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Adipocytokines and the metabolic syndrome among older persons with and without obesity - the InCHIANTI Study.

Stenholm S, Koster A, Alley DE, Visser M, Maggio M, Harris TB, Egan JM, Bandinelli S, Guralnik JM, Ferrucci L.

Clin Endocrinol (Oxf). 2009 Oct 31. [Epub ahead of print]PMID: 19878507 [PubMed - as supplied by publisher]Related articles

Hormones in the naso-oropharynx: endocrine modulation of taste and smell.

Martin B, Maudsley S, White CM, Egan JM.

Trends Endocrinol Metab. 2009 May;20(4):163-70. Epub 2009 Apr 7. Review.PMID: 19359194 [PubMed - indexed for MEDLINE]Related articlesFree article

Exogenous glucose-dependent insulinotropic polypeptide worsens post prandial hyperglycemia in type 2 diabetes.

Chia CW, Carlson OD, Kim W, Shin YK, Charles CP, Kim HS, Melvin DL, Egan JM.

Diabetes. 2009 Jun;58(6):1342-9. Epub 2009 Mar 10.PMID: 19276444 [PubMed - indexed for MEDLINE]Related articlesFree article

GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism.

Li Y, Perry T, Kindy MS, Harvey BK, Tweedie D, Holloway HW, Powers K, Shen H, Egan JM, Sambamurti K, Brossi A, Lahiri DK, Mattson MP, Hoffer BJ, Wang Y, Greig NH.

Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1285-90. Epub 2009 Jan 21.PMID: 19164583 [PubMed - indexed for MEDLINE]Related articlesFree article

Bitter taste receptors influence glucose homeostasis.

Dotson CD, Zhang L, Xu H, Shin YK, Vigues S, Ott SH, Elson AE, Choi HJ, Shaw H, Egan JM, Mitchell BD, Li X, Steinle NI, Munger SD.

PLoS One. 2008;3(12):e3974. Epub 2008 Dec 18.PMID: 19092995 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of incretins in glucose homeostasis and diabetes treatment.

Kim W, Egan JM.

Pharmacol Rev. 2008 Dec;60(4):470-512. Epub 2008 Dec 12. Review.PMID: 19074620 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced energy intake: the secret to a long and healthy life?

Martin B, Golden E, Egan JM, Mattson MP, Maudsley S.

IBS J Sci. 2007 Sep;2(2):35-39.PMID: 18985162 [PubMed]Related articlesFree article

Exendin-4 improves glycemic control, ameliorates brain and pancreatic pathologies, and extends survival in a mouse model of Huntington's disease.

Martin B, Golden E, Carlson OD, Pistell P, Zhou J, Kim W, Frank BP, Thomas S, Chadwick WA, Greig NH, Bates GP, Sathasivam K, Bernier M, Maudsley S, Mattson MP, Egan JM.

Diabetes. 2009 Feb;58(2):318-28. Epub 2008 Nov 4.PMID: 18984744 [PubMed - indexed for MEDLINE]Related articlesFree article

Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats.

Stranahan AM, Norman ED, Lee K, Cutler RG, Telljohann RS, Egan JM, Mattson MP.

Hippocampus. 2008;18(11):1085-8.PMID: 18651634 [PubMed - indexed for MEDLINE]Related articlesFree article

Incretin-based therapies in type 2 diabetes mellitus.

Chia CW, Egan JM.

J Clin Endocrinol Metab. 2008 Oct;93(10):3703-16. Epub 2008 Jul 15. Review.PMID: 18628530 [PubMed - indexed for MEDLINE]Related articlesFree article

Conserved and differential effects of dietary energy intake on the hippocampal transcriptomes of females and males.

Martin B, Pearson M, Brenneman R, Golden E, Keselman A, Iyun T, Carlson OD, Egan JM, Becker KG, Wood W 3rd, Prabhu V, de Cabo R, Maudsley S, Mattson MP.

PLoS One. 2008 Jun 11;3(6):e2398.PMID: 18545695 [PubMed - indexed for MEDLINE]Related articlesFree article

GLP-1 (9-36) amide, cleavage product of GLP-1 (7-36) amide, is a glucoregulatory peptide.

Elahi D, Egan JM, Shannon RP, Meneilly GS, Khatri A, Habener JF, Andersen DK.

Obesity (Silver Spring). 2008 Jul;16(7):1501-9. Epub 2008 Apr 17.PMID: 18421270 [PubMed - indexed for MEDLINE]Related articles

Taste cells of the gut and gastrointestinal chemosensation.

