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Direct regulation of myocardial triglyceride metabolism by the cardiomyocyte circadian clock.

Tsai JY, Kienesberger PC, Pulinilkunnil T, Sailors MH, Durgan DJ, Villegas-Montoya C, Jahoor A, Gonzalez R, Garvey ME, Boland B, Blasier Z, McElfresh TA, Nannegari V, Chow CW, Heird WC, Chandler MP, Dyck JR, Bray MS, Young ME.

J Biol Chem. 2009 Nov 25. [Epub ahead of print]PMID: 19940111 [PubMed - as supplied by publisher]Related articlesFree article

Cardiac-specific deletion of LKB1 leads to hypertrophy and dysfunction.

Ikeda Y, Sato K, Pimental DR, Sam F, Shaw RJ, Dyck JR, Walsh K.

J Biol Chem. 2009 Oct 14. [Epub ahead of print]PMID: 19828446 [PubMed - as supplied by publisher]Related articlesFree article

Dehydroepiandrosterone reverses systemic vascular remodeling through the inhibition of the Akt/GSK3-{beta}/NFAT axis.

Bonnet S, Paulin R, Sutendra G, Dromparis P, Roy M, Watson KO, Nagendran J, Haromy A, Dyck JR, Michelakis ED.

Circulation. 2009 Sep 29;120(13):1231-40. Epub 2009 Sep 14.PMID: 19752325 [PubMed - indexed for MEDLINE]Related articles

Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase.

Ussher JR, Koves TR, Jaswal JS, Zhang L, Ilkayeva O, Dyck JR, Muoio DM, Lopaschuk GD.

Diabetes. 2009 Aug;58(8):1766-75. Epub 2009 May 28. Erratum in: Diabetes. 2009 Oct;58(10):2425. PMID: 19478144 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated protein kinase influences metabolic remodeling in H9c2 cells hypertrophied by arginine vasopressin.

Saeedi R, Saran VV, Wu SS, Kume ES, Paulson K, Chan AP, Parsons HL, Wambolt RB, Dyck JR, Brownsey RW, Allard MF.

Am J Physiol Heart Circ Physiol. 2009 Jun;296(6):H1822-32. Epub 2009 Apr 17.PMID: 19376807 [PubMed - indexed for MEDLINE]Related articles

Resveratrol prevents the prohypertrophic effects of oxidative stress on LKB1.

Dolinsky VW, Chan AY, Robillard Frayne I, Light PE, Des Rosiers C, Dyck JR.

Circulation. 2009 Mar 31;119(12):1643-52. Epub 2009 Mar 16.PMID: 19289642 [PubMed - indexed for MEDLINE]Related articles

A dynamic and chamber-specific mitochondrial remodeling in right ventricular hypertrophy can be therapeutically targeted.

Nagendran J, Gurtu V, Fu DZ, Dyck JR, Haromy A, Ross DB, Rebeyka IM, Michelakis ED.

J Thorac Cardiovasc Surg. 2008 Jul;136(1):168-78, 178.e1-3. Epub 2008 May 23.PMID: 18603070 [PubMed - indexed for MEDLINE]Related articles

Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt.

Chan AY, Dolinsky VW, Soltys CL, Viollet B, Baksh S, Light PE, Dyck JR.

J Biol Chem. 2008 Aug 29;283(35):24194-201. Epub 2008 Jun 18.PMID: 18562309 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic actions of metformin in the heart can occur by AMPK-independent mechanisms.

Saeedi R, Parsons HL, Wambolt RB, Paulson K, Sharma V, Dyck JR, Brownsey RW, Allard MF.

Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2497-506. Epub 2008 Mar 28.PMID: 18375721 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance.

Koves TR, Ussher JR, Noland RC, Slentz D, Mosedale M, Ilkayeva O, Bain J, Stevens R, Dyck JR, Newgard CB, Lopaschuk GD, Muoio DM.

