PubMed

Linkage disequilibrium mapping of the replicated type 2 diabetes linkage signal on chromosome 1q.

Prokopenko I, Zeggini E, Hanson RL, Mitchell BD, Rayner NW, Akan P, Baier L, Das SK, Elliott KS, Fu M, Frayling TM, Groves CJ, Gwilliam R, Scott LJ, Voight BF, Hattersley AT, Hu C, Morris AD, Ng M, Palmer CN, Tello-Ruiz M, Vaxillaire M, Wang CR, Stein L, Chan J, Jia W, Froguel P, Elbein SC, Deloukas P, Bogardus C, Shuldiner AR, McCarthy MI; International Type 2 Diabetes 1q Consortium.

Diabetes. 2009 Jul;58(7):1704-9. Epub 2009 Apr 23.PMID: 19389826 [PubMed - indexed for MEDLINE]Related articlesFree article

Phenotypic and molecular evaluation of a chromosome 1q region with linkage and association to type 2 diabetes in humans.

Wang H, Hays NP, Das SK, Craig RL, Chu WS, Sharma N, Elbein SC.

J Clin Endocrinol Metab. 2009 Apr;94(4):1401-8. Epub 2009 Jan 13.PMID: 19141583 [PubMed - indexed for MEDLINE]Related articles

Genome-wide linkage and admixture mapping of type 2 diabetes in African American families from the American Diabetes Association GENNID (Genetics of NIDDM) Study Cohort.

Elbein SC, Das SK, Hallman DM, Hanis CL, Hasstedt SJ.

Diabetes. 2009 Jan;58(1):268-74. Epub 2008 Oct 7.PMID: 18840782 [PubMed - indexed for MEDLINE]Related articlesFree article

Endoplasmic reticulum stress markers are associated with obesity in nondiabetic subjects.

Sharma NK, Das SK, Mondal AK, Hackney OG, Chu WS, Kern PA, Rasouli N, Spencer HJ, Yao-Borengasser A, Elbein SC.

J Clin Endocrinol Metab. 2008 Nov;93(11):4532-41. Epub 2008 Aug 26.PMID: 18728164 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of pioglitazone treatment on endoplasmic reticulum stress response in human adipose and in palmitate-induced stress in human liver and adipose cell lines.

Das SK, Chu WS, Mondal AK, Sharma NK, Kern PA, Rasouli N, Elbein SC.

Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E393-400. Epub 2008 Jun 10.PMID: 18544642 [PubMed - indexed for MEDLINE]Related articlesFree article

Intermuscular lipid: a marker of disordered fat partitioning or the consequence of obesity?

Elbein SC, Rasouli N.

Am J Clin Nutr. 2008 Jun;87(6):1585-6. No abstract available. PMID: 18541542 [PubMed - indexed for MEDLINE]Related articlesFree article

Aryl hydrocarbon receptor nuclear translocator (ARNT) gene as a positional and functional candidate for type 2 diabetes and prediabetic intermediate traits: Mutation detection, case-control studies, and gene expression analysis.

Das SK, Sharma NK, Chu WS, Wang H, Elbein SC.

BMC Med Genet. 2008 Mar 17;9:16.PMID: 18366646 [PubMed - indexed for MEDLINE]Related articlesFree article

Type 2 diabetes susceptibility genes on chromosome 1q21-24.

Hasstedt SJ, Chu WS, Das SK, Wang H, Elbein SC.

Ann Hum Genet. 2008 Mar;72(Pt 2):163-9.PMID: 18269685 [PubMed - indexed for MEDLINE]Related articles

Impact of family history of diabetes and ethnicity on -cell function in obese, glucose-tolerant individuals.

Rasouli N, Spencer HJ, Rashidi AA, Elbein SC.

J Clin Endocrinol Metab. 2007 Dec;92(12):4656-63. Epub 2007 Sep 18.PMID: 17878257 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcription factor 7-like 2 polymorphisms and type 2 diabetes, glucose homeostasis traits and gene expression in US participants of European and African descent.

Elbein SC, Chu WS, Das SK, Yao-Borengasser A, Hasstedt SJ, Wang H, Rasouli N, Kern PA.

Diabetologia. 2007 Aug;50(8):1621-30. Epub 2007 Jun 20.PMID: 17579832 [PubMed - indexed for MEDLINE]Related articles

Evaluation of polymorphisms known to contribute to risk for diabetes in African and African-American populations.

Elbein SC.

Curr Opin Clin Nutr Metab Care. 2007 Jul;10(4):415-9. Review.PMID: 17563458 [PubMed - indexed for MEDLINE]Related articles

The search for type 2 diabetes susceptibility loci: the chromosome 1q story.

