PubMed

The absence of angiopoietin-2 leads to abnormal vascular maturation and persistent proliferative retinopathy.

Feng Y, Vom Hagen F, Wang Y, