PubMed

Extracellular growth factors and mitogens cooperate to drive mitochondrial biogenesis.

Echave P, Machado-da-Silva G, Arkell RS, Duchen MR, Jacobson J, Mitter R, Lloyd AC.

J Cell Sci. 2009 Nov 17. [Epub ahead of print]PMID: 19920079 [PubMed - as supplied by publisher]Related articles

Lack of oxygen deactivates mitochondrial complex I: implications for ischemic injury?

Galkin A, Abramov AY, Frakich N, Duchen MR, Moncada S.

J Biol Chem. 2009 Oct 27. [Epub ahead of print]PMID: 19861410 [PubMed - as supplied by publisher]Related articlesFree article

Impaired mitochondrial bioenergetics determines glutamate-induced delayed calcium deregulation in neurons.

Abramov AY, Duchen MR.

Biochim Biophys Acta. 2009 Aug 17. [Epub ahead of print]PMID: 19695307 [PubMed - as supplied by publisher]Related articles

Mitochondria modulate the spatio-temporal properties of intra- and intercellular Ca2+ signals in cochlear supporting cells.

Mann ZF, Duchen MR, Gale JE.

Cell Calcium. 2009 Aug;46(2):136-46. Epub 2009 Jul 23.PMID: 19631380 [PubMed - indexed for MEDLINE]Related articles

IF(1): setting the pace of the F(1)F(o)-ATP synthase.

Campanella M, Parker N, Tan CH, Hall AM, Duchen MR.

Trends Biochem Sci. 2009 Jul;34(7):343-50. Epub 2009 Jun 24. Review.PMID: 19559621 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial function and redox state in mammalian embryos.

Dumollard R, Carroll J, Duchen MR, Campbell K, Swann K.

Semin Cell Dev Biol. 2009 May;20(3):346-53. Review.PMID: 19530278 [PubMed - indexed for MEDLINE]Related articles

Multiphoton imaging reveals differences in mitochondrial function between nephron segments.

Hall AM, Unwin RJ, Parker N, Duchen MR.

J Am Soc Nephrol. 2009 Jun;20(6):1293-302. Epub 2009 May 21.PMID: 19470684 [PubMed - indexed for MEDLINE]Related articles

Mitochondria mediated cell death in diabetes.

Szabadkai G, Duchen MR.

Apoptosis. 2009 Dec;14(12):1405-23.PMID: 19466549 [PubMed - in process]Related articles

PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death.

Gandhi S, Wood-Kaczmar A, Yao Z, Plun-Favreau H, Deas E, Klupsch K, Downward J, Latchman DS, Tabrizi SJ, Wood NW, Duchen MR, Abramov AY.

Mol Cell. 2009 Mar 13;33(5):627-38.PMID: 19285945 [PubMed - indexed for MEDLINE]Related articlesFree article

IF1, the endogenous regulator of the F(1)F(o)-ATPsynthase, defines mitochondrial volume fraction in HeLa cells by regulating autophagy.

Campanella M, Seraphim A, Abeti R, Casswell E, Echave P, Duchen MR.

Biochim Biophys Acta. 2009 May;1787(5):393-401. Epub 2009 Mar 5.PMID: 19269273 [PubMed - indexed for MEDLINE]Related articles

Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice.

Cantley J, Selman C, Shukla D, Abramov AY, Forstreuter F, Esteban MA, Claret M, Lingard SJ, Clements M, Harten SK, Asare-Anane H, Batterham RL, Herrera PL, Persaud SJ, Duchen MR, Maxwell PH, Withers DJ.

J Clin Invest. 2009 Jan;119(1):125-35. doi: 10.1172/JCI26934. Epub 2008 Dec 8.PMID: 19065050 [PubMed - indexed for MEDLINE]Related articlesFree article

CLIC1 function is required for beta-amyloid-induced generation of reactive oxygen species by microglia.

Milton RH, Abeti R, Averaimo S, DeBiasi S, Vitellaro L, Jiang L, Curmi PM, Breit SN, Duchen MR, Mazzanti M.

