PubMed

The cytokines IL-1{beta} and TNF-{alpha} regulate different transcriptional and alternative splicing networks in primary beta cells.

Ortis F, Naamane N, Flamez D, Ladrière L, Moore F, Cunha DA, Colli ML, Thykjaer T, Thorsen K, Orntoft TF, Eizirik DL.

Diabetes. 2009 Nov 23. [Epub ahead of print]PMID: 19934004 [PubMed - as supplied by publisher]

MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic {beta}-cell responses to the viral by-product double stranded RNA.

Colli ML, Moore F, Gurzov EN, Ortis F, Eizirik DL.

Hum Mol Genet. 2009 Oct 13. [Epub ahead of print]PMID: 19825843 [PubMed - as supplied by publisher]Related articlesFree article

Interferon regulatory factor-1 is a key transcription factor in murine beta cells under immune attack.

Gysemans C, Callewaert H, Moore F, Nelson-Holte M, Overbergh L, Eizirik DL, Mathieu C.

Diabetologia. 2009 Sep 8. [Epub ahead of print]PMID: 19756487 [PubMed - as supplied by publisher]Related articles

Regulation and function of the cytosolic viral RNA sensor RIG-I in pancreatic beta cells.

García M, Dogusan Z, Moore F, Sato S, Hartmann G, Eizirik DL, Rasschaert J.

Biochim Biophys Acta. 2009 Nov;1793(11):1768-75. Epub 2009 Sep 10.PMID: 19747951 [PubMed - in process]Related articles

Glucagon-Like Peptide-1 Agonists Protect Pancreatic {beta}-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB.

Cunha DA, Ladrière L, Ortis F, Igoillo-Esteve M, Gurzov EN, Lupi R, Marchetti P, Eizirik DL, Cnop M.

Diabetes. 2009 Dec;58(12):2851-62. Epub 2009 Aug 31.PMID: 19720788 [PubMed - in process]Related articles

Signaling by IL-1beta+IFN-gamma and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic beta-cell apoptosis.

Gurzov EN, Ortis F, Cunha DA, Gosset G, Li M, Cardozo AK, Eizirik DL.

Cell Death Differ. 2009 Nov;16(11):1539-50. Epub 2009 Jul 24.PMID: 19629134 [PubMed - in process]Related articles

Inhibition of nuclear factor-kappaB or Bax prevents endoplasmic reticulum stress- but not nitric oxide-mediated apoptosis in INS-1E cells.

Tonnesen MF, Grunnet LG, Friberg J, Cardozo AK, Billestrup N, Eizirik DL, Størling J, Mandrup-Poulsen T.

Endocrinology. 2009 Sep;150(9):4094-103. Epub 2009 Jun 25.PMID: 19556421 [PubMed - indexed for MEDLINE]Related articles

Transient oxidative stress damages mitochondrial machinery inducing persistent beta-cell dysfunction.

Li N, Brun T, Cnop M, Cunha DA, Eizirik DL, Maechler P.

J Biol Chem. 2009 Aug 28;284(35):23602-12. Epub 2009 Jun 22.PMID: 19546218 [PubMed - indexed for MEDLINE]Related articles

The role of inflammation in insulitis and beta-cell loss in type 1 diabetes.

Eizirik DL, Colli ML, Ortis F.

Nat Rev Endocrinol. 2009 Apr;5(4):219-26. Review.PMID: 19352320 [PubMed - indexed for MEDLINE]Related articles

PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis.

Moore F, Colli ML, Cnop M, Esteve MI, Cardozo AK, Cunha DA, Bugliani M, Marchetti P, Eizirik DL.

Diabetes. 2009 Jun;58(6):1283-91. Epub 2009 Mar 31.PMID: 19336676 [PubMed - indexed for MEDLINE]Related articlesFree article

Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes: response to Nathan et al.

Eizirik DL.

Diabetes Care. 2009 Mar;32(3):e35-6; author reply e37-8. No abstract available. PMID: 19246586 [PubMed - indexed for MEDLINE]Related articlesFree article

Detailed transcriptome atlas of the pancreatic beta cell.

Kutlu B, Burdick D, Baxter D, Rasschaert J, Flamez D, Eizirik DL, Welsh N, Goodman N, Hood L.

BMC Med Genomics. 2009 Jan 15;2:3.PMID: 19146692 [PubMed - in process]Related articlesFree article

Guidelines for medical management of hyperglycaemia in type 2 diabetes and duality of interest.

Eizirik DL.

Diabetologia. 2009 Mar;52(3):550-1; author reply 554-5. Epub 2008 Nov 26. No abstract available. PMID: 19034415 [PubMed - indexed for MEDLINE]Related articles

IL-1beta-induced chemokine and Fas expression are inhibited by suppressor of cytokine signalling-3 in insulin-producing cells.

