PubMed

Insulin Resistance in Adolescents with Type 1 Diabetes and Its Relationship to Cardiovascular Function.

Nadeau KJ, Regensteiner JG, Bauer TA, Brown MS, Dorosz JL, Hull A, Zeitler P, Draznin B, Reusch JE.

J Clin Endocrinol Metab. 2009 Nov 13. [Epub ahead of print]PMID: 19915016 [PubMed - as supplied by publisher]Related articles

Multiple abnormalities of myocardial insulin signaling in a porcine model of diet-induced obesity.

Lee J, Xu Y, Lu L, Bergman BC, Leitner JW, Greyson C, Draznin B, Schwartz GG.

Am J Physiol Heart Circ Physiol. 2009 Nov 13. [Epub ahead of print]PMID: 19897715 [PubMed - as supplied by publisher]Related articles

Mitogenic action of insulin: friend, foe or 'frenemy'?

Draznin B.

Diabetologia. 2009 Oct 23. [Epub ahead of print]PMID: 19851749 [PubMed - as supplied by publisher]Related articles

Early responses of insulin signaling to high-carbohydrate and high-fat overfeeding.

Adochio RL, Leitner JW, Gray K, Draznin B, Cornier MA.

Nutr Metab (Lond). 2009 Sep 28;6:37.PMID: 19781106 [PubMed - in process]Related articlesFree article

In vivo knockdown of p85alpha with an antisense oligonucleotide improves insulin sensitivity in Lep(ob/ob) and diet-induced obese mice.

Moriarty MW, McCurdy CE, Janssen RC, Shaw T, Leitner JW, Friedman JE, Draznin B.

Horm Metab Res. 2009 Oct;41(10):757-61. Epub 2009 Jul 13.PMID: 19598077 [PubMed - in process]Related articles

Insulin resistance in adolescents with type 2 diabetes is associated with impaired exercise capacity.

Nadeau KJ, Zeitler PS, Bauer TA, Brown MS, Dorosz JL, Draznin B, Reusch JE, Regensteiner JG.

J Clin Endocrinol Metab. 2009 Oct;94(10):3687-95. Epub 2009 Jul 7.PMID: 19584191 [PubMed - indexed for MEDLINE]Related articles

Knockdown of JNK rescues 3T3-L1 adipocytes from insulin resistance induced by mitochondrial dysfunction.

Kim T, Wayne Leitner J, Adochio R, Draznin B.

Biochem Biophys Res Commun. 2009 Jan 23;378(4):772-6. Epub 2008 Dec 6.PMID: 19063863 [PubMed - indexed for MEDLINE]Related articles

Rescuing 3T3-L1 adipocytes from insulin resistance induced by stimulation of Akt-mammalian target of rapamycin/p70 S6 kinase (S6K1) pathway and serine phosphorylation of insulin receptor substrate-1: effect of reduced expression of p85alpha subunit of phosphatidylinositol 3-kinase and S6K1 kinase.

Adochio R, Leitner JW, Hedlund R, Draznin B.

Endocrinology. 2009 Mar;150(3):1165-73. Epub 2008 Oct 23.PMID: 18948408 [PubMed - indexed for MEDLINE]Related articles

Pioglitazone acutely stimulates adiponectin secretion from mouse and human adipocytes via activation of the phosphatidylinositol 3'-kinase.

Pereira RI, Leitner JW, Erickson C, Draznin B.

Life Sci. 2008 Nov 7;83(19-20):638-43. Epub 2008 Sep 16.PMID: 18824177 [PubMed - indexed for MEDLINE]Related articles

Effects of chronic hyperinsulinemia in insulin-resistant patients.

Muntoni S, Muntoni S, Draznin B.

Curr Diab Rep. 2008 Jun;8(3):233-8. Review.PMID: 18625122 [PubMed - indexed for MEDLINE]Related articles

Dietary carbohydrate restriction in type 2 diabetes mellitus and metabolic syndrome: time for a critical appraisal.

Accurso A, Bernstein RK, Dahlqvist A, Draznin B, Feinman RD, Fine EJ, Gleed A, Jacobs DB, Larson G, Lustig RH, Manninen AH, McFarlane SI, Morrison K, Nielsen JV, Ravnskov U, Roth KS, Silvestre R, Sowers JR, Sundberg R, Volek JS, Westman EC, Wood RJ, Wortman J, Vernon MC.

