PubMed

Evaluation of the potential for steady-state pharmacokinetic and pharmacodynamic interactions between the DPP-4 inhibitor linagliptin and metformin in healthy subjects.

Graefe-Mody EU, Padula S, Ring A, Withopf B, Dugi KA.

Curr Med Res Opin. 2009 Aug;25(8):1963-72.PMID: 19552619 [PubMed - indexed for MEDLINE]Related articles

The proline 12 alanine substitution in the PPARgamma2 gene is associated with increased extent of coronary artery disease in men.

Schneider JG, Schiekofer S, Eynatten M, Schlimmer P, Dugi KA.

Exp Clin Endocrinol Diabetes. 2009 Oct;117(9):519-21. Epub 2009 Jun 17.PMID: 19536733 [PubMed - in process]Related articles

Pharmacokinetics, pharmacodynamics and tolerability of multiple oral doses of linagliptin, a dipeptidyl peptidase-4 inhibitor in male type 2 diabetes patients.

Heise T, Graefe-Mody EU, Hüttner S, Ring A, Trommeshauser D, Dugi KA.

Diabetes Obes Metab. 2009 Aug;11(8):786-94. Epub 2009 May 19.PMID: 19476474 [PubMed - in process]Related articles

PPAR gamma variant influences angiographic outcome and 10-year cardiovascular risk in male symptomatic coronary artery disease patients: response to Regieli et al.

Schneider JG, Schiekofer S, von Eynatten M, Dugi KA.

Diabetes Care. 2009 Jun;32(6):e75; author reply e76. No abstract available. PMID: 19460911 [PubMed - indexed for MEDLINE]Related articlesFree article

Safety, tolerability, pharmacokinetics, and pharmacodynamics of single oral doses of BI 1356, an inhibitor of dipeptidyl peptidase 4, in healthy male volunteers.

Hüttner S, Graefe-Mody EU, Withopf B, Ring A, Dugi KA.

J Clin Pharmacol. 2008 Oct;48(10):1171-8.PMID: 18812608 [PubMed - indexed for MEDLINE]Related articles

Changes in adiponectin multimer distribution in response to atorvastatin treatment in patients with type 2 diabetes.

von Eynatten M, Liu D, Bluemm A, Schuster T, Baumann M, Lutz J, Heemann U, Dugi KA, Nawroth PP, Bierhaus A, Humpert PM.

Clin Endocrinol (Oxf). 2009 Jul;71(1):27-32.PMID: 18778396 [PubMed - indexed for MEDLINE]Related articles

High-molecular weight adiponectin is independently associated with the extent of coronary artery disease in men.

von Eynatten M, Humpert PM, Bluemm A, Lepper PM, Hamann A, Allolio B, Nawroth PP, Bierhaus A, Dugi KA.

Atherosclerosis. 2008 Jul;199(1):123-8. Epub 2007 Nov 19.PMID: 18021784 [PubMed - indexed for MEDLINE]Related articles

Retinol-binding protein 4 is associated with components of the metabolic syndrome, but not with insulin resistance, in men with type 2 diabetes or coronary artery disease.

von Eynatten M, Lepper PM, Liu D, Lang K, Baumann M, Nawroth PP, Bierhaus A, Dugi KA, Heemann U, Allolio B, Humpert PM.

Diabetologia. 2007 Sep;50(9):1930-7. Epub 2007 Jul 18.PMID: 17639305 [PubMed - indexed for MEDLINE]Related articles

Increased gene expression of scavenger receptors and proinflammatory markers in peripheral blood mononuclear cells of hyperlipidemic males.

Bonaterra GA, Hildebrandt W, Bodens A, Sauer R, Dugi KA, Deigner HP, Turcanu D, Heinle H, Dröge W, Metz J, Kinscherf R.

J Mol Med. 2007 Feb;85(2):181-90. Epub 2006 Oct 17.PMID: 17043800 [PubMed - indexed for MEDLINE]Related articles

Serum adiponectin levels are an independent predictor of the extent of coronary artery disease in men.

von Eynatten M, Schneider JG, Humpert PM, Kreuzer J, Kuecherer H, Katus HA, Nawroth PP, Dugi KA.

J Am Coll Cardiol. 2006 May 16;47(10):2124-6. Epub 2006 Apr 24. No abstract available. PMID: 16697337 [PubMed - indexed for MEDLINE]Related articles

Atorvastatin increases lipoprotein lipase expression in vitro and activity in vivo.

Schneider JG, Eynatten MV, Dugi KA.

J Atheroscler Thromb. 2005;12(4):232-3. No abstract available. PMID: 16148403 [PubMed - indexed for MEDLINE]Related articlesFree article

Low plasma adiponectin levels are associated with increased hepatic lipase activity in vivo.

Schneider JG, von Eynatten M, Schiekofer S, Nawroth PP, Dugi KA.