Jacobsen ML, Rønn SG, Bruun C, Larsen CM, Eizirik DL, Mandrup-Poulsen T, Billestrup N.

Diabetologia. 2009 Feb;52(2):281-8. Epub 2008 Nov 11.PMID: 19002429 [PubMed - indexed for MEDLINE]Related articles

An update on lipotoxic endoplasmic reticulum stress in pancreatic beta-cells.

Cnop M, Igoillo-Esteve M, Cunha DA, Ladrière L, Eizirik DL.

Biochem Soc Trans. 2008 Oct;36(Pt 5):909-15. Review.PMID: 18793160 [PubMed - indexed for MEDLINE]Related articles

JunB Inhibits ER Stress and Apoptosis in Pancreatic Beta Cells.

Gurzov EN, Ortis F, Bakiri L, Wagner EF, Eizirik DL.

PLoS One. 2008 Aug 21;3(8):e3030.PMID: 18716665 [PubMed - indexed for MEDLINE]Related articlesFree article

Initiation and execution of lipotoxic ER stress in pancreatic beta-cells.

Cunha DA, Hekerman P, Ladrière L, Bazarra-Castro A, Ortis F, Wakeham MC, Moore F, Rasschaert J, Cardozo AK, Bellomo E, Overbergh L, Mathieu C, Lupi R, Hai T, Herchuelz A, Marchetti P, Rutter GA, Eizirik DL, Cnop M.

J Cell Sci. 2008 Jul 15;121(Pt 14):2308-18. Epub 2008 Jun 17.PMID: 18559892 [PubMed - indexed for MEDLINE]Related articlesFree article

Use of a systems biology approach to understand pancreatic beta-cell death in Type 1 diabetes.

Eizirik DL, Moore F, Flamez D, Ortis F.

Biochem Soc Trans. 2008 Jun;36(Pt 3):321-7. Review.PMID: 18481950 [PubMed - indexed for MEDLINE]Related articles

Induction of nuclear factor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells.

Ortis F, Pirot P, Naamane N, Kreins AY, Rasschaert J, Moore F, Théâtre E, Verhaeghe C, Magnusson NE, Chariot A, Orntoft TF, Eizirik DL.

Diabetologia. 2008 Jul;51(7):1213-25. Epub 2008 May 8.PMID: 18463842 [PubMed - indexed for MEDLINE]Related articles

Mediators and mechanisms of pancreatic beta-cell death in type 1 diabetes.

Pirot P, Cardozo AK, Eizirik DL.

Arq Bras Endocrinol Metabol. 2008 Mar;52(2):156-65. Review.PMID: 18438526 [PubMed - indexed for MEDLINE]Related articlesFree article

Double-stranded RNA induces pancreatic beta-cell apoptosis by activation of the toll-like receptor 3 and interferon regulatory factor 3 pathways.

Dogusan Z, García M, Flamez D, Alexopoulou L, Goldman M, Gysemans C, Mathieu C, Libert C, Eizirik DL, Rasschaert J.

Diabetes. 2008 May;57(5):1236-45. Epub 2008 Jan 25.PMID: 18223009 [PubMed - indexed for MEDLINE]Related articlesFree article

The role for endoplasmic reticulum stress in diabetes mellitus.

Eizirik DL, Cardozo AK, Cnop M.

Endocr Rev. 2008 Feb;29(1):42-61. Epub 2007 Nov 29. Review.PMID: 18048764 [PubMed - indexed for MEDLINE]Related articlesFree article

Proteomics analysis of cytokine-induced dysfunction and death in insulin-producing INS-1E cells: new insights into the pathways involved.

D'Hertog W, Overbergh L, Lage K, Ferreira GB, Maris M, Gysemans C, Flamez D, Cardozo AK, Van den Bergh G, Schoofs L, Arckens L, Moreau Y, Hansen DA, Eizirik DL, Waelkens E, Mathieu C.

Mol Cell Proteomics. 2007 Dec;6(12):2180-99. Epub 2007 Oct 5.PMID: 17921177 [PubMed - indexed for MEDLINE]Related articlesFree article

The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients.

Marchetti P, Bugliani M, Lupi R, Marselli L, Masini M, Boggi U, Filipponi F, Weir GC, Eizirik DL, Cnop M.

Diabetologia. 2007 Dec;50(12):2486-94. Epub 2007 Sep 30.PMID: 17906960 [PubMed - indexed for MEDLINE]Related articles

Cell loss during pseudoislet formation hampers profound improvements in islet lentiviral transduction efficacy for transplantation purposes.

Callewaert H, Gysemans C, Cardozo AK, Elsner M, Tiedge M, Eizirik DL, Mathieu C.

Cell Transplant. 2007;16(5):527-37.PMID: 17708342 [PubMed - indexed for MEDLINE]Related articles

Cell-permeable peptides induce dose- and length-dependent cytotoxic effects.

