PubMed

In AbetaPP-overexpressing cultured human muscle fibers proteasome inhibition enhances phosphorylation of AbetaPP751 and GSK3beta activation: effects mitigated by lithium and apparently relevant to sporadic inclusion-body myositis.

Terracciano C, Nogalska A, Engel WK, Askanas V.

J Neurochem. 2009 Oct 29. [Epub ahead of print]PMID: 19878439 [PubMed - as supplied by publisher]Related articles

Intravenous immunoglobulin in relapsing-remitting multiple sclerosis: a dose-finding trial.

Engel WK.

Neurology. 2009 Sep 29;73(13):1077; author reply 1077-8. No abstract available. PMID: 19786702 [PubMed - indexed for MEDLINE]Related articles

Inclusion body myositis: a degenerative muscle disease associated with intra-muscle fiber multi-protein aggregates, proteasome inhibition, endoplasmic reticulum stress and decreased lysosomal degradation.

Askanas V, Engel WK, Nogalska A.

Brain Pathol. 2009 Jul;19(3):493-506. Review.PMID: 19563541 [PubMed - indexed for MEDLINE]Related articles

Inclusion-body myositis: muscle-fiber molecular pathology and possible pathogenic significance of its similarity to Alzheimer's and Parkinson's disease brains.

Askanas V, Engel WK.

Acta Neuropathol. 2008 Dec;116(6):583-95. Epub 2008 Oct 31. Review.PMID: 18974994 [PubMed - indexed for MEDLINE]Related articlesFree article

Decreased SIRT1 deacetylase activity in sporadic inclusion-body myositis muscle fibers.

Nogalska A, D'Agostino C, Engel WK, Davies KJ, Askanas V.

Neurobiol Aging. 2008 Oct 13. [Epub ahead of print]PMID: 18922603 [PubMed - as supplied by publisher]Related articles

In inclusion-body myositis muscle fibers Parkinson-associated DJ-1 is increased and oxidized.

Terracciano C, Nogalska A, Engel WK, Wojcik S, Askanas V.

Free Radic Biol Med. 2008 Sep 15;45(6):773-9. Epub 2008 Jun 14.PMID: 18601999 [PubMed - indexed for MEDLINE]Related articlesFree article

Myostatin and its precursor protein are increased in the skeletal muscle of patients with Type-II muscle fibre atrophy.

Wójcik S, Nogalska A, Engel WK, Askanas V.

Folia Morphol (Warsz). 2008 Feb;67(1):6-12.PMID: 18335407 [PubMed - indexed for MEDLINE]Related articles

Inclusion-body myositis, a multifactorial muscle disease associated with aging: current concepts of pathogenesis.

Askanas V, Engel WK.

Curr Opin Rheumatol. 2007 Nov;19(6):550-9. Review.PMID: 17917534 [PubMed - indexed for MEDLINE]Related articles

Expression of Nogo-A in human muscle fibers is not specific for amyotrophic lateral sclerosis.

Askanas V, Wojcik S, Engel WK.

Ann Neurol. 2007 Dec;62(6):676-7; author reply 677. No abstract available. PMID: 17894379 [PubMed - indexed for MEDLINE]Related articles

NOGO is increased and binds to BACE1 in sporadic inclusion-body myositis and in A beta PP-overexpressing cultured human muscle fibers.

Wojcik S, Engel WK, Yan R, McFerrin J, Askanas V.

Acta Neuropathol. 2007 Nov;114(5):517-26. Epub 2007 Aug 31.PMID: 17764014 [PubMed - indexed for MEDLINE]Related articles

Increased expression of Noga-A in ALS muscle biopsies is not unique for this disease.

Wojcik S, Engel WK, Askanas V.

Acta Myol. 2006 Dec;25(3):116-8.PMID: 17626519 [PubMed - indexed for MEDLINE]Related articles

Myostatin precursor protein is increased and associates with amyloid-beta precursor protein in inclusion-body myositis culture model.

Wojcik S, Nogalska A, McFerrin J, Engel WK, Oledzka G, Askanas V.

Neuropathol Appl Neurobiol. 2007 Apr;33(2):238-42. No abstract available. PMID: 17359364 [PubMed - indexed for MEDLINE]Related articles

Endoplasmic reticulum stress induces myostatin precursor protein and NF-kappaB in cultured human muscle fibers: relevance to inclusion body myositis.

