PubMed

PAX4 enhances beta-cell differentiation of human embryonic stem cells.

Liew CG, Shah NN, Briston SJ, Shepherd RM, Khoo CP, Dunne MJ, Moore HD, Cosgrove KE, Andrews PW.

PLoS One. 2008 Mar 12;3(3):e1783.PMID: 18335054 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucokinase activators: molecular tools for studying the physiology of insulin-secreting cells.

Johnson D, Shepherd RM, Gill D, Gorman T, Smith DM, Dunne MJ.

Biochem Soc Trans. 2007 Nov;35(Pt 5):1208-10. Review.PMID: 17956314 [PubMed - indexed for MEDLINE]Related articles

Glucose-dependent modulation of insulin secretion and intracellular calcium ions by GKA50, a glucokinase activator.

Johnson D, Shepherd RM, Gill D, Gorman T, Smith DM, Dunne MJ.

Diabetes. 2007 Jun;56(6):1694-702. Epub 2007 Mar 14.PMID: 17360975 [PubMed - indexed for MEDLINE]Related articlesFree article

Congenital hyperinsulinism and mosaic abnormalities of the ploidy.

Giurgea I, Sanlaville D, Fournet JC, Sempoux C, Bellanné-Chantelot C, Touati G, Hubert L, Groos MS, Brunelle F, Rahier J, Henquin JC, Dunne MJ, Jaubert F, Robert JJ, Nihoul-Fékété C, Vekemans M, Junien C, de Lonlay P.

J Med Genet. 2006 Mar;43(3):248-54. Epub 2005 Jul 20.PMID: 16033916 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyperinsulinemic hypoglycemia in Beckwith-Wiedemann syndrome due to defects in the function of pancreatic beta-cell adenosine triphosphate-sensitive potassium channels.

Hussain K, Cosgrove KE, Shepherd RM, Luharia A, Smith VV, Kassem S, Gregory JW, Sivaprasadarao A, Christesen HT, Jacobsen BB, Brusgaard K, Glaser B, Maher EA, Lindley KJ, Hindmarsh P, Dattani M, Dunne MJ.

J Clin Endocrinol Metab. 2005 Jul;90(7):4376-82. Epub 2005 Apr 5.PMID: 15811927 [PubMed - indexed for MEDLINE]Related articlesFree article

Contemporary strategies in the diagnosis and management of neonatal hyperinsulinaemic hypoglycaemia.

Lindley KJ, Dunne MJ.

Early Hum Dev. 2005 Jan;81(1):61-72. Epub 2004 Nov 23. Review.PMID: 15707716 [PubMed - indexed for MEDLINE]Related articles

Infantile hyperinsulinism associated with enteropathy, deafness and renal tubulopathy: clinical manifestations of a syndrome caused by a contiguous gene deletion located on chromosome 11p.

Hussain K, Bitner-Glindzicz M, Blaydon D, Lindley KJ, Thompson DA, Kriss T, Rajput K, Ramadan DG, Al-Mazidi Z, Cosgrove KE, Dunne MJ, Aynsley-Green A.

J Pediatr Endocrinol Metab. 2004 Dec;17(12):1613-21.PMID: 15645695 [PubMed - indexed for MEDLINE]Related articles

Hyperinsulinism of infancy: novel ABCC8 and KCNJ11 mutations and evidence for additional locus heterogeneity.

Tornovsky S, Crane A, Cosgrove KE, Hussain K, Lavie J, Heyman M, Nesher Y, Kuchinski N, Ben-Shushan E, Shatz O, Nahari E, Potikha T, Zangen D, Tenenbaum-Rakover Y, de Vries L, Argente J, Gracia R, Landau H, Eliakim A, Lindley K, Dunne MJ, Aguilar-Bryan L, Glaser B.

J Clin Endocrinol Metab. 2004 Dec;89(12):6224-34.PMID: 15579781 [PubMed - indexed for MEDLINE]Related articlesFree article

Laparoscopic diagnosis and cure of hyperinsulinism in two cases of focal adenomatous hyperplasia in infancy.

De Vroede M, Bax NM, Brusgaard K, Dunne MJ, Groenendaal F.

