PubMed

Expression of the diabetes-associated gene TCF7L2 in adult mouse brain.

Lee S, Lee CE, Elias CF, Elmquist JK.

J Comp Neurol. 2009 Dec 20;517(6):925-39.PMID: 19845015 [PubMed - in process]Related articles

Central administration of resveratrol improves diet-induced diabetes.

Ramadori G, Gautron L, Fujikawa T, Vianna CR, Elmquist JK, Coppari R.

Endocrinology. 2009 Dec;150(12):5326-33. Epub 2009 Oct 9.PMID: 19819963 [PubMed - in process]Related articles

Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis.

Hill JW, Xu Y, Preitner F, Fukuda M, Cho YR, Luo J, Balthasar N, Coppari R, Cantley LC, Kahn BB, Zhao JJ, Elmquist JK.

Endocrinology. 2009 Nov;150(11):4874-82. Epub 2009 Oct 9.PMID: 19819947 [PubMed - indexed for MEDLINE]Related articles

Colocalization of ghrelin O-acyltransferase and ghrelin in gastric mucosal cells.

Sakata I, Yang J, Lee CE, Osborne-Lawrence S, Rovinsky SA, Elmquist JK, Zigman JM.

Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E134-41. Epub 2009 Apr 28.PMID: 19401456 [PubMed - indexed for MEDLINE]Related articles

Characterization of a novel ghrelin cell reporter mouse.

Sakata I, Nakano Y, Osborne-Lawrence S, Rovinsky SA, Lee CE, Perello M, Anderson JG, Coppari R, Xiao G, Lowell BB, Elmquist JK, Zigman JM.

Regul Pept. 2009 Jun 5;155(1-3):91-8. Epub 2009 Apr 8.PMID: 19361544 [PubMed - indexed for MEDLINE]Related articles

Leptin targets in the mouse brain.

Scott MM, Lachey JL, Sternson SM, Lee CE, Elias CF, Friedman JM, Elmquist JK.

J Comp Neurol. 2009 Jun 10;514(5):518-32.PMID: 19350671 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of transcriptional regulators in central control of appetite and body weight.

Coppari R, Ramadori G, Elmquist JK.

Nat Clin Pract Endocrinol Metab. 2009 Mar;5(3):160-6. Review.PMID: 19229236 [PubMed - indexed for MEDLINE]Related articles

From observation to experimentation: leptin action in the mediobasal hypothalamus.

Williams KW, Scott MM, Elmquist JK.

Am J Clin Nutr. 2009 Mar;89(3):985S-990S. Epub 2009 Jan 28. Review.PMID: 19176744 [PubMed - indexed for MEDLINE]Related articles

Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance.

Tong Q, Ye CP, Jones JE, Elmquist JK, Lowell BB.

Nat Neurosci. 2008 Sep;11(9):998-1000.PMID: 19160495 [PubMed - indexed for MEDLINE]Related articlesFree article

Monitoring FoxO1 localization in chemically identified neurons.

Fukuda M, Jones JE, Olson D, Hill J, Lee CE, Gautron L, Choi M, Zigman JM, Lowell BB, Elmquist JK.

J Neurosci. 2008 Dec 10;28(50):13640-8.PMID: 19074037 [PubMed - indexed for MEDLINE]Related articlesFree article

5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis.

Xu Y, Jones JE, Kohno D, Williams KW, Lee CE, Choi MJ, Anderson JG, Heisler LK, Zigman JM, Lowell BB, Elmquist JK.

Neuron. 2008 Nov 26;60(4):582-9.PMID: 19038216 [PubMed - indexed for MEDLINE]Related articlesFree article

Brain SIRT1: anatomical distribution and regulation by energy availability.

Ramadori G, Lee CE, Bookout AL, Lee S, Williams KW, Anderson J, Elmquist JK, Coppari R.

J Neurosci. 2008 Oct 1;28(40):9989-96.PMID: 18829956 [PubMed - indexed for MEDLINE]Related articlesFree article

Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance.

Tong Q, Ye CP, Jones JE, Elmquist JK, Lowell BB.

Nat Neurosci. 2008 Aug 10. [Epub ahead of print]PMID: 18690230 [PubMed - as supplied by publisher]Related articles

The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress.

