PubMed

Insulin2 gene (Ins2) transcription by NOD bone marrow-derived cells does not influence autoimmune diabetes development in NOD-Ins2 knockout mice.

Martin-Pagola A, Pileggi A, Zahr E, Vendrame F, Damaris Molano R, Snowhite I, Ricordi C, Eisenbarth GS, Nakayama M, Pugliese A.

Scand J Immunol. 2009 Nov;70(5):439-46.PMID: 19874548 [PubMed - indexed for MEDLINE]Related articles

Homozygosity of the polymorphism MICA5.1 identifies extreme risk of progression to overt adrenal insufficiency among 21-hydroxylase antibody-positive patients with type 1 diabetes.

Triolo TM, Baschal EE, Armstrong TK, Toews CS, Fain PR, Rewers MJ, Yu L, Miao D, Eisenbarth GS, Gottlieb PA, Barker JM.

J Clin Endocrinol Metab. 2009 Nov;94(11):4517-23. Epub 2009 Oct 9.PMID: 19820007 [PubMed - in process]Related articles

Two novel AIRE mutations in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) among Indians.

Zaidi G, Sahu RP, Zhang L, George G, Bhavani N, Shah N, Bhatia V, Bhansali A, Jevalikar G, Jayakumar RV, Eisenbarth GS, Bhatia E.

Clin Genet. 2009 Nov;76(5):441-8. Epub 2009 Oct 6.PMID: 19807739 [PubMed - in process]Related articles

Comparison of insulin autoantibody: polyethylene glycol and micro-IAA 1-day and 7-day assays.

Babaya N, Yu L, Miao D, Wang J, Rewers M, Nakayama M, Liu E, Barker JM, Eisenbarth GS.

Diabetes Metab Res Rev. 2009 Oct;25(7):665-70.PMID: 19768733 [PubMed - in process]Related articles

Defining multiple common "completely" conserved major histocompatibility complex SNP haplotypes.

Baschal EE, Aly TA, Jasinski JM, Steck AK, Noble JA, Erlich HA, Eisenbarth GS; Type 1 Diabetes Genetics Consortium.

Clin Immunol. 2009 Aug;132(2):203-14. Epub 2009 May 7.PMID: 19427271 [PubMed - indexed for MEDLINE]Related articles

Autoimmune polyendocrine syndrome type 1 (APS-1) as a model for understanding autoimmune polyendocrine syndrome type 2 (APS-2).

Michels AW, Eisenbarth GS.

J Intern Med. 2009 May;265(5):530-40. Review.PMID: 19382992 [PubMed - indexed for MEDLINE]Related articles

Murine high specificity/sensitivity competitive europium insulin autoantibody assay.

Babaya N, Liu E, Miao D, Li M, Yu L, Eisenbarth GS.

Diabetes Technol Ther. 2009 Apr;11(4):227-33.PMID: 19344197 [PubMed - indexed for MEDLINE]Related articles

Analysis of T cell receptor beta chains that combine with dominant conserved TRAV5D-4*04 anti-insulin B:9-23 alpha chains.

Zhang L, Jasinski JM, Kobayashi M, Davenport B, Johnson K, Davidson H, Nakayama M, Haskins K, Eisenbarth GS.

J Autoimmun. 2009 Aug;33(1):42-9. Epub 2009 Mar 16.PMID: 19286348 [PubMed - in process]Related articles

Type 1 diabetes: chronic progressive autoimmune disease.

Zhang L, Gianani R, Nakayama M, Liu E, Kobayashi M, Baschal E, Yu L, Babu S, Dawson A, Johnson K, Jahromi M, Aly T, Fain P, Barker J, Rewers M, Eisenbarth GS.

Novartis Found Symp. 2008;292:85-94; discussion 94-8, 122-9, 202-3.PMID: 19203094 [PubMed - indexed for MEDLINE]Related articles

Do non-HLA genes influence development of persistent islet autoimmunity and type 1 diabetes in children with high-risk HLA-DR,DQ genotypes?