Pediatrics. 2004 Oct;114(4):e520-2.PMID: 15466080 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetics and pathophysiology of hyperinsulinism in infancy.

Cosgrove KE, Shepherd RM, Fernandez EM, Natarajan A, Lindley KJ, Aynsley-Green A, Dunne MJ.

Horm Res. 2004;61(6):270-88. Epub 2004 Feb 20. Review.PMID: 14981344 [PubMed - indexed for MEDLINE]Related articles

Y-26763: ATP-sensitive K+ channel activation and the inhibition of insulin release from human pancreatic beta-cells.

Cosgrove KE, Straub SG, Barnes PD, Chapman J, Sharp GW, Dunne MJ.

Eur J Pharmacol. 2004 Feb 20;486(2):133-9.PMID: 14975702 [PubMed - indexed for MEDLINE]Related articles

Acute insulin responses to calcium and tolbutamide do not differentiate focal from diffuse congenital hyperinsulinism.

Giurgea I, Laborde K, Touati G, Bellanné-Chantelot C, Nassogne MC, Sempoux C, Jaubert F, Khoa N, Chigot V, Rahier J, Brunelle F, Nihoul-Fékété C, Dunne MJ, Stanley C, Saudubray JM, Robert JJ, de Lonlay P.

J Clin Endocrinol Metab. 2004 Feb;89(2):925-9.PMID: 14764815 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyperinsulinism in infancy: from basic science to clinical disease.

Dunne MJ, Cosgrove KE, Shepherd RM, Aynsley-Green A, Lindley KJ.

Physiol Rev. 2004 Jan;84(1):239-75. Review.PMID: 14715916 [PubMed - indexed for MEDLINE]Related articlesFree article

Uncontrolled insulin secretion from a childhood pancreatic beta-cell adenoma is not due to the functional loss of ATP-sensitive potassium channels.

Hussain K, Cosgrove KE, Shepherd RM, Chapman JC, Swift SM, Smith VV, Kassem SA, Glaser B, Lindley KJ, Aynsley-Green A, Dunne MJ.

Endocr Relat Cancer. 2002 Dec;9(4):221-6.PMID: 12542400 [PubMed - indexed for MEDLINE]Related articlesFree article

BPDZ 154 activates adenosine 5'-triphosphate-sensitive potassium channels: in vitro studies using rodent insulin-secreting cells and islets isolated from patients with hyperinsulinism.

Cosgrove KE, Antoine MH, Lee AT, Barnes PD, de Tullio P, Clayton P, McCloy R, De Lonlay P, Nihoul-Fékété C, Robert JJ, Saudubray JM, Rahier J, Lindley KJ, Hussain K, Aynsley-Green A, Pirotte B, Lebrun P, Dunne MJ.

J Clin Endocrinol Metab. 2002 Nov;87(11):4860-8.PMID: 12414839 [PubMed - indexed for MEDLINE]Related articlesFree article

Peripheral channelopathies as targets for potassium channel openers.

Lawson K, Dunne MJ.

Expert Opin Investig Drugs. 2001 Jul;10(7):1345-59. Review.PMID: 11772256 [PubMed - indexed for MEDLINE]Related articles

Synthesis and characterization of a quinolinonic compound activating ATP-sensitive K(+) channels in endocrine and smooth muscle tissues.

Becker B, Antoine MH, Nguyen QA, Rigo B, Cosgrove KE, Barnes PD, Dunne MJ, Pirotte B, Lebrun P.

Br J Pharmacol. 2001 Sep;134(2):375-85.PMID: 11564656 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyperinsulinism of infancy: the regulated release of insulin by KATP channel-independent pathways.

Straub SG, Cosgrove KE, Ammälä C, Shepherd RM, O'Brien RE, Barnes PD, Kuchinski N, Chapman JC, Schaeppi M, Glaser B, Lindley KJ, Sharp GW, Aynsley-Green A, Dunne MJ.

Diabetes. 2001 Feb;50(2):329-39.PMID: 11272144 [PubMed - indexed for MEDLINE]Related articlesFree article

A recessive contiguous gene deletion causing infantile hyperinsulinism, enteropathy and deafness identifies the Usher type 1C gene.