Nogalska A, Wojcik S, Engel WK, McFerrin J, Askanas V.

Exp Neurol. 2007 Apr;204(2):610-8. Epub 2006 Dec 23.PMID: 17261282 [PubMed - indexed for MEDLINE]Related articlesFree article

AbetaPP-overexpression and proteasome inhibition increase alphaB-crystallin in cultured human muscle: relevance to inclusion-body myositis.

Wojcik S, Engel WK, McFerrin J, Paciello O, Askanas V.

Neuromuscul Disord. 2006 Dec;16(12):839-44. Epub 2006 Oct 23.PMID: 17056255 [PubMed - indexed for MEDLINE]Related articlesFree article

Parkin and its association with alpha-synuclein and AbetaPP in inclusion-body myositis and AbetaPP-overexpressing cultured human muscle fibers.

Paciello O, Wójcik S, Engel WK, McFerrin J, Askanas V.

Acta Myol. 2006 Jun;25(1):13-22.PMID: 17039976 [PubMed - indexed for MEDLINE]Related articles

Homocysteine-induced endoplasmic reticulum protein (Herp) is up-regulated in sporadic inclusion-body myositis and in endoplasmic reticulum stress-induced cultured human muscle fibers.

Nogalska A, Engel WK, McFerrin J, Kokame K, Komano H, Askanas V.

J Neurochem. 2006 Mar;96(5):1491-9. Epub 2006 Jan 25.PMID: 16441512 [PubMed - indexed for MEDLINE]Related articles

Inclusion-body myositis: a myodegenerative conformational disorder associated with Abeta, protein misfolding, and proteasome inhibition.

Askanas V, Engel WK.

Neurology. 2006 Jan 24;66(2 Suppl 1):S39-48. Review.PMID: 16432144 [PubMed - indexed for MEDLINE]Related articles

Inclusion-body myositis: clinical, diagnostic, and pathologic aspects.

Engel WK, Askanas V.

Neurology. 2006 Jan 24;66(2 Suppl 1):S20-9. Review.PMID: 16432141 [PubMed - indexed for MEDLINE]Related articles

Sporadic inclusion-body myositis: a proposed key pathogenetic role of the abnormalities of the ubiquitin-proteasome system, and protein misfolding and aggregation.

Askanas V, Engel WK.

Acta Myol. 2005 Jul;24(1):17-24.PMID: 16315367 [PubMed - indexed for MEDLINE]Related articles

Molecular pathology and pathogenesis of inclusion-body myositis.

Askanas V, Engel WK.

Microsc Res Tech. 2005 Jul;67(3-4):114-20. Review.PMID: 16104000 [PubMed - indexed for MEDLINE]Related articles

Proteasome inhibition and aggresome formation in sporadic inclusion-body myositis and in amyloid-beta precursor protein-overexpressing cultured human muscle fibers.

Fratta P, Engel WK, McFerrin J, Davies KJ, Lin SW, Askanas V.

Am J Pathol. 2005 Aug;167(2):517-26.PMID: 16049336 [PubMed - indexed for MEDLINE]Related articlesFree article

Myostatin is increased and complexes with amyloid-beta within sporadic inclusion-body myositis muscle fibers.

Wójcik S, Engel WK, McFerrin J, Askanas V.

Acta Neuropathol. 2005 Aug;110(2):173-7. Epub 2005 Jun 28.PMID: 15983828 [PubMed - indexed for MEDLINE]Related articles

Mutant ubiquitin UBB+1 is accumulated in sporadic inclusion-body myositis muscle fibers.

Fratta P, Engel WK, Van Leeuwen FW, Hol EM, Vattemi G, Askanas V.

Neurology. 2004 Sep 28;63(6):1114-7.PMID: 15452314 [PubMed - indexed for MEDLINE]Related articles

Ophthalmic manifestations of Wolf-Hirschhorn syndrome.

Wu-Chen WY, Christiansen SP, Berry SA, Engel WK, Fray KJ, Summers CG.

J AAPOS. 2004 Aug;8(4):345-8.PMID: 15314595 [PubMed - indexed for MEDLINE]Related articles

Unicorns, dragons, polymyositis, and other mythical beasts.

