PubMed

Genetic polymorphisms and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets.

Sørensen TI, Boutin P, Taylor MA, Larsen LH, Verdich C, Petersen L, Holst C, Echwald SM, Dina C, Toubro S, Petersen M, Polak J, Clément K, Martínez JA, Langin D, Oppert JM, Stich V, Macdonald I, Arner P, Saris WH, Pedersen O, Astrup A, Froguel P; NUGENOB Consortium.

PLoS Clin Trials. 2006 Jun;1(2):e12. Epub 2006 Jun 30.PMID: 16871334 [PubMed]Related articlesFree article

[Molecular pathogenesis in monogenic and polygenic obesity]

Larsen PJ, Echwald SM, Sørensen TI, Pedersen OB.

Ugeskr Laeger. 2006 Jan 9;168(2):152-5. Danish. PMID: 16403339 [PubMed - indexed for MEDLINE]Related articles

[The genetics of obesity]

Echwald SM, Larsen PJ, Pedersen OB, Sørensen TI.

Ugeskr Laeger. 2006 Jan 9;168(2):150-2. Danish. PMID: 16403338 [PubMed - indexed for MEDLINE]Related articles

Mutation analysis of the preproghrelin gene: no association with obesity and type 2 diabetes.

Larsen LH, Gjesing AP, Sørensen TI, Hamid YH, Echwald SM, Toubro S, Black E, Astrup A, Hansen T, Pedersen O.

Clin Biochem. 2005 May;38(5):420-4.PMID: 15820771 [PubMed - indexed for MEDLINE]Related articles

Prevalence of mutations and functional analyses of melanocortin 4 receptor variants identified among 750 men with juvenile-onset obesity.

Larsen LH, Echwald SM, Sørensen TI, Andersen T, Wulff BS, Pedersen O.

J Clin Endocrinol Metab. 2005 Jan;90(1):219-24. Epub 2004 Oct 14.PMID: 15486053 [PubMed - indexed for MEDLINE]Related articlesFree article

Variation of the McKusick-Kaufman gene and studies of relationships with common forms of obesity.

Andersen KL, Echwald SM, Larsen LH, Hamid YH, Glümer C, Jørgensen T, Borch-Johnsen K, Andersen T, Sørensen TI, Hansen T, Pedersen O.

J Clin Endocrinol Metab. 2005 Jan;90(1):225-30. Epub 2004 Oct 13.PMID: 15483080 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutation analysis of NR0B2 among 1545 Danish men identifies a novel c.278G>A (p.G93D) variant with reduced functional activity.

Echwald SM, Andersen KL, Sørensen TI, Larsen LH, Andersen T, Tonooka N, Tomura H, Takeda J, Pedersen O.

Hum Mutat. 2004 Nov;24(5):381-7.PMID: 15459958 [PubMed - indexed for MEDLINE]Related articles

A common polymorphism in the promoter of the IGF-I gene associates with increased fasting serum triglyceride levels in glucose-tolerant subjects.

Nielsen EM, Hansen L, Lajer M, Andersen KL, Echwald SM, Urhammer SA, Hansen T, Pedersen O.

Clin Biochem. 2004 Aug;37(8):660-5.PMID: 15302607 [PubMed - indexed for MEDLINE]Related articles

A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage.

Andersen JN, Jansen PG, Echwald SM, Mortensen OH, Fukada T, Del Vecchio R, Tonks NK, Møller NP.

FASEB J. 2004 Jan;18(1):8-30. Review.PMID: 14718383 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence for an association between the Leu162Val polymorphism of the PPARalpha gene and decreased fasting serum triglyceride levels in glucose tolerant subjects.

Nielsen EM, Hansen L, Echwald SM, Drivsholm T, Borch-Johnsen K, Ekstrøm CT, Hansen T, Pedersen O.

Pharmacogenetics. 2003 Jul;13(7):417-23.PMID: 12835617 [PubMed - indexed for MEDLINE]Related articles

The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes.

Nielsen EM, Hansen L, Carstensen B, Echwald SM, Drivsholm T, Glümer C, Thorsteinsson B, Borch-Johnsen K, Hansen T, Pedersen O.

Diabetes. 2003 Feb;52(2):573-7.PMID: 12540638 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact of two common polymorphisms in the PPARgamma gene on glucose tolerance and plasma insulin profiles in monozygotic and dizygotic twins: thrifty genotype, thrifty phenotype, or both?