Nutr Metab (Lond). 2008 Apr 8;5:9.PMID: 18397522 [PubMed - in process]Related articlesFree article

Discordance between intramuscular triglyceride and insulin sensitivity in skeletal muscle of Zucker diabetic rats after treatment with fenofibrate and rosiglitazone.

Nadeau KJ, Ehlers LB, Aguirre LE, Reusch JE, Draznin B.

Diabetes Obes Metab. 2007 Sep;9(5):714-23.PMID: 17697064 [PubMed - indexed for MEDLINE]Related articles

Atherosclerosis in diabetes and insulin resistance.

Reusch JE, Draznin BB.

Diabetes Obes Metab. 2007 Jul;9(4):455-63. Review.PMID: 17587387 [PubMed - indexed for MEDLINE]Related articles

Insulin attenuates vascular smooth muscle calcification but increases vascular smooth muscle cell phosphate transport.

Wang CC, Sorribas V, Sharma G, Levi M, Draznin B.

Atherosclerosis. 2007 Nov;195(1):e65-75. Epub 2007 Apr 6.PMID: 17412344 [PubMed - indexed for MEDLINE]Related articlesFree article

Growth hormone regulation of p85alpha expression and phosphoinositide 3-kinase activity in adipose tissue: mechanism for growth hormone-mediated insulin resistance.

del Rincon JP, Iida K, Gaylinn BD, McCurdy CE, Leitner JW, Barbour LA, Kopchick JJ, Friedman JE, Draznin B, Thorner MO.

Diabetes. 2007 Jun;56(6):1638-46. Epub 2007 Mar 15.PMID: 17363744 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased farnesylation of p21-Ras and neonatal macrosomia in women with gestational diabetes.

Thureen P, Reece M, Rodden D, Barbour L, Chappell J, Leitner JW, Jones RO, Draznin B.

J Pediatr. 2006 Dec;149(6):871-3.PMID: 17137910 [PubMed - indexed for MEDLINE]Related articles

Molecular mechanisms of insulin resistance: serine phosphorylation of insulin receptor substrate-1 and increased expression of p85alpha: the two sides of a coin.

Draznin B.

Diabetes. 2006 Aug;55(8):2392-7. Review.PMID: 16873706 [PubMed - indexed for MEDLINE]Related articlesFree article

Early growth response gene-1 expression in vascular smooth muscle cells effects of insulin and oxidant stress.

Wang CC, Sharma G, Draznin B.

Am J Hypertens. 2006 Apr;19(4):366-72.PMID: 16580571 [PubMed - indexed for MEDLINE]Related articles

Nutritional upregulation of p85alpha expression is an early molecular manifestation of insulin resistance.

Cornier MA, Bessesen DH, Gurevich I, Leitner JW, Draznin B.

Diabetologia. 2006 Apr;49(4):748-54. Epub 2006 Feb 21.PMID: 16491394 [PubMed - indexed for MEDLINE]Related articles

Exercise training and calorie restriction increase SREBP-1 expression and intramuscular triglyceride in skeletal muscle.

Nadeau KJ, Ehlers LB, Aguirre LE, Moore RL, Jew KN, Ortmeyer HK, Hansen BC, Reusch JE, Draznin B.

Am J Physiol Endocrinol Metab. 2006 Jul;291(1):E90-8. Epub 2006 Jan 31.PMID: 16449296 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of the phosphatidylinositol 3'-kinase signaling pathway leads to decreased insulin-stimulated adiponectin secretion from 3T3-L1 adipocytes.

Pereira RI, Draznin B.

Metabolism. 2005 Dec;54(12):1636-43.PMID: 16311098 [PubMed - indexed for MEDLINE]Related articles

Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess.

Barbour LA, Mizanoor Rahman S, Gurevich I, Leitner JW, Fischer SJ, Roper MD, Knotts TA, Vo Y, McCurdy CE, Yakar S, Leroith D, Kahn CR, Cantley LC, Friedman JE, Draznin B.

J Biol Chem. 2005 Nov 11;280(45):37489-94. Epub 2005 Sep 8.PMID: 16166093 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin sensitivity determines the effectiveness of dietary macronutrient composition on weight loss in obese women.

Cornier MA, Donahoo WT, Pereira R, Gurevich I, Westergren R, Enerback S, Eckel PJ, Goalstone ML, Hill JO, Eckel RH, Draznin B.

