PubMed

Screening for iron overload: Lessons from the HEmochromatosis and IRon Overload Screening (HEIRS) Study.

Adams P, Barton JC, McLaren GD, Acton RT, Speechley M, McLaren CE, Reboussin DM, Leiendecker-Foster C, Harris EL, Snively BM, Vogt T, Sholinsky P, Thomson E, Dawkins FW, Gordeuk VR, Eckfeldt JH.

Can J Gastroenterol. 2009 Nov;23(11):769-72.PMID: 19893773 [PubMed - in process]Related articlesFree article

HAMP promoter mutation nc.-153C>T in 785 HEIRS Study participants.

Barton JC, Leiendecker-Foster C, Li H, DelRio-LaFreniere S, Acton RT, Eckfeldt JH; HEIRS Study.

Haematologica. 2009 Oct;94(10):1465; author reply 1465-6. No abstract available. PMID: 19794094 [PubMed - in process]Related articlesFree article

HFE, SLC40A1, HAMP, HJV, TFR2, and FTL mutations detected by denaturing high-performance liquid chromatography after iron phenotyping and HFE C282Y and H63D genotyping in 785 HEIRS Study participants.

Barton JC, Lafreniere SA, Leiendecker-Foster C, Li H, Acton RT, Press RD, Eckfeldt JH.

Am J Hematol. 2009 Nov;84(11):710-4.PMID: 19787796 [PubMed - in process]Related articles

Relationships of serum free thyroxine and erythrocyte measures in euthyroid HFE C282Y homozygotes and control subjects: the HEIRS Study.

Barton JC, Leiendecker-Foster C, Reboussin DM, Adams PC, Acton RT, Eckfeldt JH; FOR THE HEMOCHROMATOSIS AND IRON OVERLOAD SCREENING STUDY RESEARCH INVESTIGATORS.

Int J Lab Hematol. 2009 Aug 25. [Epub ahead of print]PMID: 19706067 [PubMed - as supplied by publisher]Related articles

The effect of nine common polymorphisms in coagulation factor genes (F2, F5, F7, F12 and F13 ) on the effectiveness of statins: the GenHAT study.

Maitland-van der Zee AH, Peters BJ, Lynch AI, Boerwinkle E, Arnett DK, Cheng S, Davis BR, Leiendecker-Foster C, Ford CE, Eckfeldt JH.

Pharmacogenet Genomics. 2009 May;19(5):338-44.PMID: 19415820 [PubMed - indexed for MEDLINE]Related articles

Antihypertensive pharmacogenetic effect of fibrinogen-beta variant -455G>A on cardiovascular disease, end-stage renal disease, and mortality: the GenHAT study.

Lynch AI, Boerwinkle E, Davis BR, Ford CE, Eckfeldt JH, Leiendecker-Foster C, Arnett DK.

Pharmacogenet Genomics. 2009 Jun;19(6):415-21.PMID: 19352213 [PubMed - indexed for MEDLINE]Related articles

The association of cell cycle checkpoint 2 variants and kidney function: findings of the Family Blood Pressure Program and the Atherosclerosis Risk In Communities study.

Franceschini N, North KE, Arnett D, Pankow JS, Chung JH, Baird L, Leppert MF, Eckfeldt JH, Boerwinkle E, Gu CC, Lewis CE, Myers RH, Turner ST, Weder A, Kao WH, Mosley TH, Chakravarti A, Kramer H, Zhang J, Hunt SC.

Am J Hypertens. 2009 May;22(5):552-8. Epub 2009 Mar 5.PMID: 19265784 [PubMed - indexed for MEDLINE]Related articles

Heme carrier protein 1 (HCP1) genetic variants in the Hemochromatosis and Iron Overload Screening (HEIRS) Study participants.

Wang X, Leiendecker-Foster C, Acton RT, Barton JC, McLaren CE, McLaren GD, Gordeuk VR, Eckfeldt JH.

Blood Cells Mol Dis. 2009 Mar-Apr;42(2):150-4. Epub 2009 Jan 26.PMID: 19176287 [PubMed - indexed for MEDLINE]Related articles

Polymorphisms in the nonmuscle myosin heavy chain 9 gene (MYH9) are associated with albuminuria in hypertensive African Americans: the HyperGEN study.