Askanas V, Engel WK.

Neurology. 2004 Jul 27;63(2):403-4; author reply 404. No abstract available. PMID: 15277658 [PubMed - indexed for MEDLINE]Related articles

Intravenous immunoglobulin G is remarkably beneficial in chronic immune dysschwannian/dysneuronal polyneuropathy, diabetes-2 neuropathy, and potentially in severe acute respiratory syndrome.

Engel WK.

Acta Myol. 2003 Dec;22(3):97-103. Review.PMID: 15088499 [PubMed - indexed for MEDLINE]Related articles

Endoplasmic reticulum stress and unfolded protein response in inclusion body myositis muscle.

Vattemi G, Engel WK, McFerrin J, Askanas V.

Am J Pathol. 2004 Jan;164(1):1-7.PMID: 14695312 [PubMed - indexed for MEDLINE]Related articlesFree article

Guidelines for the diagnosis and treatment of chronic inflammatory demyelinating polyneuropathy.

Berger AR, Bradley WG, Brannagan TH, Busis NA, Cros DP, Dalakas MC, Danon MJ, Donofrio P, Engel WK, England JD, Feldman EL, Freeman RL, Kinsella LJ, Lacomis D, Latov N, Menkes DL, Sander HW, Thomas FP, Triggs WJ, Windebank AJ, Wolfe GI; Neuropathy Association, Medical Advisory Committee.

J Peripher Nerv Syst. 2003 Dec;8(4):282-4. No abstract available. PMID: 14641652 [PubMed - indexed for MEDLINE]Related articles

Proposed pathogenetic cascade of inclusion-body myositis: importance of amyloid-beta, misfolded proteins, predisposing genes, and aging.

Askanas V, Engel WK.

Curr Opin Rheumatol. 2003 Nov;15(6):737-44. Review.PMID: 14569203 [PubMed - indexed for MEDLINE]Related articles

Transthyretin Val122Ile, accumulated Abeta, and inclusion-body myositis aspects in cultured muscle.

Askanas V, Engel WK, McFerrin J, Vattemi G.

Neurology. 2003 Jul 22;61(2):257-60.PMID: 12874414 [PubMed - indexed for MEDLINE]Related articles

Cystatin C colocalizes with amyloid-beta and coimmunoprecipitates with amyloid-beta precursor protein in sporadic inclusion-body myositis muscles.

Vattemi G, Engel WK, McFerrin J, Askanas V.

J Neurochem. 2003 Jun;85(6):1539-46.PMID: 12787072 [PubMed - indexed for MEDLINE]Related articles

Unfolding story of inclusion-body myositis and myopathies: role of misfolded proteins, amyloid-beta, cholesterol, and aging.

Askanas V, Engel WK.

J Child Neurol. 2003 Mar;18(3):185-90.PMID: 12731644 [PubMed - indexed for MEDLINE]Related articles

BACE1 and BACE2 in pathologic and normal human muscle.

Vattemi G, Engel WK, McFerrin J, Pastorino L, Buxbaum JD, Askanas V.

Exp Neurol. 2003 Feb;179(2):150-8.PMID: 12618121 [PubMed - indexed for MEDLINE]Related articles

Reversible ocular myasthenia gravis or mitochondrial myopathy from statins?

Engel WK.

Lancet. 2003 Jan 4;361(9351):85-6. No abstract available. PMID: 12517506 [PubMed - indexed for MEDLINE]Related articles

Inclusion-body myositis and myopathies: different etiologies, possibly similar pathogenic mechanisms.

Askanas V, Engel WK.

Curr Opin Neurol. 2002 Oct;15(5):525-31. Review.PMID: 12351995 [PubMed - indexed for MEDLINE]Related articles

Newest pathogenetic considerations in inclusion-body myositis: possible role of amyloid-beta, cholesterol, relation to aging and to Alzheimer's disease.

Askanas V, Engel WK.

Curr Rheumatol Rep. 2002 Oct;4(5):427-33. Review.PMID: 12217248 [PubMed - indexed for MEDLINE]Related articles

Three lipoprotein receptors and cholesterol in inclusion-body myositis muscle.

Jaworska-Wilczynska M, Wilczynski GM, Engel WK, Strickland DK, Weisgraber KH, Askanas V.