J Neurosci. 2008 Nov 5;28(45):11488-99.PMID: 18987185 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of mutant SOD1 in astrocytes induces functional deficits in motoneuron mitochondria.

Bilsland LG, Nirmalananthan N, Yip J, Greensmith L, Duchen MR.

J Neurochem. 2008 Dec;107(5):1271-83. Epub 2008 Oct 25.PMID: 18808448 [PubMed - indexed for MEDLINE]Related articles

Regulation of mitochondrial structure and function by the F1Fo-ATPase inhibitor protein, IF1.

Campanella M, Casswell E, Chong S, Farah Z, Wieckowski MR, Abramov AY, Tinker A, Duchen MR.

Cell Metab. 2008 Jul;8(1):13-25.PMID: 18590689 [PubMed - indexed for MEDLINE]Related articles

PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons.

Wood-Kaczmar A, Gandhi S, Yao Z, Abramov AY, Miljan EA, Keen G, Stanyer L, Hargreaves I, Klupsch K, Deas E, Downward J, Mansfield L, Jat P, Taylor J, Heales S, Duchen MR, Latchman D, Tabrizi SJ, Wood NW.

PLoS One. 2008 Jun 18;3(6):e2455. Erratum in: PLoS ONE. 2008;3(7). doi: 10.1371/annotation/17d5aaa1-c6d8-4aad-a9a4-56b2c1220c83. Abramov, Andrey S Y [corrected to Abramov, Andrey Y]. PLoS ONE. 2008;3(7). doi: 10.1371/annotation/ba489c2a-5cf2-481c-aff7-d2c8c4ecdcfa. PMID: 18560593 [PubMed - indexed for MEDLINE]Related articlesFree article

Renal function and mitochondrial cytopathy (MC): more questions than answers?

Hall AM, Unwin RJ, Hanna MG, Duchen MR.

QJM. 2008 Oct;101(10):755-66. Epub 2008 May 16. Review.PMID: 18487272 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms underlying the loss of mitochondrial membrane potential in glutamate excitotoxicity.

Abramov AY, Duchen MR.

Biochim Biophys Acta. 2008 Jul-Aug;1777(7-8):953-64. Epub 2008 Apr 18.PMID: 18471431 [PubMed - indexed for MEDLINE]Related articles

Mitochondria: the hub of cellular Ca2+ signaling.

Szabadkai G, Duchen MR.

Physiology (Bethesda). 2008 Apr;23:84-94. Review. Erratum in: Physiology (Bethesda). 2008 Aug;23:230. PMID: 18400691 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondria and calcium in health and disease.

Duchen MR, Verkhratsky A, Muallem S.

Cell Calcium. 2008 Jul;44(1):1-5. Epub 2008 Apr 18. Review. No abstract available. PMID: 18378306 [PubMed - indexed for MEDLINE]Related articles

Assessing mitochondrial potential, calcium, and redox state in isolated mammalian cells using confocal microscopy.

Davidson SM, Yellon D, Duchen MR.

Methods Mol Biol. 2007;372:421-30.PMID: 18314743 [PubMed - indexed for MEDLINE]Related articles

Targeted polyphosphatase expression alters mitochondrial metabolism and inhibits calcium-dependent cell death.

Abramov AY, Fraley C, Diao CT, Winkfein R, Colicos MA, Duchen MR, French RJ, Pavlov E.

Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18091-6. Epub 2007 Nov 6.PMID: 17986607 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial ND5 gene variation associated with encephalomyopathy and mitochondrial ATP consumption.

McKenzie M, Liolitsa D, Akinshina N, Campanella M, Sisodiya S, Hargreaves I, Nirmalananthan N, Sweeney MG, Abou-Sleiman PM, Wood NW, Hanna MG, Duchen MR.

J Biol Chem. 2007 Dec 21;282(51):36845-52. Epub 2007 Oct 16.PMID: 17940288 [PubMed - indexed for MEDLINE]Related articlesFree article

Endothelial mitochondria: contributing to vascular function and disease.

Davidson SM, Duchen MR.