Poulsen P, Andersen G, Fenger M, Hansen T, Echwald SM, Vølund A, Beck-Nielsen H, Pedersen O, Vaag A.

Diabetes. 2003 Jan;52(1):194-8.PMID: 12502512 [PubMed - indexed for MEDLINE]Related articlesFree article

Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians.

Rasmussen SK, Urhammer SA, Berglund L, Jensen JN, Hansen L, Echwald SM, Borch-Johnsen K, Horikawa Y, Mashima H, Lithell H, Cox NJ, Hansen T, Bell GI, Pedersen O.

Diabetes. 2002 Dec;51(12):3561-7.PMID: 12453914 [PubMed - indexed for MEDLINE]Related articlesFree article

Association studies between microsatellite markers within the gene encoding human 11beta-hydroxysteroid dehydrogenase type 1 and body mass index, waist to hip ratio, and glucocorticoid metabolism.

Draper N, Echwald SM, Lavery GG, Walker EA, Fraser R, Davies E, Sørensen TI, Astrup A, Adamski J, Hewison M, Connell JM, Pedersen O, Stewart PM.

J Clin Endocrinol Metab. 2002 Nov;87(11):4984-90.PMID: 12414862 [PubMed - indexed for MEDLINE]Related articlesFree article

[Chasing the genetic determinants of the presumed polygenic forms of type 2 diabetes. Status and perspectives]

Pedersen OB, Hansen T, Hansen L, Echwald SM, Urhammer SA.

Ugeskr Laeger. 2002 Apr 15;164(16):2163-6. Danish. No abstract available. PMID: 11989062 [PubMed - indexed for MEDLINE]Related articles

A P387L variant in protein tyrosine phosphatase-1B (PTP-1B) is associated with type 2 diabetes and impaired serine phosphorylation of PTP-1B in vitro.

Echwald SM, Bach H, Vestergaard H, Richelsen B, Kristensen K, Drivsholm T, Borch-Johnsen K, Hansen T, Pedersen O.

Diabetes. 2002 Jan;51(1):1-6.PMID: 11756316 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic variability of the SUR1 promoter in relation to beta-cell function and Type II diabetes mellitus.

Hansen T, Ambye L, Grarup N, Hansen L, Echwald SM, Ferrer J, Pedersen O.

Diabetologia. 2001 Oct;44(10):1330-4.PMID: 11692183 [PubMed - indexed for MEDLINE]Related articles

The Asn363Ser variant of the glucocorticoid receptor gene is not associated with obesity or weight gain in Danish men.

Echwald SM, Sørensen TI, Andersen T, Pedersen O.

Int J Obes Relat Metab Disord. 2001 Oct;25(10):1563-5.PMID: 11673782 [PubMed - indexed for MEDLINE]Related articlesFree article

Obesity genes.

Sørensen TI, Echwald SM.

BMJ. 2001 Mar 17;322(7287):630-1. No abstract available. PMID: 11250836 [PubMed - indexed for MEDLINE]Related articlesFree article

The K121Q variant of the human PC-1 gene is not associated with insulin resistance or type 2 diabetes among Danish Caucasians.

Rasmussen SK, Urhammer SA, Pizzuti A, Echwald SM, Ekstrøm CT, Hansen L, Hansen T, Borch-Johnsen K, Frittitta L, Trischitta V, Pedersen O.

Diabetes. 2000 Sep;49(9):1608-11.PMID: 10969849 [PubMed - indexed for MEDLINE]Related articlesFree article

Studies of the variability of the genes encoding the insulin-like growth factor I receptor and its ligand in relation to type 2 diabetes mellitus.

Rasmussen SK, Lautier C, Hansen L, Echwald SM, Hansen T, Ekstrøm CT, Urhammer SA, Borch-Johnsen K, Grigorescu F, Smith RJ, Pedersen O.

J Clin Endocrinol Metab. 2000 Apr;85(4):1606-10.PMID: 10770205 [PubMed - indexed for MEDLINE]Related articlesFree article

Sequence variants in the human cocaine and amphetamine-regulated transcript (CART) gene in subjects with early onset obesity.

Echwald SM, Sørensen TI, Andersen T, Hansen C, Tommerup N, Pedersen O.

Obes Res. 1999 Nov;7(6):532-6.PMID: 10574510 [PubMed - indexed for MEDLINE]Related articles

Genetics of human obesity: lessons from mouse models and candidate genes.

Echwald SM.

