PubMed

Differential Importance of GIP Versus GLP-1 Receptor Signaling for Beta Cell Survival in Mice.

Maida A, Hansotia T, Longuet C, Seino Y, Drucker DJ.

Gastroenterology. 2009 Sep 17. [Epub ahead of print]PMID: 19766644 [PubMed - as supplied by publisher]Related articles

Differences in the central anorectic effects of glucagon-like peptide-1 and exendin-4 in rats.

Barrera JG, D'Alessio DA, Drucker DJ, Woods SC, Seeley RJ.

Diabetes. 2009 Dec;58(12):2820-7. Epub 2009 Sep 9.PMID: 19741167 [PubMed - in process]Related articles

Ciliary neurotrophic factor recruitment of glucagon-like peptide-1 mediates neurogenesis, allowing immortalization of adult murine hypothalamic neurons.

Belsham DD, Fick LJ, Dalvi PS, Centeno ML, Chalmers JA, Lee PK, Wang Y, Drucker DJ, Koletar MM.

FASEB J. 2009 Dec;23(12):4256-65. Epub 2009 Aug 24.PMID: 19703933 [PubMed - in process]Related articles

Modulation of taste sensitivity by GLP-1 signaling in taste buds.

Martin B, Dotson CD, Shin YK, Ji S, Drucker DJ, Maudsley S, Munger SD.

Ann N Y Acad Sci. 2009 Jul;1170:98-101.PMID: 19686117 [PubMed - indexed for MEDLINE]Related articles

Normalization of obesity-associated insulin resistance through immunotherapy.

Winer S, Chan Y, Paltser G, Truong D, Tsui H, Bahrami J, Dorfman R, Wang Y, Zielenski J, Mastronardi F, Maezawa Y, Drucker DJ, Engleman E, Winer D, Dosch HM.

Nat Med. 2009 Aug;15(8):921-9. Epub 2009 Jul 26.PMID: 19633657 [PubMed - indexed for MEDLINE]Related articles

A new glucagon and GLP-1 co-agonist eliminates obesity in rodents.

Day JW, Ottaway N, Patterson JT, Gelfanov V, Smiley D, Gidda J, Findeisen H, Bruemmer D, Drucker DJ, Chaudhary N, Holland J, Hembree J, Abplanalp W, Grant E, Ruehl J, Wilson H, Kirchner H, Lockie SH, Hofmann S, Woods SC, Nogueiras R, Pfluger PT, Perez-Tilve D, DiMarchi R, Tschöp MH.

Nat Chem Biol. 2009 Oct;5(10):749-57. Epub 2009 Jul 13.PMID: 19597507 [PubMed - indexed for MEDLINE]Related articles

ErbB signaling is required for the proliferative actions of GLP-2 in the murine gut.

Yusta B, Holland D, Koehler JA, Maziarz M, Estall JL, Higgins R, Drucker DJ.

Gastroenterology. 2009 Sep;137(3):986-96. Epub 2009 Jun 9.PMID: 19523469 [PubMed - indexed for MEDLINE]Related articles

Glucagon-like peptide-1 receptor activation modulates pancreatitis-associated gene expression but does not modify the susceptibility to experimental pancreatitis in mice.

Koehler JA, Baggio LL, Lamont BJ, Ali S, Drucker DJ.

Diabetes. 2009 Sep;58(9):2148-61. Epub 2009 Jun 9.PMID: 19509017 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon-like peptide-2 increases intestinal lipid absorption and chylomicron production via CD36.

Hsieh J, Longuet C, Maida A, Bahrami J, Xu E, Baker CL, Brubaker PL, Drucker DJ, Adeli K.

Gastroenterology. 2009 Sep;137(3):997-1005, 1005.e1-4. Epub 2009 May 29.PMID: 19482026 [PubMed - indexed for MEDLINE]Related articles

Incretin-based therapies for type 2 diabetes mellitus.

Lovshin JA, Drucker DJ.

Nat Rev Endocrinol. 2009 May;5(5):262-9. Review.PMID: 19444259 [PubMed - indexed for MEDLINE]Related articles

Distinguishing conjoint and independent neural tuning for stimulus features with fMRI adaptation.

Drucker DM, Kerr WT, Aguirre GK.

J Neurophysiol. 2009 Jun;101(6):3310-24. Epub 2009 Apr 8.PMID: 19357342 [PubMed - indexed for MEDLINE]Related articles

Different spatial scales of shape similarity representation in lateral and ventral LOC.