Cardozo AK, Buchillier V, Mathieu M, Chen J, Ortis F, Ladrière L, Allaman-Pillet N, Poirot O, Kellenberger S, Beckmann JS, Eizirik DL, Bonny C, Maurer F.

Biochim Biophys Acta. 2007 Sep;1768(9):2222-34. Epub 2007 Jun 14.PMID: 17626783 [PubMed - indexed for MEDLINE]Related articles

Loss of PPAR gamma in immune cells impairs the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage infiltration into white adipose tissue.

Guri AJ, Hontecillas R, Ferrer G, Casagran O, Wankhade U, Noble AM, Eizirik DL, Ortis F, Cnop M, Liu D, Si H, Bassaganya-Riera J.

J Nutr Biochem. 2008 Apr;19(4):216-28. Epub 2007 Jul 6.PMID: 17618105 [PubMed - indexed for MEDLINE]Related articles

Using genomics and systems biology to address complex problems: pancreatic Beta cell apoptosis in diabetes mellitus.

Eizirik DL.

ALTEX. 2006;23 Suppl:385-7.PMID: 17492218 [PubMed - in process]Related articles

Deletion of STAT-1 pancreatic islets protects against streptozotocin-induced diabetes and early graft failure but not against late rejection.

Callewaert HI, Gysemans CA, Ladrière L, D'Hertog W, Hagenbrock J, Overbergh L, Eizirik DL, Mathieu C.

Diabetes. 2007 Aug;56(8):2169-73. Epub 2007 May 1.PMID: 17473223 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells.

Pirot P, Ortis F, Cnop M, Ma Y, Hendershot LM, Eizirik DL, Cardozo AK.

Diabetes. 2007 Apr;56(4):1069-77.PMID: 17395747 [PubMed - indexed for MEDLINE]Related articlesFree article

Global profiling of genes modified by endoplasmic reticulum stress in pancreatic beta cells reveals the early degradation of insulin mRNAs.

Pirot P, Naamane N, Libert F, Magnusson NE, Ørntoft TF, Cardozo AK, Eizirik DL.

Diabetologia. 2007 May;50(5):1006-14. Epub 2007 Mar 1.PMID: 17333111 [PubMed - indexed for MEDLINE]Related articles

In silico identification of NF-kappaB-regulated genes in pancreatic beta-cells.

Naamane N, van Helden J, Eizirik DL.

BMC Bioinformatics. 2007 Feb 15;8:55.PMID: 17302974 [PubMed - indexed for MEDLINE]Related articlesFree article

T1DBase: integration and presentation of complex data for type 1 diabetes research.

Hulbert EM, Smink LJ, Adlem EC, Allen JE, Burdick DB, Burren OS, Cassen VM, Cavnor CC, Dolman GE, Flamez D, Friery KF, Healy BC, Killcoyne SA, Kutlu B, Schuilenburg H, Walker NM, Mychaleckyj J, Eizirik DL, Wicker LS, Todd JA, Goodman N.

Nucleic Acids Res. 2007 Jan;35(Database issue):D742-6. Epub 2006 Dec 14. Erratum in: Nucleic Acids Res. 2007;35(18):6338. Cassen, Victor M [added]. PMID: 17169983 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis.

Cnop M, Ladriere L, Hekerman P, Ortis F, Cardozo AK, Dogusan Z, Flamez D, Boyce M, Yuan J, Eizirik DL.

J Biol Chem. 2007 Feb 9;282(6):3989-97. Epub 2006 Dec 8.PMID: 17158450 [PubMed - indexed for MEDLINE]Related articlesFree article

BCL-6: a possible missing link for anti-inflammatory PPAR-delta signalling in pancreatic beta cells.

Kharroubi I, Lee CH, Hekerman P, Darville MI, Evans RM, Eizirik DL, Cnop M.

Diabetologia. 2006 Oct;49(10):2350-8. Epub 2006 Aug 5.PMID: 16896941 [PubMed - indexed for MEDLINE]Related articles

Interferon-gamma potentiates endoplasmic reticulum stress-induced death by reducing pancreatic beta cell defence mechanisms.

Pirot P, Eizirik DL, Cardozo AK.

Diabetologia. 2006 Jun;49(6):1229-36. Epub 2006 Apr 8.PMID: 16604358 [PubMed - indexed for MEDLINE]Related articles

Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-kappaB activation.

Ortis F, Cardozo AK, Crispim D, Störling J, Mandrup-Poulsen T, Eizirik DL.

Mol Endocrinol. 2006 Aug;20(8):1867-79. Epub 2006 Mar 23.PMID: 16556731 [PubMed - indexed for MEDLINE]Related articlesFree article

Conditional and specific NF-kappaB blockade protects pancreatic beta cells from diabetogenic agents.