Bitner-Glindzicz M, Lindley KJ, Rutland P, Blaydon D, Smith VV, Milla PJ, Hussain K, Furth-Lavi J, Cosgrove KE, Shepherd RM, Barnes PD, O'Brien RE, Farndon PA, Sowden J, Liu XZ, Scanlan MJ, Malcolm S, Dunne MJ, Aynsley-Green A, Glaser B.

Nat Genet. 2000 Sep;26(1):56-60.PMID: 10973248 [PubMed - indexed for MEDLINE]Related articles

Glucose modulation of insulin mRNA levels is dependent on transcription factor PDX-1 and occurs independently of changes in intracellular Ca2+.

Macfarlane WM, Shepherd RM, Cosgrove KE, James RF, Dunne MJ, Docherty K.

Diabetes. 2000 Mar;49(3):418-23.PMID: 10868963 [PubMed - indexed for MEDLINE]Related articlesFree article

Sulfonylurea receptor 1 and Kir6.2 expression in the novel human insulin-secreting cell line NES2Y.

Macfarlane WM, O'Brien RE, Barnes PD, Shepherd RM, Cosgrove KE, Lindley KJ, Aynsley-Green A, James RF, Docherty K, Dunne MJ.

Diabetes. 2000 Jun;49(6):953-60.PMID: 10866047 [PubMed - indexed for MEDLINE]Related articlesFree article

Persistent hyperinsulinaemic hyperglycaemia of infancy-derived cells; implications for beta-cells that replicate in vitro.

Dunne MJ, Shepherd RM, Cosgrove KE, Macfarlane WM, Lindley KJ, James RF, Aynsley-Green A.

J Mol Endocrinol. 2000 Jun;24(3):313-20. Review. No abstract available. PMID: 10828824 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose regulates islet amyloid polypeptide gene transcription in a PDX1- and calcium-dependent manner.

Macfarlane WM, Campbell SC, Elrick LJ, Oates V, Bermano G, Lindley KJ, Aynsley-Green A, Dunne MJ, James RF, Docherty K.

J Biol Chem. 2000 May 19;275(20):15330-5.PMID: 10748090 [PubMed - indexed for MEDLINE]Related articlesFree article

Ions, genes and insulin release: from basic science to clinical disease. Based on the 1998 R. D. Lawrence Lecture.

Dunne MJ.

Diabet Med. 2000 Feb;17(2):91-104. Review.PMID: 10746478 [PubMed - indexed for MEDLINE]Related articles

Hyperinsulinism of infancy: towards an understanding of unregulated insulin release. European Network for Research into Hyperinsulinism in Infancy.

Shepherd RM, Cosgrove KE, O'Brien RE, Barnes PD, Ammälä C, Dunne MJ.

Arch Dis Child Fetal Neonatal Ed. 2000 Mar;82(2):F87-97. Review.PMID: 10685980 [PubMed - indexed for MEDLINE]Related articlesFree article

ATP-sensitive potassium channels and efaroxan-induced insulin release in the electrofusion-derived BRIN-BD11 beta-cell line.

Chapman JC, McClenaghan NH, Cosgrove KE, Hashmi MN, Shepherd RM, Giesberts AN, White SJ, Ammälä C, Flatt PR, Dunne MJ.

Diabetes. 1999 Dec;48(12):2349-57.PMID: 10580423 [PubMed - indexed for MEDLINE]Related articlesFree article

Engineering a glucose-responsive human insulin-secreting cell line from islets of Langerhans isolated from a patient with persistent hyperinsulinemic hypoglycemia of infancy.

MacFarlane WM, Chapman JC, Shepherd RM, Hashmi MN, Kamimura N, Cosgrove KE, O'Brien RE, Barnes PD, Hart AW, Docherty HM, Lindley KJ, Aynsley-Green A, James RF, Docherty K, Dunne MJ.

J Biol Chem. 1999 Nov 26;274(48):34059-66.PMID: 10567373 [PubMed - indexed for MEDLINE]Related articlesFree article

A point mutation inactivating the sulfonylurea receptor causes the severe form of persistent hyperinsulinemic hypoglycemia of infancy in Finland.