Drucker DM, Aguirre GK.

Cereb Cortex. 2009 Oct;19(10):2269-80. Epub 2009 Jan 28.PMID: 19176637 [PubMed - in process]Related articles

GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice.

Noyan-Ashraf MH, Momen MA, Ban K, Sadi AM, Zhou YQ, Riazi AM, Baggio LL, Henkelman RM, Husain M, Drucker DJ.

Diabetes. 2009 Apr;58(4):975-83. Epub 2009 Jan 16.PMID: 19151200 [PubMed - indexed for MEDLINE]Related articlesFree article

Benefits and limitations of reducing glucagon action for the treatment of type 2 diabetes.

Ali S, Drucker DJ.

Am J Physiol Endocrinol Metab. 2009 Mar;296(3):E415-21. Epub 2008 Dec 30. Review.PMID: 19116373 [PubMed - indexed for MEDLINE]Related articles

The glucagon receptor is required for the adaptive metabolic response to fasting.

Longuet C, Sinclair EM, Maida A, Baggio LL, Maziarz M, Charron MJ, Drucker DJ.

Cell Metab. 2008 Nov;8(5):359-71.PMID: 19046568 [PubMed - indexed for MEDLINE]Related articlesFree article

The glucagon-like peptide-1 receptor regulates endogenous glucose production and muscle glucose uptake independent of its incretin action.

Ayala JE, Bracy DP, James FD, Julien BM, Wasserman DH, Drucker DJ.

Endocrinology. 2009 Mar;150(3):1155-64. Epub 2008 Nov 13.PMID: 19008308 [PubMed - indexed for MEDLINE]Related articles

Glucagon-like peptide-2 reduces intestinal permeability but does not modify the onset of type 1 diabetes in the nonobese diabetic mouse.

Hadjiyanni I, Li KK, Drucker DJ.

Endocrinology. 2009 Feb;150(2):592-9. Epub 2008 Oct 9.PMID: 18845625 [PubMed - indexed for MEDLINE]Related articles

Glucagon-like peptide-2 does not modify the growth or survival of murine or human intestinal tumor cells.

Koehler JA, Harper W, Barnard M, Yusta B, Drucker DJ.

Cancer Res. 2008 Oct 1;68(19):7897-904.PMID: 18829546 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon receptor signaling is essential for control of murine hepatocyte survival.

Sinclair EM, Yusta B, Streutker C, Baggio LL, Koehler J, Charron MJ, Drucker DJ.

Gastroenterology. 2008 Dec;135(6):2096-106. Epub 2008 Aug 3.PMID: 18809404 [PubMed - indexed for MEDLINE]Related articles

Acute dipeptidyl peptidase-4 inhibition rapidly enhances insulin-mediated suppression of endogenous glucose production in mice.

Duez H, Smith AC, Xiao C, Giacca A, Szeto L, Drucker DJ, Lewis GF.

Endocrinology. 2009 Jan;150(1):56-62. Epub 2008 Sep 18.PMID: 18801896 [PubMed - indexed for MEDLINE]Related articles

Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study.

Drucker DJ, Buse JB, Taylor K, Kendall DM, Trautmann M, Zhuang D, Porter L; DURATION-1 Study Group.

Lancet. 2008 Oct 4;372(9645):1240-50. Epub 2008 Sep 7.PMID: 18782641 [PubMed - indexed for MEDLINE]Related articles

Tissue-specific role of glycogen synthase kinase 3beta in glucose homeostasis and insulin action.

Patel S, Doble BW, MacAulay K, Sinclair EM, Drucker DJ, Woodgett JR.

Mol Cell Biol. 2008 Oct;28(20):6314-28. Epub 2008 Aug 11.PMID: 18694957 [PubMed - indexed for MEDLINE]Related articlesFree article

The glucagon-like peptide-1 receptor agonist oxyntomodulin enhances beta-cell function but does not inhibit gastric emptying in mice.

Maida A, Lovshin JA, Baggio LL, Drucker DJ.

Endocrinology. 2008 Nov;149(11):5670-8. Epub 2008 Jul 31.PMID: 18669601 [PubMed - indexed for MEDLINE]Related articlesFree article

Brain glucagon-like peptide-1 regulates arterial blood flow, heart rate, and insulin sensitivity.

