PubMed

Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I.

Böni-Schnetzler M, Boller S, Debray S, Bouzakri K, Meier DT, Prazak R, Kerr-Conte J, Pattou F, Ehses JA, Schuit FC, Donath MY.

Endocrinology. 2009 Dec;150(12):5218-29. Epub 2009 Oct 9.PMID: 19819943 [PubMed - in process]Related articles

Islet endothelial activation and oxidative stress gene expression is reduced by IL-1Ra treatment in the type 2 diabetic GK rat.

Lacraz G, Giroix MH, Kassis N, Coulaud J, Galinier A, Noll C, Cornut M, Schmidlin F, Paul JL, Janel N, Irminger JC, Kergoat M, Portha B, Donath MY, Ehses JA, Homo-Delarche F.

PLoS One. 2009 Sep 9;4(9):e6963.PMID: 19742300 [PubMed - in process]Related articlesFree article

IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat.

Ehses JA, Lacraz G, Giroix MH, Schmidlin F, Coulaud J, Kassis N, Irminger JC, Kergoat M, Portha B, Homo-Delarche F, Donath MY.

Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13998-4003. Epub 2009 Jul 30.PMID: 19666548 [PubMed - indexed for MEDLINE]Related articles

Pancreatic islet inflammation in type 2 diabetes: from alpha and beta cell compensation to dysfunction.

Ehses JA, Ellingsgaard H, Böni-Schnetzler M, Donath MY.

Arch Physiol Biochem. 2009 Oct;115(4):240-7.PMID: 19645635 [PubMed - in process]Related articles

Low- and high-density lipoproteins modulate function, apoptosis, and proliferation of primary human and murine pancreatic beta-cells.

Rütti S, Ehses JA, Sibler RA, Prazak R, Rohrer L, Georgopoulos S, Meier DT, Niclauss N, Berney T, Donath MY, von Eckardstein A.

Endocrinology. 2009 Oct;150(10):4521-30. Epub 2009 Jul 23.PMID: 19628574 [PubMed - indexed for MEDLINE]Related articles

Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes.

Larsen CM, Faulenbach M, Vaag A, Ehses JA, Donath MY, Mandrup-Poulsen T.

Diabetes Care. 2009 Sep;32(9):1663-8. Epub 2009 Jun 19.PMID: 19542207 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulitis in type 2 diabetes.

Böni-Schnetzler M, Ehses JA, Faulenbach M, Donath MY.

Diabetes Obes Metab. 2008 Nov;10 Suppl 4:201-4.PMID: 18834448 [PubMed - indexed for MEDLINE]Related articles

Interleukin-6 regulates pancreatic alpha-cell mass expansion.

Ellingsgaard H, Ehses JA, Hammar EB, Van Lommel L, Quintens R, Martens G, Kerr-Conte J, Pattou F, Berney T, Pipeleers D, Halban PA, Schuit FC, Donath MY.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13163-8. Epub 2008 Aug 21.PMID: 18719127 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation.

Böni-Schnetzler M, Thorne J, Parnaud G, Marselli L, Ehses JA, Kerr-Conte J, Pattou F, Halban PA, Weir GC, Donath MY.

J Clin Endocrinol Metab. 2008 Oct;93(10):4065-74. Epub 2008 Jul 29.PMID: 18664535 [PubMed - indexed for MEDLINE]Related articlesFree article

Macrophages, cytokines and beta-cell death in Type 2 diabetes.

Ehses JA, Böni-Schnetzler M, Faulenbach M, Donath MY.

Biochem Soc Trans. 2008 Jun;36(Pt 3):340-2. Review.PMID: 18481953 [PubMed - indexed for MEDLINE]Related articles

Islet inflammation in type 2 diabetes: from metabolic stress to therapy.

Donath MY, Schumann DM, Faulenbach M, Ellingsgaard H, Perren A, Ehses JA.

Diabetes Care. 2008 Feb;31 Suppl 2:S161-4. Review.PMID: 18227479 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of CXCL1 by extracellular matrix and autocrine enhancement by interleukin-1 in rat pancreatic beta-cells.

Ribaux P, Ehses JA, Lin-Marq N, Carrozzino F, Böni-Schnetzler M, Hammar E, Irminger JC, Donath MY, Halban PA.

Endocrinology. 2007 Nov;148(11):5582-90. Epub 2007 Aug 16.PMID: 17702850 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased number of islet-associated macrophages in type 2 diabetes.

