PubMed

High prevalence of metabolic syndrome in first-degree male relatives of women with polycystic ovary syndrome is related to high rates of obesity.

Coviello AD, Sam S, Legro RS, Dunaif A.

J Clin Endocrinol Metab. 2009 Nov;94(11):4361-6. Epub 2009 Oct 16.PMID: 19837913 [PubMed - in process]Related articles

PDE8A genetic variation, polycystic ovary syndrome and androgen levels in women.

Chen C, Wickenheisser J, Ewens KG, Ankener W, Legro RS, Dunaif A, McAllister JM, Spielman RS, Strauss JF 3rd.

Mol Hum Reprod. 2009 Aug;15(8):459-69. Epub 2009 May 29.PMID: 19482904 [PubMed - indexed for MEDLINE]Related articles

The role of genetic variation in the lamin a/c gene in the etiology of polycystic ovary syndrome.

Urbanek M, Nampiaparampil G, D'Souza J, Sefton E, Ackerman C, Legro RS, Dunaif A.

J Clin Endocrinol Metab. 2009 Jul;94(7):2665-9. Epub 2009 Apr 28.PMID: 19401371 [PubMed - indexed for MEDLINE]Related articles

Evidence for association between polycystic ovary syndrome (PCOS) and TCF7L2 and glucose intolerance in women with PCOS and TCF7L2.

Biyasheva A, Legro RS, Dunaif A, Urbanek M.

J Clin Endocrinol Metab. 2009 Jul;94(7):2617-25. Epub 2009 Apr 7.PMID: 19351735 [PubMed - indexed for MEDLINE]Related articles

The vital role of ORWH.

Hultgren S, Goldstein JM, Delancey JO, Bandstra ES, Brady KT, Brown JS, Deng HW, Dunaif A, Ehrmann DA, Mayer EA, Sinha R, Tobet S, Levine JE.

Science. 2009 Feb 20;323(5917):1009-10. No abstract available. PMID: 19229019 [PubMed - indexed for MEDLINE]Related articles

Transient prenatal androgen exposure produces metabolic syndrome in adult female rats.

Demissie M, Lazic M, Foecking EM, Aird F, Dunaif A, Levine JE.

Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E262-8. Epub 2008 Jun 10.PMID: 18544644 [PubMed - indexed for MEDLINE]Related articlesFree article

Drug insight: insulin-sensitizing drugs in the treatment of polycystic ovary syndrome--a reappraisal.

Dunaif A; Medscape.

Nat Clin Pract Endocrinol Metab. 2008 May;4(5):272-83. Epub 2008 Mar 25. Review.PMID: 18364705 [PubMed - indexed for MEDLINE]Related articles

Metabolic phenotype in the brothers of women with polycystic ovary syndrome.

Sam S, Coviello AD, Sung YA, Legro RS, Dunaif A.

Diabetes Care. 2008 Jun;31(6):1237-41. Epub 2008 Mar 10.PMID: 18332151 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence for pancreatic beta-cell dysfunction in brothers of women with polycystic ovary syndrome.

Sam S, Sung YA, Legro RS, Dunaif A.

Metabolism. 2008 Jan;57(1):84-9.PMID: 18078863 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of a polycystic ovary syndrome susceptibility variant in fibrillin-3 and association with a metabolic phenotype.

Urbanek M, Sam S, Legro RS, Dunaif A.

J Clin Endocrinol Metab. 2007 Nov;92(11):4191-8. Epub 2007 Sep 4.PMID: 17785364 [PubMed - indexed for MEDLINE]Related articlesFree article

The adipose cell lineage is not intrinsically insulin resistant in polycystic ovary syndrome.

Corbould A, Dunaif A.

Metabolism. 2007 May;56(5):716-22.PMID: 17445549 [PubMed - indexed for MEDLINE]Related articlesFree article

Endothelial function varies according to insulin resistance disease type.

Beckman JA, Goldfine AB, Dunaif A, Gerhard-Herman M, Creager MA.

Diabetes Care. 2007 May;30(5):1226-32. Epub 2007 Jan 29.PMID: 17261751 [PubMed - indexed for MEDLINE]Related articlesFree article

Fine mapping of genetic susceptibility to polycystic ovary syndrome on chromosome 19p13.2 and tests for regulatory activity.

