PubMed

Inflammatory arthritis in caspase 1 gene-deficient mice: Contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta.

Joosten LA, Netea MG, Fantuzzi G, Koenders MI, Helsen MM, Sparrer H, Pham CT, van der Meer JW, Dinarello CA, van den Berg WB.

Arthritis Rheum. 2009 Nov 30;60(12):3651-3662. [Epub ahead of print]PMID: 19950280 [PubMed - as supplied by publisher]Related articles

Tumor Necrosis Factor-{alpha} Causes Release of Cytosolic Interleukin-18 from Human Neutrophils.

Silliman CC, Kelher MR, Gamboni-Robertson F, Hamiel CR, England KM, Dinarello CA, Wyman TH, Khan SY, McLaughlin NJ, Bercovitz RS, Banerjee A.

Am J Physiol Cell Physiol. 2009 Nov 11. [Epub ahead of print]PMID: 19907017 [PubMed - as supplied by publisher]Related articles

Suppressing IL-32 in monocytes impairs the induction of the proinflammatory cytokines TNFalpha and IL-1beta.

Hong J, Bae S, Kang Y, Yoon D, Bai X, Chan ED, Azam T, Dinarello CA, Lee S, Her E, Rho G, Kim S.

Cytokine. 2009 Oct 30. [Epub ahead of print]PMID: 19880327 [PubMed - as supplied by publisher]Related articles

IL-18 binding protein-expressing mesenchymal stem cells improve myocardial protection after ischemia or infarction.

Wang M, Tan J, Wang Y, Meldrum KK, Dinarello CA, Meldrum DR.

Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17499-504. Epub 2009 Sep 25.PMID: 19805173 [PubMed - indexed for MEDLINE]Related articlesFree article

Low-flux hemodialysis suppresses interferon-gamma production: the possible role of beta2-microglobulin.

Lonnemann G, Bahlmann FH, Freise J, Hertel B, Dinarello CA.

Clin Nephrol. 2009 Sep;72(3):170-6.PMID: 19761720 [PubMed - in process]Related articles

IL-18 activity in systemic lupus erythematosus.

Favilli F, Anzilotti C, Martinelli L, Quattroni P, De Martino S, Pratesi F, Neumann D, Beermann S, Novick D, Dinarello CA, Boraschi D, Migliorini P.

Ann N Y Acad Sci. 2009 Sep;1173:301-9.PMID: 19758166 [PubMed - indexed for MEDLINE]Related articles

The role of macrophage-derived IL-1 in induction and maintenance of angiogenesis.

Carmi Y, Voronov E, Dotan S, Lahat N, Rahat MA, Fogel M, Huszar M, White MR, Dinarello CA, Apte RN.

J Immunol. 2009 Oct 1;183(7):4705-14. Epub 2009 Sep 14.PMID: 19752225 [PubMed - indexed for MEDLINE]Related articles

Histone deacetylase inhibitor ITF2357 is neuroprotective, improves functional recovery, and induces glial apoptosis following experimental traumatic brain injury.

Shein NA, Grigoriadis N, Alexandrovich AG, Simeonidou C, Lourbopoulos A, Polyzoidou E, Trembovler V, Mascagni P, Dinarello CA, Shohami E.

FASEB J. 2009 Dec;23(12):4266-75. Epub 2009 Sep 1.PMID: 19723705 [PubMed - in process]Related articles

High circulating levels of free interleukin-18 in patients with active SLE in the presence of elevated levels of interleukin-18 binding protein.

Novick D, Elbirt D, Miller G, Dinarello CA, Rubinstein M, Sthoeger ZM.

J Autoimmun. 2009 Aug 20. [Epub ahead of print]PMID: 19699611 [PubMed - as supplied by publisher]Related articles

Peptides modulating conformational changes in secreted chaperones: from in silico design to preclinical proof of concept.