Freedman BI, Kopp JB, Winkler CA, Nelson GW, Rao DC, Eckfeldt JH, Leppert MF, Hicks PJ, Divers J, Langefeld CD, Hunt SC.

Am J Nephrol. 2009;29(6):626-32. Epub 2009 Jan 20.PMID: 19153477 [PubMed - indexed for MEDLINE]Related articlesFree article

Clinical manifestations of hemochromatosis in HFE C282Y homozygotes identified by screening.

McLaren GD, McLaren CE, Adams PC, Barton JC, Reboussin DM, Gordeuk VR, Acton RT, Harris EL, Speechley MR, Sholinsky P, Dawkins FW, Snively BM, Vogt TM, Eckfeldt JH; Hemochromatosis and Iron Overload Screen (HEIRS) Study Research Investigators.

Can J Gastroenterol. 2008 Nov;22(11):923-30.PMID: 19018338 [PubMed - indexed for MEDLINE]Related articlesFree article

Serial serum ferritin measurements in untreated HFE C282Y homozygotes in the Hemochromatosis and Iron Overload Screening Study.

Adams PC, Reboussin DM, Barton JC, Acton RT, Speechley M, Leiendecker-Foster C, Meenan R, Passmore L, McLaren CE, McLaren GD, Gordeuk V, Dawkins F, Eckfeldt JH.

Int J Lab Hematol. 2008 Aug;30(4):300-5.PMID: 18665827 [PubMed - indexed for MEDLINE]Related articles

Thyroid-stimulating hormone and free thyroxine levels in persons with HFE C282Y homozygosity, a common hemochromatosis genotype: the HEIRS study.

Barton JC, Leiendecker-Foster C, Reboussin DM, Adams PC, Acton RT, Eckfeldt JH; Hemochromatosis and Iron Overload Screening Study Research Investigators.

Thyroid. 2008 Aug;18(8):831-8.PMID: 18651828 [PubMed - indexed for MEDLINE]Related articles

Interactions between the single nucleotide polymorphisms in the homocysteine pathway (MTHFR 677C>T, MTHFR 1298 A>C, and CBSins) and the efficacy of HMG-CoA reductase inhibitors in preventing cardiovascular disease in high-risk patients of hypertension: the GenHAT study.

Maitland-van der Zee AH, Lynch A, Boerwinkle E, Arnett DK, Davis BR, Leiendecker-Foster C, Ford CE, Eckfeldt JH.

Pharmacogenet Genomics. 2008 Aug;18(8):651-6.PMID: 18622257 [PubMed - indexed for MEDLINE]Related articlesFree article

HFE C282Y homozygotes have reduced low-density lipoprotein cholesterol: the Atherosclerosis Risk in Communities (ARIC) Study.

Pankow JS, Boerwinkle E, Adams PC, Guallar E, Leiendecker-Foster C, Rogowski J, Eckfeldt JH.

Transl Res. 2008 Jul;152(1):3-10. Epub 2008 Jun 13.PMID: 18593631 [PubMed - indexed for MEDLINE]Related articlesFree article

Leukocyte telomeres are longer in African Americans than in whites: the National Heart, Lung, and Blood Institute Family Heart Study and the Bogalusa Heart Study.

Hunt SC, Chen W, Gardner JP, Kimura M, Srinivasan SR, Eckfeldt JH, Berenson GS, Aviv A.

Aging Cell. 2008 Aug;7(4):451-8. Epub 2008 May 2.PMID: 18462274 [PubMed - indexed for MEDLINE]Related articles

Serum ferritin concentrations and body iron stores in a multicenter, multiethnic primary-care population.

Gordeuk VR, Reboussin DM, McLaren CE, Barton JC, Acton RT, McLaren GD, Harris EL, Reiss JA, Adams PC, Speechley M, Phatak PD, Sholinsky P, Eckfeldt JH, Chen WP, Passmore L, Dawkins FW.

Am J Hematol. 2008 Aug;83(8):618-26.PMID: 18429050 [PubMed - indexed for MEDLINE]Related articles

NYD-SP18 is associated with obesity in the NHLBI Family Heart Study.