Cell Metab. 2008 Jan;7(1):45-56.PMID: 18177724 [PubMed - indexed for MEDLINE]Related articles

Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression.

Bray MS, Shaw CA, Moore MW, Garcia RA, Zanquetta MM, Durgan DJ, Jeong WJ, Tsai JY, Bugger H, Zhang D, Rohrwasser A, Rennison JH, Dyck JR, Litwin SE, Hardin PE, Chow CW, Chandler MP, Abel ED, Young ME.

Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H1036-47. Epub 2007 Dec 21.PMID: 18156197 [PubMed - indexed for MEDLINE]Related articlesFree article

The ischemic heart: starving to stimulate the adiponectin-AMPK signaling axis.

Dyck JR.

Circulation. 2007 Dec 11;116(24):2779-81. No abstract available. PMID: 18071087 [PubMed - indexed for MEDLINE]Related articlesFree article

CD36 expression contributes to age-induced cardiomyopathy in mice.

Koonen DP, Febbraio M, Bonnet S, Nagendran J, Young ME, Michelakis ED, Dyck JR.

Circulation. 2007 Nov 6;116(19):2139-47. Epub 2007 Oct 22.PMID: 17967771 [PubMed - indexed for MEDLINE]Related articlesFree article

The AMPK gamma1 R70Q mutant regulates multiple metabolic and growth pathways in neonatal cardiac myocytes.

Folmes KD, Witters LA, Allard MF, Young ME, Dyck JR.

Am J Physiol Heart Circ Physiol. 2007 Dec;293(6):H3456-64. Epub 2007 Sep 28.PMID: 17906100 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity.

Koonen DP, Jacobs RL, Febbraio M, Young ME, Soltys CL, Ong H, Vance DE, Dyck JR.

Diabetes. 2007 Dec;56(12):2863-71. Epub 2007 Aug 29.PMID: 17728375 [PubMed - indexed for MEDLINE]Related articlesFree article

Circadian rhythms in myocardial metabolism and contractile function: influence of workload and oleate.

Durgan DJ, Moore MW, Ha NP, Egbejimi O, Fields A, Mbawuike U, Egbejimi A, Shaw CA, Bray MS, Nannegari V, Hickson-Bick DL, Heird WC, Dyck JR, Chandler MP, Young ME.

Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2385-93. Epub 2007 Jul 6.PMID: 17616739 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility.

Nagendran J, Archer SL, Soliman D, Gurtu V, Moudgil R, Haromy A, St Aubin C, Webster L, Rebeyka IM, Ross DB, Light PE, Dyck JR, Michelakis ED.

Circulation. 2007 Jul 17;116(3):238-48. Epub 2007 Jul 2.PMID: 17606845 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic and signaling alterations in dystrophin-deficient hearts precede overt cardiomyopathy.

Khairallah M, Khairallah R, Young ME, Dyck JR, Petrof BJ, Des Rosiers C.

J Mol Cell Cardiol. 2007 Aug;43(2):119-29. Epub 2007 May 24.PMID: 17583724 [PubMed - indexed for MEDLINE]Related articles

Inhibition of p38 MAPK and AMPK restores adenosine-induced cardioprotection in hearts stressed by antecedent ischemia by altering glucose utilization.

Jaswal JS, Gandhi M, Finegan BA, Dyck JR, Clanachan AS.

Am J Physiol Heart Circ Physiol. 2007 Aug;293(2):H1107-14. Epub 2007 May 11.PMID: 17496214 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of hepatic phosphatidylcholine synthesis by 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside is independent of AMP-activated protein kinase activation.

Jacobs RL, Lingrell S, Dyck JR, Vance DE.

J Biol Chem. 2007 Feb 16;282(7):4516-23. Epub 2006 Dec 19.PMID: 17179149 [PubMed - indexed for MEDLINE]Related articlesFree article

p38 mitogen-activated protein kinase mediates adenosine-induced alterations in myocardial glucose utilization via 5'-AMP-activated protein kinase.