Kliger Y, Levy O, Oren A, Ashkenazy H, Tiran Z, Novik A, Rosenberg A, Amir A, Wool A, Toporik A, Schreiber E, Eshel D, Levine Z, Cohen Y, Nold-Petry C, Dinarello CA, Borukhov I.

Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13797-801. Epub 2009 Aug 5.PMID: 19666568 [PubMed - indexed for MEDLINE]Related articles

Increased cytokine production in interleukin-18 receptor alpha-deficient cells is associated with dysregulation of suppressors of cytokine signaling.

Nold-Petry CA, Nold MF, Nielsen JW, Bustamante A, Zepp JA, Storm KA, Hong JW, Kim SH, Dinarello CA.

J Biol Chem. 2009 Sep 18;284(38):25900-11. Epub 2009 Jul 10.PMID: 19592492 [PubMed - indexed for MEDLINE]Related articles

Intravitreal anakinra inhibits choroidal neovascular membrane growth in a rat model.

Olson JL, Courtney RJ, Rouhani B, Mandava N, Dinarello CA.

Ocul Immunol Inflamm. 2009 May-Jun;17(3):195-200.PMID: 19585363 [PubMed - indexed for MEDLINE]Related articles

Hyperosmolar sodium chloride, p38 mitogen activated protein and cytokine-mediated inflammation.

Dinarello CA.

Semin Dial. 2009 May-Jun;22(3):256-9. Review.PMID: 19573005 [PubMed - indexed for MEDLINE]Related articles

Transcriptional and inflammasome-mediated pathways for the induction of IL-1beta production by Mycobacterium tuberculosis.

Kleinnijenhuis J, Joosten LA, van de Veerdonk FL, Savage N, van Crevel R, Kullberg BJ, van der Ven A, Ottenhoff TH, Dinarello CA, van der Meer JW, Netea MG.

Eur J Immunol. 2009 Jul;39(7):1914-22.PMID: 19544485 [PubMed - indexed for MEDLINE]Related articles

IL-18 neutralization ameliorates obstruction-induced epithelial-mesenchymal transition and renal fibrosis.

Bani-Hani AH, Leslie JA, Asanuma H, Dinarello CA, Campbell MT, Meldrum DR, Zhang H, Hile K, Meldrum KK.

Kidney Int. 2009 Sep;76(5):500-11. Epub 2009 Jun 17.PMID: 19536084 [PubMed - indexed for MEDLINE]Related articles

Interleukin-1beta and the autoinflammatory diseases.

Dinarello CA.

N Engl J Med. 2009 Jun 4;360(23):2467-70. No abstract available. PMID: 19494224 [PubMed - indexed for MEDLINE]Related articles

Modulation of muramyl dipeptide stimulation of cytokine production by blood components.

van der Meer JH, Netea MG, Dinarello CA.

Clin Exp Immunol. 2009 Jun;156(3):428-33.PMID: 19438594 [PubMed - indexed for MEDLINE]Related articles

Cutting edge: Negative regulation of dendritic cells through acetylation of the nonhistone protein STAT-3.

Sun Y, Chin YE, Weisiger E, Malter C, Tawara I, Toubai T, Gatza E, Mascagni P, Dinarello CA, Reddy P.

J Immunol. 2009 May 15;182(10):5899-903.PMID: 19414739 [PubMed - indexed for MEDLINE]Related articles

IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation.

Ben-Sasson SZ, Hu-Li J, Quiel J, Cauchetaux S, Ratner M, Shapira I, Dinarello CA, Paul WE.

Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7119-24. Epub 2009 Apr 9.PMID: 19359475 [PubMed - indexed for MEDLINE]Related articlesFree article

Host-derived interleukin-1alpha is important in determining the immunogenicity of 3-methylcholantrene tumor cells.

Elkabets M, Krelin Y, Dotan S, Cerwenka A, Porgador A, Lichtenstein RG, White MR, Zoller M, Iwakura Y, Dinarello CA, Voronov E, Apte RN.