Das SK, Elbein SC.

Curr Diab Rep. 2007 Apr;7(2):154-64. Review.PMID: 17425920 [PubMed - indexed for MEDLINE]Related articles

Meta-analysis of genome-wide linkage studies of quantitative lipid traits in families ascertained for type 2 diabetes.

Malhotra A, Elbein SC, Ng MC, Duggirala R, Arya R, Imperatore G, Adeyemo A, Pollin TI, Hsueh WC, Chan JC, Rotimi C, Hanson RL, Hasstedt SJ, Wolford JK.

Diabetes. 2007 Mar;56(3):890-6.PMID: 17327462 [PubMed - indexed for MEDLINE]Related articlesFree article

Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects.

Owen KR, Groves CJ, Hanson RL, Knowler WC, Shuldiner AR, Elbein SC, Mitchell BD, Froguel P, Ng MC, Chan JC, Jia W, Deloukas P, Hitman GA, Walker M, Frayling TM, Hattersley AT, Zeggini E, McCarthy MI.

Diabetes. 2007 Mar;56(3):879-83.PMID: 17327460 [PubMed - indexed for MEDLINE]Related articlesFree article

Activating transcription factor 6 (ATF6) sequence polymorphisms in type 2 diabetes and pre-diabetic traits.

Chu WS, Das SK, Wang H, Chan JC, Deloukas P, Froguel P, Baier LJ, Jia W, McCarthy MI, Ng MC, Damcott C, Shuldiner AR, Zeggini E, Elbein SC.

Diabetes. 2007 Mar;56(3):856-62.PMID: 17327457 [PubMed - indexed for MEDLINE]Related articlesFree article

Ectopic fat accumulation and metabolic syndrome.

Rasouli N, Molavi B, Elbein SC, Kern PA.

Diabetes Obes Metab. 2007 Jan;9(1):1-10. Review.PMID: 17199713 [PubMed - indexed for MEDLINE]Related articles

Detection of allelic imbalance in gene expression using pyrosequencing.

Wang H, Elbein SC.

Methods Mol Biol. 2007;373:157-76.PMID: 17185765 [PubMed - indexed for MEDLINE]Related articles

Retinol binding protein 4 as a candidate gene for type 2 diabetes and prediabetic intermediate traits.

Craig RL, Chu WS, Elbein SC.

Mol Genet Metab. 2007 Mar;90(3):338-44. Epub 2006 Dec 14.PMID: 17174134 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of a proline insertion in the insulin promoter factor 1 (IPF1) gene in African Americans with type 2 diabetes.

Elbein SC, Wang X, Karim MA, Freedman BI, Bowden DW, Shuldiner AR, Brancati FL, Kao WH.

Diabetes. 2006 Oct;55(10):2909-14.PMID: 17003361 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of pioglitazone and metformin on beta-cell function in nondiabetic subjects at high risk for type 2 diabetes.

Rasouli N, Kern PA, Reece EA, Elbein SC.

Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E359-65. Epub 2006 Sep 12.PMID: 16968813 [PubMed - indexed for MEDLINE]Related articlesFree article

Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes.

Das SK, Chu WS, Hale TC, Wang X, Craig RL, Wang H, Shuldiner AR, Froguel P, Deloukas P, McCarthy MI, Zeggini E, Hasstedt SJ, Elbein SC.

Diabetes. 2006 Sep;55(9):2631-9.PMID: 16936214 [PubMed - indexed for MEDLINE]Related articlesFree article

Variation within the gene encoding the upstream stimulatory factor 1 does not influence susceptibility to type 2 diabetes in samples from populations with replicated evidence of linkage to chromosome 1q.

Zeggini E, Damcott CM, Hanson RL, Karim MA, Rayner NW, Groves CJ, Baier LJ, Hale TC, Hattersley AT, Hitman GA, Hunt SE, Knowler WC, Mitchell BD, Ng MC, O'Connell JR, Pollin TI, Vaxillaire M, Walker M, Wang X, Whittaker P, Xiang K, Jia W, Chan JC, Froguel P, Deloukas P, Shuldiner AR, Elbein SC, McCarthy MI; International Type 2 Diabetes 1q Consortium.

Diabetes. 2006 Sep;55(9):2541-8. Erratum in: Diabetes. 2006 Nov;55(11):3197. Kunsun, Xiang [corrected to Xiang, Kunsan]. PMID: 16936202 [PubMed - indexed for MEDLINE]Related articlesFree article

The Genetic Basis of Type 2 Diabetes.

Das SK, Elbein SC.

