PubMed

Mutagenicity testing for chemical risk assessment: update of the WHO/IPCS Harmonized Scheme.

Eastmond DA, Hartwig A, Anderson D, Anwar WA, Cimino MC, Dobrev I, Douglas GR, Nohmi T, Phillips DH, Vickers C.

Mutagenesis. 2009 Jul;24(4):341-9. Epub 2009 Jun 17.PMID: 19535363 [PubMed - indexed for MEDLINE]Related articles

Toxicogenomic analysis of mainstream tobacco smoke-exposed mice reveals repression of plasminogen activator inhibitor-1 gene in heart.

Halappanavar S, Stampfli MR, Berndt-Weis L, Williams A, Douglas GR, Yauk CL.

Inhal Toxicol. 2009 Jan;21(1):78-85.PMID: 18925475 [PubMed - indexed for MEDLINE]Related articlesFree article

Genotoxicity of 3-nitrobenzanthrone and 3-aminobenzanthrone in MutaMouse and lung epithelial cells derived from MutaMouse.

Arlt VM, Gingerich J, Schmeiser HH, Phillips DH, Douglas GR, White PA.

Mutagenesis. 2008 Nov;23(6):483-90. Epub 2008 Jul 16.PMID: 18635558 [PubMed - indexed for MEDLINE]Related articlesFree article

Tissue-specific metabolic activation and mutagenicity of 3-nitrobenzanthrone in MutaMouse.

Chen G, Gingerich J, Soper L, Douglas GR, White PA.

Environ Mol Mutagen. 2008 Oct;49(8):602-13.PMID: 18613036 [PubMed - indexed for MEDLINE]Related articles

Mutagenic and carcinogenic hazards of settled house dust. II: Salmonella mutagenicity.

Maertens RM, Gagné RW, Douglas GR, Zhu J, White PA.

Environ Sci Technol. 2008 Mar 1;42(5):1754-60.PMID: 18441831 [PubMed - indexed for MEDLINE]Related articles

Mutagenic and carcinogenic hazards of settled house dust. I: Polycyclic aromatic hydrocarbon content and excess lifetime cancer risk from preschool exposure.

Maertens RM, Yang X, Zhu J, Gagne RW, Douglas GR, White PA.

Environ Sci Technol. 2008 Mar 1;42(5):1747-53.PMID: 18441830 [PubMed - indexed for MEDLINE]Related articles

Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location.

Yauk C, Polyzos A, Rowan-Carroll A, Somers CM, Godschalk RW, Van Schooten FJ, Berndt ML, Pogribny IP, Koturbash I, Williams A, Douglas GR, Kovalchuk O.

Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):605-10. Epub 2008 Jan 14.PMID: 18195365 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of gene expression in two human-derived cell lines exposed in vitro to a 1.9 GHz pulse-modulated radiofrequency field.

Chauhan V, Qutob SS, Lui S, Mariampillai A, Bellier PV, Yauk CL, Douglas GR, Williams A, McNamee JP.

Proteomics. 2007 Nov;7(21):3896-905.PMID: 17902192 [PubMed - indexed for MEDLINE]Related articles

Increased mutant frequency by carbon black, but not quartz, in the lacZ and cII transgenes of muta mouse lung epithelial cells.

Jacobsen NR, Saber AT, White P, Møller P, Pojana G, Vogel U, Loft S, Gingerich J, Soper L, Douglas GR, Wallin H.

Environ Mol Mutagen. 2007 Jul;48(6):451-61.PMID: 17584883 [PubMed - indexed for MEDLINE]Related articles

Mainstream tobacco smoke causes paternal germ-line DNA mutation.

Yauk CL, Berndt ML, Williams A, Rowan-Carroll A, Douglas GR, Stämpfli MR.

Cancer Res. 2007 Jun 1;67(11):5103-6.PMID: 17545587 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic gene expression changes in hypothyroid juvenile mice: characterization of a novel negative thyroid-responsive element.

Dong H, Yauk CL, Williams A, Lee A, Douglas GR, Wade MG.

Endocrinology. 2007 Aug;148(8):3932-40. Epub 2007 Apr 26.PMID: 17463053 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel design and controls for focused DNA microarrays: applications in quality assurance/control and normalization for the Health Canada ToxArray.

Yauk CL, Williams A, Boucher S, Berndt LM, Zhou G, Zheng JL, Rowan-Carroll A, Dong H, Lambert IB, Douglas GR, Parfett CL.

