PubMed

Activation of liver X receptors and retinoid X receptors induces growth arrest and apoptosis in insulin-secreting cells.

Wente W, Brenner MB, Zitzer H, Gromada J, Efanov AM.

Endocrinology. 2007 Apr;148(4):1843-9. Epub 2006 Dec 28.PMID: 17194744 [PubMed - indexed for MEDLINE]Related articlesFree article

Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways.

Wente W, Efanov AM, Brenner M, Kharitonenkov A, Köster A, Sandusky GE, Sewing S, Treinies I, Zitzer H, Gromada J.

Diabetes. 2006 Sep;55(9):2470-8.PMID: 16936195 [PubMed - indexed for MEDLINE]Related articlesFree article

Sterol regulatory element-binding protein 1 mediates liver X receptor-beta-induced increases in insulin secretion and insulin messenger ribonucleic acid levels.

Zitzer H, Wente W, Brenner MB, Sewing S, Buschard K, Gromada J, Efanov AM.

Endocrinology. 2006 Aug;147(8):3898-905. Epub 2006 Apr 27.PMID: 16644917 [PubMed - indexed for MEDLINE]Related articlesFree article

The PDZ/coiled-coil domain containing protein PIST modulates insulin secretion in MIN6 insulinoma cells by interacting with somatostatin receptor subtype 5.

Wente W, Efanov AM, Treinies I, Zitzer H, Gromada J, Richter D, Kreienkamp HJ.

FEBS Lett. 2005 Nov 21;579(28):6305-10. Epub 2005 Oct 21.PMID: 16263117 [PubMed - indexed for MEDLINE]Related articles

Neuronal calcium sensor-1 potentiates glucose-dependent exocytosis in pancreatic beta cells through activation of phosphatidylinositol 4-kinase beta.

Gromada J, Bark C, Smidt K, Efanov AM, Janson J, Mandic SA, Webb DL, Zhang W, Meister B, Jeromin A, Berggren PO.

Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10303-8. Epub 2005 Jul 12.PMID: 16014415 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel glucokinase activator modulates pancreatic islet and hepatocyte function.

Efanov AM, Barrett DG, Brenner MB, Briggs SL, Delaunois A, Durbin JD, Giese U, Guo H, Radloff M, Gil GS, Sewing S, Wang Y, Weichert A, Zaliani A, Gromada J.

Endocrinology. 2005 Sep;146(9):3696-701. Epub 2005 May 26.PMID: 15919746 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver X receptor activation stimulates insulin secretion via modulation of glucose and lipid metabolism in pancreatic beta-cells.

Efanov AM, Sewing S, Bokvist K, Gromada J.

Diabetes. 2004 Dec;53 Suppl 3:S75-8.PMID: 15561926 [PubMed - indexed for MEDLINE]Related articlesFree article

Removal of Ca2+ channel beta3 subunit enhances Ca2+ oscillation frequency and insulin exocytosis.

Berggren PO, Yang SN, Murakami M, Efanov AM, Uhles S, Köhler M, Moede T, Fernström A, Appelskog IB, Aspinwall CA, Zaitsev SV, Larsson O, de Vargas LM, Fecher-Trost C, Weissgerber P, Ludwig A, Leibiger B, Juntti-Berggren L, Barker CJ, Gromada J, Freichel M, Leibiger IB, Flockerzi V.

Cell. 2004 Oct 15;119(2):273-84.PMID: 15479643 [PubMed - indexed for MEDLINE]Related articles

Restoration of first-phase insulin secretion by the imidazoline compound LY374284 in pancreatic islets of diabetic db/db mice.

Brenner MB, Gromada J, Efanov AM, Bokvist K, Mest HJ.

Ann N Y Acad Sci. 2003 Dec;1009:332-40.PMID: 15028607 [PubMed - indexed for MEDLINE]Related articles

Secretory phospholipase A2 is released from pancreatic beta-cells and stimulates insulin secretion via inhibition of ATP-dependent K+ channels.