Egan JM, Margolskee RF.

Mol Interv. 2008 Apr;8(2):78-81. No abstract available. PMID: 18403652 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulation of taste sensitivity by GLP-1 signaling.

Shin YK, Martin B, Golden E, Dotson CD, Maudsley S, Kim W, Jang HJ, Mattson MP, Drucker DJ, Egan JM, Munger SD.

J Neurochem. 2008 Jul;106(1):455-63. Epub 2008 Jul 1.PMID: 18397368 [PubMed - indexed for MEDLINE]Related articlesFree article

Caloric restriction: impact upon pituitary function and reproduction.

Martin B, Golden E, Carlson OD, Egan JM, Mattson MP, Maudsley S.

Ageing Res Rev. 2008 Jul;7(3):209-24. Epub 2008 Feb 7. Review.PMID: 18329344 [PubMed - indexed for MEDLINE]Related articlesFree article

Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction.

Pearson KJ, Lewis KN, Price NL, Chang JW, Perez E, Cascajo MV, Tamashiro KL, Poosala S, Csiszar A, Ungvari Z, Kensler TW, Yamamoto M, Egan JM, Longo DL, Ingram DK, Navas P, de Cabo R.

Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2325-30. Epub 2008 Feb 19.PMID: 18287083 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons.

Stranahan AM, Arumugam TV, Cutler RG, Lee K, Egan JM, Mattson MP.

Nat Neurosci. 2008 Mar;11(3):309-17. Epub 2008 Feb 17.PMID: 18278039 [PubMed - indexed for MEDLINE]Related articles

Glucose and insulin measurements from the oral glucose tolerance test and mortality prediction.

Metter EJ, Windham BG, Maggio M, Simonsick EM, Ling SM, Egan JM, Ferrucci L.

Diabetes Care. 2008 May;31(5):1026-30. Epub 2008 Feb 11.PMID: 18268070 [PubMed - indexed for MEDLINE]Related articlesFree article

Therapeutic perspectives for the treatment of Huntington's disease: treating the whole body.

Martin B, Golden E, Keselman A, Stone M, Mattson MP, Egan JM, Maudsley S.

Histol Histopathol. 2008 Feb;23(2):237-50. Review.PMID: 17999380 [PubMed - indexed for MEDLINE]Related articlesFree article

Contribution of nonesterified fatty acids to insulin resistance in the elderly with normal fasting but diabetic 2-hour postchallenge plasma glucose levels: the Baltimore Longitudinal Study of Aging.

Carlson OD, David JD, Schrieder JM, Muller DC, Jang HJ, Kim BJ, Egan JM.

Metabolism. 2007 Oct;56(10):1444-51.PMID: 17884459 [PubMed - indexed for MEDLINE]Related articlesFree article

Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.

Jang HJ, Kokrashvili Z, Theodorakis MJ, Carlson OD, Kim BJ, Zhou J, Kim HH, Xu X, Chan SL, Juhaszova M, Bernier M, Mosinger B, Margolskee RF, Egan JM.

Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15069-74. Epub 2007 Aug 27.PMID: 17724330 [PubMed - indexed for MEDLINE]Related articlesFree article

Ubiquitination is involved in glucose-mediated downregulation of GIP receptors in islets.

Zhou J, Livak MF, Bernier M, Muller DC, Carlson OD, Elahi D, Maudsley S, Egan JM.

Am J Physiol Endocrinol Metab. 2007 Aug;293(2):E538-47. Epub 2007 May 15.PMID: 17505054 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms of action of glucagon-like peptide 1 in the pancreas.

Doyle ME, Egan JM.

Pharmacol Ther. 2007 Mar;113(3):546-93. Epub 2006 Dec 28. Review.PMID: 17306374 [PubMed - indexed for MEDLINE]Related articlesFree article

Bank security dye packs: synthesis, isolation, and characterization of chlorinated products of bleached 1-(methylamino)anthraquinone.

Egan JM, Rickenbach M, Mooney KE, Palenik CS, Golombeck R, Mueller KT.

J Forensic Sci. 2006 Nov;51(6):1276-83.PMID: 17199613 [PubMed]Related articles

Association of hormonal dysregulation with metabolic syndrome in older women: data from the InCHIANTI study.