Steck AK, Zhang W, Bugawan TL, Barriga KJ, Blair A, Erlich HA, Eisenbarth GS, Norris JM, Rewers MJ.

Diabetes. 2009 Apr;58(4):1028-33. Epub 2009 Feb 2.PMID: 19188433 [PubMed - indexed for MEDLINE]Related articlesFree article

The frequent and conserved DR3-B8-A1 extended haplotype confers less diabetes risk than other DR3 haplotypes.

Baschal EE, Aly TA, Jasinski JM, Steck AK, Johnson KN, Noble JA, Erlich HA, Eisenbarth GS; Type 1 Diabetes Genetics Consortium.

Diabetes Obes Metab. 2009 Feb;11 Suppl 1:25-30.PMID: 19143812 [PubMed - indexed for MEDLINE]Related articlesFree article

SlC30A8 is a major target of humoral autoimmunity in type 1 diabetes and a predictive marker in prediabetes.

Wenzlau JM, Moua O, Sarkar SA, Yu L, Rewers M, Eisenbarth GS, Davidson HW, Hutton JC.

Ann N Y Acad Sci. 2008 Dec;1150:256-9.PMID: 19120307 [PubMed - indexed for MEDLINE]Related articles

Identification of a major humoral epitope in Slc30A8 (ZnT8).

Wenzlau JM, Moua O, Liu Y, Eisenbarth GS, Hutton JC, Davidson HW.

Ann N Y Acad Sci. 2008 Dec;1150:252-5.PMID: 19120306 [PubMed - indexed for MEDLINE]Related articles

Conserved epitopes in the protein tyrosine phosphatase family of diabetes autoantigens.

Liu Y, Wenzlau JM, Yu L, Patel C, Eisenbarth GS, Hutton JC, Davidson HW.

Ann N Y Acad Sci. 2008 Dec;1150:245-7.PMID: 19120304 [PubMed - indexed for MEDLINE]Related articles

Concordance for islet autoimmunity among monozygotic twins.

Redondo MJ, Jeffrey J, Fain PR, Eisenbarth GS, Orban T.

N Engl J Med. 2008 Dec 25;359(26):2849-50. No abstract available. PMID: 19109586 [PubMed - indexed for MEDLINE]Related articles

Single nucleotide transcription factor 7-like 2 (TCF7L2) gene polymorphisms in antiislet autoantibody-negative patients at onset of diabetes.

Yu J, Steck AK, Babu S, Yu L, Miao D, McFann K, Hutton J, Eisenbarth GS, Klingensmith G.

J Clin Endocrinol Metab. 2009 Feb;94(2):504-10. Epub 2008 Dec 2.PMID: 19050058 [PubMed - indexed for MEDLINE]Related articles

In vivo BLyS/BAFF neutralization ameliorates islet-directed autoimmunity in nonobese diabetic mice.

Zekavat G, Rostami SY, Badkerhanian A, Parsons RF, Koeberlein B, Yu M, Ward CD, Migone TS, Yu L, Eisenbarth GS, Cancro MP, Naji A, Noorchashm H.

J Immunol. 2008 Dec 1;181(11):8133-44.PMID: 19018006 [PubMed - indexed for MEDLINE]Related articles

Primer: immunity and autoimmunity.

Pietropaolo M, Surhigh JM, Nelson PW, Eisenbarth GS.

Diabetes. 2008 Nov;57(11):2872-82. No abstract available. PMID: 18971434 [PubMed - indexed for MEDLINE]Related articlesFree article

The TrialNet Natural History Study of the Development of Type 1 Diabetes: objectives, design, and initial results.