Circ Res. 2007 Apr 27;100(8):1128-41. Review.PMID: 17463328 [PubMed - indexed for MEDLINE]Related articlesFree article

Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation.

Abramov AY, Scorziello A, Duchen MR.

J Neurosci. 2007 Jan 31;27(5):1129-38.PMID: 17267568 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of redox metabolism in the mouse oocyte and embryo.

Dumollard R, Ward Z, Carroll J, Duchen MR.

Development. 2007 Feb;134(3):455-65. Epub 2006 Dec 21.PMID: 17185319 [PubMed - indexed for MEDLINE]Related articlesFree article

Calcium microdomains and oxidative stress.

Davidson SM, Duchen MR.

Cell Calcium. 2006 Nov-Dec;40(5-6):561-74. Epub 2006 Oct 17.PMID: 17049598 [PubMed - indexed for MEDLINE]Related articles

FCCP is cardioprotective at concentrations that cause mitochondrial oxidation without detectable depolarisation.

Brennan JP, Berry RG, Baghai M, Duchen MR, Shattock MJ.

Cardiovasc Res. 2006 Nov 1;72(2):322-30. Epub 2006 Aug 16.PMID: 16979603 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial uncoupling, with low concentration FCCP, induces ROS-dependent cardioprotection independent of KATP channel activation.

Brennan JP, Southworth R, Medina RA, Davidson SM, Duchen MR, Shattock MJ.

Cardiovasc Res. 2006 Nov 1;72(2):313-21. Epub 2006 Jul 29.PMID: 16950237 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of NO on mitochondrial function in cardiomyocytes: Pathophysiological relevance.

Davidson SM, Duchen MR.

Cardiovasc Res. 2006 Jul 1;71(1):10-21. Epub 2006 Mar 3. Review.PMID: 16515774 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of an astrocytic NADPH oxidase in the neurotoxicity of amyloid beta peptides.

Abramov AY, Duchen MR.

Philos Trans R Soc Lond B Biol Sci. 2005 Dec 29;360(1464):2309-14. Review.PMID: 16321801 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of beauvericin on the metabolic state and ionic homeostasis of ventricular myocytes of the guinea pig.

Kouri K, Duchen MR, Lemmens-Gruber R.

Chem Res Toxicol. 2005 Nov;18(11):1661-8.PMID: 16300374 [PubMed - indexed for MEDLINE]Related articles

Signalling via the reperfusion injury signalling kinase (RISK) pathway links closure of the mitochondrial permeability transition pore to cardioprotection.

Davidson SM, Hausenloy D, Duchen MR, Yellon DM.

Int J Biochem Cell Biol. 2006 Mar;38(3):414-9. Epub 2005 Oct 21.PMID: 16280253 [PubMed - indexed for MEDLINE]Related articles

IL-6 induces PI 3-kinase and nitric oxide-dependent protection and preserves mitochondrial function in cardiomyocytes.

Smart N, Mojet MH, Latchman DS, Marber MS, Duchen MR, Heads RJ.

Cardiovasc Res. 2006 Jan;69(1):164-77. Epub 2005 Oct 10.PMID: 16219301 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression and modulation of an NADPH oxidase in mammalian astrocytes.

Abramov AY, Jacobson J, Wientjes F, Hothersall J, Canevari L, Duchen MR.

J Neurosci. 2005 Oct 5;25(40):9176-84.PMID: 16207877 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of mitochondrial oxidative stress in astrocytes by nitric oxide precedes disruption of energy metabolism.

Jacobson J, Duchen MR, Hothersall J, Clark JB, Heales SJ.

J Neurochem. 2005 Oct;95(2):388-95. Epub 2005 Aug 16.PMID: 16104850 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial permeability transition pore as a target for cardioprotection in the human heart.

Shanmuganathan S, Hausenloy DJ, Duchen MR, Yellon DM.

Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H237-42.PMID: 15961375 [PubMed - indexed for MEDLINE]Related articlesFree article

Calcium signals induced by amyloid beta peptide and their consequences in neurons and astrocytes in culture.

Abramov AY, Canevari L, Duchen MR.

