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Free Fatty Acids Induce a Proinflammatory Response in Islets via the Abundantly Expressed Interleukin-1 Receptor I.

Böni-Schnetzler M, Boller S, Debray S, Bouzakri K, Meier DT, Prazak R, Kerr-Conte J, Pattou F, Ehses JA, Schuit FC, Donath MY.

Endocrinology. 2009 Oct 9. [Epub ahead of print]PMID: 19819943 [PubMed - as supplied by publisher]Related articles

Islet endothelial activation and oxidative stress gene expression is reduced by IL-1Ra treatment in the type 2 diabetic GK rat.

Lacraz G, Giroix MH, Kassis N, Coulaud J, Galinier A, Noll C, Cornut M, Schmidlin F, Paul JL, Janel N, Irminger JC, Kergoat M, Portha B, Donath MY, Ehses JA, Homo-Delarche F.

PLoS One. 2009 Sep 9;4(9):e6963.PMID: 19742300 [PubMed - in process]Related articlesFree article

IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat.

Ehses JA, Lacraz G, Giroix MH, Schmidlin F, Coulaud J, Kassis N, Irminger JC, Kergoat M, Portha B, Homo-Delarche F, Donath MY.

Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13998-4003. Epub 2009 Jul 30.PMID: 19666548 [PubMed - indexed for MEDLINE]Related articles

Pancreatic islet inflammation in type 2 diabetes: from alpha and beta cell compensation to dysfunction.

Ehses JA, Ellingsgaard H, Böni-Schnetzler M, Donath MY.

Arch Physiol Biochem. 2009 Oct;115(4):240-7.PMID: 19645635 [PubMed - in process]Related articles

Low- and high-density lipoproteins modulate function, apoptosis, and proliferation of primary human and murine pancreatic beta-cells.

Rütti S, Ehses JA, Sibler RA, Prazak R, Rohrer L, Georgopoulos S, Meier DT, Niclauss N, Berney T, Donath MY, von Eckardstein A.

Endocrinology. 2009 Oct;150(10):4521-30. Epub 2009 Jul 23.PMID: 19628574 [PubMed - indexed for MEDLINE]Related articles

Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes.

Larsen CM, Faulenbach M, Vaag A, Ehses JA, Donath MY, Mandrup-Poulsen T.

Diabetes Care. 2009 Sep;32(9):1663-8. Epub 2009 Jun 19.PMID: 19542207 [PubMed - indexed for MEDLINE]Related articles

Atherosclerotic mice exhibit systemic inflammation in periadventitial and visceral adipose tissue, liver, and pancreatic islets.

Lohmann C, Schäfer N, von Lukowicz T, Sokrates Stein MA, Borén J, Rütti S, Wahli W, Donath MY, Lüscher TF, Matter CM.

Atherosclerosis. 2009 May 14. [Epub ahead of print]PMID: 19481752 [PubMed - as supplied by publisher]Related articles

Signaling pathways implicated in the stimulation of beta-cell proliferation by extracellular matrix.

Parnaud G, Hammar E, Ribaux P, Donath MY, Berney T, Halban PA.

Mol Endocrinol. 2009 Aug;23(8):1264-71. Epub 2009 May 14.PMID: 19443607 [PubMed - in process]Related articles

Hyperglycaemia but not hyperlipidaemia causes beta cell dysfunction and beta cell loss in the domestic cat.

Zini E, Osto M, Franchini M, Guscetti F, Donath MY, Perren A, Heller RS, Linscheid P, Bouwman M, Ackermann M, Lutz TA, Reusch CE.

Diabetologia. 2009 Feb;52(2):336-46. Epub 2008 Nov 26.PMID: 19034421 [PubMed - indexed for MEDLINE]Related articles

Insulitis in type 2 diabetes.

Böni-Schnetzler M, Ehses JA, Faulenbach M, Donath MY.

Diabetes Obes Metab. 2008 Nov;10 Suppl 4:201-4.PMID: 18834448 [PubMed - indexed for MEDLINE]Related articles

Interleukin-6 regulates pancreatic alpha-cell mass expansion.

Ellingsgaard H, Ehses JA, Hammar EB, Van Lommel L, Quintens R, Martens G, Kerr-Conte J, Pattou F, Berney T, Pipeleers D, Halban PA, Schuit FC, Donath MY.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13163-8. Epub 2008 Aug 21.PMID: 18719127 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation.