J Intern Med. 1999 Jun;245(6):653-66. Review.PMID: 10395195 [PubMed - indexed for MEDLINE]Related articles

Mutational analysis of the coding regions of the genes encoding protein kinase B-alpha and -beta, phosphoinositide-dependent protein kinase-1, phosphatase targeting to glycogen, protein phosphatase inhibitor-1, and glycogenin: lessons from a search for genetic variability of the insulin-stimulated glycogen synthesis pathway of skeletal muscle in NIDDM patients.

Hansen L, Fjordvang H, Rasmussen SK, Vestergaard H, Echwald SM, Hansen T, Alessi D, Shenolikar S, Saltiel AR, Barbetti F, Pedersen O.

Diabetes. 1999 Feb;48(2):403-7.PMID: 10334321 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutational analysis of the proopiomelanocortin gene in Caucasians with early onset obesity.

Echwald SM, Sørensen TI, Andersen T, Tybjaerg-Hansen A, Clausen JO, Pedersen O.

Int J Obes Relat Metab Disord. 1999 Mar;23(3):293-8.PMID: 10193875 [PubMed - indexed for MEDLINE]Related articles

Analysis of the relationship between fasting serum leptin levels and estimates of beta-cell function and insulin sensitivity in a population sample of 380 healthy young Caucasians.

Echwald SM, Clausen JO, Hansen T, Urhammer SA, Hansen L, Dinesen B, Borch-Johnsen K.

Eur J Endocrinol. 1999 Feb;140(2):180-5.PMID: 10069665 [PubMed - indexed for MEDLINE]Related articlesFree article

Discovery of amino acid variants in the human glucose-dependent insulinotropic polypeptide (GIP) receptor: the impact on the pancreatic beta cell responses and functional expression studies in Chinese hamster fibroblast cells.

Almind K, Ambye L, Urhammer SA, Hansen T, Echwald SM, Holst JJ, Gromada J, Thorens B, Pedersen O.

Diabetologia. 1998 Oct;41(10):1194-8.PMID: 9794107 [PubMed - indexed for MEDLINE]Related articles

Gln27Glu variant of the human beta2-adrenoreceptor gene is not associated with early-onset obesity in Danish men.

Echwald SM, Sørensen TI, Tybjaerg-Hansen A, Andersen T, Pedersen O.

Diabetes. 1998 Oct;47(10):1657-8. No abstract available. PMID: 9753308 [PubMed - indexed for MEDLINE]Related articlesFree article

Decreased tolbutamide-stimulated insulin secretion in healthy subjects with sequence variants in the high-affinity sulfonylurea receptor gene.

Hansen T, Echwald SM, Hansen L, Møller AM, Almind K, Clausen JO, Urhammer SA, Inoue H, Ferrer J, Bryan J, Aguilar-Bryan L, Permutt MA, Pedersen O.

Diabetes. 1998 Apr;47(4):598-605.PMID: 9568693 [PubMed - indexed for MEDLINE]Related articlesFree article

Organisation of the coding exons and mutational screening of the uncoupling protein 3 gene in subjects with juvenile-onset obesity.

Urhammer SA, Dalgaard LT, Sørensen TI, Tybjaerg-Hansen A, Echwald SM, Andersen T, Clausen JO, Pedersen O.

Diabetologia. 1998 Feb;41(2):241-4.PMID: 9498661 [PubMed - indexed for MEDLINE]Related articles

Studies of genetic variability of the uncoupling protein 1 gene in Caucasian subjects with juvenile-onset obesity.

Urhammer SA, Fridberg M, Sørensen TI, Echwald SM, Andersen T, Tybjaerg-Hansen A, Clausen JO, Pedersen O.

J Clin Endocrinol Metab. 1997 Dec;82(12):4069-74.PMID: 9398715 [PubMed - indexed for MEDLINE]Related articlesFree article

The Val985Met insulin-receptor variant in the Danish Caucasian population: lack of associations with non-insulin-dependent diabetes mellitus or insulin resistance.

Hansen L, Hansen T, Clausen JO, Echwald SM, Urhammer SA, Rasmussen SK, Pedersen O.

Am J Hum Genet. 1997 Jun;60(6):1532-5. No abstract available. PMID: 9199575 [PubMed - indexed for MEDLINE]Related articlesFree article

Amino acid variants in the human leptin receptor: lack of association to juvenile onset obesity.