Eldor R, Yeffet A, Baum K, Doviner V, Amar D, Ben-Neriah Y, Christofori G, Peled A, Carel JC, Boitard C, Klein T, Serup P, Eizirik DL, Melloul D.

Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5072-7. Epub 2006 Mar 21.PMID: 16551748 [PubMed - indexed for MEDLINE]Related articlesFree article

Construction and validation of the APOCHIP, a spotted oligo-microarray for the study of beta-cell apoptosis.

Magnusson NE, Cardozo AK, Kruhøffer M, Eizirik DL, Ørntoft TF, Jensen JL.

BMC Bioinformatics. 2005 Dec 29;6:311.PMID: 16384535 [PubMed - indexed for MEDLINE]Related articlesFree article

Notch signaling: a mediator of beta-cell de-differentiation in diabetes?

Darville MI, Eizirik DL.

Biochem Biophys Res Commun. 2006 Jan 27;339(4):1063-8. Epub 2005 Dec 1.PMID: 16337608 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities.

Cnop M, Welsh N, Jonas JC, Jörns A, Lenzen S, Eizirik DL.

Diabetes. 2005 Dec;54 Suppl 2:S97-107. Review.PMID: 16306347 [PubMed - indexed for MEDLINE]Related articlesFree article

Extracellular signal-regulated kinase is essential for interleukin-1-induced and nuclear factor kappaB-mediated gene expression in insulin-producing INS-1E cells.

Larsen L, Størling J, Darville M, Eizirik DL, Bonny C, Billestrup N, Mandrup-Poulsen T.

Diabetologia. 2005 Dec;48(12):2582-90. Epub 2005 Nov 11.PMID: 16283237 [PubMed - indexed for MEDLINE]Related articles

Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?

Welsh N, Cnop M, Kharroubi I, Bugliani M, Lupi R, Marchetti P, Eizirik DL.

Diabetes. 2005 Nov;54(11):3238-44.PMID: 16249450 [PubMed - indexed for MEDLINE]Related articlesFree article

Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress.

Guo D, Han J, Adam BL, Colburn NH, Wang MH, Dong Z, Eizirik DL, She JX, Wang CY.

Biochem Biophys Res Commun. 2005 Dec 2;337(4):1308-18. Epub 2005 Oct 10.PMID: 16236267 [PubMed - indexed for MEDLINE]Related articles

Disruption of the gamma-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of beta-cells.

Gysemans CA, Ladrière L, Callewaert H, Rasschaert J, Flamez D, Levy DE, Matthys P, Eizirik DL, Mathieu C.

Diabetes. 2005 Aug;54(8):2396-403.PMID: 16046307 [PubMed - indexed for MEDLINE]Related articlesFree article

Toll-like receptor 3 and STAT-1 contribute to double-stranded RNA+ interferon-gamma-induced apoptosis in primary pancreatic beta-cells.

Rasschaert J, Ladrière L, Urbain M, Dogusan Z, Katabua B, Sato S, Akira S, Gysemans C, Mathieu C, Eizirik DL.

J Biol Chem. 2005 Oct 7;280(40):33984-91. Epub 2005 Jul 15.PMID: 16027122 [PubMed - indexed for MEDLINE]Related articlesFree article

Global profiling of coxsackievirus- and cytokine-induced gene expression in human pancreatic islets.

Ylipaasto P, Kutlu B, Rasilainen S, Rasschaert J, Salmela K, Teerijoki H, Korsgren O, Lahesmaa R, Hovi T, Eizirik DL, Otonkoski T, Roivainen M.

Diabetologia. 2005 Aug;48(8):1510-22. Epub 2005 Jul 1.PMID: 15991020 [PubMed - indexed for MEDLINE]Related articles

SUMO wrestling with type 1 diabetes.

Li M, Guo D, Isales CM, Eizirik DL, Atkinson M, She JX, Wang CY.

J Mol Med. 2005 Jul;83(7):504-13. Epub 2005 Apr 2. Review.PMID: 15806321 [PubMed - indexed for MEDLINE]Related articles

High glucose and hydrogen peroxide increase c-Myc and haeme-oxygenase 1 mRNA levels in rat pancreatic islets without activating NFkappaB.

Elouil H, Cardozo AK, Eizirik DL, Henquin JC, Jonas JC.

Diabetologia. 2005 Mar;48(3):496-505. Epub 2005 Mar 1. Erratum in: Diabetologia. 2005 Dec;48(12):2693. PMID: 15739117 [PubMed - indexed for MEDLINE]Related articles

New approaches for in silico identification of cytokine-modified beta cell gene networks.

Kutlu B, Naamane N, Berthou L, Eizirik DL.

Ann N Y Acad Sci. 2004 Dec;1037:41-58. Review.PMID: 15699492 [PubMed - indexed for MEDLINE]Related articles