Mahon JL, Sosenko JM, Rafkin-Mervis L, Krause-Steinrauf H, Lachin JM, Thompson C, Bingley PJ, Bonifacio E, Palmer JP, Eisenbarth GS, Wolfsdorf J, Skyler JS; TrialNet Natural History Committee; Type 1 Diabetes TrialNet Study Group.

Pediatr Diabetes. 2009 Apr;10(2):97-104. Epub 2008 Sep 24.PMID: 18823409 [PubMed - indexed for MEDLINE]Related articles

Do NALP5 antibodies correlate with hypoparathyroidism in patients with APS-1?

Eisenbarth GS.

Nat Clin Pract Endocrinol Metab. 2008 Oct;4(10):544-5. Epub 2008 Aug 19. No abstract available. PMID: 18711407 [PubMed]Related articles

Two single nucleotide polymorphisms identify the highest-risk diabetes HLA genotype: potential for rapid screening.

Barker JM, Triolo TM, Aly TA, Baschal EE, Babu SR, Kretowski A, Rewers MJ, Eisenbarth GS.

Diabetes. 2008 Nov;57(11):3152-5. Epub 2008 Aug 11.PMID: 18694972 [PubMed - indexed for MEDLINE]Related articlesFree article

Dietary glycemic index, development of islet autoimmunity, and subsequent progression to type 1 diabetes in young children.

Lamb MM, Yin X, Barriga K, Hoffman MR, Barón AE, Eisenbarth GS, Rewers M, Norris JM.

J Clin Endocrinol Metab. 2008 Oct;93(10):3936-42. Epub 2008 Aug 5.PMID: 18682514 [PubMed - indexed for MEDLINE]Related articlesFree article

Conserved T cell receptor alpha-chain induces insulin autoantibodies.

Kobayashi M, Jasinski J, Liu E, Li M, Miao D, Zhang L, Yu L, Nakayama M, Eisenbarth GS.

Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):10090-4. Epub 2008 Jul 14.PMID: 18626021 [PubMed - indexed for MEDLINE]Related articlesFree article

A common nonsynonymous single nucleotide polymorphism in the SLC30A8 gene determines ZnT8 autoantibody specificity in type 1 diabetes.

Wenzlau JM, Liu Y, Yu L, Moua O, Fowler KT, Rangasamy S, Walters J, Eisenbarth GS, Davidson HW, Hutton JC.

Diabetes. 2008 Oct;57(10):2693-7. Epub 2008 Jun 30.PMID: 18591387 [PubMed - indexed for MEDLINE]Related articlesFree article

Extreme genetic risk for type 1A diabetes in the post-genome era.

Baschal EE, Eisenbarth GS.

J Autoimmun. 2008 Aug;31(1):1-6. Epub 2008 May 1. Review.PMID: 18450419 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic similarities between latent autoimmune diabetes and type 1 and type 2 diabetes.

Steck AK, Eisenbarth GS.

Diabetes. 2008 May;57(5):1160-2. No abstract available. PMID: 18443373 [PubMed - indexed for MEDLINE]Related articlesFree article

The natural history of type 1A diabetes.

Eisenbarth GS, Jeffrey J.

Arq Bras Endocrinol Metabol. 2008 Mar;52(2):146-55. Review.PMID: 18438525 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin as an autoantigen in NOD/human diabetes.

Zhang L, Nakayama M, Eisenbarth GS.

Curr Opin Immunol. 2008 Feb;20(1):111-8. Review.PMID: 18178393 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of single nucleotide polymorphisms identifies major type 1A diabetes locus telomeric of the major histocompatibility complex.

Aly TA, Baschal EE, Jahromi MM, Fernando MS, Babu SR, Fingerlin TE, Kretowski A, Erlich HA, Fain PR, Rewers MJ, Eisenbarth GS.

Diabetes. 2008 Mar;57(3):770-6. Epub 2007 Dec 7.PMID: 18065518 [PubMed - indexed for MEDLINE]Related articlesFree article

The MHC type 1 diabetes susceptibility gene is centromeric to HLA-DQB1.