J Immunol. 2009 Apr 15;182(8):4874-81.PMID: 19342666 [PubMed - indexed for MEDLINE]Related articles

Immunological and inflammatory functions of the interleukin-1 family.

Dinarello CA.

Annu Rev Immunol. 2009;27:519-50. Review.PMID: 19302047 [PubMed - indexed for MEDLINE]Related articles

IL-32-dependent effects of IL-1beta on endothelial cell functions.

Nold-Petry CA, Nold MF, Zepp JA, Kim SH, Voelkel NF, Dinarello CA.

Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3883-8. Epub 2009 Feb 19.PMID: 19228941 [PubMed - indexed for MEDLINE]Related articlesFree article

Bypassing pathogen-induced inflammasome activation for the regulation of interleukin-1beta production by the fungal pathogen Candida albicans.

van de Veerdonk FL, Joosten LA, Devesa I, Mora-Montes HM, Kanneganti TD, Dinarello CA, van der Meer JW, Gow NA, Kullberg BJ, Netea MG.

J Infect Dis. 2009 Apr 1;199(7):1087-96. Erratum in: J Infect Dis. 2009 Jun 1;199(11):1716. PMID: 19222370 [PubMed - indexed for MEDLINE]Related articles

Alpha-1-antitrypsin is an endogenous inhibitor of proinflammatory cytokine production in whole blood.

Pott GB, Chan ED, Dinarello CA, Shapiro L.

J Leukoc Biol. 2009 May;85(5):886-95. Epub 2009 Feb 5.PMID: 19197072 [PubMed - indexed for MEDLINE]Related articles

Targeting the pathogenic role of interleukin 1{beta} in the progression of smoldering/indolent myeloma to active disease.

Dinarello CA.

Mayo Clin Proc. 2009 Feb;84(2):105-7. No abstract available. PMID: 19181642 [PubMed - indexed for MEDLINE]Related articlesFree article

Inflammation in human disease: anticytokine therapy.

Dinarello CA.

Biol Blood Marrow Transplant. 2009 Jan;15(1 Suppl):134-6. Review. No abstract available. PMID: 19147092 [PubMed - indexed for MEDLINE]Related articles

Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages.

Netea MG, Nold-Petry CA, Nold MF, Joosten LA, Opitz B, van der Meer JH, van de Veerdonk FL, Ferwerda G, Heinhuis B, Devesa I, Funk CJ, Mason RJ, Kullberg BJ, Rubartelli A, van der Meer JW, Dinarello CA.

Blood. 2009 Mar 5;113(10):2324-35. Epub 2008 Dec 22.PMID: 19104081 [PubMed - indexed for MEDLINE]Related articles

Proteinase 3-processed form of the recombinant IL-32 separate domain.

Kim S, Lee S, Her E, Bae S, Choi J, Hong J, Jaekal J, Yoon D, Azam T, Dinarello CA, Kim S.

BMB Rep. 2008 Nov 30;41(11):814-9.PMID: 19017495 [PubMed - indexed for MEDLINE]Related articlesFree article

Extracellular superoxide dismutase haplotypes are associated with acute lung injury and mortality.

Arcaroli JJ, Hokanson JE, Abraham E, Geraci M, Murphy JR, Bowler RP, Dinarello CA, Silveira L, Sankoff J, Heyland D, Wischmeyer P, Crapo JD.

Am J Respir Crit Care Med. 2009 Jan 15;179(2):105-12. Epub 2008 Oct 23.PMID: 18948423 [PubMed - indexed for MEDLINE]Related articles

alpha1-Antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in mice.

Lewis EC, Mizrahi M, Toledano M, Defelice N, Wright JL, Churg A, Shapiro L, Dinarello CA.

Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16236-41. Epub 2008 Oct 13.PMID: 18852465 [PubMed - indexed for MEDLINE]Related articlesFree article

Blocking TH17-polarizing cytokines by histone deacetylase inhibitors in vitro and in vivo.