Böni-Schnetzler M, Thorne J, Parnaud G, Marselli L, Ehses JA, Kerr-Conte J, Pattou F, Halban PA, Weir GC, Donath MY.

J Clin Endocrinol Metab. 2008 Oct;93(10):4065-74. Epub 2008 Jul 29.PMID: 18664535 [PubMed - indexed for MEDLINE]Related articlesFree article

Macrophages, cytokines and beta-cell death in Type 2 diabetes.

Ehses JA, Böni-Schnetzler M, Faulenbach M, Donath MY.

Biochem Soc Trans. 2008 Jun;36(Pt 3):340-2. Review.PMID: 18481953 [PubMed - indexed for MEDLINE]Related articles

The use of interleukin-1-receptor antagonists in the treatment of diabetes mellitus.

Donath MY, Mandrup-Poulsen T.

Nat Clin Pract Endocrinol Metab. 2008 May;4(5):240-1. Epub 2008 Mar 4. No abstract available. PMID: 18317479 [PubMed - indexed for MEDLINE]Related articles

Islet inflammation in type 2 diabetes: from metabolic stress to therapy.

Donath MY, Schumann DM, Faulenbach M, Ellingsgaard H, Perren A, Ehses JA.

Diabetes Care. 2008 Feb;31 Suppl 2:S161-4. Review.PMID: 18227479 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose and leptin induce apoptosis in human beta-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases.

Maedler K, Schulthess FT, Bielman C, Berney T, Bonny C, Prentki M, Donath MY, Roduit R.

FASEB J. 2008 Jun;22(6):1905-13. Epub 2008 Feb 8.PMID: 18263705 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytokines and beta-cell biology: from concept to clinical translation.

Donath MY, Størling J, Berchtold LA, Billestrup N, Mandrup-Poulsen T.

Endocr Rev. 2008 May;29(3):334-50. Epub 2007 Nov 29. Review.PMID: 18048762 [PubMed - indexed for MEDLINE]Related articlesFree article

Unsuspected osteomyelitis is frequent in persistent diabetic foot ulcer and better diagnosed by MRI than by 18F-FDG PET or 99mTc-MOAB.

Schwegler B, Stumpe KD, Weishaupt D, Strobel K, Spinas GA, von Schulthess GK, Hodler J, Böni T, Donath MY.

J Intern Med. 2008 Jan;263(1):99-106. Epub 2007 Nov 23.PMID: 18036160 [PubMed - indexed for MEDLINE]Related articles

Proliferation of sorted human and rat beta cells.

Parnaud G, Bosco D, Berney T, Pattou F, Kerr-Conte J, Donath MY, Bruun C, Mandrup-Poulsen T, Billestrup N, Halban PA.

Diabetologia. 2008 Jan;51(1):91-100. Epub 2007 Nov 10.PMID: 17994216 [PubMed - indexed for MEDLINE]Related articles

Induction of CXCL1 by extracellular matrix and autocrine enhancement by interleukin-1 in rat pancreatic beta-cells.

Ribaux P, Ehses JA, Lin-Marq N, Carrozzino F, Böni-Schnetzler M, Hammar E, Irminger JC, Donath MY, Halban PA.

Endocrinology. 2007 Nov;148(11):5582-90. Epub 2007 Aug 16.PMID: 17702850 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased number of islet-associated macrophages in type 2 diabetes.

Ehses JA, Perren A, Eppler E, Ribaux P, Pospisilik JA, Maor-Cahn R, Gueripel X, Ellingsgaard H, Schneider MK, Biollaz G, Fontana A, Reinecke M, Homo-Delarche F, Donath MY.

Diabetes. 2007 Sep;56(9):2356-70. Epub 2007 Jun 19.PMID: 17579207 [PubMed - indexed for MEDLINE]Related articlesFree article

Interleukin-1-receptor antagonist in type 2 diabetes mellitus.

Larsen CM, Faulenbach M, Vaag A, Vølund A, Ehses JA, Seifert B, Mandrup-Poulsen T, Donath MY.

N Engl J Med. 2007 Apr 12;356(15):1517-26.PMID: 17429083 [PubMed - indexed for MEDLINE]Related articlesFree article

The Fas pathway is involved in pancreatic beta cell secretory function.

Schumann DM, Maedler K, Franklin I, Konrad D, Størling J, Böni-Schnetzler M, Gjinovci A, Kurrer MO, Gauthier BR, Bosco D, Andres A, Berney T, Greter M, Becher B, Chervonsky AV, Halban PA, Mandrup-Poulsen T, Wollheim CB, Donath MY.

Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2861-6. Epub 2007 Feb 13.PMID: 17299038 [PubMed - indexed for MEDLINE]Related articlesFree article

Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets.

Maedler K, Schumann DM, Sauter N, Ellingsgaard H, Bosco D, Baertschiger R, Iwakura Y, Oberholzer J, Wollheim CB, Gauthier BR, Donath MY.

Diabetes. 2006 Oct;55(10):2713-22.PMID: 17003335 [PubMed - indexed for MEDLINE]Related articlesFree article

Aging correlates with decreased beta-cell proliferative capacity and enhanced sensitivity to apoptosis: a potential role for Fas and pancreatic duodenal homeobox-1.

Maedler K, Schumann DM, Schulthess F, Oberholzer J, Bosco D, Berney T, Donath MY.

Diabetes. 2006 Sep;55(9):2455-62.PMID: 16936193 [PubMed - indexed for MEDLINE]Related articlesFree article

Type 1, type 1.5, and type 2 diabetes: NOD the diabetes we thought it was.

Donath MY, Ehses JA.

Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12217-8. Epub 2006 Aug 7. No abstract available. PMID: 16894143 [PubMed - indexed for MEDLINE]Related articlesFree article

High glucose alters cardiomyocyte contacts and inhibits myofibrillar formation.

Dyntar D, Sergeev P, Klisic J, Ambühl P, Schaub MC, Donath MY.

J Clin Endocrinol Metab. 2006 May;91(5):1961-7. Epub 2006 Mar 7.PMID: 16522700 [PubMed - indexed for MEDLINE]Related articlesFree article

Psammomys obesus, a model for environment-gene interactions in type 2 diabetes.

Kaiser N, Nesher R, Donath MY, Fraenkel M, Behar V, Magnan C, Ktorza A, Cerasi E, Leibowitz G.

Diabetes. 2005 Dec;54 Suppl 2:S137-44. Review.PMID: 16306331 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms of beta-cell death in type 2 diabetes.

Donath MY, Ehses JA, Maedler K, Schumann DM, Ellingsgaard H, Eppler E, Reinecke M.

Diabetes. 2005 Dec;54 Suppl 2:S108-13. Review.PMID: 16306327 [PubMed - indexed for MEDLINE]Related articlesFree article

Dynamic changes in {beta}-cell mass and pancreatic insulin during the evolution of nutrition-dependent diabetes in psammomys obesus: impact of glycemic control.

Kaiser N, Yuli M, Uçkaya G, Oprescu AI, Berthault MF, Kargar C, Donath MY, Cerasi E, Ktorza A.

Diabetes. 2005 Jan;54(1):138-45.PMID: 15616021 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human beta-cells from hyperglycemia-induced apoptosis.

Mohanty S, Spinas GA, Maedler K, Zuellig RA, Lehmann R, Donath MY, Trüb T, Niessen M.

Exp Cell Res. 2005 Feb 1;303(1):68-78.PMID: 15572028 [PubMed - indexed for MEDLINE]Related articles

Islets secretory capacity determines glucose homoeostasis in the face of insulin resistance.

Wiesli P, Schäffler E, Seifert B, Schmid C, Donath MY.

Swiss Med Wkly. 2004 Sep 18;134(37-38):559-64.PMID: 15551159 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cells in type 2 diabetes: a loss of function and mass.

Maedler K, Donath MY.

Horm Res. 2004;62 Suppl 3:67-73. Review.PMID: 15539803 [PubMed - indexed for MEDLINE]Related articles

Sulfonylurea induced beta-cell apoptosis in cultured human islets.

Maedler K, Carr RD, Bosco D, Zuellig RA, Berney T, Donath MY.

J Clin Endocrinol Metab. 2005 Jan;90(1):501-6. Epub 2004 Oct 13.PMID: 15483097 [PubMed - indexed for MEDLINE]Related articlesFree article

Pioglitazone and sodium salicylate protect human beta-cells against apoptosis and impaired function induced by glucose and interleukin-1beta.

Zeender E, Maedler K, Bosco D, Berney T, Donath MY, Halban PA.

J Clin Endocrinol Metab. 2004 Oct;89(10):5059-66.PMID: 15472206 [PubMed - indexed for MEDLINE]Related articlesFree article

[Type 1 and type 2 diabetes: molecular parallels]

Donath MY.