Echwald SM, Sørensen TD, Sørensen TI, Tybjaerg-Hansen A, Andersen T, Chung WK, Leibel RL, Pedersen O.

Biochem Biophys Res Commun. 1997 Apr 7;233(1):248-52.PMID: 9144432 [PubMed - indexed for MEDLINE]Related articles

Identification of two novel missense mutations in the human OB gene.

Echwald SM, Rasmussen SB, Sørensen TI, Andersen T, Tybjaerg-Hansen A, Clausen JO, Hansen L, Hansen T, Pedersen O.

Int J Obes Relat Metab Disord. 1997 Apr;21(4):321-6.PMID: 9130031 [PubMed - indexed for MEDLINE]Related articles

Novel MODY3 mutations in the hepatocyte nuclear factor-1alpha gene: evidence for a hyperexcitability of pancreatic beta-cells to intravenous secretagogues in a glucose-tolerant carrier of a P447L mutation.

Hansen T, Eiberg H, Rouard M, Vaxillaire M, Møller AM, Rasmussen SK, Fridberg M, Urhammer SA, Holst JJ, Almind K, Echwald SM, Hansen L, Bell GI, Pedersen O.

Diabetes. 1997 Apr;46(4):726-30.PMID: 9075819 [PubMed - indexed for MEDLINE]Related articles

Amino acid polymorphisms in the ATP-regulatable inward rectifier Kir6.2 and their relationships to glucose- and tolbutamide-induced insulin secretion, the insulin sensitivity index, and NIDDM.

Hansen L, Echwald SM, Hansen T, Urhammer SA, Clausen JO, Pedersen O.

Diabetes. 1997 Mar;46(3):508-12.PMID: 9032110 [PubMed - indexed for MEDLINE]Related articles

Identification of a common amino acid polymorphism in the p85alpha regulatory subunit of phosphatidylinositol 3-kinase: effects on glucose disappearance constant, glucose effectiveness, and the insulin sensitivity index.

Hansen T, Andersen CB, Echwald SM, Urhammer SA, Clausen JO, Vestergaard H, Owens D, Hansen L, Pedersen O.

Diabetes. 1997 Mar;46(3):494-501.PMID: 9032108 [PubMed - indexed for MEDLINE]Related articles

Insulin resistance: interactions between obesity and a common variant of insulin receptor substrate-1.

Clausen JO, Hansen T, Bjørbaek C, Echwald SM, Urhammer SA, Rasmussen S, Andersen CB, Hansen L, Almind K, Winther K, et al.

Lancet. 1995 Aug 12;346(8972):397-402.PMID: 7623569 [PubMed - indexed for MEDLINE]Related articles

A widespread amino acid polymorphism at codon 905 of the glycogen-associated regulatory subunit of protein phosphatase-1 is associated with insulin resistance and hypersecretion of insulin.

Hansen L, Hansen T, Vestergaard H, Bjørbaek C, Echwald SM, Clausen JO, Chen YH, Chen MX, Cohen PT, Pedersen O.

Hum Mol Genet. 1995 Aug;4(8):1313-20.PMID: 7581368 [PubMed - indexed for MEDLINE]Related articles

Identification of four amino acid substitutions in hexokinase II and studies of relationships to NIDDM, glucose effectiveness, and insulin sensitivity.

Echwald SM, Bjørbaek C, Hansen T, Clausen JO, Vestergaard H, Zierath JR, Printz RL, Granner DK, Pedersen O.

Diabetes. 1995 Mar;44(3):347-53.PMID: 7883123 [PubMed - indexed for MEDLINE]Related articles

Cloning of a human insulin-stimulated protein kinase (ISPK-1) gene and analysis of coding regions and mRNA levels of the ISPK-1 and the protein phosphatase-1 genes in muscle from NIDDM patients.

Bjørbaek C, Vik TA, Echwald SM, Yang PY, Vestergaard H, Wang JP, Webb GC, Richmond K, Hansen T, Erikson RL, et al.

Diabetes. 1995 Jan;44(1):90-7.PMID: 7813820 [PubMed - indexed for MEDLINE]Related articles

Genetic variants in promoters and coding regions of the muscle glycogen synthase and the insulin-responsive GLUT4 genes in NIDDM.

Bjørbaek C, Echwald SM, Hubricht P, Vestergaard H, Hansen T, Zierath J, Pedersen O.

Diabetes. 1994 Aug;43(8):976-83.PMID: 8039605 [PubMed - indexed for MEDLINE]Related articles