Bosisio D, Vulcano M, Del Prete A, Sironi M, Salvi V, Salogni L, Riboldi E, Leoni F, Dinarello CA, Girolomoni G, Sozzani S.

J Leukoc Biol. 2008 Dec;84(6):1540-8. Epub 2008 Sep 9.PMID: 18780875 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of the most active interleukin-32 isoform.

Choi JD, Bae SY, Hong JW, Azam T, Dinarello CA, Her E, Choi WS, Kim BK, Lee CK, Yoon DY, Kim SJ, Kim SH.

Immunology. 2009 Apr;126(4):535-42. Epub 2008 Sep 2.PMID: 18771438 [PubMed - indexed for MEDLINE]Related articles

Interleukin-18 binding protein transgenic mice are protected against ischemic acute kidney injury.

He Z, Lu L, Altmann C, Hoke TS, Ljubanovic D, Jani A, Dinarello CA, Faubel S, Edelstein CL.

Am J Physiol Renal Physiol. 2008 Nov;295(5):F1414-21. Epub 2008 Aug 27.PMID: 18753296 [PubMed - indexed for MEDLINE]Related articlesFree article

Resistant Behçet disease responsive to anakinra.

Botsios C, Sfriso P, Furlan A, Punzi L, Dinarello CA.

Ann Intern Med. 2008 Aug 19;149(4):284-6. No abstract available. PMID: 18711165 [PubMed - indexed for MEDLINE]Related articlesFree article

IL-32, a novel proinflammatory cytokine in chronic obstructive pulmonary disease.

Calabrese F, Baraldo S, Bazzan E, Lunardi F, Rea F, Maestrelli P, Turato G, Lokar-Oliani K, Papi A, Zuin R, Sfriso P, Balestro E, Dinarello CA, Saetta M.

Am J Respir Crit Care Med. 2008 Nov 1;178(9):894-901. Epub 2008 Aug 14.PMID: 18703789 [PubMed - indexed for MEDLINE]Related articlesFree article

Interleukin-18 binding protein in the sera of patients with Wegener's granulomatosis.

Novick D, Elbirt D, Dinarello CA, Rubinstein M, Sthoeger ZM.

J Clin Immunol. 2009 Jan;29(1):38-45. Epub 2008 Jul 2.PMID: 18594952 [PubMed - indexed for MEDLINE]Related articles

Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase-dependent DC functions and regulates experimental graft-versus-host disease in mice.

Reddy P, Sun Y, Toubai T, Duran-Struuck R, Clouthier SG, Weisiger E, Maeda Y, Tawara I, Krijanovski O, Gatza E, Liu C, Malter C, Mascagni P, Dinarello CA, Ferrara JL.

J Clin Invest. 2008 Jul;118(7):2562-73.PMID: 18568076 [PubMed - indexed for MEDLINE]Related articlesFree article

Endogenous IL-32 controls cytokine and HIV-1 production.

Nold MF, Nold-Petry CA, Pott GB, Zepp JA, Saavedra MT, Kim SH, Dinarello CA.

J Immunol. 2008 Jul 1;181(1):557-65.PMID: 18566422 [PubMed - indexed for MEDLINE]Related articlesFree article

Interleukin-18, together with interleukin-12, induces severe acute pancreatitis in obese but not in nonobese leptin-deficient mice.

Sennello JA, Fayad R, Pini M, Gove ME, Ponemone V, Cabay RJ, Siegmund B, Dinarello CA, Fantuzzi G.

Proc Natl Acad Sci U S A. 2008 Jun 10;105(23):8085-90. Epub 2008 May 30.PMID: 18515422 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytokines link Toll-like receptor 4 signaling to cardiac dysfunction after global myocardial ischemia.

Cha J, Wang Z, Ao L, Zou N, Dinarello CA, Banerjee A, Fullerton DA, Meng X.