Stewart DR, Dombroski BA, Urbanek M, Ankener W, Ewens KG, Wood JR, Legro RS, Strauss JF 3rd, Dunaif A, Spielman RS.

J Clin Endocrinol Metab. 2006 Oct;91(10):4112-7. Epub 2006 Jul 25.PMID: 16868051 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin resistance in women with polycystic ovary syndrome.

Dunaif A.

Fertil Steril. 2006 Jul;86 Suppl 1:S13-4.PMID: 16798274 [PubMed - indexed for MEDLINE]Related articles

Evidence for metabolic and reproductive phenotypes in mothers of women with polycystic ovary syndrome.

Sam S, Legro RS, Essah PA, Apridonidze T, Dunaif A.

Proc Natl Acad Sci U S A. 2006 May 2;103(18):7030-5. Epub 2006 Apr 21.PMID: 16632599 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced mitogenic signaling in skeletal muscle of women with polycystic ovary syndrome.

Corbould A, Zhao H, Mirzoeva S, Aird F, Dunaif A.

Diabetes. 2006 Mar;55(3):751-9.PMID: 16505239 [PubMed - indexed for MEDLINE]Related articlesFree article

Adolescent girls with polycystic ovary syndrome have an increased risk of the metabolic syndrome associated with increasing androgen levels independent of obesity and insulin resistance.

Coviello AD, Legro RS, Dunaif A.

J Clin Endocrinol Metab. 2006 Feb;91(2):492-7. Epub 2005 Oct 25.PMID: 16249280 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased transcription and increased messenger ribonucleic acid (mRNA) stability contribute to increased GATA6 mRNA abundance in polycystic ovary syndrome theca cells.

Ho CK, Wood JR, Stewart DR, Ewens K, Ankener W, Wickenheisser J, Nelson-Degrave V, Zhang Z, Legro RS, Dunaif A, McAllister JM, Spielman R, Strauss JF 3rd.

J Clin Endocrinol Metab. 2005 Dec;90(12):6596-602. Epub 2005 Sep 13.PMID: 16159937 [PubMed - indexed for MEDLINE]Related articlesFree article

Candidate gene region for polycystic ovary syndrome on chromosome 19p13.2.

Urbanek M, Woodroffe A, Ewens KG, Diamanti-Kandarakis E, Legro RS, Strauss JF 3rd, Dunaif A, Spielman RS.

J Clin Endocrinol Metab. 2005 Dec;90(12):6623-9. Epub 2005 Aug 9.PMID: 16091490 [PubMed - indexed for MEDLINE]Related articlesFree article

Dyslipidemia and metabolic syndrome in the sisters of women with polycystic ovary syndrome.

Sam S, Legro RS, Bentley-Lewis R, Dunaif A.

J Clin Endocrinol Metab. 2005 Aug;90(8):4797-802. Epub 2005 May 17.PMID: 15899949 [PubMed - indexed for MEDLINE]Related articlesFree article

Changes in glucose tolerance over time in women with polycystic ovary syndrome: a controlled study.

Legro RS, Gnatuk CL, Kunselman AR, Dunaif A.

J Clin Endocrinol Metab. 2005 Jun;90(6):3236-42. Epub 2005 Mar 29.PMID: 15797965 [PubMed - indexed for MEDLINE]Related articlesFree article

Polycystic ovaries are common in women with hyperandrogenic chronic anovulation but do not predict metabolic or reproductive phenotype.

Legro RS, Chiu P, Kunselman AR, Bentley CM, Dodson WC, Dunaif A.

J Clin Endocrinol Metab. 2005 May;90(5):2571-9. Epub 2005 Feb 15.PMID: 15713728 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin resistance in the skeletal muscle of women with PCOS involves intrinsic and acquired defects in insulin signaling.

Corbould A, Kim YB, Youngren JF, Pender C, Kahn BB, Lee A, Dunaif A.

Am J Physiol Endocrinol Metab. 2005 May;288(5):E1047-54. Epub 2004 Dec 21.PMID: 15613682 [PubMed - indexed for MEDLINE]Related articlesFree article

Polycystic ovary syndrome: syndrome XX?