Wilk JB, Laramie JM, Latourelle JC, Williamson S, Nagle MW, Tobin JE, Foster CL, Eckfeldt JH, Province MA, Borecki IB, Myers RH.

Int J Obes (Lond). 2008 Jun;32(6):930-5. Epub 2008 Mar 4.PMID: 18317470 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacogenetic association of the NPPA T2238C genetic variant with cardiovascular disease outcomes in patients with hypertension.

Lynch AI, Boerwinkle E, Davis BR, Ford CE, Eckfeldt JH, Leiendecker-Foster C, Arnett DK.

JAMA. 2008 Jan 23;299(3):296-307. Erratum in: JAMA. 2009 Sep 9;302(10):1057-8. PMID: 18212314 [PubMed - indexed for MEDLINE]Related articlesFree article

Health-related quality of life in a racially diverse population screened for hemochromatosis: results from the Hemochromatosis and Iron Overload Screening (HEIRS) study.

Wenzel LB, Anderson R, Tucker DC, Palla S, Thomson E, Speechley M, Harrison H, Lewis-Jack O, Fadojutimi-Akinsiku M, Eckfeldt JH, Reiss JA, Rivers CA, Bookman E, Snively BM, McLaren CE; Hemochromatosis and Iron Overload Study Research Investigators.

Genet Med. 2007 Oct;9(10):705-12.PMID: 18073584 [PubMed - indexed for MEDLINE]Related articles

Circulating soluble ICAM-1 levels shows linkage to ICAM gene cluster region on chromosome 19: the NHLBI Family Heart Study follow-up examination.

Bielinski SJ, Pankow JS, Foster CL, Miller MB, Hopkins PN, Eckfeldt JH, Hixson J, Liu Y, Register T, Myers RH, Arnett DK.

Atherosclerosis. 2008 Jul;199(1):172-8. Epub 2007 Nov 28.PMID: 18045607 [PubMed - indexed for MEDLINE]Related articlesFree article

Biological variability of transferrin saturation and unsaturated iron-binding capacity.

Adams PC, Reboussin DM, Press RD, Barton JC, Acton RT, Moses GC, Leiendecker-Foster C, McLaren GD, Dawkins FW, Gordeuk VR, Lovato L, Eckfeldt JH.

Am J Med. 2007 Nov;120(11):999.e1-7.PMID: 17976429 [PubMed - indexed for MEDLINE]Related articlesFree article

HFE C282Y homozygotes aged 25-29 years at HEIRS Study initial screening.

Barton JC, Acton RT, Leiendecker-Foster C, Lovato L, Adams PC, McLaren GD, Eckfeldt JH, McLaren CE, Reboussin DM, Gordeuk VR, Speechley MR, Reiss JA, Press RD, Dawkins FW; Hemochromatosis and Iron Overload Screening (HEIRS) Study Research Investigators.

Genet Test. 2007 Fall;11(3):269-75.PMID: 17949288 [PubMed - indexed for MEDLINE]Related articles

Circulating MCP-1 levels shows linkage to chemokine receptor gene cluster on chromosome 3: the NHLBI family heart study follow-up examination.

Bielinski SJ, Pankow JS, Miller MB, Hopkins PN, Eckfeldt JH, Hixson J, Liu Y, Register T, Myers RH, Arnett DK.

Genes Immun. 2007 Dec;8(8):684-90. Epub 2007 Oct 4.PMID: 17917677 [PubMed - indexed for MEDLINE]Related articles

An investigation of the effects of lipid-lowering medications: genome-wide linkage analysis of lipids in the HyperGEN study.

Wu J, Province MA, Coon H, Hunt SC, Eckfeldt JH, Arnett DK, Heiss G, Lewis CE, Ellison RC, Rao DC, Rice T, Kraja AT.

BMC Genet. 2007 Sep 10;8:60.PMID: 17845730 [PubMed - indexed for MEDLINE]Related articlesFree article

Characteristics of participants with self-reported hemochromatosis or iron overload at HEIRS study initial screening.