Jaswal JS, Gandhi M, Finegan BA, Dyck JR, Clanachan AS.

Am J Physiol Heart Circ Physiol. 2007 Apr;292(4):H1978-85. Epub 2006 Dec 15.PMID: 17172269 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of an active LKB1 complex in cardiac myocytes results in decreased protein synthesis associated with phenylephrine-induced hypertrophy.

Noga AA, Soltys CL, Barr AJ, Kovacic S, Lopaschuk GD, Dyck JR.

Am J Physiol Heart Circ Physiol. 2007 Mar;292(3):H1460-9. Epub 2006 Nov 10.PMID: 17098823 [PubMed - indexed for MEDLINE]Related articlesFree article

A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway.

Xie M, Zhang D, Dyck JR, Li Y, Zhang H, Morishima M, Mann DL, Taffet GE, Baldini A, Khoury DS, Schneider MD.

Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17378-83. Epub 2006 Nov 3.PMID: 17085580 [PubMed - indexed for MEDLINE]Related articlesFree article

Absence of malonyl coenzyme A decarboxylase in mice increases cardiac glucose oxidation and protects the heart from ischemic injury.

Dyck JR, Hopkins TA, Bonnet S, Michelakis ED, Young ME, Watanabe M, Kawase Y, Jishage K, Lopaschuk GD.

Circulation. 2006 Oct 17;114(16):1721-8. Epub 2006 Oct 9.PMID: 17030679 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic regulation of sodium-calcium exchange by intracellular acyl CoAs.

Riedel MJ, Baczkó I, Searle GJ, Webster N, Fercho M, Jones L, Lang J, Lytton J, Dyck JR, Light PE.

EMBO J. 2006 Oct 4;25(19):4605-14. Epub 2006 Sep 14.PMID: 16977318 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice.

Dentin R, Benhamed F, Hainault I, Fauveau V, Foufelle F, Dyck JR, Girard J, Postic C.

Diabetes. 2006 Aug;55(8):2159-70.PMID: 16873678 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of AMP-activated protein kinase in healthy and diseased hearts.

Dolinsky VW, Dyck JR.

Am J Physiol Heart Circ Physiol. 2006 Dec;291(6):H2557-69. Epub 2006 Jul 14. Review.PMID: 16844922 [PubMed - indexed for MEDLINE]Related articlesFree article

Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents.

Cheng JF, Huang Y, Penuliar R, Nishimoto M, Liu L, Arrhenius T, Yang G, O'leary E, Barbosa M, Barr R, Dyck JR, Lopaschuk GD, Nadzan AM.

J Med Chem. 2006 Jul 13;49(14):4055-8.PMID: 16821767 [PubMed - indexed for MEDLINE]Related articles

AMPK alterations in cardiac physiology and pathology: enemy or ally?

Dyck JR, Lopaschuk GD.

J Physiol. 2006 Jul 1;574(Pt 1):95-112. Epub 2006 May 11. Review.PMID: 16690706 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of adenosine on myocardial glucose and palmitate metabolism after transient ischemia: role of 5'-AMP-activated protein kinase.

Jaswal JS, Gandhi M, Finegan BA, Dyck JR, Clanachan AS.

Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1883-92. Epub 2006 Apr 28.PMID: 16648181 [PubMed - indexed for MEDLINE]Related articlesFree article

Heteroaryl substituted bis-trifluoromethyl carbinols as malonyl-CoA decarboxylase inhibitors.

Cheng JF, Mak CC, Huang Y, Penuliar R, Nishimoto M, Zhang L, Chen M, Wallace D, Arrhenius T, Chu D, Yang G, Barbosa M, Barr R, Dyck JR, Lopaschuk GD, Nadzan AM.