Sam S, Dunaif A.

Trends Endocrinol Metab. 2003 Oct;14(8):365-70. Review.PMID: 14516934 [PubMed - indexed for MEDLINE]Related articles

Hyperandrogenemia is necessary but not sufficient for polycystic ovary syndrome.

Dunaif A.

Fertil Steril. 2003 Aug;80(2):262-3. No abstract available. PMID: 12909482 [PubMed - indexed for MEDLINE]Related articles

Stromal cells of the human postmenopausal ovary display a distinctive biochemical and molecular phenotype.

Jabara S, Christenson LK, Wang CY, McAllister JM, Javitt NB, Dunaif A, Strauss JF 3rd.

J Clin Endocrinol Metab. 2003 Jan;88(1):484-92.PMID: 12519894 [PubMed - indexed for MEDLINE]Related articlesFree article

Variation in resistin gene promoter not associated with polycystic ovary syndrome.

Urbanek M, Du Y, Silander K, Collins FS, Steppan CM, Strauss JF 3rd, Dunaif A, Spielman RS, Legro RS.

Diabetes. 2003 Jan;52(1):214-7.PMID: 12502516 [PubMed - indexed for MEDLINE]Related articlesFree article

Toward optimal health: the experts discuss polycystic ovary syndrome.

Dunaif A, Lobo RA.

J Womens Health Gend Based Med. 2002 Sep;11(7):579-84. No abstract available. PMID: 12396891 [PubMed - indexed for MEDLINE]Related articles

Decreased insulin receptor (IR) autophosphorylation in fibroblasts from patients with PCOS: effects of serine kinase inhibitors and IR activators.

Li M, Youngren JF, Dunaif A, Goldfine ID, Maddux BA, Zhang BB, Evans JL.

J Clin Endocrinol Metab. 2002 Sep;87(9):4088-93.PMID: 12213853 [PubMed - indexed for MEDLINE]Related articlesFree article

Self-selected women with polycystic ovary syndrome are reproductively and metabolically abnormal and undertreated.

Legro RS, Urbanek M, Kunselman AR, Leiby BE, Dunaif A.

Fertil Steril. 2002 Jul;78(1):51-7.PMID: 12095490 [PubMed - indexed for MEDLINE]Related articles

Elevated dehydroepiandrosterone sulfate levels as the reproductive phenotype in the brothers of women with polycystic ovary syndrome.

Legro RS, Kunselman AR, Demers L, Wang SC, Bentley-Lewis R, Dunaif A.

J Clin Endocrinol Metab. 2002 May;87(5):2134-8.PMID: 11994353 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin resistance in the sisters of women with polycystic ovary syndrome: association with hyperandrogenemia rather than menstrual irregularity.

Legro RS, Bentley-Lewis R, Driscoll D, Wang SC, Dunaif A.

J Clin Endocrinol Metab. 2002 May;87(5):2128-33.PMID: 11994352 [PubMed - indexed for MEDLINE]Related articlesFree article

Menstrual cycle irregularity and risk for future cardiovascular disease.

Solomon CG, Hu FB, Dunaif A, Rich-Edwards JE, Stampfer MJ, Willett WC, Speizer FE, Manson JE.

J Clin Endocrinol Metab. 2002 May;87(5):2013-7.PMID: 11994334 [PubMed - indexed for MEDLINE]Related articlesFree article

Screening for abnormal glucose tolerance in adolescents with polycystic ovary syndrome.

Palmert MR, Gordon CM, Kartashov AI, Legro RS, Emans SJ, Dunaif A.

J Clin Endocrinol Metab. 2002 Mar;87(3):1017-23.PMID: 11889155 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevalence and predictors of dyslipidemia in women with polycystic ovary syndrome.

Legro RS, Kunselman AR, Dunaif A.

Am J Med. 2001 Dec 1;111(8):607-13.PMID: 11755503 [PubMed - indexed for MEDLINE]Related articles

Long or highly irregular menstrual cycles as a marker for risk of type 2 diabetes mellitus.

Solomon CG, Hu FB, Dunaif A, Rich-Edwards J, Willett WC, Hunter DJ, Colditz GA, Speizer FE, Manson JE.