BMC Genomics. 2006 Oct 19;7:266.PMID: 17052352 [PubMed - indexed for MEDLINE]Related articlesFree article

Microarray gene expression profiling of a human glioblastoma cell line exposed in vitro to a 1.9 GHz pulse-modulated radiofrequency field.

Qutob SS, Chauhan V, Bellier PV, Yauk CL, Douglas GR, Berndt L, Williams A, Gajda GB, Lemay E, Thansandote A, McNamee JP.

Radiat Res. 2006 Jun;165(6):636-44.PMID: 16802863 [PubMed - indexed for MEDLINE]Related articles

Detection of induced male germline mutation: correlations and comparisons between traditional germline mutation assays, transgenic rodent assays and expanded simple tandem repeat instability assays.

Singer TM, Lambert IB, Williams A, Douglas GR, Yauk CL.

Mutat Res. 2006 Jun 25;598(1-2):164-93. Epub 2006 Mar 20. Review.PMID: 16542687 [PubMed - indexed for MEDLINE]Related articles

Instability of expanded simple tandem repeats is induced in cell culture by a variety of agents: N-Nitroso-N-ethylurea, benzo(a)pyrene, etoposide and okadaic acid.

Polyzos A, Parfett C, Healy C, Douglas GR, Yauk CL.

Mutat Res. 2006 Jun 25;598(1-2):73-84. Epub 2006 Mar 3.PMID: 16516931 [PubMed - indexed for MEDLINE]Related articles

Meeting report: Validation of toxicogenomics-based test systems: ECVAM-ICCVAM/NICEATM considerations for regulatory use.

Corvi R, Ahr HJ, Albertini S, Blakey DH, Clerici L, Coecke S, Douglas GR, Gribaldo L, Groten JP, Haase B, Hamernik K, Hartung T, Inoue T, Indans I, Maurici D, Orphanides G, Rembges D, Sansone SA, Snape JR, Toda E, Tong W, van Delft JH, Weis B, Schechtman LM.

Environ Health Perspect. 2006 Mar;114(3):420-9.PMID: 16507466 [PubMed - indexed for MEDLINE]Related articlesFree article

Assessment of 3-nitrobenzanthrone reductase activity in mammalian tissues by normal-phase HPLC with fluorescence detection.

Chen G, Lambert IB, Douglas GR, White PA.

J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Sep 25;824(1-2):229-37.PMID: 16095987 [PubMed - indexed for MEDLINE]Related articles

Detailed review of transgenic rodent mutation assays.

Lambert IB, Singer TM, Boucher SE, Douglas GR.

Mutat Res. 2005 Sep;590(1-3):1-280. Review.PMID: 16081315 [PubMed - indexed for MEDLINE]Related articles

A lacZ transgenic mouse assay for the detection of mutations in follicular granulosa cells.

Yauk CL, Gingerich JD, Soper L, MacMahon A, Foster WG, Douglas GR.

Mutat Res. 2005 Oct 15;578(1-2):117-23. Epub 2005 Jul 21.PMID: 16039675 [PubMed - indexed for MEDLINE]Related articles

Automation of cDNA microarray hybridization and washing yields improved data quality.

Yauk C, Berndt L, Williams A, Douglas GR.

J Biochem Biophys Methods. 2005 Jul 29;64(1):69-75.PMID: 16005076 [PubMed - indexed for MEDLINE]Related articles

Molecular insight into the effects of hypothyroidism on the developing cerebellum.

Dong H, Wade M, Williams A, Lee A, Douglas GR, Yauk C.

Biochem Biophys Res Commun. 2005 May 20;330(4):1182-93.PMID: 15823568 [PubMed - indexed for MEDLINE]Related articles

Comprehensive comparison of six microarray technologies.

Yauk CL, Berndt ML, Williams A, Douglas GR.

Nucleic Acids Res. 2004 Aug 27;32(15):e124.PMID: 15333675 [PubMed - indexed for MEDLINE]Related articlesFree article

Development and characterization of a stable epithelial cell line from Muta Mouse lung.

White PA, Douglas GR, Gingerich J, Parfett C, Shwed P, Seligy V, Soper L, Berndt L, Bayley J, Wagner S, Pound K, Blakey D.

Environ Mol Mutagen. 2003;42(3):166-84.PMID: 14556224 [PubMed - indexed for MEDLINE]Related articles

In vivo transgenic mutation assays.

Thybaud V, Dean S, Nohmi T, de Boer J, Douglas GR, Glickman BW, Gorelick NJ, Heddle JA, Heflich RH, Lambert I, Martus HJ, Mirsalis JC, Suzuki T, Yajima N.