Bioorg Med Chem Lett. 2006 Jul 1;16(13):3484-8. Epub 2006 Apr 27.PMID: 16644218 [PubMed - indexed for MEDLINE]Related articles

Synthesis and structure-activity relationship of small-molecule malonyl coenzyme A decarboxylase inhibitors.

Cheng JF, Chen M, Wallace D, Tith S, Haramura M, Liu B, Mak CC, Arrhenius T, Reily S, Brown S, Thorn V, Harmon C, Barr R, Dyck JR, Lopaschuk GD, Nadzan AM.

J Med Chem. 2006 Mar 9;49(5):1517-25.PMID: 16509570 [PubMed - indexed for MEDLINE]Related articles

Activation of cardiac AMP-activated protein kinase by LKB1 expression or chemical hypoxia is blunted by increased Akt activity.

Soltys CL, Kovacic S, Dyck JR.

Am J Physiol Heart Circ Physiol. 2006 Jun;290(6):H2472-9. Epub 2006 Jan 20.PMID: 16428351 [PubMed - indexed for MEDLINE]Related articlesFree article

Distinct transcriptional regulation of long-chain acyl-CoA synthetase isoforms and cytosolic thioesterase 1 in the rodent heart by fatty acids and insulin.

Durgan DJ, Smith JK, Hotze MA, Egbejimi O, Cuthbert KD, Zaha VG, Dyck JR, Abel ED, Young ME.

Am J Physiol Heart Circ Physiol. 2006 Jun;290(6):H2480-97. Epub 2006 Jan 20.PMID: 16428347 [PubMed - indexed for MEDLINE]Related articlesFree article

Malonyl-CoA decarboxylase is a major regulator of myocardial fatty acid oxidation.

Cuthbert KD, Dyck JR.

Curr Hypertens Rep. 2005 Dec;7(6):407-11. Review.PMID: 16386195 [PubMed - indexed for MEDLINE]Related articles

Malonyl-CoA decarboxylase inhibition suppresses fatty acid oxidation and reduces lactate production during demand-induced ischemia.

Stanley WC, Morgan EE, Huang H, McElfresh TA, Sterk JP, Okere IC, Chandler MP, Cheng J, Dyck JR, Lopaschuk GD.

Am J Physiol Heart Circ Physiol. 2005 Dec;289(6):H2304-9. Epub 2005 Aug 12.PMID: 16100246 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of cardiac malonyl-CoA content and fatty acid oxidation during increased cardiac power.

King KL, Okere IC, Sharma N, Dyck JR, Reszko AE, McElfresh TA, Kerner J, Chandler MP, Lopaschuk GD, Stanley WC.

Am J Physiol Heart Circ Physiol. 2005 Sep;289(3):H1033-7. Epub 2005 Apr 8.PMID: 15821035 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of AMP-activated protein kinase (AMPK) inhibits protein synthesis: a potential strategy to prevent the development of cardiac hypertrophy.

Chan AY, Dyck JR.

Can J Physiol Pharmacol. 2005 Jan;83(1):24-8. Review.PMID: 15759047 [PubMed - indexed for MEDLINE]Related articles

Metabolic effects of insulin on cardiomyocytes from control and diabetic db/db mouse hearts.

Carroll R, Carley AN, Dyck JR, Severson DL.

Am J Physiol Endocrinol Metab. 2005 May;288(5):E900-6. Epub 2005 Jan 4.PMID: 15632103 [PubMed - indexed for MEDLINE]Related articlesFree article

Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis.

McMurtry MS, Bonnet S, Wu X, Dyck JR, Haromy A, Hashimoto K, Michelakis ED.

Circ Res. 2004 Oct 15;95(8):830-40. Epub 2004 Sep 16.PMID: 15375007 [PubMed - indexed for MEDLINE]Related articlesFree article

Oxygen-sensitive Kv channel gene transfer confers oxygen responsiveness to preterm rabbit and remodeled human ductus arteriosus: implications for infants with patent ductus arteriosus.