Juhl K, Efanov AM, Olsen HL, Gromada J.

Biochem Biophys Res Commun. 2003 Oct 17;310(2):274-9.PMID: 14521906 [PubMed - indexed for MEDLINE]Related articles

Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic beta cells.

Olsen HL, Hoy M, Zhang W, Bertorello AM, Bokvist K, Capito K, Efanov AM, Meister B, Thams P, Yang SN, Rorsman P, Berggren PO, Gromada J.

Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5187-92. Epub 2003 Apr 16.PMID: 12700357 [PubMed - indexed for MEDLINE]Related articlesFree article

cPLA2alpha-evoked formation of arachidonic acid and lysophospholipids is required for exocytosis in mouse pancreatic beta-cells.

Juhl K, Høy M, Olsen HL, Bokvist K, Efanov AM, Hoffmann EK, Gromada J.

Am J Physiol Endocrinol Metab. 2003 Jul;285(1):E73-81. Epub 2003 Mar 18.PMID: 12644445 [PubMed - indexed for MEDLINE]Related articlesFree article

Two generations of insulinotropic imidazoline compounds.

Efendic S, Efanov AM, Berggren PO, Zaitsev SV.

Diabetes. 2002 Dec;51 Suppl 3:S448-54. Review.PMID: 12475789 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose metabolites inhibit protein phosphatases and directly promote insulin exocytosis in pancreatic beta-cells.

Sjöholm A, Lehtihet M, Efanov AM, Zaitsev SV, Berggren PO, Honkanen RE.

Endocrinology. 2002 Dec;143(12):4592-8.PMID: 12446586 [PubMed - indexed for MEDLINE]Related articlesFree article

Increase in cellular glutamate levels stimulates exocytosis in pancreatic beta-cells.

Høy M, Maechler P, Efanov AM, Wollheim CB, Berggren PO, Gromada J.

FEBS Lett. 2002 Nov 6;531(2):199-203.PMID: 12417312 [PubMed - indexed for MEDLINE]Related articles

Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose.

Shiota C, Larsson O, Shelton KD, Shiota M, Efanov AM, Hoy M, Lindner J, Kooptiwut S, Juntti-Berggren L, Gromada J, Berggren PO, Magnuson MA.

J Biol Chem. 2002 Oct 4;277(40):37176-83. Epub 2002 Jul 30.PMID: 12149271 [PubMed - indexed for MEDLINE]Related articlesFree article

Inositol hexakisphosphate promotes dynamin I- mediated endocytosis.

Høy M, Efanov AM, Bertorello AM, Zaitsev SV, Olsen HL, Bokvist K, Leibiger B, Leibiger IB, Zwiller J, Berggren PO, Gromada J.

Proc Natl Acad Sci U S A. 2002 May 14;99(10):6773-7.PMID: 12011438 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulinotropic activity of the imidazoline derivative RX871024 in the diabetic GK rat.

Efanov AM, Appelskog IB, Abdel-Halim SM, Khan A, Bränström R, Larsson O, Ostenson CG, Mest HJ, Berggren PO, Efendic S, Zaitsev SV.

Am J Physiol Endocrinol Metab. 2002 Jan;282(1):E117-24.PMID: 11739091 [PubMed - indexed for MEDLINE]Related articlesFree article

The imidazoline RX871024 stimulates insulin secretion in pancreatic beta-cells from mice deficient in K(ATP) channel function.

Efanov AM, Høy M, Bränström R, Zaitsev SV, Magnuson MA, Efendic S, Gromada J, Berggren PO.

Biochem Biophys Res Commun. 2001 Jun 22;284(4):918-22.PMID: 11409880 [PubMed - indexed for MEDLINE]Related articles

The novel imidazoline compound BL11282 potentiates glucose-induced insulin secretion in pancreatic beta-cells in the absence of modulation of K(ATP) channel activity.