Otonkoski T, Ammälä C, Huopio H, Cote GJ, Chapman J, Cosgrove K, Ashfield R, Huang E, Komulainen J, Ashcroft FM, Dunne MJ, Kere J, Thomas PM.

Diabetes. 1999 Feb;48(2):408-15.PMID: 10334322 [PubMed - indexed for MEDLINE]Related articlesFree article

Potassium Channels, Sulphonylurea Receptors and Control of Insulin Release.

Dunne MJ, Cosgrove KE, Shepherd RM, Ämmälä C.

Trends Endocrinol Metab. 1999 May;10(4):146-152.PMID: 10322409 [PubMed - as supplied by publisher]Related articles

Affinity isolation of imidazoline binding proteins from rat brain using 5-amino-efaroxan as a ligand.

Monks LK, Cosgrove KE, Dunne MJ, Ramsden CA, Morgan NG, Chan SL.

FEBS Lett. 1999 Mar 19;447(1):61-4.PMID: 10218583 [PubMed - indexed for MEDLINE]Related articles

Insulinotropic effect of new glibenclamide isosteres.

Ouedraogo R, Nguyen QA, Kane MH, Dunne MJ, Pochet L, Masereel B, Lebrun P.

J Pharmacol Exp Ther. 1999 May;289(2):625-31.PMID: 10215632 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterisation of new efaroxan derivatives for use in purification of imidazoline-binding sites.

Chan SL, Pallett AL, Clews J, Ramsden CA, Chapman JC, Kane C, Dunne MJ, Morgan NG.

Eur J Pharmacol. 1998 Aug 14;355(1):67-76.PMID: 9754940 [PubMed - indexed for MEDLINE]Related articles

Glucose augmentation of mastoparan-stimulated insulin secretion in rat and human pancreatic islets.

Straub SG, James RF, Dunne MJ, Sharp GW.

Diabetes. 1998 Jul;47(7):1053-7.PMID: 9648828 [PubMed - indexed for MEDLINE]Related articlesFree article

Ions and genes in persistent hyperinsulinaemic hypoglycaemia in infancy: a commentary on the implications for tailoring treatment to disease pathogenesis.

Aynsley-Green A, Dunne MJ, James RF, Lindley KJ.

J Pediatr Endocrinol Metab. 1998 Mar;11 Suppl 1:121-9. Review. No abstract available. PMID: 9642650 [PubMed - indexed for MEDLINE]Related articles

Intra-arterial calcium stimulation test in the investigation of hyperinsulinaemic hypoglycaemia.

Abernethy LJ, Davidson DC, Lamont GL, Shepherd RM, Dunne MJ.

Arch Dis Child. 1998 Apr;78(4):359-63.PMID: 9623401 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose activates both K(ATP) channel-dependent and K(ATP) channel-independent signaling pathways in human islets.

Straub SG, James RF, Dunne MJ, Sharp GW.

Diabetes. 1998 May;47(5):758-63.PMID: 9588447 [PubMed - indexed for MEDLINE]Related articlesFree article

Verapamil, a phenylalkylamine Ca2+ channel blocker, inhibits ATP-sensitive K+ channels in insulin-secreting cells from rats.

Lebrun P, Antoine MH, Ouedraogo R, Pirotte B, Herchuelz A, Cosgrove KE, Kane C, Dunne MJ.

Diabetologia. 1997 Dec;40(12):1403-10.PMID: 9447947 [PubMed - indexed for MEDLINE]Related articles

Therapy for persistent hyperinsulinemic hypoglycemia of infancy. Understanding the responsiveness of beta cells to diazoxide and somatostatin.

Kane C, Lindley KJ, Johnson PR, James RF, Milla PJ, Aynsley-Green A, Dunne MJ.

J Clin Invest. 1997 Oct 1;100(7):1888-93.PMID: 9312191 [PubMed - indexed for MEDLINE]Related articlesFree article

Familial persistent hyperinsulinemic hypoglycemia of infancy and mutations in the sulfonylurea receptor.

Dunne MJ, Kane C, Shepherd RM, Sanchez JA, James RF, Johnson PR, Aynsley-Green A, Lu S, Clement JP 4th, Lindley KJ, Seino S, Aguilar-Bryan L.