Journ Annu Diabetol Hotel Dieu. 2004:11-7. Review. French. No abstract available. PMID: 15259301 [PubMed - indexed for MEDLINE]Related articles

Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets.

Maedler K, Størling J, Sturis J, Zuellig RA, Spinas GA, Arkhammar PO, Mandrup-Poulsen T, Donath MY.

Diabetes. 2004 Jul;53(7):1706-13.PMID: 15220194 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets.

Maedler K, Sergeev P, Ehses JA, Mathe Z, Bosco D, Berney T, Dayer JM, Reinecke M, Halban PA, Donath MY.

Proc Natl Acad Sci U S A. 2004 May 25;101(21):8138-43. Epub 2004 May 12.PMID: 15141093 [PubMed - indexed for MEDLINE]Related articlesFree article

Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications.

Donath MY, Halban PA.

Diabetologia. 2004 Mar;47(3):581-9. Epub 2004 Feb 7. Review.PMID: 14767595 [PubMed - indexed for MEDLINE]Related articles

Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes.

Donath MY, Størling J, Maedler K, Mandrup-Poulsen T.

J Mol Med. 2003 Aug;81(8):455-70. Epub 2003 Jul 18. Review.PMID: 12879149 [PubMed - indexed for MEDLINE]Related articles

Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function.

Maedler K, Oberholzer J, Bucher P, Spinas GA, Donath MY.

Diabetes. 2003 Mar;52(3):726-33.PMID: 12606514 [PubMed - indexed for MEDLINE]Related articlesFree article

[The pathogenesis of type 2 diabetes--new aspects and clinical consequences]

Donath MY, Maedler K, Sergeev P, Dyntar D, Thomas D, Spinas GA.

Ther Umsch. 2002 Aug;59(8):381-5. German. PMID: 12235729 [PubMed - indexed for MEDLINE]Related articles

Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets.

Maedler K, Sergeev P, Ris F, Oberholzer J, Joller-Jemelka HI, Spinas GA, Kaiser N, Halban PA, Donath MY.

J Clin Invest. 2002 Sep;110(6):851-60.PMID: 12235117 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact of integrin-matrix matching and inhibition of apoptosis on the survival of purified human beta-cells in vitro.

Ris F, Hammar E, Bosco D, Pilloud C, Maedler K, Donath MY, Oberholzer J, Zeender E, Morel P, Rouiller D, Halban PA.

Diabetologia. 2002 Jun;45(6):841-50. Epub 2002 May 8.PMID: 12107728 [PubMed - indexed for MEDLINE]Related articles

FLIP switches Fas-mediated glucose signaling in human pancreatic beta cells from apoptosis to cell replication.

Maedler K, Fontana A, Ris F, Sergeev P, Toso C, Oberholzer J, Lehmann R, Bachmann F, Tasinato A, Spinas GA, Halban PA, Donath MY.

Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8236-41.PMID: 12060768 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose and palmitic acid induce degeneration of myofibrils and modulate apoptosis in rat adult cardiomyocytes.

Dyntar D, Eppenberger-Eberhardt M, Maedler K, Pruschy M, Eppenberger HM, Spinas GA, Donath MY.

Diabetes. 2001 Sep;50(9):2105-13.PMID: 11522678 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets.

Maedler K, Spinas GA, Lehmann R, Sergeev P, Weber M, Fontana A, Kaiser N, Donath MY.

Diabetes. 2001 Aug;50(8):1683-90.PMID: 11473025 [PubMed - indexed for MEDLINE]Related articlesFree article

beta-cell glucotoxicity in the Psammomys obesus model of type 2 diabetes.

Leibowitz G, Yuli M, Donath MY, Nesher R, Melloul D, Cerasi E, Gross DJ, Kaiser N.

Diabetes. 2001 Feb;50 Suppl 1:S113-7.PMID: 11272167 [PubMed - indexed for MEDLINE]Related articles

Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function.

Maedler K, Spinas GA, Dyntar D, Moritz W, Kaiser N, Donath MY.

Diabetes. 2001 Jan;50(1):69-76.PMID: 11147797 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-like growth factor I and cardiac performance in heart failure.

Donath MY, Froesch ER, Zapf J.

Growth Horm IGF Res. 1998 Apr;8 Suppl B:167-70. Review. No abstract available. PMID: 10990156 [PubMed - indexed for MEDLINE]Related articles