Diabetes Care. 2005 Sep;28(9):2181-6.PMID: 16123487 [PubMed - indexed for MEDLINE]Related articlesFree article

Adipocytokines as a novel target for the anti-inflammatory effect of atorvastatin in patients with type 2 diabetes.

von Eynatten M, Schneider JG, Hadziselimovic S, Hamann A, Bierhaus A, Nawroth PP, Dugi KA.

Diabetes Care. 2005 Mar;28(3):754-5. No abstract available. PMID: 15735224 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased cyclooxygenase-2 expression in peripheral blood mononuclear cells of smokers and hyperlipidemic subjects.

Bonaterra GA, Hildebrandt W, Bodens A, Sauer R, Dugi KA, Deigner HP, Dröge W, Metz J, Kinscherf R.

Free Radic Biol Med. 2005 Jan 15;38(2):235-42.PMID: 15607906 [PubMed - indexed for MEDLINE]Related articles

Decreased plasma lipoprotein lipase in hypoadiponectinemia: an association independent of systemic inflammation and insulin resistance.

von Eynatten M, Schneider JG, Humpert PM, Rudofsky G, Schmidt N, Barosch P, Hamann A, Morcos M, Kreuzer J, Bierhaus A, Nawroth PP, Dugi KA.

Diabetes Care. 2004 Dec;27(12):2925-9.PMID: 15562208 [PubMed - indexed for MEDLINE]Related articlesFree article

Atorvastatin improves diabetic dyslipidemia and increases lipoprotein lipase activity in vivo.

Schneider JG, von Eynatten M, Parhofer KG, Volkmer JE, Schiekofer S, Hamann A, Nawroth PP, Dugi KA.

Atherosclerosis. 2004 Aug;175(2):325-31.PMID: 15262189 [PubMed - indexed for MEDLINE]Related articles

Activation of tubular epithelial cells in diabetic nephropathy.

Morcos M, Sayed AA, Bierhaus A, Yard B, Waldherr R, Merz W, Kloeting I, Schleicher E, Mentz S, Abd el Baki RF, Tritschler H, Kasper M, Schwenger V, Hamann A, Dugi KA, Schmidt AM, Stern D, Ziegler R, Haering HU, Andrassy M, van der Woude F, Nawroth PP.

Diabetes. 2002 Dec;51(12):3532-44.PMID: 12453911 [PubMed - indexed for MEDLINE]Related articlesFree article

Siblings with hepatosplenomegaly and lipoprotein lipase deficiency.

Schneider JG, Schaefer S, Lettgen B, Keiper T, Nawroth PP, Dugi KA.

Lancet. 2002 Oct 12;360(9340):1150. No abstract available. PMID: 12387965 [PubMed - indexed for MEDLINE]Related articles

Recurrent deep venous thrombosis caused by congenital interruption of the inferior vena cava and heterozygous factor V Leiden mutation.

Schneider JG, Eynatten MV, Dugi KA, Duex M, Nawroth PP.

J Intern Med. 2002 Sep;252(3):276-80.PMID: 12270010 [PubMed - indexed for MEDLINE]Related articles

Activity and concentration of lipoprotein lipase in post-heparin plasma and the extent of coronary artery disease.

Dugi KA, Schmidt N, Brandauer K, Ramacher D, Fiehn W, Kreuzer J.

Atherosclerosis. 2002 Jul;163(1):127-34.PMID: 12048130 [PubMed - indexed for MEDLINE]Related articles

The proline 12 alanine substitution in the peroxisome proliferator--activated receptor-gamma2 gene is associated with lower lipoprotein lipase activity in vivo.

Schneider J, Kreuzer J, Hamann A, Nawroth PP, Dugi KA.

Diabetes. 2002 Mar;51(3):867-70.PMID: 11872694 [PubMed - indexed for MEDLINE]Related articlesFree article

Low hepatic lipase activity is a novel risk factor for coronary artery disease.

Dugi KA, Brandauer K, Schmidt N, Nau B, Schneider JG, Mentz S, Keiper T, Schaefer JR, Meissner C, Kather H, Bahner ML, Fiehn W, Kreuzer J.

Circulation. 2001 Dec 18;104(25):3057-62.PMID: 11748100 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel site in lipoprotein lipase (LPL415;-438) essential for substrate interaction and dimer stability.

Keiper T, Schneider JG, Dugi KA.

J Lipid Res. 2001 Aug;42(8):1180-6.PMID: 11483618 [PubMed - indexed for MEDLINE]Related articlesFree article

The endothelium and lipoproteins: insights from recent cell biology and animal studies.

Rader DJ, Dugi KA.

Semin Thromb Hemost. 2000;26(5):521-8. Review.PMID: 11129408 [PubMed - indexed for MEDLINE]Related articles

Lipoproteins and the endothelium: insights from clinical research.

Dugi KA, Rader DJ.

Semin Thromb Hemost. 2000;26(5):513-9. Review.PMID: 11129407 [PubMed - indexed for MEDLINE]Related articles

In vivo evidence for both lipolytic and nonlipolytic function of hepatic lipase in the metabolism of HDL.