Husain Z, Kelly MA, Eisenbarth GS, Pugliese A, Awdeh ZL, Larsen CE, Alper CA.

J Autoimmun. 2008 Jun;30(4):266-72. Epub 2007 Dec 11.PMID: 18065200 [PubMed - indexed for MEDLINE]Related articles

The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes.

Wenzlau JM, Juhl K, Yu L, Moua O, Sarkar SA, Gottlieb P, Rewers M, Eisenbarth GS, Jensen J, Davidson HW, Hutton JC.

Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17040-5. Epub 2007 Oct 17.PMID: 17942684 [PubMed - indexed for MEDLINE]Related articlesFree article

Accepting clocks that tell time poorly: fluid-phase versus standard ELISA autoantibody assays.

Liu E, Eisenbarth GS.

Clin Immunol. 2007 Nov;125(2):120-6. Epub 2007 Sep 27. Review.PMID: 17904423 [PubMed - indexed for MEDLINE]Related articlesFree article

Omega-3 polyunsaturated fatty acid intake and islet autoimmunity in children at increased risk for type 1 diabetes.

Norris JM, Yin X, Lamb MM, Barriga K, Seifert J, Hoffman M, Orton HD, Barón AE, Clare-Salzler M, Chase HP, Szabo NJ, Erlich H, Eisenbarth GS, Rewers M.

JAMA. 2007 Sep 26;298(12):1420-8.PMID: 17895458 [PubMed - indexed for MEDLINE]Related articlesFree article

Natural history of antibodies to deamidated gliadin peptides and transglutaminase in early childhood celiac disease.

Liu E, Li M, Emery L, Taki I, Barriga K, Tiberti C, Eisenbarth GS, Rewers MJ, Hoffenberg EJ.

J Pediatr Gastroenterol Nutr. 2007 Sep;45(3):293-300.PMID: 17873740 [PubMed - indexed for MEDLINE]Related articles

A robust immunoassay for anti-interferon autoantibodies that is highly specific for patients with autoimmune polyglandular syndrome type 1.

Zhang L, Barker JM, Babu S, Su M, Stenerson M, Cheng M, Shum A, Zamir E, Badolato R, Law A, Eisenbarth GS, Anderson MS.

Clin Immunol. 2007 Nov;125(2):131-7. Epub 2007 Sep 6.PMID: 17825626 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential effects of DRB1*0301 and DQA1*0501-DQB1*0201 on the activation and progression of islet cell autoimmunity.

Eller E, Vardi P, McFann KK, Babu SR, Yu L, Bugawan TL, Erlich HA, Eisenbarth GS, Fain PR.

Genes Immun. 2007 Dec;8(8):628-33. Epub 2007 Aug 30.PMID: 17728790 [PubMed - indexed for MEDLINE]Related articles

Deleting islet autoimmunity.

Liu E, Li M, Jasinski J, Kobayashi M, Gianani R, Nakayama M, Eisenbarth GS.

Cell Biochem Biophys. 2007;48(2-3):177-82. Review.PMID: 17709887 [PubMed - indexed for MEDLINE]Related articles

Altered B:9-23 insulin, when administered intranasally with cholera toxin adjuvant, suppresses the expression of insulin autoantibodies and prevents diabetes.

Kobayashi M, Abiru N, Arakawa T, Fukushima K, Zhou H, Kawasaki E, Yamasaki H, Liu E, Miao D, Wong FS, Eisenbarth GS, Eguchi K.

J Immunol. 2007 Aug 15;179(4):2082-8.PMID: 17675466 [PubMed - indexed for MEDLINE]Related articlesFree article

Update in type 1 diabetes.

Eisenbarth GS.

J Clin Endocrinol Metab. 2007 Jul;92(7):2403-7. Review.PMID: 17616634 [PubMed - indexed for MEDLINE]Related articlesFree article

Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunity.