Obes Res. 2005 Apr;13(4):703-9.PMID: 15897479 [PubMed - indexed for MEDLINE]Related articles

Molecular mechanisms of insulin resistance that impact cardiovascular biology.

Wang CC, Goalstone ML, Draznin B.

Diabetes. 2004 Nov;53(11):2735-40. Review.PMID: 15504952 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin regulation of sterol regulatory element-binding protein-1 expression in L-6 muscle cells and 3T3 L1 adipocytes.

Nadeau KJ, Leitner JW, Gurerich I, Draznin B.

J Biol Chem. 2004 Aug 13;279(33):34380-7. Epub 2004 Jun 8.PMID: 15187085 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced insulin signaling via Shc in human breast cancer.

Finlayson CA, Chappell J, Leitner JW, Goalstone ML, Garrity M, Nawaz S, Ciaraldi TP, Draznin B.

Metabolism. 2003 Dec;52(12):1606-11.PMID: 14669164 [PubMed - indexed for MEDLINE]Related articles

Human placental growth hormone increases expression of the p85 regulatory unit of phosphatidylinositol 3-kinase and triggers severe insulin resistance in skeletal muscle.

Barbour LA, Shao J, Qiao L, Leitner W, Anderson M, Friedman JE, Draznin B.

Endocrinology. 2004 Mar;145(3):1144-50. Epub 2003 Nov 21.PMID: 14633976 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin affects vascular smooth muscle cell phenotype and migration via distinct signaling pathways.

Wang CC, Gurevich I, Draznin B.

Diabetes. 2003 Oct;52(10):2562-9.PMID: 14514641 [PubMed - indexed for MEDLINE]Related articlesFree article

Garlic extract methylallyl thiosulfinate blocks insulin potentiation of platelet-derived growth factor-stimulated migration of vascular smooth muscle cells.

Golovchenko I, Yang CH, Goalstone ML, Draznin B.

Metabolism. 2003 Feb;52(2):254-9.PMID: 12601642 [PubMed - indexed for MEDLINE]Related articles

Human placental growth hormone causes severe insulin resistance in transgenic mice.

Barbour LA, Shao J, Qiao L, Pulawa LK, Jensen DR, Bartke A, Garrity M, Draznin B, Friedman JE.

Am J Obstet Gynecol. 2002 Mar;186(3):512-7.PMID: 11904616 [PubMed - indexed for MEDLINE]Related articles

Phosphatidylinositol 3-kinase redistribution is associated with skeletal muscle insulin resistance in gestational diabetes mellitus.

Shao J, Yamashita H, Qiao L, Draznin B, Friedman JE.

Diabetes. 2002 Jan;51(1):19-29.PMID: 11756318 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of phosphatidylinositol 3-kinase enhances mitogenic actions of insulin in endothelial cells.

Montagnani M, Golovchenko I, Kim I, Koh GY, Goalstone ML, Mundhekar AN, Johansen M, Kucik DF, Quon MJ, Draznin B.

J Biol Chem. 2002 Jan 18;277(3):1794-9. Epub 2001 Nov 13.PMID: 11707433 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of insulin on cell cycle progression in MCF-7 breast cancer cells. Direct and potentiating influence.

Chappell J, Leitner JW, Solomon S, Golovchenko I, Goalstone ML, Draznin B.

J Biol Chem. 2001 Oct 12;276(41):38023-8. Epub 2001 Aug 10.PMID: 11500498 [PubMed - indexed for MEDLINE]Related articlesFree article

Fetal hyperinsulinemia increases farnesylation of p21 Ras in fetal tissues.

Stephens E, Thureen PJ, Goalstone ML, Anderson MS, Leitner JW, Hay WW Jr, Draznin B.

Am J Physiol Endocrinol Metab. 2001 Aug;281(2):E217-23.PMID: 11440896 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-induced adipocyte differentiation. Activation of CREB rescues adipogenesis from the arrest caused by inhibition of prenylation.

Klemm DJ, Leitner JW, Watson P, Nesterova A, Reusch JE, Goalstone ML, Draznin B.

J Biol Chem. 2001 Jul 27;276(30):28430-5. Epub 2001 May 25.PMID: 11375992 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin signals to prenyltransferases via the Shc branch of intracellular signaling.

Goalstone ML, Leitner JW, Berhanu P, Sharma PM, Olefsky JM, Draznin B.

