PubMed

gamma-radiation-induced gammaH2AX formation occurs preferentially in actively transcribing euchromatic loci.

Vasireddy RS, Karagiannis TC, El-Osta A.

Cell Mol Life Sci. 2009 Oct 27. [Epub ahead of print]PMID: 19859659 [PubMed - as supplied by publisher]Related articles

The emerging role of epigenetic modifications and chromatin remodeling in spinal muscular atrophy.

Lunke S, El-Osta A.

J Neurochem. 2009 Jun;109(6):1557-69. Epub 2009 Apr 4. Review.PMID: 19383090 [PubMed - indexed for MEDLINE]Related articles

Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail.

Brasacchio D, Okabe J, Tikellis C, Balcerczyk A, George P, Baker EK, Calkin AC, Brownlee M, Cooper ME, El-Osta A.

Diabetes. 2009 May;58(5):1229-36. Epub 2009 Feb 10.PMID: 19208907 [PubMed - indexed for MEDLINE]Related articlesFree article

Human sympathetic nerve biology: parallel influences of stress and epigenetics in essential hypertension and panic disorder.

Esler M, Eikelis N, Schlaich M, Lambert G, Alvarenga M, Kaye D, El-Osta A, Guo L, Barton D, Pier C, Brenchley C, Dawood T, Jennings G, Lambert E.

Ann N Y Acad Sci. 2008 Dec;1148:338-48.PMID: 19120127 [PubMed - indexed for MEDLINE]Related articles

Survival motor neuron gene 2 silencing by DNA methylation correlates with spinal muscular atrophy disease severity and can be bypassed by histone deacetylase inhibition.

Hauke J, Riessland M, Lunke S, Eyüpoglu IY, Blümcke I, El-Osta A, Wirth B, Hahnen E.

Hum Mol Genet. 2009 Jan 15;18(2):304-17. Epub 2008 Oct 29.PMID: 18971205 [PubMed - indexed for MEDLINE]Related articlesFree article

Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia.

El-Osta A, Brasacchio D, Yao D, Pocai A, Jones PL, Roeder RG, Cooper ME, Brownlee M.

J Exp Med. 2008 Sep 29;205(10):2409-17. Epub 2008 Sep 22. Erratum in: J Exp Med. 2008 Oct 27;205(11):2683. PMID: 18809715 [PubMed - indexed for MEDLINE]Related articlesFree article

Scleral hydraulic conductivity and macromolecular diffusion in patients with uveal effusion syndrome.

Jackson TL, Hussain A, Morley AM, Sullivan PM, Hodgetts A, El-Osta A, Hillenkamp J, Charles SJ, Sheard R, Williamson TH, Kumar A, Laidlaw DA, Woon WH, Costen MJ, Luff AJ, Marshall J.

Invest Ophthalmol Vis Sci. 2008 Nov;49(11):5033-40. Epub 2008 Jun 14.PMID: 18552396 [PubMed - indexed for MEDLINE]Related articlesFree article

Epigenetic regulation and fetal programming.

Gicquel C, El-Osta A, Le Bouc Y.

Best Pract Res Clin Endocrinol Metab. 2008 Feb;22(1):1-16. Review.PMID: 18279777 [PubMed - indexed for MEDLINE]Related articles

Effect of valproic acid on radiation-induced DNA damage in euchromatic and heterochromatic compartments.

Harikrishnan KN, Karagiannis TC, Chow MZ, El-Osta A.

Cell Cycle. 2008 Feb 15;7(4):468-76. Epub 2007 Dec 4.PMID: 18239454 [PubMed - indexed for MEDLINE]Related articles

The epigenetic modifier, valproic acid, enhances radiation sensitivity.

Karagiannis TC, Kn H, El-Osta A.

Epigenetics. 2006 Jul-Sep;1(3):131-7. Epub 2006 May 17.PMID: 17965607 [PubMed - indexed for MEDLINE]Related articlesFree article

Clinical potential of histone deacetylase inhibitors as stand alone therapeutics and in combination with other chemotherapeutics or radiotherapy for cancer.