Nakayama M, Beilke JN, Jasinski JM, Kobayashi M, Miao D, Li M, Coulombe MG, Liu E, Elliott JF, Gill RG, Eisenbarth GS.

J Clin Invest. 2007 Jul;117(7):1835-43.PMID: 17607359 [PubMed - indexed for MEDLINE]Related articlesFree article

Primary prevention of type 1A diabetes: are we there yet?

Barker JM, Eisenbarth GS.

Pediatr Diabetes. 2007 Jun;8(3):115-6. No abstract available. PMID: 17550421 [PubMed - indexed for MEDLINE]Related articles

HLA-DPB1*0402 protects against type 1A diabetes autoimmunity in the highest risk DR3-DQB1*0201/DR4-DQB1*0302 DAISY population.

Baschal EE, Aly TA, Babu SR, Fernando MS, Yu L, Miao D, Barriga KJ, Norris JM, Noble JA, Erlich HA, Rewers MJ, Eisenbarth GS.

Diabetes. 2007 Sep;56(9):2405-9. Epub 2007 May 18.PMID: 17513705 [PubMed - indexed for MEDLINE]Related articlesFree article

Cellular and molecular pathogenesis of type 1A diabetes.

Jahromi MM, Eisenbarth GS.

Cell Mol Life Sci. 2007 Apr;64(7-8):865-72. Review.PMID: 17429581 [PubMed - indexed for MEDLINE]Related articles

Anti-dsDNA antibody assay: high specificity and sensitivity with a filtration radioassay in comparison to low specificity with the standard ELISA.

Yu L, Wang J, O'Dell JR, Oates J, Arend WP, Eisenbarth GS.

J Rheumatol. 2007 Apr;34(4):734-9.PMID: 17407230 [PubMed - indexed for MEDLINE]Related articles

Pre-type 1 diabetes dysmetabolism: maximal sensitivity achieved with both oral and intravenous glucose tolerance testing.

Barker JM, McFann K, Harrison LC, Fourlanos S, Krischer J, Cuthbertson D, Chase HP, Eisenbarth GS; DPT-1 Study Group.

J Pediatr. 2007 Jan;150(1):31-36.e6.PMID: 17188609 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic determinants of type 1 diabetes across populations.

Jahromi MM, Eisenbarth GS.

Ann N Y Acad Sci. 2006 Oct;1079:289-99. Review.PMID: 17130568 [PubMed - indexed for MEDLINE]Related articles

Pancreatic autoimmunity induction with insulin B:9-23 peptide and viral mimics in the NZB mouse.

Devendra D, Miao D, Nakayama M, Eisenbarth GS, Liu E.

Ann N Y Acad Sci. 2006 Oct;1079:135-7.PMID: 17130544 [PubMed - indexed for MEDLINE]Related articles

Long-term prevention of diabetes and marked suppression of insulin autoantibodies and insulitis in mice lacking native insulin B9-23 sequence.

Nakayama M, Babaya N, Miao D, Gianani R, Liu E, Elliott JF, Eisenbarth GS.

Ann N Y Acad Sci. 2006 Oct;1079:122-9.PMID: 17130542 [PubMed - indexed for MEDLINE]Related articles

Role of autoantibodies in type 1 diabetes.

Miao D, Yu L, Eisenbarth GS.

Front Biosci. 2007 Jan 1;12:1889-98. Review.PMID: 17127428 [PubMed - indexed for MEDLINE]Related articles

Prevalence of autoantibody-negative diabetes is not rare at all ages and increases with older age and obesity.

Wang J, Miao D, Babu S, Yu J, Barker J, Klingensmith G, Rewers M, Eisenbarth GS, Yu L.

J Clin Endocrinol Metab. 2007 Jan;92(1):88-92. Epub 2006 Oct 24.PMID: 17062766 [PubMed - indexed for MEDLINE]Related articlesFree article