Maggio M, Lauretani F, Ceda GP, Bandinelli S, Basaria S, Paolisso G, Ble A, Egan JM, Metter EJ, Abbatecola AM, Zuliani G, Ruggiero C, Valenti G, Guralnik JM, Ferrucci L.

Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E353-8. Epub 2006 Sep 12.PMID: 16968811 [PubMed - indexed for MEDLINE]Related articlesFree article

Human duodenal enteroendocrine cells: source of both incretin peptides, GLP-1 and GIP.

Theodorakis MJ, Carlson O, Michopoulos S, Doyle ME, Juhaszova M, Petraki K, Egan JM.

Am J Physiol Endocrinol Metab. 2006 Mar;290(3):E550-9. Epub 2005 Oct 11.PMID: 16219666 [PubMed - indexed for MEDLINE]Related articlesFree article

Peptide YY is secreted after oral glucose administration in a gender-specific manner.

Kim BJ, Carlson OD, Jang HJ, Elahi D, Berry C, Egan JM.

J Clin Endocrinol Metab. 2005 Dec;90(12):6665-71. Epub 2005 Sep 20.PMID: 16174724 [PubMed - indexed for MEDLINE]Related articlesFree article

In vivo biological activity of exendin (1-30).

Doyle ME, McConville P, Theodorakis MJ, Goetschkes MM, Bernier M, Spencer RG, Holloway HW, Greig NH, Egan JM.

Endocrine. 2005 Jun;27(1):1-9.PMID: 16077164 [PubMed - indexed for MEDLINE]Related articles

Elevated plasma glucose-dependent insulinotropic polypeptide associates with hyperinsulinemia in impaired glucose tolerance.

Theodorakis MJ, Carlson O, Muller DC, Egan JM.

Diabetes Care. 2004 Jul;27(7):1692-8.PMID: 15220248 [PubMed - indexed for MEDLINE]Related articlesFree article

Exendin-4 pharmacodynamics: insights from the hyperglycemic clamp technique.

Mager DE, Abernethy DR, Egan JM, Elahi D.

J Pharmacol Exp Ther. 2004 Nov;311(2):830-5. Epub 2004 Jun 15.PMID: 15199095 [PubMed - indexed for MEDLINE]Related articlesFree article

Assessment of insulin sensitivity and secretion indices from oral glucose tolerance testing in subjects with fasting euglycemia but impaired 2-hour plasma glucose.

Theodorakis MJ, Muller DC, Carlson O, Egan JM.

Metabolism. 2003 Nov;52(11):1523-4; discussion 1524-5. No abstract available. PMID: 14635635 [PubMed - indexed for MEDLINE]Related articles

Glucagon-like peptide 1 modulates calcium responses to glutamate and membrane depolarization in hippocampal neurons.

Gilman CP, Perry T, Furukawa K, Grieg NH, Egan JM, Mattson MP.

J Neurochem. 2003 Dec;87(5):1137-44.PMID: 14622093 [PubMed - indexed for MEDLINE]Related articles

Effects of 3 months of continuous subcutaneous administration of glucagon-like peptide 1 in elderly patients with type 2 diabetes.

Meneilly GS, Greig N, Tildesley H, Habener JF, Egan JM, Elahi D.

Diabetes Care. 2003 Oct;26(10):2835-41.PMID: 14514588 [PubMed - indexed for MEDLINE]Related articlesFree article

Plasma adiponectin and leptin levels, body composition, and glucose utilization in adult women with wide ranges of age and obesity.

Ryan AS, Berman DM, Nicklas BJ, Sinha M, Gingerich RL, Meneilly GS, Egan JM, Elahi D.

Diabetes Care. 2003 Aug;26(8):2383-8.PMID: 12882866 [PubMed - indexed for MEDLINE]Related articlesFree article

The importance of the nine-amino acid C-terminal sequence of exendin-4 for binding to the GLP-1 receptor and for biological activity.

Doyle ME, Theodorakis MJ, Holloway HW, Bernier M, Greig NH, Egan JM.

Regul Pept. 2003 Jul 15;114(2-3):153-8.PMID: 12832104 [PubMed - indexed for MEDLINE]Related articles

Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron.

Perry T, Lahiri DK, Sambamurti K, Chen D, Mattson MP, Egan JM, Greig NH.

J Neurosci Res. 2003 Jun 1;72(5):603-12.PMID: 12749025 [PubMed - indexed for MEDLINE]Related articles

GLP-1 receptor agonists are growth and differentiation factors for pancreatic islet beta cells.