Barton JC, Acton RT, Leiendecker-Foster C, Lovato L, Adams PC, Eckfeldt JH, McLaren CE, Reiss JA, McLaren GD, Reboussin DM, Gordeuk VR, Speechley MR, Press RD, Dawkins FW; Hemochromatosis and Iron Overload Screening (HEIRS) Study Research Investigators.

Am J Hematol. 2008 Feb;83(2):126-32.PMID: 17726683 [PubMed - indexed for MEDLINE]Related articles

Sex-specific effects of AGT-6 and ACE I/D on pulse pressure after 6 months on antihypertensive treatment: the GenHAT study.

Lynch AI, Arnett DK, Davis BR, Boerwinkle E, Ford CE, Eckfeldt JH, Leiendecker-Foster C.

Ann Hum Genet. 2007 Nov;71(Pt 6):735-45. Epub 2007 Jun 30.PMID: 17608790 [PubMed - indexed for MEDLINE]Related articles

A genome-wide linkage scan for iron phenotype quantitative trait loci: the HEIRS Family Study.

Acton RT, Snively BM, Barton JC, McLaren CE, Adams PC, Rich SS, Eckfeldt JH, Press RD, Sholinsky P, Leiendecker-Foster C, McLaren GD, Speechley MR, Harris EL, Dawkins FW, Gordeuk VR; Hemochromatosis and Iron Overload Screening Study Research Investigators.

Clin Genet. 2007 Jun;71(6):518-29.PMID: 17539901 [PubMed - indexed for MEDLINE]Related articles

Sex-specific effects of ACE I/D and AGT-M235T on pulse pressure: the HyperGEN Study.

Lynch AI, Arnett DK, Pankow JS, Miller MB, North KE, Eckfeldt JH, Hunt SC, Rao DC, Djoussé L.

Hum Genet. 2007 Aug;122(1):33-40. Epub 2007 May 10.PMID: 17492314 [PubMed - indexed for MEDLINE]Related articles

Serum ferritin and transferrin saturation in Asians and Pacific Islanders.

Harris EL, McLaren CE, Reboussin DM, Gordeuk VR, Barton JC, Acton RT, McLaren GD, Vogt TM, Snively BM, Leiendecker-Foster C, Holup JL, Passmore LV, Eckfeldt JH, Lin E, Adams PC.

Arch Intern Med. 2007 Apr 9;167(7):722-6.PMID: 17420432 [PubMed - indexed for MEDLINE]Related articlesFree article

Hemochromatosis (HFE) gene splice site mutation IVS5+1 G/A in North American Vietnamese with and without phenotypic evidence of iron overload.

Steiner M, Leiendecker-Foster C, McLaren GD, Snively BM, McLaren CE, Adams PC, Eckfeldt JH.

Transl Res. 2007 Feb;149(2):92-5.PMID: 17240320 [PubMed - indexed for MEDLINE]Related articles

Calculating eGFR using the MDRD equation.

Miller G, Myers GL, Eckfeldt JH, Greenberg N.

QJM. 2007 Feb;100(2):142-3. Epub 2007 Jan 10. No abstract available. PMID: 17215256 [PubMed - indexed for MEDLINE]Related articlesFree article

Genome scan of glomerular filtration rate and albuminuria: the HyperGEN study.

Leon JM, Freedman BI, Miller MB, North KE, Hunt SC, Eckfeldt JH, Lewis CE, Kraja AT, Djoussé L, Arnett DK.

Nephrol Dial Transplant. 2007 Mar;22(3):763-71. Epub 2006 Dec 21.PMID: 17189282 [PubMed - indexed for MEDLINE]Related articlesFree article

Absence of an interaction between the angiotensin-converting enzyme insertion-deletion polymorphism and pravastatin on cardiovascular disease in high-risk hypertensive patients: the Genetics of Hypertension-Associated Treatment (GenHAT) study.

Maitland-van der Zee AH, Boerwinkle E, Arnett DK, Davis BR, Leiendecker-Foster C, Miller MB, Klungel OH, Ford CE, Eckfeldt JH.

Am Heart J. 2007 Jan;153(1):54-8.PMID: 17174637 [PubMed - indexed for MEDLINE]Related articlesFree article

Mixture models of serum iron measures in population screening for hemochromatosis and iron overload.

