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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2005 2
2007 1
2009 2
2010 5
2011 4
2012 8
2013 3
2014 8
2015 7
2016 10
2017 7
2018 8
2019 14
2020 22
2021 16
2022 11
2023 17
2024 7

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Search Results

132 results

Results by year

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Page 1
Past, present and future of therapeutic strategies against amyloid-beta peptides in Alzheimer's disease: a systematic review.
Jeremic D, Jiménez-Díaz L, Navarro-López JD. Jeremic D, et al. Ageing Res Rev. 2021 Dec;72:101496. doi: 10.1016/j.arr.2021.101496. Epub 2021 Oct 21. Ageing Res Rev. 2021. PMID: 34687956 Free article. Review.
Accumulation of amyloid-beta (Abeta) peptides is considered one of the fundamental neuropathological pillars of the disease, and its dyshomeostasis has shown a crucial role in AD onset. Therefore, many amyloid-targeted therapies have been investigated. Here, we will system …
Accumulation of amyloid-beta (Abeta) peptides is considered one of the fundamental neuropathological pillars of the disease, and its dyshome …
Efficacy of innovative therapies in myasthenia gravis: A systematic review, meta-analysis and network meta-analysis.
Saccà F, Pane C, Espinosa PE, Sormani MP, Signori A. Saccà F, et al. Eur J Neurol. 2023 Dec;30(12):3854-3867. doi: 10.1111/ene.15872. Epub 2023 May 30. Eur J Neurol. 2023. PMID: 37204031
The aim of this study was to perform a meta-analysis and network meta-analysis of randomized and placebo-controlled trials of innovative therapies in MG with available efficacy data. METHODS: We assessed statistical heterogeneity across trials based on the Cochrane Q test …
The aim of this study was to perform a meta-analysis and network meta-analysis of randomized and placebo-controlled trials of innovative …
New biologics and targeted therapies in systemic lupus: From new molecular targets to new indications. A systematic review.
Felten R, Scherlinger M, Mertz P, Chasset F, Arnaud L. Felten R, et al. Joint Bone Spine. 2023 Mar;90(2):105523. doi: 10.1016/j.jbspin.2023.105523. Epub 2023 Jan 7. Joint Bone Spine. 2023. PMID: 36623799
METHODS: We performed a systematic review of targeted therapies in clinical development in SLE in clinicaltrials.gov (search date: 28th of August 2022). ...For each investigational drug, we considered only the study at the most advanced stage of clinical development …
METHODS: We performed a systematic review of targeted therapies in clinical development in SLE in clinicaltrials.gov (search date: 28 …
Recent Antifungal Pipeline Developments against Candida auris: A Systematic Review.
Treviño-Rangel RJ, González GM, Montoya AM, Rojas OC, Elizondo-Zertuche M, Álvarez-Villalobos NA. Treviño-Rangel RJ, et al. J Fungi (Basel). 2022 Oct 28;8(11):1144. doi: 10.3390/jof8111144. J Fungi (Basel). 2022. PMID: 36354911 Free PMC article. Review.
A systematic search in MEDLINE, EMBASE, Web of Science, and Scopus up to 27 June 2022 was conducted to find relevant articles reporting data of in vitro activity and in vivo efficacy of investigational antifungals against C. auris. These included new additions to existing …
A systematic search in MEDLINE, EMBASE, Web of Science, and Scopus up to 27 June 2022 was conducted to find relevant articles reporting data …
Cannabinoid therapies in the management of sleep disorders: A systematic review of preclinical and clinical studies.
Suraev AS, Marshall NS, Vandrey R, McCartney D, Benson MJ, McGregor IS, Grunstein RR, Hoyos CM. Suraev AS, et al. Sleep Med Rev. 2020 Oct;53:101339. doi: 10.1016/j.smrv.2020.101339. Epub 2020 May 16. Sleep Med Rev. 2020. PMID: 32603954
Promising preliminary evidence provides the rationale for future randomised controlled trials of cannabinoid therapies in individuals with sleep apnea, insomnia, post-traumatic stress disorder-related nightmares, restless legs syndrome, rapid eye movement sleep beha …