Cabou C, Campistron G, Marsollier N, Leloup C, Cruciani-Guglielmacci C, Pénicaud L, Drucker DJ, Magnan C, Burcelin R.

Diabetes. 2008 Oct;57(10):2577-87. Epub 2008 Jul 15.PMID: 18633100 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of central nervous system glucagon-like Peptide-1 receptors in enteric glucose sensing.

Knauf C, Cani PD, Kim DH, Iglesias MA, Chabo C, Waget A, Colom A, Rastrelli S, Delzenne NM, Drucker DJ, Seeley RJ, Burcelin R.

Diabetes. 2008 Oct;57(10):2603-12. Epub 2008 Jun 2.PMID: 18519802 [PubMed - indexed for MEDLINE]Related articlesFree article

Intensive insulin therapy in newly diagnosed type 2 diabetes.

Retnakaran R, Drucker DJ.

Lancet. 2008 May 24;371(9626):1725-6. No abstract available. PMID: 18502278 [PubMed - indexed for MEDLINE]Related articles

Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways.

Ban K, Noyan-Ashraf MH, Hoefer J, Bolz SS, Drucker DJ, Husain M.

Circulation. 2008 May 6;117(18):2340-50. Epub 2008 Apr 21. Erratum in: Circulation. 2008 Jul 22;118(4):e81. PMID: 18427132 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein engineering strategies for sustained glucagon-like peptide-1 receptor-dependent control of glucose homeostasis.

Picha KM, Cunningham MR, Drucker DJ, Mathur A, Ort T, Scully M, Soderman A, Spinka-Doms T, Stojanovic-Susulic V, Thomas BA, O'Neil KT.

Diabetes. 2008 Jul;57(7):1926-34. Epub 2008 Apr 21.PMID: 18426860 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulation of taste sensitivity by GLP-1 signaling.

Shin YK, Martin B, Golden E, Dotson CD, Maudsley S, Kim W, Jang HJ, Mattson MP, Drucker DJ, Egan JM, Munger SD.

J Neurochem. 2008 Jul;106(1):455-63. Epub 2008 Jul 1.PMID: 18397368 [PubMed - indexed for MEDLINE]Related articlesFree article

An albumin-exendin-4 conjugate engages central and peripheral circuits regulating murine energy and glucose homeostasis.

Baggio LL, Huang Q, Cao X, Drucker DJ.

Gastroenterology. 2008 Apr;134(4):1137-47. Epub 2008 Jan 11.PMID: 18313669 [PubMed - indexed for MEDLINE]Related articles

Beta-cell replication by loosening the brakes of glucagon-like peptide-1 receptor signaling.

Schuit FC, Drucker DJ.

Diabetes. 2008 Mar;57(3):529-31. No abstract available. PMID: 18305147 [PubMed - indexed for MEDLINE]Related articlesFree article

Clinical decisions. Management of type 2 diabetes.

Goldberg RB, Holman R, Drucker DJ.

N Engl J Med. 2008 Jan 17;358(3):293-7. No abstract available. Erratum in: N Engl J Med. 2008 May 1;358(18):1977. PMID: 18199869 [PubMed - indexed for MEDLINE]Related articles

Genetic variation in Glp1r expression influences the rate of gastric emptying in mice.

Kumar KG, Byerley LO, Volaufova J, Drucker DJ, Churchill GA, Li R, York B, Zuberi A, Richards BK.

Am J Physiol Regul Integr Comp Physiol. 2008 Feb;294(2):R362-71. Epub 2007 Dec 12.PMID: 18077508 [PubMed - indexed for MEDLINE]Related articles

Exendin-4 modulates diabetes onset in nonobese diabetic mice.

Hadjiyanni I, Baggio LL, Poussier P, Drucker DJ.

Endocrinology. 2008 Mar;149(3):1338-49. Epub 2007 Dec 6.PMID: 18063685 [PubMed - indexed for MEDLINE]Related articlesFree article

The murine glucagon-like peptide-1 receptor is essential for control of bone resorption.

Yamada C, Yamada Y, Tsukiyama K, Yamada K, Udagawa N, Takahashi N, Tanaka K, Drucker DJ, Seino Y, Inagaki N.

Endocrinology. 2008 Feb;149(2):574-9. Epub 2007 Nov 26.PMID: 18039776 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin action in the double incretin receptor knockout mouse.