Thébaud B, Michelakis ED, Wu XC, Moudgil R, Kuzyk M, Dyck JR, Harry G, Hashimoto K, Haromy A, Rebeyka I, Archer SL.

Circulation. 2004 Sep 14;110(11):1372-9. Epub 2004 Sep 7.PMID: 15353504 [PubMed - indexed for MEDLINE]Related articlesFree article

Malonyl-CoA decarboxylase (MCD) is differentially regulated in subcellular compartments by 5'AMP-activated protein kinase (AMPK). Studies using H9c2 cells overexpressing MCD and AMPK by adenoviral gene transfer technique.

Sambandam N, Steinmetz M, Chu A, Altarejos JY, Dyck JR, Lopaschuk GD.

Eur J Biochem. 2004 Jul;271(13):2831-40.PMID: 15206948 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of malonyl-CoA concentration and turnover in the normal heart.

Reszko AE, Kasumov T, David F, Thomas KR, Jobbins KA, Cheng JF, Lopaschuk GD, Dyck JR, Diaz M, Des Rosiers C, Stanley WC, Brunengraber H.

J Biol Chem. 2004 Aug 13;279(33):34298-301. Epub 2004 Jun 4.PMID: 15181001 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte.

Chan AY, Soltys CL, Young ME, Proud CG, Dyck JR.

J Biol Chem. 2004 Jul 30;279(31):32771-9. Epub 2004 May 24.PMID: 15159410 [PubMed - indexed for MEDLINE]Related articlesFree article

Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation.

Dyck JR, Cheng JF, Stanley WC, Barr R, Chandler MP, Brown S, Wallace D, Arrhenius T, Harmon C, Yang G, Nadzan AM, Lopaschuk GD.

Circ Res. 2004 May 14;94(9):e78-84. Epub 2004 Apr 22.PMID: 15105298 [PubMed - indexed for MEDLINE]Related articlesFree article

Fatty acid translocase/CD36 deficiency does not energetically or functionally compromise hearts before or after ischemia.

Kuang M, Febbraio M, Wagg C, Lopaschuk GD, Dyck JR.

Circulation. 2004 Mar 30;109(12):1550-7. Epub 2004 Mar 15.PMID: 15023869 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression, purification, and characterization of human malonyl-CoA decarboxylase.

Zhou D, Yuen P, Chu D, Thon V, McConnell S, Brown S, Tsang A, Pena M, Russell A, Cheng JF, Nadzan AM, Barbosa MS, Dyck JR, Lopaschuk GD, Yang G.

Protein Expr Purif. 2004 Apr;34(2):261-9.PMID: 15003260 [PubMed - indexed for MEDLINE]Related articles

Prolonged repolarization and triggered activity induced by adenoviral expression of HERG N629D in cardiomyocytes derived from stem cells.

Teng G, Zhao X, Cross JC, Li P, Lees-Miller JP, Guo J, Dyck JR, Duff HJ.

Cardiovasc Res. 2004 Feb 1;61(2):268-77.PMID: 14736543 [PubMed - indexed for MEDLINE]Related articlesFree article

Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart.

Kovacic S, Soltys CL, Barr AJ, Shiojima I, Walsh K, Dyck JR.

J Biol Chem. 2003 Oct 10;278(41):39422-7. Epub 2003 Jul 29. Erratum in: J Biol Chem. 2004 Jan 16;279(3):2332. PMID: 12890675 [PubMed - indexed for MEDLINE]Related articlesFree article

Beneficial effects of trimetazidine in ex vivo working ischemic hearts are due to a stimulation of glucose oxidation secondary to inhibition of long-chain 3-ketoacyl coenzyme a thiolase.

Lopaschuk GD, Barr R, Thomas PD, Dyck JR.

Circ Res. 2003 Aug 8;93(3):e33-7. Epub 2003 Jul 17.PMID: 12869392 [PubMed - indexed for MEDLINE]Related articlesFree article