Mutat Res. 2003 Oct 7;540(2):141-51.PMID: 14550498 [PubMed - indexed for MEDLINE]Related articles

Treatment and sampling protocols for transgenic mutation assays.

Heddle JA, Martus HJ, Douglas GR.

Environ Mol Mutagen. 2003;41(1):1-6. Review.PMID: 12552586 [PubMed - indexed for MEDLINE]Related articles

Mutagenicity of the oral carcinogen 4-nitroquinoline-1-oxide in cultured BigBlue rat tongue epithelial cells and fibroblasts.

Papp-Szabó E, Douglas GR, Coomber BL, Josephy PD.

Mutat Res. 2003 Jan 28;522(1-2):107-17.PMID: 12517416 [PubMed - indexed for MEDLINE]Related articles

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mutagenesis in cultured Big Blue rat mammary epithelial and fibroblast cells.

McDiarmid HM, Douglas GR, Coomber BL, Josephy PD.

Environ Mol Mutagen. 2002;39(2-3):245-53. Erratum in: Environ Mol Mutagen 2002;40(1):78. PMID: 11921195 [PubMed - indexed for MEDLINE]Related articles

Epithelial and fibroblast cell lines cultured from the transgenic BigBlue rat: an in vitro mutagenesis assay.

McDiarmid HM, Douglas GR, Coomber BL, Josephy PD.

Mutat Res. 2001 Oct 18;497(1-2):39-47.PMID: 11525906 [PubMed - indexed for MEDLINE]Related articles

Survival analysis for success of Molteno tube implants.

Broadway DC, Iester M, Schulzer M, Douglas GR.

Br J Ophthalmol. 2001 Jun;85(6):689-95.PMID: 11371490 [PubMed - indexed for MEDLINE]Related articlesFree article

IPCS guidelines for the monitoring of genotoxic effects of carcinogens in humans. International Programme on Chemical Safety.

Albertini RJ, Anderson D, Douglas GR, Hagmar L, Hemminki K, Merlo F, Natarajan AT, Norppa H, Shuker DE, Tice R, Waters MD, Aitio A.

Mutat Res. 2000 Aug;463(2):111-72.PMID: 10913908 [PubMed - indexed for MEDLINE]Related articles

Discussion by gordon R. Douglas, MD

Douglas GR.

Ophthalmology. 2000 Jul;107(7):1308. No abstract available. PMID: 10889103 [PubMed - as supplied by publisher]Related articles

In vivo transgenic mutation assays.

Heddle JA, Dean S, Nohmi T, Boerrigter M, Casciano D, Douglas GR, Glickman BW, Gorelick NJ, Mirsalis JC, Martus HJ, Skopek TR, Thybaud V, Tindall KR, Yajima N.

Environ Mol Mutagen. 2000;35(3):253-9.PMID: 10737959 [PubMed - indexed for MEDLINE]Related articles

Evidence for the lack of base-change and small-deletion mutation induction by trichloroethylene in lacZ transgenic mice.

Douglas GR, Gingerich JD, Soper LM, Potvin M, Bjarnason S.

Environ Mol Mutagen. 1999;34(2-3):190-4.PMID: 10529743 [PubMed - indexed for MEDLINE]Related articles

Statistical analysis of lacZ mutant frequency data from MutaMouse mutagenicity assays.

Fung KY, Douglas GR, Krewski D.

Mutagenesis. 1998 May;13(3):249-55.PMID: 9643583 [PubMed - indexed for MEDLINE]Related articlesFree article

Pathogenetic mechanisms of glaucoma not related to intraocular pressure.

Douglas GR.

Curr Opin Ophthalmol. 1998 Apr;9(2):34-8. Review.PMID: 10180511 [PubMed - indexed for MEDLINE]Related articles

Databases and software for the analysis of mutations in the human p53 gene, human hprt gene and both the lacI and lacZ gene in transgenic rodents.

Cariello NF, Douglas GR, Gorelick NJ, Hart DW, Wilson JD, Soussi T.

Nucleic Acids Res. 1998 Jan 1;26(1):198-9.PMID: 9399835 [PubMed - indexed for MEDLINE]Related articlesFree article

Automated perimetry in detecting threats to fixation.

Zhang L, Drance SM, Douglas GR.

Ophthalmology. 1997 Nov;104(11):1918-20.PMID: 9373126 [PubMed - indexed for MEDLINE]Related articles

Analysis of tissue-specific lacZ mutations induced by N-nitrosodibenzylamine in transgenic mice.