Cellscience. 2006 Apr 30;2(4):100-131.PMID: 16892160 [PubMed]Related articlesFree article

Analysis of coding variants in the betacellulin gene in type 2 diabetes and insulin secretion in African American subjects.

Elbein SC, Wang X, Karim MA, Chu WS, Silver KD.

BMC Med Genet. 2006 Jul 25;7:62.PMID: 16869959 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of FOXO1A as a candidate gene for type 2 diabetes.

Karim MA, Craig RL, Wang X, Hale TC, Elbein SC.

Mol Genet Metab. 2006 Jun;88(2):171-7. Epub 2006 Feb 23.PMID: 16497530 [PubMed - indexed for MEDLINE]Related articles

Insulin Promoter Factor 1 variation is associated with type 2 diabetes in African Americans.

Karim MA, Wang X, Hale TC, Elbein SC.

BMC Med Genet. 2005 Oct 17;6:37.PMID: 16229747 [PubMed - indexed for MEDLINE]Related articlesFree article

Evaluation of sequence variants in the pre-B cell leukemia transcription factor 1 gene: a positional and functional candidate for type 2 diabetes and impaired insulin secretion.

Wang H, Chu W, Wang X, Zhang Z, Elbein SC.

Mol Genet Metab. 2005 Nov;86(3):384-91. Epub 2005 Sep 2.PMID: 16140554 [PubMed - indexed for MEDLINE]Related articles

Increased plasma adiponectin in response to pioglitazone does not result from increased gene expression.

Rasouli N, Yao-Borengasser A, Miles LM, Elbein SC, Kern PA.

Am J Physiol Endocrinol Metab. 2006 Jan;290(1):E42-E46. Epub 2005 Aug 23.PMID: 16118250 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of short-term experimental insulin resistance and family history of diabetes on pancreatic beta-cell function in nondiabetic individuals.

Rasouli N, Hale T, Kahn SE, Spencer HJ, Elbein SC.

J Clin Endocrinol Metab. 2005 Oct;90(10):5825-33. Epub 2005 Aug 9.PMID: 16091496 [PubMed - indexed for MEDLINE]Related articlesFree article

Pioglitazone improves insulin sensitivity through reduction in muscle lipid and redistribution of lipid into adipose tissue.

Rasouli N, Raue U, Miles LM, Lu T, Di Gregorio GB, Elbein SC, Kern PA.

Am J Physiol Endocrinol Metab. 2005 May;288(5):E930-4. Epub 2005 Jan 4.PMID: 15632102 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of an insulin gene promoter insertion polymorphism with type 2 diabetes and diabetic nephropathy in African Americans.

Karim MA, Wang X, Zhang Z, Bowden DW, Freedman BI, Elbein SC.

Mol Genet Metab. 2004 Dec;83(4):344-6.PMID: 15589123 [PubMed - indexed for MEDLINE]Related articles

Improved glycemic control in subjects with atypical diabetes results from restored insulin secretion, but not improved insulin sensitivity.

Rasouli N, Elbein SC.

J Clin Endocrinol Metab. 2004 Dec;89(12):6331-5.PMID: 15579799 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular screening and association analyses of the interleukin 6 receptor gene variants with type 2 diabetes, diabetic nephropathy, and insulin sensitivity.

Wang H, Zhang Z, Chu W, Hale T, Cooper JJ, Elbein SC.

J Clin Endocrinol Metab. 2005 Feb;90(2):1123-9. Epub 2004 Nov 23.PMID: 15562008 [PubMed - indexed for MEDLINE]Related articlesFree article

Calsquestrin 1 (CASQ1) gene polymorphisms under chromosome 1q21 linkage peak are associated with type 2 diabetes in Northern European Caucasians.

Das SK, Chu W, Zhang Z, Hasstedt SJ, Elbein SC.

Diabetes. 2004 Dec;53(12):3300-6.PMID: 15561963 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular screening of the human glutamine-fructose-6-phosphate amidotransferase 1 (GFPT1) gene and association studies with diabetes and diabetic nephropathy.

Elbein SC, Zheng H, Jia Y, Chu W, Cooper JJ, Hale T, Zhang Z.

Mol Genet Metab. 2004 Aug;82(4):321-8.PMID: 15308130 [PubMed - indexed for MEDLINE]Related articles

Does the aspartic acid to asparagine substitution at position 76 in the pancreas duodenum homeobox gene (PDX1) cause late-onset type 2 diabetes?

Elbein SC, Karim MA.

Diabetes Care. 2004 Aug;27(8):1968-73.PMID: 15277425 [PubMed - indexed for MEDLINE]Related articlesFree article

Adiponectin receptor 1 gene (ADIPOR1) as a candidate for type 2 diabetes and insulin resistance.

