for the treatment of ischemic diseases.

Emanueli C, Madeddu P.

Arch Mal Coeur Vaiss. 2004 Jun;97(6):679-87. Review.PMID: 15283043 [PubMed - indexed for MEDLINE]Related articles

Levels of human tissue kallikrein in the vitreous fluid of patients with severe proliferative diabetic retinopathy.

Pinna A, Emanueli C, Dore S, Salvo M, Madeddu P, Carta F.

Ophthalmologica. 2004 Jul-Aug;218(4):260-3.PMID: 15258415 [PubMed - indexed for MEDLINE]Related articles

Genetically engineered stem cell therapy for tissue regeneration.

Alessandri G, Emanueli C, Madeddu P.

Ann N Y Acad Sci. 2004 May;1015:271-84. Review.PMID: 15201167 [PubMed - indexed for MEDLINE]Related articles

Nerve growth factor supplementation reverses the impairment, induced by Type 1 diabetes, of hindlimb post-ischaemic recovery in mice.

Salis MB, Graiani G, Desortes E, Caldwell RB, Madeddu P, Emanueli C.

Diabetologia. 2004 Jun;47(6):1055-63. Epub 2004 Jun 8.PMID: 15184980 [PubMed - indexed for MEDLINE]Related articles

Nerve growth factor promotes reparative angiogenesis and inhibits endothelial apoptosis in cutaneous wounds of Type 1 diabetic mice.

Graiani G, Emanueli C, Desortes E, Van Linthout S, Pinna A, Figueroa CD, Manni L, Madeddu P.

Diabetologia. 2004 Jun;47(6):1047-54. Epub 2004 May 26.PMID: 15164170 [PubMed - indexed for MEDLINE]Related articles

Circulating tissue kallikrein levels correlate with severity of carotid atherosclerosis.

Porcu P, Emanueli C, Desortes E, Marongiu GM, Piredda F, Chao L, Chao J, Madeddu P.

Arterioscler Thromb Vasc Biol. 2004 Jun;24(6):1104-10. Epub 2004 Apr 8.PMID: 15072994 [PubMed - indexed for MEDLINE]Related articlesFree article

Prophylactic gene therapy with human tissue kallikrein ameliorates limb ischemia recovery in type 1 diabetic mice.

Emanueli C, Graiani G, Salis MB, Gadau S, Desortes E, Madeddu P.

Diabetes. 2004 Apr;53(4):1096-103.PMID: 15047627 [PubMed - indexed for MEDLINE]Related articlesFree article

Paracrine control of vascularization and neurogenesis by neurotrophins.

Emanueli C, Schratzberger P, Kirchmair R, Madeddu P.

Br J Pharmacol. 2003 Oct;140(4):614-9. Epub 2003 Aug 26. Review.PMID: 12970083 [PubMed - indexed for MEDLINE]Related articlesFree article

Cardiac hypertrophy and microvascular deficit in kinin B2 receptor knockout mice.

Maestri R, Milia AF, Salis MB, Graiani G, Lagrasta C, Monica M, Corradi D, Emanueli C, Madeddu P.

Hypertension. 2003 May;41(5):1151-5. Epub 2003 Mar 24.PMID: 12654715 [PubMed - indexed for MEDLINE]Related articlesFree article

Nerve growth factor promotes angiogenesis and arteriogenesis in ischemic hindlimbs.

Emanueli C, Salis MB, Pinna A, Graiani G, Manni L, Madeddu P.

Circulation. 2002 Oct 22;106(17):2257-62.PMID: 12390957 [PubMed - indexed for MEDLINE]Related articlesFree article

Protease-activated receptor-2 stimulates angiogenesis and accelerates hemodynamic recovery in a mouse model of hindlimb ischemia.

Milia AF, Salis MB, Stacca T, Pinna A, Madeddu P, Trevisani M, Geppetti P, Emanueli C.

Circ Res. 2002 Aug 23;91(4):346-52.PMID: 12193468 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevention of diabetes-induced microangiopathy by human tissue kallikrein gene transfer.

Emanueli C, Salis MB, Pinna A, Stacca T, Milia AF, Spano A, Chao J, Chao L, Sciola L, Madeddu P.

Circulation. 2002 Aug 20;106(8):993-9.PMID: 12186806 [PubMed - indexed for MEDLINE]Related articlesFree article

Renin-angiotensin and kallikrein-kinin systems coordinately modulate angiogenesis.

Emanueli C, Madeddu P.

Hypertension. 2002 Jun;39(6):e29. No abstract available. PMID: 12052854 [PubMed - indexed for MEDLINE]Related articlesFree article

Ramipril improves hemodynamic recovery but not microvascular response to ischemia in spontaneously hypertensive rats.

Emanueli C, Salis MB, Stacca T, Pinna A, Gaspa L, Spano A, Madeddu P.

Am J Hypertens. 2002 May;15(5):410-5.PMID: 12022243 [PubMed - indexed for MEDLINE]Related articles

Targeting kinin B(1) receptor for therapeutic neovascularization.

Emanueli C, Bonaria Salis M, Stacca T, Pintus G, Kirchmair R, Isner JM, Pinna A, Gaspa L, Regoli D, Cayla C, Pesquero JB, Bader M, Madeddu P.

Circulation. 2002 Jan 22;105(3):360-6.PMID: 11804993 [PubMed - indexed for MEDLINE]Related articlesFree article

Angiotensin AT(1) receptor signalling modulates reparative angiogenesis induced by limb ischaemia.

Emanueli C, Salis MB, Stacca T, Pinna A, Gaspa L, Madeddu P.

Br J Pharmacol. 2002 Jan;135(1):87-92. Erratum in: Br J Pharmacol 2002 May 1;136(1):157. Maddeddu Paolo [corrected to Madeddu Paolo]. PMID: 11786483 [PubMed - indexed for MEDLINE]Related articlesFree article

Reversal of angiogenic growth factor upregulation by revascularization of lower limb ischemia.

Porcu P, Emanueli C, Kapatsoris M, Chao J, Chao L, Madeddu P.

Circulation. 2002 Jan 1;105(1):67-72.PMID: 11772878 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeting kinin receptors for the treatment of tissue ischaemia.

Emanueli C, Madeddu P.

Trends Pharmacol Sci. 2001 Sep;22(9):478-84. Review.PMID: 11543876 [PubMed - indexed for MEDLINE]Related articles

Angiogenesis gene therapy to rescue ischaemic tissues: achievements and future directions.

Emanueli C, Madeddu P.

Br J Pharmacol. 2001 Aug;133(7):951-8. Review.PMID: 11487503 [PubMed - indexed for MEDLINE]Related articlesFree article

Rescue of impaired angiogenesis in spontaneously hypertensive rats by intramuscular human tissue kallikrein gene transfer.

Emanueli C, Salis MB, Stacca T, Gaspa L, Chao J, Chao L, Piana A, Madeddu P.

Hypertension. 2001 Jul;38(1):136-41.PMID: 11463774 [PubMed - indexed for MEDLINE]Related articlesFree article