Efanov AM, Zaitsev SV, Mest HJ, Raap A, Appelskog IB, Larsson O, Berggren PO, Efendic S.

Diabetes. 2001 Apr;50(4):797-802.PMID: 11289044 [PubMed - indexed for MEDLINE]Related articlesFree article

Imidazoline RX871024 raises diacylglycerol levels in rat pancreatic islets.

Efanov AM, Zaitsev SV, Berggren PO, Mest HJ, Efendic S.

Biochem Biophys Res Commun. 2001 Mar;281(5):1070-3.PMID: 11243843 [PubMed - indexed for MEDLINE]Related articles

Different modes of action of the imidazoline compound RX871024 in pancreatic beta-cells. Blocking of K+ channels, mobilization of Ca2+ from endoplasmic reticulum, and interaction with exocytotic machinery.

Zaitsev SV, Efanov AM, Raap A, Efanova IB, Schloos J, Steckel-Hamann B, Larsson O, Ostenson CG, Berggren PO, Mest HJ, Efendic S.

Ann N Y Acad Sci. 1999 Jun 21;881:241-52.PMID: 10415922 [PubMed - indexed for MEDLINE]Related articles

An endogenous peptide isolated from the gut, NK-lysin, stimulates insulin secretion without changes in cytosolic free Ca2+ concentration.

Zaitsev SV, Andersson M, Efanov AM, Efanova IB, Ostenson CG, Juntti-Berggren L, Berggren PO, Mutt V, Efendić S.

FEBS Lett. 1998 Nov 20;439(3):267-70.PMID: 9845335 [PubMed - indexed for MEDLINE]Related articles

Effects of imidazoline derivative RX871024 on insulin, glucagon, and somatostatin secretion from isolated perfused rat pancreas.

Efanova IB, Zaitsev SV, Efanov AM, Ostenson C, Raap A, Mest H, Berggren P, Efendi.

Biochem Biophys Res Commun. 1998 Nov 9;252(1):162-5.PMID: 9813163 [PubMed - indexed for MEDLINE]Related articles

Signaling and sites of interaction for RX-871024 and sulfonylurea in the stimulation of insulin release.

Efanov AM, Zaitsev SV, Efanova IB, Zhu S, Ostenson CG, Berggren PO, Efendić S.

Am J Physiol. 1998 Apr;274(4 Pt 1):E751-7.PMID: 9575838 [PubMed - indexed for MEDLINE]Related articlesFree article

Inositol hexakisphosphate stimulates non-Ca2+-mediated and primes Ca2+-mediated exocytosis of insulin by activation of protein kinase C.

Efanov AM, Zaitsev SV, Berggren PO.

Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4435-9.PMID: 9114007 [PubMed - indexed for MEDLINE]Related articlesFree article

Imidazoline compounds stimulate insulin release by inhibition of K(ATP) channels and interaction with the exocytotic machinery.

Zaitsev SV, Efanov AM, Efanova IB, Larsson O, Ostenson CG, Gold G, Berggren PO, Efendić S.

Diabetes. 1996 Nov;45(11):1610-8.PMID: 8866568 [PubMed - indexed for MEDLINE]Related articles

Insulin exocytosis and glucose-mediated increase in cytoplasmic free Ca2+ concentration in the pancreatic beta-cell are independent of cyclic ADP-ribose.

Webb DL, Islam MS, Efanov AM, Brown G, Köhler M, Larsson O, Berggren PO.

J Biol Chem. 1996 Aug 9;271(32):19074-9.PMID: 8702579 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of the respiratory burst in mouse macrophages by ultra-low doses of an opioid peptide is consistent with a possible adaptation mechanism.

Efanov AM, Koshkin AA, Sazanov LA, Borodulina OI, Varfolomeev SD, Zaitsev SV.

FEBS Lett. 1994 Nov 28;355(2):114-6.PMID: 7982481 [PubMed - indexed for MEDLINE]Related articles