N Engl J Med. 1997 Mar 6;336(10):703-6. No abstract available. PMID: 9041101 [PubMed - indexed for MEDLINE]Related articles

Characterization of purinergic receptor-evoked increases in intracellular Ca2+ transients in isolated human and rodent insulin-secreting cells. Purinergic receptor signalling and [Ca2+]i in human beta-cells.

Squires PE, James RF, London NJ, Dunne MJ.

Adv Exp Med Biol. 1997;426:173-9. No abstract available. PMID: 9544271 [PubMed - indexed for MEDLINE]Related articles

Novel actions of the potassium channel modulator SDZ PCO 400 on ATP-regulated potassium channels in insulin secreting cells. SDZ PCO 400 and beta-cells.

Harding EA, Dunne MJ.

Adv Exp Med Biol. 1997;426:51-8. No abstract available. PMID: 9544255 [PubMed - indexed for MEDLINE]Related articles

Modulation of three types of potassium selective channels by NAD and other pyridine nucleotides in human pancreatic beta-cells. NAD and K+ channels in human beta-cells.

Harding EA, Kane C, James RF, London NJ, Dunne MJ.

Adv Exp Med Biol. 1997;426:43-50. No abstract available. PMID: 9544254 [PubMed - indexed for MEDLINE]Related articles

Loss of functional KATP channels in pancreatic beta-cells causes persistent hyperinsulinemic hypoglycemia of infancy.

Kane C, Shepherd RM, Squires PE, Johnson PR, James RF, Milla PJ, Aynsley-Green A, Lindley KJ, Dunne MJ.

Nat Med. 1996 Dec;2(12):1344-7.PMID: 8946833 [PubMed - indexed for MEDLINE]Related articles

Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: implications for stimulus-response coupling of insulin release.

Shepherd RM, Hashmi MN, Kane C, Squires PE, Dunne MJ.

Br J Pharmacol. 1996 Nov;119(5):911-6.PMID: 8922740 [PubMed - indexed for MEDLINE]Related articlesFree article

Ionic control of beta cell function in nesidioblastosis. A possible therapeutic role for calcium channel blockade.

Lindley KJ, Dunne MJ, Kane C, Shepherd RM, Squires PE, James RF, Johnson PR, Eckhardt S, Wakeling E, Dattani M, Milla PJ, Aynsley-Green A.

Arch Dis Child. 1996 May;74(5):373-8.PMID: 8669951 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of intracellular Ca2+ in response to muscarinic and glutamate receptor agonists during the differentiation of NTERA2 human embryonal carcinoma cells into neurons.

Squires PE, Wakeman JA, Chapman H, Kumpf S, Fidock MD, Andrews PW, Dunne MJ.

Eur J Neurosci. 1996 Apr;8(4):783-93.PMID: 9081629 [PubMed - indexed for MEDLINE]Related articles

Potassium channels, imidazolines, and insulin-secreting cells.

Dunne MJ, Harding EA, Jaggar JH, Squires PE, Liang R, Kane C, James RF, London NJ.

Ann N Y Acad Sci. 1995 Jul 12;763:243-61. Review. No abstract available. PMID: 7677335 [PubMed - indexed for MEDLINE]Related articles

Intracellular Ca2+ signals in human-derived pancreatic somatostatin-secreting cells (QGP-1N).

Squires PE, Amiranoff B, Dunne MJ.

Pflugers Arch. 1994 Oct;428(3-4):275-82.PMID: 7816549 [PubMed - indexed for MEDLINE]Related articles

Phorbol myristate acetate and ATP-sensitive potassium channels in insulin-secreting cells.

Dunne MJ.

Am J Physiol. 1994 Aug;267(2 Pt 1):C501-6.PMID: 8074184 [PubMed - indexed for MEDLINE]Related articles

ATP-induced intracellular Ca2+ signals in isolated human insulin-secreting cells.

Squires PE, James RF, London NJ, Dunne MJ.

Pflugers Arch. 1994 May;427(1-2):181-3.PMID: 8058469 [PubMed - indexed for MEDLINE]Related articles