Wang H, Zhang H, Jia Y, Zhang Z, Craig R, Wang X, Elbein SC.

Diabetes. 2004 Aug;53(8):2132-6.PMID: 15277397 [PubMed - indexed for MEDLINE]Related articlesFree article

Common variants in glutamine:fructose-6-phosphate amidotransferase 2 (GFPT2) gene are associated with type 2 diabetes, diabetic nephropathy, and increased GFPT2 mRNA levels.

Zhang H, Jia Y, Cooper JJ, Hale T, Zhang Z, Elbein SC.

J Clin Endocrinol Metab. 2004 Feb;89(2):748-55.PMID: 14764791 [PubMed - indexed for MEDLINE]Related articlesFree article

Linkage and association mapping of a chromosome 1q21-q24 type 2 diabetes susceptibility locus in northern European Caucasians.

Das SK, Hasstedt SJ, Zhang Z, Elbein SC.

Diabetes. 2004 Feb;53(2):492-9.PMID: 14747303 [PubMed - indexed for MEDLINE]Related articlesFree article

Alpha-endosulfine, a positional and functional candidate gene for type 2 diabetes: molecular screening, association studies, and role in reduced insulin secretion.

Wang H, Craig RL, Schay J, Chu W, Das SK, Zhang Z, Elbein SC.

Mol Genet Metab. 2004 Jan;81(1):9-15.PMID: 14728986 [PubMed - indexed for MEDLINE]Related articles

Uncoupling protein-2 polymorphisms in type 2 diabetes, obesity, and insulin secretion.

Wang H, Chu WS, Lu T, Hasstedt SJ, Kern PA, Elbein SC.

Am J Physiol Endocrinol Metab. 2004 Jan;286(1):E1-7. Epub 2003 Aug 12.PMID: 12915397 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular screening and association studies of retinoid-related orphan receptor gamma (RORC): a positional and functional candidate for type 2 diabetes.

Wang H, Chu W, Das SK, Zheng Z, Hasstedt SJ, Elbein SC.

Mol Genet Metab. 2003 Jul;79(3):176-82.PMID: 12855222 [PubMed - indexed for MEDLINE]Related articles

The impact of genetic studies of type 2 diabetes on clinical practice.

Elbein SC.

Curr Diab Rep. 2003 Apr;3(2):93-4. No abstract available. PMID: 12728634 [PubMed - indexed for MEDLINE]Related articles

Liver pyruvate kinase polymorphisms are associated with type 2 diabetes in northern European Caucasians.

Wang H, Chu W, Das SK, Ren Q, Hasstedt SJ, Elbein SC.

Diabetes. 2002 Sep;51(9):2861-5.PMID: 12196482 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutation screening and association of human retinoid X receptor gamma variation with lipid levels in familial type 2 diabetes.

Wang H, Chu W, Hemphill C, Hasstedt SJ, Elbein SC.

Mol Genet Metab. 2002 May;76(1):14-22.PMID: 12175776 [PubMed - indexed for MEDLINE]Related articles

Evaluation of apolipoprotein A-II as a positional candidate gene for familial Type II diabetes, altered lipid concentrations, and insulin resistance.

Elbein SC, Chu W, Ren Q, Wang H, Hemphill C, Hasstedt SJ.

Diabetologia. 2002 Jul;45(7):1026-33. Epub 2002 May 8.PMID: 12136402 [PubMed - indexed for MEDLINE]Related articles

Human resistin gene: molecular scanning and evaluation of association with insulin sensitivity and type 2 diabetes in Caucasians.

Wang H, Chu WS, Hemphill C, Elbein SC.

J Clin Endocrinol Metab. 2002 Jun;87(6):2520-4.PMID: 12050208 [PubMed - indexed for MEDLINE]Related articlesFree article

Perspective: the search for genes for type 2 diabetes in the post-genome era.

Elbein SC.

Endocrinology. 2002 Jun;143(6):2012-8. Review.PMID: 12021163 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of calpain-10 gene variants in familial type 2 diabetes in Caucasians.

Elbein SC, Chu W, Ren Q, Hemphill C, Schay J, Cox NJ, Hanis CL, Hasstedt SJ.

J Clin Endocrinol Metab. 2002 Feb;87(2):650-4.PMID: 11836299 [PubMed - indexed for MEDLINE]Related articlesFree article

Quantitative trait linkage analysis of lipid-related traits in familial type 2 diabetes: evidence for linkage of triglyceride levels to chromosome 19q.

Elbein SC, Hasstedt SJ.

Diabetes. 2002 Feb;51(2):528-35.PMID: 11812765 [PubMed - indexed for MEDLINE]Related articlesFree article