Lutter M, Sakata I, Osborne-Lawrence S, Rovinsky SA, Anderson JG, Jung S, Birnbaum S, Yanagisawa M, Elmquist JK, Nestler EJ, Zigman JM.

Nat Neurosci. 2008 Jul;11(7):752-3. Epub 2008 Jun 15.PMID: 18552842 [PubMed - indexed for MEDLINE]Related articlesFree article

PANIC-ATTAC: a mouse model for inducible and reversible beta-cell ablation.

Wang ZV, Mu J, Schraw TD, Gautron L, Elmquist JK, Zhang BB, Brownlee M, Scherer PE.

Diabetes. 2008 Aug;57(8):2137-48. Epub 2008 May 9.PMID: 18469203 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice.

Hill JW, Williams KW, Ye C, Luo J, Balthasar N, Coppari R, Cowley MA, Cantley LC, Lowell BB, Elmquist JK.

J Clin Invest. 2008 May;118(5):1796-805.PMID: 18382766 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypothalamic pathways linking energy balance and reproduction.

Hill JW, Elmquist JK, Elias CF.

Am J Physiol Endocrinol Metab. 2008 May;294(5):E827-32. Epub 2008 Feb 19. Review.PMID: 18285524 [PubMed - indexed for MEDLINE]Related articlesFree article

Serotonin 2C receptor agonists improve type 2 diabetes via melanocortin-4 receptor signaling pathways.

Zhou L, Sutton GM, Rochford JJ, Semple RK, Lam DD, Oksanen LJ, Thornton-Jones ZD, Clifton PG, Yueh CY, Evans ML, McCrimmon RJ, Elmquist JK, Butler AA, Heisler LK.

Cell Metab. 2007 Nov;6(5):398-405.PMID: 17983585 [PubMed - indexed for MEDLINE]Related articlesFree article

Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice.

Morioka T, Asilmaz E, Hu J, Dishinger JF, Kurpad AJ, Elias CF, Li H, Elmquist JK, Kennedy RT, Kulkarni RN.

J Clin Invest. 2007 Oct;117(10):2860-8.PMID: 17909627 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity.

Parton LE, Ye CP, Coppari R, Enriori PJ, Choi B, Zhang CY, Xu C, Vianna CR, Balthasar N, Lee CE, Elmquist JK, Cowley MA, Lowell BB.

Nature. 2007 Sep 13;449(7159):228-32. Epub 2007 Aug 29.PMID: 17728716 [PubMed - indexed for MEDLINE]Related articles

"AMPing up" our understanding of the hypothalamic control of energy balance.

Williams KW, Coppari R, Elmquist JK.

J Clin Invest. 2007 Aug;117(8):2089-92.PMID: 17671647 [PubMed - indexed for MEDLINE]Related articlesFree article

Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation.

Heisler LK, Pronchuk N, Nonogaki K, Zhou L, Raber J, Tung L, Yeo GS, O'Rahilly S, Colmers WF, Elmquist JK, Tecott LH.

J Neurosci. 2007 Jun 27;27(26):6956-64.PMID: 17596444 [PubMed - indexed for MEDLINE]Related articlesFree article

Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network.

McHugh TJ, Jones MW, Quinn JJ, Balthasar N, Coppari R, Elmquist JK, Lowell BB, Fanselow MS, Wilson MA, Tonegawa S.

Science. 2007 Jul 6;317(5834):94-9. Epub 2007 Jun 7.PMID: 17556551 [PubMed - indexed for MEDLINE]Related articlesFree article

Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21.

Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, Parameswara V, Li Y, Goetz R, Mohammadi M, Esser V, Elmquist JK, Gerard RD, Burgess SC, Hammer RE, Mangelsdorf DJ, Kliewer SA.

Cell Metab. 2007 Jun;5(6):415-25.PMID: 17550777 [PubMed - indexed for MEDLINE]Related articles

Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia.

Tong Q, Ye C, McCrimmon RJ, Dhillon H, Choi B, Kramer MD, Yu J, Yang Z, Christiansen LM, Lee CE, Choi CS, Zigman JM, Shulman GI, Sherwin RS, Elmquist JK, Lowell BB.

Cell Metab. 2007 May;5(5):383-93.PMID: 17488640 [PubMed - indexed for MEDLINE]Related articlesFree article

Neuropeptide Y deficiency attenuates responses to fasting and high-fat diet in obesity-prone mice.