Karagiannis TC, El-Osta A.

Epigenetics. 2006 Jul-Sep;1(3):121-6. Epub 2006 Aug 28. Review.PMID: 17965606 [PubMed - indexed for MEDLINE]Related articlesFree article

FOXO1 regulates the expression of 4E-BP1 and inhibits mTOR signaling in mammalian skeletal muscle.

Southgate RJ, Neill B, Prelovsek O, El-Osta A, Kamei Y, Miura S, Ezaki O, McLoughlin TJ, Zhang W, Unterman TG, Febbraio MA.

J Biol Chem. 2007 Jul 20;282(29):21176-86. Epub 2007 May 17. Retraction in: J Biol Chem. 2009 Jul 24;284(30):20440. PMID: 17510058 [PubMed - indexed for MEDLINE]Related articlesFree article

Disparity of histone deacetylase inhibition on repair of radiation-induced DNA damage on euchromatin and constitutive heterochromatin compartments.

Karagiannis TC, Harikrishnan KN, El-Osta A.

Oncogene. 2007 Jun 7;26(27):3963-71. Epub 2007 Jan 8. Erratum in: Oncogene. 2007 Jul 26;26(34):5028. Kn, H [corrected to Harikrishnan, K N]. PMID: 17213813 [PubMed - indexed for MEDLINE]Related articles

Chromatin modifications and DNA double-strand breaks: the current state of play.

Karagiannis TC, El-Osta A.

Leukemia. 2007 Feb;21(2):195-200. Epub 2006 Dec 7. Review.PMID: 17151702 [PubMed - indexed for MEDLINE]Related articles

Will broad-spectrum histone deacetylase inhibitors be superseded by more specific compounds?

Karagiannis TC, El-Osta A.

Leukemia. 2007 Jan;21(1):61-5. Epub 2006 Nov 16. Review.PMID: 17109024 [PubMed - indexed for MEDLINE]Related articles

The neuronal noradrenaline transporter, anxiety and cardiovascular disease.

Esler M, Alvarenga M, Pier C, Richards J, El-Osta A, Barton D, Haikerwal D, Kaye D, Schlaich M, Guo L, Jennings G, Socratous F, Lambert G.

J Psychopharmacol. 2006 Jul;20(4 Suppl):60-6. Review.PMID: 16785272 [PubMed - indexed for MEDLINE]Related articles

Modulation of cellular radiation responses by histone deacetylase inhibitors.

Karagiannis TC, El-Osta A.

Oncogene. 2006 Jun 29;25(28):3885-93. Epub 2006 Feb 6. Review.PMID: 16462761 [PubMed - indexed for MEDLINE]Related articles

The paradox of histone deacetylase inhibitor-mediated modulation of cellular responses to radiation.

Karagiannis TC, El-Osta A.

Cell Cycle. 2006 Feb;5(3):288-95. Epub 2006 Feb 17. Review.PMID: 16418577 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms of abnormal gene expression in tumor cells.

El-Osta A.

EXS. 2006;(96):351-61. Review.PMID: 16383026 [PubMed - indexed for MEDLINE]Related articles

Epigenetic changes to the MDR1 locus in response to chemotherapeutic drugs.

Baker EK, Johnstone RW, Zalcberg JR, El-Osta A.

Oncogene. 2005 Dec 1;24(54):8061-75.PMID: 16091741 [PubMed - indexed for MEDLINE]Related articles

The histone deacetylase inhibitor, Trichostatin A, enhances radiation sensitivity and accumulation of gammaH2A.X.

Karagiannis TC, Harikrishnan KN, El-Osta A.

Cancer Biol Ther. 2005 Jul;4(7):787-93. Epub 2005 Jul 16.PMID: 16082178 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulation of soluble receptor for advanced glycation end products by angiotensin-converting enzyme-1 inhibition in diabetic nephropathy.