Jiao J, Douglas GR, Gingerich JD, Soper LM.

Carcinogenesis. 1997 Nov;18(11):2239-45.PMID: 9395227 [PubMed - indexed for MEDLINE]Related articlesFree article

The ability of Medmont M600 automated perimetry to detect threats to fixation.

Zhang L, Drance SM, Douglas GR.

J Glaucoma. 1997 Aug;6(4):259-62.PMID: 9264306 [PubMed - indexed for MEDLINE]Related articles

Sources of variability in data from a positive selection lacZ transgenic mouse mutation assay: an interlaboratory study.

Piegorsch WW, Lockhart AC, Carr GJ, Margolin BH, Brooks T, Douglas GR, Liegibel UM, Suzuki T, Thybaud V, van Delft JH, Gorelick NJ.

Mutat Res. 1997 Feb 14;388(2-3):249-89.PMID: 9057887 [PubMed - indexed for MEDLINE]Related articles

Toward an understanding of the use of transgenic mice for the detection of gene mutations in germ cells.

Douglas GR, Gingerich JD, Soper LM, Jiao J.

Mutat Res. 1997 Feb 14;388(2-3):197-212.PMID: 9057881 [PubMed - indexed for MEDLINE]Related articles

Databases and software for the analysis of mutations in the human p53 gene, the human hprt gene and both the lacI and lacZ gene in transgenic rodents.

Cariello NF, Douglas GR, Dycaico MJ, Gorelick NJ, Provost GS, Soussi T.

Nucleic Acids Res. 1997 Jan 1;25(1):136-7.PMID: 9016522 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparison of psychophysical and electrophysiological testing in early glaucoma.

Graham SL, Drance SM, Chauhan BC, Swindale NV, Hnik P, Mikelberg FS, Douglas GR.

Invest Ophthalmol Vis Sci. 1996 Dec;37(13):2651-62.PMID: 8977479 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparison of the molecular characteristics of lacZ transgenic mouse mutations detected by visual and positive selection.

Jiao J, Douglas GR, Gingerich JD, Soper LM.

Mutat Res. 1996 Nov 11;372(1):141-5.PMID: 9003541 [PubMed - indexed for MEDLINE]Related articles

IPCS harmonization of methods for the prediction and quantification of human carcinogenic/mutagenic hazard, and for indicating the probable mechanism of action of carcinogens.

Ashby J, Waters MD, Preston J, Adler ID, Douglas GR, Fielder R, Shelby MD, Anderson D, Sofuni T, Gopalan HN, Becking G, Sonich-Mullin C.

Mutat Res. 1996 Jun 10;352(1-2):153-7.PMID: 8676904 [PubMed - indexed for MEDLINE]Related articles

Temporal and molecular characteristics of lacZ mutations in somatic tissues of transgenic mice.

Douglas GR, Jiao J, Gingerich JD, Soper LM, Gossen JA.

Environ Mol Mutagen. 1996;28(4):317-24.PMID: 8991059 [PubMed - indexed for MEDLINE]Related articles

Database and software for the analysis of mutations at the lacZ locus in transgenic rodents.

Cariello NF, Douglas GR.

Environ Mol Mutagen. 1996;28(2):145-53.PMID: 8844996 [PubMed - indexed for MEDLINE]Related articles

Databases and software for the analysis of mutations in the human p53 gene, the human hprt gene and the lacZ gene in transgenic rodents.

Cariello NF, Douglas GR, Soussi T.

Nucleic Acids Res. 1996 Jan 1;24(1):119-20.PMID: 8594557 [PubMed - indexed for MEDLINE]Related articlesFree article

Temporal and molecular characteristics of mutations induced by ethylnitrosourea in germ cells isolated from seminiferous tubules and in spermatozoa of lacZ transgenic mice.

Douglas GR, Jiao J, Gingerich JD, Gossen JA, Soper LM.

Proc Natl Acad Sci U S A. 1995 Aug 1;92(16):7485-9.PMID: 7638217 [PubMed - indexed for MEDLINE]Related articlesFree article

Acrylamide: a review of its genotoxicity and an assessment of heritable genetic risk.

Dearfield KL, Douglas GR, Ehling UH, Moore MM, Sega GA, Brusick DJ.

Mutat Res. 1995 Aug;330(1-2):71-99. Review.PMID: 7623872 [PubMed - indexed for MEDLINE]Related articles