Ayala JE, Bracy DP, Hansotia T, Flock G, Seino Y, Wasserman DH, Drucker DJ.

Diabetes. 2008 Feb;57(2):288-97. Epub 2007 Oct 31.PMID: 17977951 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon-like peptide 1 and type 1 diabetes: NOD ready for prime time?

Hadjiyanni I, Drucker DJ.

Endocrinology. 2007 Nov;148(11):5133-5. No abstract available. PMID: 17940186 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential antidiabetic efficacy of incretin agonists versus DPP-4 inhibition in high fat fed mice.

Lamont BJ, Drucker DJ.

Diabetes. 2008 Jan;57(1):190-8. Epub 2007 Oct 10.PMID: 17928394 [PubMed - indexed for MEDLINE]Related articlesFree article

Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolism.

MacAulay K, Doble BW, Patel S, Hansotia T, Sinclair EM, Drucker DJ, Nagy A, Woodgett JR.

Cell Metab. 2007 Oct;6(4):329-37.PMID: 17908561 [PubMed - indexed for MEDLINE]Related articles

Incretin receptors for glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide are essential for the sustained metabolic actions of vildagliptin in mice.

Flock G, Baggio LL, Longuet C, Drucker DJ.

Diabetes. 2007 Dec;56(12):3006-13. Epub 2007 Aug 23.PMID: 17717280 [PubMed - indexed for MEDLINE]Related articlesFree article

A switch from prohormone convertase (PC)-2 to PC1/3 expression in transplanted alpha-cells is accompanied by differential processing of proglucagon and improved glucose homeostasis in mice.

Wideman RD, Covey SD, Webb GC, Drucker DJ, Kieffer TJ.

Diabetes. 2007 Nov;56(11):2744-52. Epub 2007 Aug 13.PMID: 17698597 [PubMed - indexed for MEDLINE]Related articlesFree article

GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion.

Cani PD, Holst JJ, Drucker DJ, Delzenne NM, Thorens B, Burcelin R, Knauf C.

Mol Cell Endocrinol. 2007 Sep 30;276(1-2):18-23. Epub 2007 Jun 29.PMID: 17681422 [PubMed - indexed for MEDLINE]Related articles

Biology of incretins: GLP-1 and GIP.

Baggio LL, Drucker DJ.

Gastroenterology. 2007 May;132(6):2131-57. Review.PMID: 17498508 [PubMed - indexed for MEDLINE]Related articles

Interleukin-1 receptor antagonist gene polymorphism and gingivitis in children.

Dashash M, Drucker DB, Hutchinson IV, Bazrafshani MR, Blinkhorn AS.

Oral Dis. 2007 May;13(3):308-13.PMID: 17448214 [PubMed - indexed for MEDLINE]Related articles

Unraveling the complexities of gut endocrinology.

Drucker DJ.

Nat Clin Pract Endocrinol Metab. 2007 Apr;3(4):317. No abstract available. PMID: 17377614 [PubMed - indexed for MEDLINE]Related articles

Sitagliptin.

Drucker D, Easley C, Kirkpatrick P.

Nat Rev Drug Discov. 2007 Feb;6(2):109-10. No abstract available. PMID: 17342863 [PubMed - indexed for MEDLINE]Related articles

Dipeptidyl peptidase-4 inhibition and the treatment of type 2 diabetes: preclinical biology and mechanisms of action.

Drucker DJ.

Diabetes Care. 2007 Jun;30(6):1335-43. Epub 2007 Mar 2. Review. No abstract available. PMID: 17337495 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of gut hormones in glucose homeostasis.

Drucker DJ.

J Clin Invest. 2007 Jan;117(1):24-32. Review.PMID: 17200703 [PubMed - indexed for MEDLINE]Related articlesFree article

Extrapancreatic incretin receptors modulate glucose homeostasis, body weight, and energy expenditure.

Hansotia T, Maida A, Flock G, Yamada Y, Tsukiyama K, Seino Y, Drucker DJ.

J Clin Invest. 2007 Jan;117(1):143-52. Epub 2006 Dec 21.PMID: 17187081 [PubMed - indexed for MEDLINE]Related articlesFree article

The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes.

Drucker DJ, Nauck MA.

Lancet. 2006 Nov 11;368(9548):1696-705. Review.PMID: 17098089 [PubMed - indexed for MEDLINE]Related articles