Patel HR, Qi Y, Hawkins EJ, Hileman SM, Elmquist JK, Imai Y, Ahima RS.

Diabetes. 2006 Nov;55(11):3091-8.PMID: 17065347 [PubMed - indexed for MEDLINE]Related articlesFree article

In search of an effective obesity treatment: a shot in the dark or a shot in the arm?

Zigman JM, Elmquist JK.

Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):12961-2. Epub 2006 Aug 21. No abstract available. Erratum in: Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14977. PMID: 16924097 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells.

Kievit P, Howard JK, Badman MK, Balthasar N, Coppari R, Mori H, Lee CE, Elmquist JK, Yoshimura A, Flier JS.

Cell Metab. 2006 Aug;4(2):123-32.PMID: 16890540 [PubMed - indexed for MEDLINE]Related articles

Serotonin reciprocally regulates melanocortin neurons to modulate food intake.

Heisler LK, Jobst EE, Sutton GM, Zhou L, Borok E, Thornton-Jones Z, Liu HY, Zigman JM, Balthasar N, Kishi T, Lee CE, Aschkenasi CJ, Zhang CY, Yu J, Boss O, Mountjoy KG, Clifton PG, Lowell BB, Friedman JM, Horvath T, Butler AA, Elmquist JK, Cowley MA.

Neuron. 2006 Jul 20;51(2):239-49.PMID: 16846858 [PubMed - indexed for MEDLINE]Related articles

Orexin neurons and the TASK of glucosensing.

Scott MM, Marcus JN, Elmquist JK.

Neuron. 2006 Jun 1;50(5):665-7. Review.PMID: 16731504 [PubMed - indexed for MEDLINE]Related articles

Movin' on up: adipocytes become regulators of nutrient homeostasis.

Unger RH, Elmquist JK.

Cell Metab. 2006 Mar;3(3):147-8.PMID: 16517400 [PubMed - indexed for MEDLINE]Related articles

Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis.

Dhillon H, Zigman JM, Ye C, Lee CE, McGovern RA, Tang V, Kenny CD, Christiansen LM, White RD, Edelstein EA, Coppari R, Balthasar N, Cowley MA, Chua S Jr, Elmquist JK, Lowell BB.

Neuron. 2006 Jan 19;49(2):191-203.PMID: 16423694 [PubMed - indexed for MEDLINE]Related articles

Mice lacking ghrelin receptors resist the development of diet-induced obesity.

Zigman JM, Nakano Y, Coppari R, Balthasar N, Marcus JN, Lee CE, Jones JE, Deysher AE, Waxman AR, White RD, Williams TD, Lachey JL, Seeley RJ, Lowell BB, Elmquist JK.

J Clin Invest. 2005 Dec;115(12):3564-72.PMID: 16322794 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of ghrelin receptor mRNA in the rat and the mouse brain.

Zigman JM, Jones JE, Lee CE, Saper CB, Elmquist JK.

J Comp Neurol. 2006 Jan 20;494(3):528-48. Erratum in: J Comp Neurol. 2006 Dec 1;499(4):690. PMID: 16320257 [PubMed - indexed for MEDLINE]Related articles

Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes.

de Luca C, Kowalski TJ, Zhang Y, Elmquist JK, Lee C, Kilimann MW, Ludwig T, Liu SM, Chua SC Jr.

J Clin Invest. 2005 Dec;115(12):3484-93. Epub 2005 Nov 10.PMID: 16284652 [PubMed - indexed for MEDLINE]Related articlesFree article

Divergence of melanocortin pathways in the control of food intake and energy expenditure.

Balthasar N, Dalgaard LT, Lee CE, Yu J, Funahashi H, Williams T, Ferreira M, Tang V, McGovern RA, Kenny CD, Christiansen LM, Edelstein E, Choi B, Boss O, Aschkenasi C, Zhang CY, Mountjoy K, Kishi T, Elmquist JK, Lowell BB.

Cell. 2005 Nov 4;123(3):493-505.PMID: 16269339 [PubMed - indexed for MEDLINE]Related articles

Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis.

Elmquist JK, Coppari R, Balthasar N, Ichinose M, Lowell BB.