Neurology. 2002 Feb 12;58(3):438-45.PMID: 11839845 [PubMed - indexed for MEDLINE]Related articles

Polyneuropathy in type 2 diabetes mellitus.

Engel WK.

Lancet. 2001 Dec 15;358(9298):2086. No abstract available. PMID: 11755652 [PubMed - indexed for MEDLINE]Related articles

Presence of BACE1 and BACE2 in muscle fibres of patients with sporadic inclusion-body myositis.

Vattemi G, Engel WK, McFerrin J, Buxbaum JD, Pastorino L, Askanas V.

Lancet. 2001 Dec 8;358(9297):1962-4.PMID: 11747923 [PubMed - indexed for MEDLINE]Related articles

Novel cytoplasmic immunolocalization of RNA polymerase II in inclusion-body myositis muscle.

Wilczynski GM, Engel WK, Askanas V.

Neuroreport. 2001 Jul 3;12(9):1809-14.PMID: 11435903 [PubMed - indexed for MEDLINE]Related articles

High injection pressure during intralesional injection of corticosteroids into capillary hemangiomas.

Egbert JE, Paul S, Engel WK, Summers CG.

Arch Ophthalmol. 2001 May;119(5):677-83.PMID: 11346395 [PubMed - indexed for MEDLINE]Related articles

Infiltration and tendon rupture.

Engel WK.

Lancet. 2001 Apr 28;357(9265):1363-4. No abstract available. PMID: 11347581 [PubMed - indexed for MEDLINE]Related articles

Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication.

Wang Y, Michikawa Y, Mallidis C, Bai Y, Woodhouse L, Yarasheski KE, Miller CA, Askanas V, Engel WK, Bhasin S, Attardi G.

Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):4022-7. Epub 2001 Mar 13.PMID: 11274426 [PubMed - indexed for MEDLINE]Related articlesFree article

Inclusion-body myositis: newest concepts of pathogenesis and relation to aging and Alzheimer disease.

Askanas V, Engel WK.

J Neuropathol Exp Neurol. 2001 Jan;60(1):1-14. Review.PMID: 11202170 [PubMed - indexed for MEDLINE]Related articles

Cyclin-dependent kinase 5 colocalizes with phosphorylated tau in human inclusion-body myositis paired-helical filaments and may play a role in tau phosphorylation.

Wilczynski GM, Engel WK, Askanas V.

Neurosci Lett. 2000 Oct 20;293(1):33-6.PMID: 11065131 [PubMed - indexed for MEDLINE]Related articles

Novel immunolocalization of alpha-synuclein in human muscle of inclusion-body myositis, regenerating and necrotic muscle fibers, and at neuromuscular junctions.

Askanas V, Engel WK, Alvarez RB, McFerrin J, Broccolini A.

J Neuropathol Exp Neurol. 2000 Jul;59(7):592-8.PMID: 10901230 [PubMed - indexed for MEDLINE]Related articles

Association of active extracellular signal-regulated protein kinase with paired helical filaments of inclusion-body myositis muscle suggests its role in inclusion-body myositis tau phosphorylation.

Wilczynski GM, Engel WK, Askanas V.

Am J Pathol. 2000 Jun;156(6):1835-40.PMID: 10854206 [PubMed - indexed for MEDLINE]Related articlesFree article

Redox factor-1 in muscle biopsies of patients with inclusion-body myositis.

Broccolini A, Engel WK, Alvarez RB, Askanas V.

Neurosci Lett. 2000 Jun 16;287(1):1-4.PMID: 10841976 [PubMed - indexed for MEDLINE]Related articles

Inclusion body myositis, muscle blood vessel and cardiac amyloidosis, and transthyretin Val122Ile allele.

Askanas V, Engel WK, Alvarez RB, Frangione B, Ghiso J, Vidal R.

Ann Neurol. 2000 Apr;47(4):544-9.PMID: 10762172 [PubMed - indexed for MEDLINE]Related articles

Paired helical filaments of inclusion-body myositis muscle contain RNA and survival motor neuron protein.

Broccolini A, Engel WK, Alvarez RB, Askanas V.

Am J Pathol. 2000 Apr;156(4):1151-5.PMID: 10751338 [PubMed - indexed for MEDLINE]Related articlesFree article