Ann Thorac Surg. 2008 May;85(5):1678-85.PMID: 18442564 [PubMed - indexed for MEDLINE]Related articles

Measurement of soluble and membrane-bound interleukin 1 using a fibroblast bioassay.

Dinarello CA, Muegge K, Durum SK.

Curr Protoc Immunol. 2001 May;Chapter 6:Unit 6.2.PMID: 18432810 [PubMed - indexed for MEDLINE]Related articles

The IL-1 family member 7b translocates to the nucleus and down-regulates proinflammatory cytokines.

Sharma S, Kulk N, Nold MF, Gräf R, Kim SH, Reinhardt D, Dinarello CA, Bufler P.

J Immunol. 2008 Apr 15;180(8):5477-82.PMID: 18390730 [PubMed - indexed for MEDLINE]Related articlesFree article

Interleukin-32 induces the differentiation of monocytes into macrophage-like cells.

Netea MG, Lewis EC, Azam T, Joosten LA, Jaekal J, Bae SY, Dinarello CA, Kim SH.

Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3515-20. Epub 2008 Feb 22.PMID: 18296636 [PubMed - indexed for MEDLINE]Related articlesFree article

Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function.

Marcondes AM, Mhyre AJ, Stirewalt DL, Kim SH, Dinarello CA, Deeg HJ.

Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2865-70. Epub 2008 Feb 19.PMID: 18287021 [PubMed - indexed for MEDLINE]Related articlesFree article

Interleukin-32 monoclonal antibodies for immunohistochemistry, Western blotting, and ELISA.

Kim KH, Shim JH, Seo EH, Cho MC, Kang JW, Kim SH, Yu DY, Song EY, Lee HG, Sohn JH, Kim J, Dinarello CA, Yoon DY.

J Immunol Methods. 2008 Apr 20;333(1-2):38-50. Epub 2008 Jan 28.PMID: 18252253 [PubMed - indexed for MEDLINE]Related articles

Abrogation of anti-inflammatory transcription factor LKLF in neutrophil-dominated airways.

Saavedra MT, Patterson AD, West J, Randell SH, Riches DW, Malcolm KC, Cool CD, Nick JA, Dinarello CA.

Am J Respir Cell Mol Biol. 2008 Jun;38(6):679-88. Epub 2008 Jan 24.PMID: 18218994 [PubMed - indexed for MEDLINE]Related articlesFree article

Histone deacetylases: novel targets for prevention of colitis-associated cancer in mice.

Glauben R, Batra A, Stroh T, Erben U, Fedke I, Lehr HA, Leoni F, Mascagni P, Dinarello CA, Zeitz M, Siegmund B.

Gut. 2008 May;57(5):613-22. Epub 2008 Jan 14.PMID: 18194985 [PubMed - indexed for MEDLINE]Related articles

Individual LPS responsiveness depends on the variation of toll-like receptor (TLR) expression level.

Jaekal J, Abraham E, Azam T, Netea MG, Dinarello CA, Lim JS, Yang Y, Yoon DY, Kim SH.

J Microbiol Biotechnol. 2007 Nov;17(11):1862-7.PMID: 18092472 [PubMed - indexed for MEDLINE]Related articlesFree article

Historical insights into cytokines.

Dinarello CA.

Eur J Immunol. 2007 Nov;37 Suppl 1:S34-45. Review.PMID: 17972343 [PubMed - indexed for MEDLINE]Related articles

Expression of functional Toll-like receptors 2 and 4 in human aortic valve interstitial cells: potential roles in aortic valve inflammation and stenosis.

Meng X, Ao L, Song Y, Babu A, Yang X, Wang M, Weyant MJ, Dinarello CA, Cleveland JC Jr, Fullerton DA.

Am J Physiol Cell Physiol. 2008 Jan;294(1):C29-35. Epub 2007 Oct 17.PMID: 17942642 [PubMed - indexed for MEDLINE]Related articlesFree article