Forbes JM, Thorpe SR, Thallas-Bonke V, Pete J, Thomas MC, Deemer ER, Bassal S, El-Osta A, Long DM, Panagiotopoulos S, Jerums G, Osicka TM, Cooper ME.

J Am Soc Nephrol. 2005 Aug;16(8):2363-72. Epub 2005 Jun 1.PMID: 15930093 [PubMed - indexed for MEDLINE]Related articlesFree article

RNA interference and potential therapeutic applications of short interfering RNAs.

Karagiannis TC, El-Osta A.

Cancer Gene Ther. 2005 Oct;12(10):787-95. Review.PMID: 15891770 [PubMed - indexed for MEDLINE]Related articles

Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing.

Harikrishnan KN, Chow MZ, Baker EK, Pal S, Bassal S, Brasacchio D, Wang L, Craig JM, Jones PL, Sif S, El-Osta A.

Nat Genet. 2005 Mar;37(3):254-64. Epub 2005 Feb 6.PMID: 15696166 [PubMed - indexed for MEDLINE]Related articles

DNA damage detection and repair, and the involvement of epigenetic states.

Bassal S, El-Osta A.

Hum Mutat. 2005 Feb;25(2):101-9. Review.PMID: 15643607 [PubMed - indexed for MEDLINE]Related articles

siRNAs: mechanism of RNA interference, in vivo and potential clinical applications.

Karagiannis TC, El-Osta A.

Cancer Biol Ther. 2004 Nov;3(11):1069-74. Epub 2004 Nov 12. Review.PMID: 15539939 [PubMed - indexed for MEDLINE]Related articles

Demethylation using the epigenetic modifier, 5-azacytidine, increases the efficiency of transient transfection of macrophages.

Escher G, Hoang A, Georges S, Tchoua U, El-Osta A, Krozowski Z, Sviridov D.

J Lipid Res. 2005 Feb;46(2):356-65. Epub 2004 Nov 1.PMID: 15520456 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression analysis of the epigenetic methyltransferases and methyl-CpG binding protein families in the normal B-cell and B-cell chronic lymphocytic leukemia (CLL).

Kn H, Bassal S, Tikellis C, El-Osta A.

Cancer Biol Ther. 2004 Oct;3(10):989-94. Epub 2004 Oct 2.PMID: 15467427 [PubMed - indexed for MEDLINE]Related articles

Functional links between transcription, DNA repair and apoptosis.

Berardi P, Russell M, El-Osta A, Riabowol K.

Cell Mol Life Sci. 2004 Sep;61(17):2173-80. Review.PMID: 15338048 [PubMed - indexed for MEDLINE]Related articles

Double-strand breaks: signaling pathways and repair mechanisms.

Karagiannis TC, El-Osta A.

Cell Mol Life Sci. 2004 Sep;61(17):2137-47. Review.PMID: 15338043 [PubMed - indexed for MEDLINE]Related articles

Coordination of epigenetic events.

El-Osta A.

Cell Mol Life Sci. 2004 Sep;61(17):2135-6.PMID: 15338042 [PubMed - indexed for MEDLINE]Related articles

MDR1, chemotherapy and chromatin remodeling.

Baker EK, El-Osta A.

Cancer Biol Ther. 2004 Sep;3(9):819-24. Epub 2004 Sep 23. Review.PMID: 15326379 [PubMed - indexed for MEDLINE]Related articlesFree article

Understanding the consequences of epigenetic mechanisms and its effects on transcription in health and disease.

El-Osta A.

Cancer Biol Ther. 2004 Sep;3(9):816-8. Epub 2004 Sep 23.PMID: 15326369 [PubMed - indexed for MEDLINE]Related articlesFree article

Epigenetic changes activate widespread signals in response to double-strand breaks.

Karagiannis TC, El-Osta A.

Cancer Biol Ther. 2004 Jul;3(7):617-23. Epub 2004 Jul 9. Review.PMID: 15136760 [PubMed - indexed for MEDLINE]Related articlesFree article

The rise and fall of genomic methylation in cancer.