McLaren CE, Li KT, McLaren GD, Gordeuk VR, Snively BM, Reboussin DM, Barton JC, Acton RT, Dawkins FW, Harris EL, Eckfeldt JH, Moses GC, Adams PC.

Transl Res. 2006 Oct;148(4):196-206.PMID: 17002922 [PubMed - indexed for MEDLINE]Related articles

Alcohol consumption and plasma atrial natriuretic peptide (from the HyperGEN study).

Djoussé L, Hunt SC, Eckfeldt JH, Arnett DK, Province MA, Ellison RC.

Am J Cardiol. 2006 Sep 1;98(5):628-32. Epub 2006 Jul 5.PMID: 16923450 [PubMed - indexed for MEDLINE]Related articles

Liver diseases in the hemochromatosis and iron overload screening study.

Adams PC, Passmore L, Chakrabarti S, Reboussin DM, Acton RT, Barton JC, McLaren GD, Eckfeldt JH, Dawkins FW, Gordeuk VR, Harris EL, Leiendecker-Foster C, Gossman E, Sholinsky P; Hemochromatosis and Iron Overload Screening Study Research Investigators.

Clin Gastroenterol Hepatol. 2006 Jul;4(7):918-23; quiz 807.PMID: 16797244 [PubMed - indexed for MEDLINE]Related articles

Association study of CRP gene polymorphisms with serum CRP level and cardiovascular risk in the NHLBI Family Heart Study.

Wang Q, Hunt SC, Xu Q, Chen YE, Province MA, Eckfeldt JH, Pankow JS, Song Q.

Am J Physiol Heart Circ Physiol. 2006 Dec;291(6):H2752-7. Epub 2006 May 26.PMID: 16731635 [PubMed - indexed for MEDLINE]Related articlesFree article

Antihypertensive therapy, the alpha-adducin polymorphism, and cardiovascular disease in high-risk hypertensive persons: the Genetics of Hypertension-Associated Treatment Study.

Davis BR, Arnett DK, Boerwinkle E, Ford CE, Leiendecker-Foster C, Miller MB, Black H, Eckfeldt JH.

Pharmacogenomics J. 2007 Apr;7(2):112-22. Epub 2006 May 16.PMID: 16702981 [PubMed - indexed for MEDLINE]Related articles

Reporting genetic results in research studies: summary and recommendations of an NHLBI working group.

Bookman EB, Langehorne AA, Eckfeldt JH, Glass KC, Jarvik GP, Klag M, Koski G, Motulsky A, Wilfond B, Manolio TA, Fabsitz RR, Luepker RV; NHLBI Working Group.

Am J Med Genet A. 2006 May 15;140(10):1033-40.PMID: 16575896 [PubMed - indexed for MEDLINE]Related articlesFree article

Dietary linolenic acid and fasting glucose and insulin: the National Heart, Lung, and Blood Institute Family Heart Study.

Djoussé L, Hunt SC, Tang W, Eckfeldt JH, Province MA, Ellison RC.

Obesity (Silver Spring). 2006 Feb;14(2):295-300.PMID: 16571856 [PubMed - indexed for MEDLINE]Related articles

Familial clustering for features of the metabolic syndrome: the National Heart, Lung, and Blood Institute (NHLBI) Family Heart Study.

Tang W, Hong Y, Province MA, Rich SS, Hopkins PN, Arnett DK, Pankow JS, Miller MB, Eckfeldt JH.

Diabetes Care. 2006 Mar;29(3):631-6.PMID: 16505518 [PubMed - indexed for MEDLINE]Related articlesFree article

Cardiovascular outcomes in high-risk hypertensive patients stratified by baseline glomerular filtration rate.

Rahman M, Pressel S, Davis BR, Nwachuku C, Wright JT Jr, Whelton PK, Barzilay J, Batuman V, Eckfeldt JH, Farber MA, Franklin S, Henriquez M, Kopyt N, Louis GT, Saklayen M, Stanford C, Walworth C, Ward H, Wiegmann T; ALLHAT Collaborative Research Group.