Promising preliminary evidence provides the rationale for future randomised controlled trials of cannabinoid therapies in indi …
Intravenous thrombolytic treatment and endovascular thrombectomy for ischaemic wake-up stroke.
Roaldsen MB, Lindekleiv H, Mathiesen EB. Roaldsen MB, et al. Cochrane Database Syst Rev. 2021 Dec 1;12(12):CD010995. doi: 10.1002/14651858.CD010995.pub3. Cochrane Database Syst Rev. 2021. PMID: 34850380 Free PMC article. Review.
However, recent studies suggest benefit from recanalisation therapies in selected patients. OBJECTIVES: To assess the effects of intravenous thrombolysis and endovascular thrombectomy versus control in people with acute ischaemic stroke presenting on awakening from sleep. …
However, recent studies suggest benefit from recanalisation therapies in selected patients. OBJECTIVES: To assess the effects of intr …
Efficacy and safety of very low calorie ketogenic diet (VLCKD) in patients with overweight and obesity: A systematic review and meta-analysis.
Castellana M, Conte E, Cignarelli A, Perrini S, Giustina A, Giovanella L, Giorgino F, Trimboli P. Castellana M, et al. Rev Endocr Metab Disord. 2020 Mar;21(1):5-16. doi: 10.1007/s11154-019-09514-y. Rev Endocr Metab Disord. 2020. PMID: 31705259
Also, VLCKD was associated with reductions of BMI (-5.3 kg/m(2)), waist circumference (-12.6 cm), HbA1c (-0.7%), total cholesterol (-28 mg/dl), triglycerides (-30 mg/dl), AST (-7 U/l), ALT (-8 U/l), GGT (-8 U/l), systolic and diastolic blood pressure (-8 and - 7 mmHg, resp …
Also, VLCKD was associated with reductions of BMI (-5.3 kg/m(2)), waist circumference (-12.6 cm), HbA1c (-0.7%), total cholesterol (-28 mg/d …
Behavioral and psychological treatments for chronic insomnia disorder in adults: an American Academy of Sleep Medicine systematic review, meta-analysis, and GRADE assessment.
Edinger JD, Arnedt JT, Bertisch SM, Carney CE, Harrington JJ, Lichstein KL, Sateia MJ, Troxel WM, Zhou ES, Kazmi U, Heald JL, Martin JL. Edinger JD, et al. J Clin Sleep Med. 2021 Feb 1;17(2):263-298. doi: 10.5664/jcsm.8988. J Clin Sleep Med. 2021. PMID: 33164741 Free PMC article.
Evidence for the following interventions is presented in this review: cognitive-behavioral therapy for insomnia, brief therapies for insomnia, stimulus control, sleep restriction therapy, relaxation training, sleep hygiene, biofeedback, paradoxical intention, intensive sle …
Evidence for the following interventions is presented in this review: cognitive-behavioral therapy for insomnia, brief therapies for …
Cardiovascular effects of electronic cigarettes: A systematic review and meta-analysis.
Skotsimara G, Antonopoulos AS, Oikonomou E, Siasos G, Ioakeimidis N, Tsalamandris S, Charalambous G, Galiatsatos N, Vlachopoulos C, Tousoulis D. Skotsimara G, et al. Eur J Prev Cardiol. 2019 Jul;26(11):1219-1228. doi: 10.1177/2047487319832975. Epub 2019 Mar 1. Eur J Prev Cardiol. 2019. PMID: 30823865

The meta-analysis of 14 studies (N + 441 participants) suggested that despite the negative acute effects of the electronic cigarette on heart rate (pooled mean difference (MD) + 2.27, 95% confidence interval (CI): 1.64 to 2.89, p < 0.001), diastolic (pooled MD + 2.01 mm

…
The meta-analysis of 14 studies (N + 441 participants) suggested that despite the negative acute effects of the electronic cigarette on hear …
Funding breakthrough therapies: A systematic review and recommendation.
Hanna E, Toumi M, Dussart C, Borissov B, Dabbous O, Badora K, Auquier P. Hanna E, et al. Health Policy. 2018 Mar;122(3):217-229. doi: 10.1016/j.healthpol.2017.11.012. Epub 2017 Dec 2. Health Policy. 2018. PMID: 29223847 Review.
BACKGROUND: Advanced therapy medicinal products (ATMPs) are innovative therapies likely associated with high prices. Payers need guidance to create a balance between ensuring patient access to breakthrough therapies and maintaining the financial sustainability of th …
BACKGROUND: Advanced therapy medicinal products (ATMPs) are innovative therapies likely associated with high prices. Payers need guid …
132 results