Dugi KA, Amar MJ, Haudenschild CC, Shamburek RD, Bensadoun A, Hoyt RF Jr, Fruchart-Najib J, Madj Z, Brewer HB Jr, Santamarina-Fojo S.

Arterioscler Thromb Vasc Biol. 2000 Mar;20(3):793-800.PMID: 10712405 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic lipase facilitates the selective uptake of cholesteryl esters from remnant lipoproteins in apoE-deficient mice.

Amar MJ, Dugi KA, Haudenschild CC, Shamburek RD, Foger B, Chase M, Bensadoun A, Hoyt RF Jr, Brewer HB Jr, Santamarina-Fojo S.

J Lipid Res. 1998 Dec;39(12):2436-42.PMID: 9831632 [PubMed - indexed for MEDLINE]Related articlesFree article

Adenovirus-mediated expression of hepatic lipase in LCAT transgenic mice.

Dugi KA, Vaisman BL, Sakai N, Knapper CL, Meyn SM, Brewer HB Jr, Santamarina-Fojo S.

J Lipid Res. 1997 Sep;38(9):1822-32.PMID: 9323591 [PubMed - indexed for MEDLINE]Related articlesFree article

Therapeutic response to medium-chain triglycerides and omega-3 fatty acids in a patient with the familial chylomicronemia syndrome.

Rouis M, Dugi KA, Previato L, Patterson AP, Brunzell JD, Brewer HB, Santamarina-Fojo S.

Arterioscler Thromb Vasc Biol. 1997 Jul;17(7):1400-6.PMID: 9261273 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipoprotein lipase correlates positively and hepatic lipase inversely with calcific atherosclerosis in homozygous familial hypercholesterolemia.

Dugi KA, Feuerstein IM, Hill S, Shih J, Santamarina-Fojo S, Brewer HB Jr, Hoeg JM.

Arterioscler Thromb Vasc Biol. 1997 Feb;17(2):354-64.PMID: 9081692 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of protein structure-function in vivo. Adenovirus-mediated transfer of lipase lid mutants in hepatic lipase-deficient mice.

Kobayashi J, Applebaum-Bowden D, Dugi KA, Brown DR, Kashyap VS, Parrott C, Duarte C, Maeda N, Santamarina-Fojo S.

J Biol Chem. 1996 Oct 18;271(42):26296-301.PMID: 8824281 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel A-->G mutation in intron I of the hepatic lipase gene leads to alternative splicing resulting in enzyme deficiency.

Brand K, Dugi KA, Brunzell JD, Nevin DN, Santamarina-Fojo S.

J Lipid Res. 1996 Jun;37(6):1213-23.PMID: 8808756 [PubMed - indexed for MEDLINE]Related articlesFree article

Relation of cholesterol-year score to severity of calcific atherosclerosis and tissue deposition in homozygous familial hypercholesterolemia.

Schmidt HH, Hill S, Makariou EV, Feuerstein IM, Dugi KA, Hoeg JM.

Am J Cardiol. 1996 Mar 15;77(8):575-80.PMID: 8610605 [PubMed - indexed for MEDLINE]Related articles

Homozygosity for two point mutations in the lipoprotein lipase (LPL) gene in a patient with familial LPL deficiency: LPL(Asp9-->Asn, Tyr262-->His).

Rouis M, Lohse P, Dugi KA, Lohse P, Beg OU, Ronan R, Talley GD, Brunzell JD, Santamarina-Fojo S.

J Lipid Res. 1996 Mar;37(3):651-61.PMID: 8728326 [PubMed - indexed for MEDLINE]Related articlesFree article

Human hepatic and lipoprotein lipase: the loop covering the catalytic site mediates lipase substrate specificity.

Dugi KA, Dichek HL, Santamarina-Fojo S.

J Biol Chem. 1995 Oct 27;270(43):25396-401.PMID: 7592706 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel missense mutation in the C-terminal domain of lipoprotein lipase (Glu410-->Val) leads to enzyme inactivation and familial chylomicronemia.

Previato L, Guardamagna O, Dugi KA, Ronan R, Talley GD, Santamarina-Fojo S, Brewer HB Jr.

J Lipid Res. 1994 Sep;35(9):1552-60.PMID: 7806969 [PubMed - indexed for MEDLINE]Related articlesFree article

Structure, function and role of lipoprotein lipase in lipoprotein metabolism.

Santamarina-Fojo S, Dugi KA.

Curr Opin Lipidol. 1994 Apr;5(2):117-25. Review.PMID: 8044414 [PubMed - indexed for MEDLINE]Related articles

Human lipoprotein lipase: the loop covering the catalytic site is essential for interaction with lipid substrates.

Dugi KA, Dichek HL, Talley GD, Brewer HB Jr, Santamarina-Fojo S.

J Biol Chem. 1992 Dec 15;267(35):25086-91.PMID: 1460010 [PubMed - indexed for MEDLINE]Related articlesFree article