Egan JM, Bulotta A, Hui H, Perfetti R.

Diabetes Metab Res Rev. 2003 Mar-Apr;19(2):115-23. Review.PMID: 12673779 [PubMed - indexed for MEDLINE]Related articles

Pharmacological agents that directly modulate insulin secretion.

Doyle ME, Egan JM.

Pharmacol Rev. 2003 Mar;55(1):105-31. Review.PMID: 12615955 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of glucagon-like peptide 1 (7-36 amide) on insulin-mediated glucose uptake in patients with type 1 diabetes.

Meneilly GS, McIntosh CH, Pederson RA, Habener JF, Ehlers MR, Egan JM, Elahi D.

Diabetes Care. 2003 Mar;26(3):837-42.PMID: 12610046 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of 1-mo bolus subcutaneous administration of exendin-4 in type 2 diabetes.

Egan JM, Meneilly GS, Elahi D.

Am J Physiol Endocrinol Metab. 2003 Jun;284(6):E1072-9. Epub 2002 Dec 10.PMID: 12475750 [PubMed - indexed for MEDLINE]Related articlesFree article

Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4.

Perry T, Haughey NJ, Mattson MP, Egan JM, Greig NH.

J Pharmacol Exp Ther. 2002 Sep;302(3):881-8.PMID: 12183643 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon-like peptide-1 augments insulin-mediated glucose uptake in the obese state.

Egan JM, Meneilly GS, Habener JF, Elahi D.

J Clin Endocrinol Metab. 2002 Aug;87(8):3768-73.PMID: 12161508 [PubMed - indexed for MEDLINE]Related articlesFree article

Exendin-4 differentiation of a human pancreatic duct cell line into endocrine cells: involvement of PDX-1 and HNF3beta transcription factors.

Zhou J, Pineyro MA, Wang X, Doyle ME, Egan JM.

J Cell Physiol. 2002 Sep;192(3):304-14.PMID: 12124776 [PubMed - indexed for MEDLINE]Related articles

The insulinotropic effect of acute exendin-4 administered to humans: comparison of nondiabetic state to type 2 diabetes.

Egan JM, Clocquet AR, Elahi D.

J Clin Endocrinol Metab. 2002 Mar;87(3):1282-90.PMID: 11889200 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel neurotrophic property of glucagon-like peptide 1: a promoter of nerve growth factor-mediated differentiation in PC12 cells.

Perry T, Lahiri DK, Chen D, Zhou J, Shaw KT, Egan JM, Greig NH.

J Pharmacol Exp Ther. 2002 Mar;300(3):958-66.PMID: 11861804 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose tolerance, glucose utilization and insulin secretion in ageing.

Elahi D, Muller DC, Egan JM, Andres R, Veldhuist J, Meneilly GS.

Novartis Found Symp. 2002;242:222-42; discussion 242-6. Review.PMID: 11855690 [PubMed - indexed for MEDLINE]Related articles

Glucagon-like peptide-1 (7-37) augments insulin-mediated glucose uptake in elderly patients with diabetes.

Meneilly GS, McIntosh CH, Pederson RA, Habener JF, Gingerich R, Egan JM, Elahi D.

J Gerontol A Biol Sci Med Sci. 2001 Nov;56(11):M681-5.PMID: 11682575 [PubMed - indexed for MEDLINE]Related articles

Effect of glucagon-like peptide 1 on non-insulin-mediated glucose uptake in the elderly patient with diabetes.

Meneilly GS, McIntosh CH, Pederson RA, Habener JF, Gingerich R, Egan JM, Finegood DT, Elahi D.

Diabetes Care. 2001 Nov;24(11):1951-6.PMID: 11679463 [PubMed - indexed for MEDLINE]Related articlesFree article

Insertion of an N-terminal 6-aminohexanoic acid after the 7 amino acid position of glucagon-like peptide-1 produces a long-acting hypoglycemic agent.

Doyle ME, Greig NH, Holloway HW, Betkey JA, Bernier M, Egan JM.

Endocrinology. 2001 Oct;142(10):4462-8.PMID: 11564711 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon-like peptide-1 increases cAMP but fails to augment contraction in adult rat cardiac myocytes.

Vila Petroff MG, Egan JM, Wang X, Sollott SJ.

Circ Res. 2001 Aug 31;89(5):445-52.PMID: 11532906 [PubMed - indexed for MEDLINE]Related articlesFree article