JAMA. 2001 Nov 21;286(19):2421-6.PMID: 11712937 [PubMed - indexed for MEDLINE]Related articlesFree article

Defects in insulin receptor signaling in vivo in the polycystic ovary syndrome (PCOS).

Dunaif A, Wu X, Lee A, Diamanti-Kandarakis E.

Am J Physiol Endocrinol Metab. 2001 Aug;281(2):E392-9.PMID: 11440917 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased prevalence of obstructive sleep apnea syndrome in obese women with polycystic ovary syndrome.

Fogel RB, Malhotra A, Pillar G, Pittman SD, Dunaif A, White DP.

J Clin Endocrinol Metab. 2001 Mar;86(3):1175-80.PMID: 11238505 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin resistance in polycystic ovary syndrome: progress and paradoxes.

Venkatesan AM, Dunaif A, Corbould A.

Recent Prog Horm Res. 2001;56:295-308. Review.PMID: 11237218 [PubMed - indexed for MEDLINE]Related articlesFree article

Current concepts in the polycystic ovary syndrome.

Dunaif A, Thomas A.

Annu Rev Med. 2001;52:401-19. Review.PMID: 11160786 [PubMed - indexed for MEDLINE]Related articles

Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways.

Rui L, Aguirre V, Kim JK, Shulman GI, Lee A, Corbould A, Dunaif A, White MF.

J Clin Invest. 2001 Jan;107(2):181-9.PMID: 11160134 [PubMed - indexed for MEDLINE]Related articlesFree article

Allelic variants of the follistatin gene in polycystic ovary syndrome.

Urbanek M, Wu X, Vickery KR, Kao LC, Christenson LK, Schneyer A, Legro RS, Driscoll DA, Strauss JF 3rd, Dunaif A, Spielman RS.

J Clin Endocrinol Metab. 2000 Dec;85(12):4455-61.PMID: 11134093 [PubMed - indexed for MEDLINE]Related articlesFree article

Searching for the polycystic ovary syndrome genes.

Urbanek M, Legro RS, Driscoll D, Strauss JF 3rd, Dunaif A, Spielman RS.

J Pediatr Endocrinol Metab. 2000;13 Suppl 5:1311-3. Review.PMID: 11117677 [PubMed - indexed for MEDLINE]Related articles

Enzymatic activities of P450c17 stably expressed in fibroblasts from patients with the polycystic ovary syndrome.

Martens JW, Geller DH, Arlt W, Auchus RJ, Ossovskaya VS, Rodriguez H, Dunaif A, Miller WL.

J Clin Endocrinol Metab. 2000 Nov;85(11):4338-46.PMID: 11095477 [PubMed - indexed for MEDLINE]Related articlesFree article

Citation for the 2000 Monsanto Clinical Investigator Award Lecture of The Endocrine Society to Dr. William F. Crowley.

Dunaif A.

Endocr Rev. 2000 Aug;21(4):449-50. No abstract available. PMID: 10950164 [PubMed - indexed for MEDLINE]Related articles

Minimal-model estimates of insulin sensitivity are insensitive to errors in glucose effectiveness.

McDonald C, Dunaif A, Finegood DT.

J Clin Endocrinol Metab. 2000 Jul;85(7):2504-8.PMID: 10902801 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective insulin resistance in the polycystic ovary syndrome.

Book CB, Dunaif A.

J Clin Endocrinol Metab. 1999 Sep;84(9):3110-6.PMID: 10487672 [PubMed - indexed for MEDLINE]Related articlesFree article

Thirty-seven candidate genes for polycystic ovary syndrome: strongest evidence for linkage is with follistatin.

Urbanek M, Legro RS, Driscoll DA, Azziz R, Ehrmann DA, Norman RJ, Strauss JF 3rd, Spielman RS, Dunaif A.

Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8573-8.PMID: 10411917 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular mysteries of polycystic ovary syndrome.

Strauss JF 3rd, Dunaif A.

Mol Endocrinol. 1999 Jun;13(6):800-5. Review. No abstract available. PMID: 10379878 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin action in the polycystic ovary syndrome.

Dunaif A.

Endocrinol Metab Clin North Am. 1999 Jun;28(2):341-59. Review.PMID: 10352922 [PubMed - indexed for MEDLINE]Related articles