J Biol Chem. 2001 Apr 20;276(16):12805-12. Epub 2001 Jan 25.PMID: 11278505 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyperinsulinemia enhances transcriptional activity of nuclear factor-kappaB induced by angiotensin II, hyperglycemia, and advanced glycosylation end products in vascular smooth muscle cells.

Golovchenko I, Goalstone ML, Watson P, Brownlee M, Draznin B.

Circ Res. 2000 Oct 27;87(9):746-52.PMID: 11055977 [PubMed - indexed for MEDLINE]Related articlesFree article

Potentiation of Rho-A-mediated lysophosphatidic acid activity by hyperinsulinemia.

Chappell J, Golovchenko I, Wall K, Stjernholm R, Leitner JW, Goalstone M, Draznin B.

J Biol Chem. 2000 Oct 13;275(41):31792-7.PMID: 10930411 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of insulin on prenylation as a mechanism of potentially detrimental influence of hyperinsulinemia.

Draznin B, Miles P, Kruszynska Y, Olefsky J, Friedman J, Golovchenko I, Stjernholm R, Wall K, Reitman M, Accili D, Cooksey R, McClain D, Goalstone M.

Endocrinology. 2000 Apr;141(4):1310-6.PMID: 10746633 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin, cation metabolism and insulin resistance.

Sowers JR, Draznin B.

J Basic Clin Physiol Pharmacol. 1998;9(2-4):223-33. Review.PMID: 10212836 [PubMed - indexed for MEDLINE]Related articles

Increased amounts of farnesylated p21Ras in tissues of hyperinsulinaemic animals.

Goalstone ML, Wall K, Leitner JW, Kurowski T, Ruderman N, Pan SJ, Ivy JL, Moller DE, Draznin B.

Diabetologia. 1999 Mar;42(3):310-6.PMID: 10096783 [PubMed - indexed for MEDLINE]Related articles

Effect of insulin on farnesyltransferase gene transcription and mRNA stability.

Goalstone ML, Draznin B.

Biochem Biophys Res Commun. 1999 Jan 8;254(1):243-7.PMID: 9920764 [PubMed - indexed for MEDLINE]Related articles

Insulin promotes phosphorylation and activation of geranylgeranyltransferase II. Studies with geranylgeranylation of rab-3 and rab-4.

Goalstone ML, Leitner JW, Golovchenko I, Stjernholm MR, Cormont M, Le Marchand-Brustel Y, Draznin B.

J Biol Chem. 1999 Jan 29;274(5):2880-4.PMID: 9915824 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin potentiates platelet-derived growth factor action in vascular smooth muscle cells.

Goalstone ML, Natarajan R, Standley PR, Walsh MF, Leitner JW, Carel K, Scott S, Nadler J, Sowers JR, Draznin B.

Endocrinology. 1998 Oct;139(10):4067-72.PMID: 9751484 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of insulin on farnesyltransferase. Specificity of insulin action and potentiation of nuclear effects of insulin-like growth factor-1, epidermal growth factor, and platelet-derived growth factor.

Goalstone ML, Leitner JW, Wall K, Dolgonos L, Rother KI, Accili D, Draznin B.

J Biol Chem. 1998 Sep 11;273(37):23892-6.PMID: 9727002 [PubMed - indexed for MEDLINE]Related articlesFree article

What does insulin do to Ras?

Goalstone ML, Draznin B.

Cell Signal. 1998 May;10(5):297-301. Review.PMID: 9692672 [PubMed - indexed for MEDLINE]Related articles

Insulin stimulates the phosphorylation and activity of farnesyltransferase via the Ras-mitogen-activated protein kinase pathway.

Goalstone M, Carel K, Leitner JW, Draznin B.

Endocrinology. 1997 Dec;138(12):5119-24.PMID: 9389491 [PubMed - indexed for MEDLINE]Related articlesFree article

GTP loading of farnesylated p21Ras by insulin at the plasma membrane.

Goalstone M, Leitner JW, Draznin B.

Biochem Biophys Res Commun. 1997 Oct 9;239(1):42-5.PMID: 9345266 [PubMed - indexed for MEDLINE]Related articles

Insulin signaling.

Goalstone ML, Draznin B.

West J Med. 1997 Sep;167(3):166-73. Review.PMID: 9308409 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyperinsulinemia potentiates activation of p21Ras by growth factors.

Leitner JW, Kline T, Carel K, Goalstone M, Draznin B.

Endocrinology. 1997 May;138(5):2211-4.PMID: 9112423 [PubMed - indexed for MEDLINE]Related articlesFree article