El-Osta A.

Leukemia. 2004 Feb;18(2):233-7. Review.PMID: 14628069 [PubMed - indexed for MEDLINE]Related articles

DNMT cooperativity--the developing links between methylation, chromatin structure and cancer.

El-Osta A.

Bioessays. 2003 Nov;25(11):1071-84. Review.PMID: 14579248 [PubMed - indexed for MEDLINE]Related articles

The rise of DNA methylation and the importance of chromatin on multidrug resistance in cancer.

Baker EK, El-Osta A.

Exp Cell Res. 2003 Nov 1;290(2):177-94. Review.PMID: 14567978 [PubMed - indexed for MEDLINE]Related articles

In vitro model for the study of human posterior capsule opacification.

El-Osta AA, Spalton DJ, Marshall J.

J Cataract Refract Surg. 2003 Aug;29(8):1593-600.PMID: 12954312 [PubMed - indexed for MEDLINE]Related articles

On the use of DNA methylation inhibitors and the reversal of transcriptional silencing.

El-Osta A.

Blood. 2003 Feb 15;101(4):1656; author reply 1657-8. No abstract available. PMID: 12560246 [PubMed - indexed for MEDLINE]Related articlesFree article

Mathematical modeling of the forces between an intraocular lens and the capsule.

Boyce JF, Bhermi GS, Spalton DJ, El-Osta AR.

J Cataract Refract Surg. 2002 Oct;28(10):1853-9.PMID: 12388041 [PubMed - indexed for MEDLINE]Related articles

Profiling methyl-CpG specific determinants on transcriptionally silent chromatin.

El-Osta A, Baker EK, Wolffe AP.

Mol Biol Rep. 2001;28(4):209-15.PMID: 12153140 [PubMed - indexed for MEDLINE]Related articles

Failure of a discontinuous bend to prevent lens epithelial cell migration in vitro.

Bhermi GS, Spalton DJ, El-Osta AA, Marshall J.

J Cataract Refract Surg. 2002 Jul;28(7):1256-61.PMID: 12106737 [PubMed - indexed for MEDLINE]Related articles

FMR1 silencing and the signals to chromatin: a unified model of transcriptional regulation.

El-Osta A.

Biochem Biophys Res Commun. 2002 Jul 19;295(3):575-81. Review.PMID: 12099676 [PubMed - indexed for MEDLINE]Related articles

Precipitous release of methyl-CpG binding protein 2 and histone deacetylase 1 from the methylated human multidrug resistance gene (MDR1) on activation.

El-Osta A, Kantharidis P, Zalcberg JR, Wolffe AP.

Mol Cell Biol. 2002 Mar;22(6):1844-57.PMID: 11865062 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of chromatin-immunopurified MeCP2-associated fragments.

El-Osta A, Wolffe AP.

Biochem Biophys Res Commun. 2001 Dec 7;289(3):733-7.PMID: 11726209 [PubMed - indexed for MEDLINE]Related articles

DNA methylation and histone deacetylation in the control of gene expression: basic biochemistry to human development and disease.

El-Osta A, Wolffe AP.

Gene Expr. 2000;9(1-2):63-75. Review.PMID: 11097425 [PubMed - indexed for MEDLINE]Related articles

Absolute quantitation of MDR1 transcripts using heterologous DNA standards--validation of the competitive RT-PCR (CRT-PCR) approach.

el-Osta A, Kantharidis P, Zalcberg J.

Biotechniques. 1999 Jun;26(6):1114-6, 1118-20, 1122 passim.PMID: 10376151 [PubMed - indexed for MEDLINE]Related articles

Altered methylation of the human MDR1 promoter is associated with acquired multidrug resistance.

Kantharidis P, El-Osta A, deSilva M, Wall DM, Hu XF, Slater A, Nadalin G, Parkin JD, Zalcberg JR.

Clin Cancer Res. 1997 Nov;3(11):2025-32.PMID: 9815593 [PubMed - indexed for MEDLINE]Related articlesFree article