J Comp Neurol. 2005 Dec 5;493(1):63-71. Review.PMID: 16254991 [PubMed - indexed for MEDLINE]Related articles

The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity.

Coppari R, Ichinose M, Lee CE, Pullen AE, Kenny CD, McGovern RA, Tang V, Liu SM, Ludwig T, Chua SC Jr, Lowell BB, Elmquist JK.

Cell Metab. 2005 Jan;1(1):63-72.PMID: 16054045 [PubMed - indexed for MEDLINE]Related articles

Use of laser-capture microdissection for the identification of marker genes for the ventromedial hypothalamic nucleus.

Segal JP, Stallings NR, Lee CE, Zhao L, Socci N, Viale A, Harris TM, Soares MB, Childs G, Elmquist JK, Parker KL, Friedman JM.

J Neurosci. 2005 Apr 20;25(16):4181-8.PMID: 15843621 [PubMed - indexed for MEDLINE]Related articlesFree article

Physiology: do neural signals remodel bone?

Elmquist JK, Strewler GJ.

Nature. 2005 Mar 24;434(7032):447-8. No abstract available. PMID: 15791237 [PubMed - indexed for MEDLINE]Related articles

Neuropeptide Y Y1 receptor mRNA in rodent brain: distribution and colocalization with melanocortin-4 receptor.

Kishi T, Aschkenasi CJ, Choi BJ, Lopez ME, Lee CE, Liu H, Hollenberg AN, Friedman JM, Elmquist JK.

J Comp Neurol. 2005 Feb 14;482(3):217-43.PMID: 15690487 [PubMed - indexed for MEDLINE]Related articles

Body weight is regulated by the brain: a link between feeding and emotion.

Kishi T, Elmquist JK.

Mol Psychiatry. 2005 Feb;10(2):132-46. Review.PMID: 15630408 [PubMed - indexed for MEDLINE]Related articles

A good night's sleep: future antidote to the obesity epidemic?

Flier JS, Elmquist JK.

Ann Intern Med. 2004 Dec 7;141(11):885-6. No abstract available. PMID: 15583232 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of central glucagon-like peptide-1 in mediating the effects of visceral illness: differential effects in rats and mice.

Lachey JL, D'Alessio DA, Rinaman L, Elmquist JK, Drucker DJ, Seeley RJ.

Endocrinology. 2005 Jan;146(1):458-62. Epub 2004 Sep 30.PMID: 15459118 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis.

Balthasar N, Coppari R, McMinn J, Liu SM, Lee CE, Tang V, Kenny CD, McGovern RA, Chua SC Jr, Elmquist JK, Lowell BB.

Neuron. 2004 Jun 24;42(6):983-91.PMID: 15207242 [PubMed - indexed for MEDLINE]Related articles

Neuroscience. The fat-brain axis enters a new dimension.

Elmquist JK, Flier JS.

Science. 2004 Apr 2;304(5667):63-4. No abstract available. PMID: 15064411 [PubMed - indexed for MEDLINE]Related articles

Ciliary neurotrophic factor and leptin induce distinct patterns of immediate early gene expression in the brain.

Kelly JF, Elias CF, Lee CE, Ahima RS, Seeley RJ, Bjørbaek C, Oka T, Saper CB, Flier JS, Elmquist JK.

Diabetes. 2004 Apr;53(4):911-20.PMID: 15047605 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of a novel binding partner of the melanocortin-4 receptor: attractin-like protein.

Haqq AM, René P, Kishi T, Khong K, Lee CE, Liu H, Friedman JM, Elmquist JK, Cone RD.

Biochem J. 2003 Dec 15;376(Pt 3):595-605.PMID: 14531729 [PubMed - indexed for MEDLINE]Related articlesFree article

Minireview: From anorexia to obesity--the yin and yang of body weight control.

Zigman JM, Elmquist JK.

Endocrinology. 2003 Sep;144(9):3749-56. Review.PMID: 12933644 [PubMed - indexed for MEDLINE]Related articlesFree article

Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter.

Liu H, Kishi T, Roseberry AG, Cai X, Lee CE, Montez JM, Friedman JM, Elmquist JK.

J Neurosci. 2003 Aug 6;23(18):7143-54.PMID: 12904474 [PubMed - indexed for MEDLINE]Related articlesFree article