Ann Intern Med. 2006 Feb 7;144(3):172-80.PMID: 16461961 [PubMed - indexed for MEDLINE]Related articlesFree article

Recommendations for improving serum creatinine measurement: a report from the Laboratory Working Group of the National Kidney Disease Education Program.

Myers GL, Miller WG, Coresh J, Fleming J, Greenberg N, Greene T, Hostetter T, Levey AS, Panteghini M, Welch M, Eckfeldt JH; National Kidney Disease Education Program Laboratory Working Group.

Clin Chem. 2006 Jan;52(1):5-18. Epub 2005 Dec 6. Review.PMID: 16332993 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacogenetic association of the angiotensin-converting enzyme insertion/deletion polymorphism on blood pressure and cardiovascular risk in relation to antihypertensive treatment: the Genetics of Hypertension-Associated Treatment (GenHAT) study.

Arnett DK, Davis BR, Ford CE, Boerwinkle E, Leiendecker-Foster C, Miller MB, Black H, Eckfeldt JH.

Circulation. 2005 Jun 28;111(25):3374-83. Epub 2005 Jun 20.PMID: 15967849 [PubMed - indexed for MEDLINE]Related articlesFree article

Dietary linolenic acid is inversely associated with calcified atherosclerotic plaque in the coronary arteries: the National Heart, Lung, and Blood Institute Family Heart Study.

Djoussé L, Arnett DK, Carr JJ, Eckfeldt JH, Hopkins PN, Province MA, Ellison RC; Investigators of the NHLBI FHS.

Circulation. 2005 Jun 7;111(22):2921-6. Epub 2005 May 31.PMID: 15927976 [PubMed - indexed for MEDLINE]Related articlesFree article

Interarm differences in seated systolic and diastolic blood pressure: the Hypertension Genetic Epidemiology Network study.

Arnett DK, Tang W, Province MA, Oberman A, Ellison RC, Morgan D, Eckfeldt JH, Hunt SC.

J Hypertens. 2005 Jun;23(6):1141-7.PMID: 15894889 [PubMed - indexed for MEDLINE]Related articles

Dietary linolenic acid and adjusted QT and JT intervals in the National Heart, Lung, and Blood Institute Family Heart study.

Djoussé L, Rautaharju PM, Hopkins PN, Whitsel EA, Arnett DK, Eckfeldt JH, Province MA, Ellison RC; Investigators of the NHLBI Family Heart Study.

J Am Coll Cardiol. 2005 May 17;45(10):1716-22.PMID: 15893192 [PubMed - indexed for MEDLINE]Related articles

Relation of the metabolic syndrome to calcified atherosclerotic plaque in the coronary arteries and aorta.

Ellison RC, Zhang Y, Wagenknecht LE, Eckfeldt JH, Hopkins PN, Pankow JS, Djoussé L, Carr JJ.

Am J Cardiol. 2005 May 15;95(10):1180-6.PMID: 15877990 [PubMed - indexed for MEDLINE]Related articles

Hemochromatosis and iron-overload screening in a racially diverse population.

Adams PC, Reboussin DM, Barton JC, McLaren CE, Eckfeldt JH, McLaren GD, Dawkins FW, Acton RT, Harris EL, Gordeuk VR, Leiendecker-Foster C, Speechley M, Snively BM, Holup JL, Thomson E, Sholinsky P; Hemochromatosis and Iron Overload Screening (HEIRS) Study Research Investigators.

N Engl J Med. 2005 Apr 28;352(17):1769-78.PMID: 15858186 [PubMed - indexed for MEDLINE]Related articlesFree article

Renal outcomes in high-risk hypertensive patients treated with an angiotensin-converting enzyme inhibitor or a calcium channel blocker vs a diuretic: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).

Rahman M, Pressel S, Davis BR, Nwachuku C, Wright JT Jr, Whelton PK, Barzilay J, Batuman V, Eckfeldt JH, Farber M, Henriquez M, Kopyt N, Louis GT, Saklayen M, Stanford C, Walworth C, Ward H, Wiegmann T.

Arch Intern Med. 2005 Apr 25;165(8):936-46.PMID: 15851647 [PubMed - indexed for MEDLINE]Related articlesFree article