Ehses JA, Perren A, Eppler E, Ribaux P, Pospisilik JA, Maor-Cahn R, Gueripel X, Ellingsgaard H, Schneider MK, Biollaz G, Fontana A, Reinecke M, Homo-Delarche F, Donath MY.

Diabetes. 2007 Sep;56(9):2356-70. Epub 2007 Jun 19.PMID: 17579207 [PubMed - indexed for MEDLINE]Related articlesFree article

TNF-alpha -308G>A polymorphism modulates cytokine serum concentrations and macrovascular complications in diabetic patients on aspirin.

Krayenbuehl PA, Wiesli P, Schmid M, Schmid C, Ehses JA, Hersberger M, Vetter W, Schulthess G.

Exp Clin Endocrinol Diabetes. 2007 May;115(5):322-6.PMID: 17516296 [PubMed - indexed for MEDLINE]Related articles

Interleukin-1-receptor antagonist in type 2 diabetes mellitus.

Larsen CM, Faulenbach M, Vaag A, Vølund A, Ehses JA, Seifert B, Mandrup-Poulsen T, Donath MY.

N Engl J Med. 2007 Apr 12;356(15):1517-26.PMID: 17429083 [PubMed - indexed for MEDLINE]Related articlesFree article

Type 1, type 1.5, and type 2 diabetes: NOD the diabetes we thought it was.

Donath MY, Ehses JA.

Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12217-8. Epub 2006 Aug 7. No abstract available. PMID: 16894143 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms of beta-cell death in type 2 diabetes.

Donath MY, Ehses JA, Maedler K, Schumann DM, Ellingsgaard H, Eppler E, Reinecke M.

Diabetes. 2005 Dec;54 Suppl 2:S108-13. Review.PMID: 16306327 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets.

Maedler K, Sergeev P, Ehses JA, Mathe Z, Bosco D, Berney T, Dayer JM, Reinecke M, Halban PA, Donath MY.

Proc Natl Acad Sci U S A. 2004 May 25;101(21):8138-43. Epub 2004 May 12.PMID: 15141093 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-dependent insulinotropic polypeptide promotes beta-(INS-1) cell survival via cyclic adenosine monophosphate-mediated caspase-3 inhibition and regulation of p38 mitogen-activated protein kinase.

Ehses JA, Casilla VR, Doty T, Pospisilik JA, Winter KD, Demuth HU, Pederson RA, McIntosh CH.

Endocrinology. 2003 Oct;144(10):4433-45. Epub 2003 Jun 19.PMID: 12960055 [PubMed - indexed for MEDLINE]Related articlesFree article

Dipeptidyl peptidase IV inhibition in animal models of diabetes.

Pospisilik JA, Ehses JA, Doty T, McIntosh CH, Demuth HU, Pederson RA.

Adv Exp Med Biol. 2003;524:281-91. No abstract available. PMID: 12675250 [PubMed - indexed for MEDLINE]Related articles

Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats.

Pospisilik JA, Martin J, Doty T, Ehses JA, Pamir N, Lynn FC, Piteau S, Demuth HU, McIntosh CH, Pederson RA.

Diabetes. 2003 Mar;52(3):741-50.PMID: 12606516 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel pathway for regulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta cells.

Lynn FC, Thompson SA, Pospisilik JA, Ehses JA, Hinke SA, Pamir N, McIntosh CH, Pederson RA.

FASEB J. 2003 Jan;17(1):91-3. Epub 2002 Nov 15.PMID: 12475913 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-dependent insulinotropic polypeptide activates the Raf-Mek1/2-ERK1/2 module via a cyclic AMP/cAMP-dependent protein kinase/Rap1-mediated pathway.

Ehses JA, Pelech SL, Pederson RA, McIntosh CH.

J Biol Chem. 2002 Oct 4;277(40):37088-97. Epub 2002 Jul 22.PMID: 12138104 [PubMed - indexed for MEDLINE]Related articlesFree article

A new pathway for glucose-dependent insulinotropic polypeptide (GIP) receptor signaling: evidence for the involvement of phospholipase A2 in GIP-stimulated insulin secretion.

Ehses JA, Lee SS, Pederson RA, McIntosh CH.

J Biol Chem. 2001 Jun 29;276(26):23667-73. Epub 2001 Apr 25.PMID: 11323439 [PubMed - indexed for MEDLINE]Related articlesFree article