Biochim Biophys Acta. 2004 Dec 6;1742(1-3):81-7. Review.PMID: 15590058 [PubMed - indexed for MEDLINE]Related articles

Prostaglandin F2alpha potentiates the calcium dependent activation of mitochondrial metabolism in luteal cells.

Pitter JG, Szanda G, Duchen MR, Spät A.

Cell Calcium. 2005 Jan;37(1):35-44.PMID: 15541462 [PubMed - indexed for MEDLINE]Related articles

Mitochondria in health and disease: perspectives on a new mitochondrial biology.

Duchen MR.

Mol Aspects Med. 2004 Aug;25(4):365-451. Review.PMID: 15302203 [PubMed - indexed for MEDLINE]Related articles

Vascular endothelial growth factor (VEGF)-D and VEGF-A differentially regulate KDR-mediated signaling and biological function in vascular endothelial cells.

Jia H, Bagherzadeh A, Bicknell R, Duchen MR, Liu D, Zachary I.

J Biol Chem. 2004 Aug 20;279(34):36148-57. Epub 2004 Jun 23. Erratum in: J Biol Chem. 2006 Feb 24;281(8):5328. PMID: 15215251 [PubMed - indexed for MEDLINE]Related articlesFree article

Preconditioning protects by inhibiting the mitochondrial permeability transition.

Hausenloy DJ, Yellon DM, Mani-Babu S, Duchen MR.

Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H841-9. Epub 2004 Apr 8.PMID: 15072953 [PubMed - indexed for MEDLINE]Related articlesFree article

Toxicity of amyloid beta peptide: tales of calcium, mitochondria, and oxidative stress.

Canevari L, Abramov AY, Duchen MR.

Neurochem Res. 2004 Mar;29(3):637-50. Review.PMID: 15038611 [PubMed - indexed for MEDLINE]Related articles

The large-conductance Ca2+-activated K+ channel is essential for innate immunity.

Ahluwalia J, Tinker A, Clapp LH, Duchen MR, Abramov AY, Pope S, Nobles M, Segal AW.

Nature. 2004 Feb 26;427(6977):853-8.PMID: 14985765 [PubMed - indexed for MEDLINE]Related articlesFree article

Interplay between mitochondria and cellular calcium signalling.

Jacobson J, Duchen MR.

Mol Cell Biochem. 2004 Jan-Feb;256-257(1-2):209-18. Review.PMID: 14977182 [PubMed - indexed for MEDLINE]Related articles

Roles of mitochondria in health and disease.

Duchen MR.

Diabetes. 2004 Feb;53 Suppl 1:S96-102. Review.PMID: 14749273 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase.

Abramov AY, Canevari L, Duchen MR.

J Neurosci. 2004 Jan 14;24(2):565-75.PMID: 14724257 [PubMed - indexed for MEDLINE]Related articlesFree article

Flirting in little space: the ER/mitochondria Ca2+ liaison.

Rizzuto R, Duchen MR, Pozzan T.

Sci STKE. 2004 Jan 13;2004(215):re1. Review.PMID: 14722345 [PubMed - indexed for MEDLINE]Related articles

Inhibiting mitochondrial permeability transition pore opening at reperfusion protects against ischaemia-reperfusion injury.

Hausenloy DJ, Duchen MR, Yellon DM.

Cardiovasc Res. 2003 Dec 1;60(3):617-25.PMID: 14659807 [PubMed - indexed for MEDLINE]Related articlesFree article

Adaptation to heat of cardiomyoblasts in culture protects them against heat shock: role of nitric oxide and heat shock proteins.

Monastyrskaya EA, Andreeva LV, Duchen MR, Wiegant F, Bayda LA, Manukhina EB, Malyshev IY.

Biochemistry (Mosc). 2003 Jul;68(7):816-21.PMID: 12946265 [PubMed - indexed for MEDLINE]Related articles

Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity.

Abramov AY, Canevari L, Duchen MR.

J Neurosci. 2003 Jun 15;23(12):5088-95.PMID: 12832532 [PubMed - indexed for MEDLINE]Related articlesFree article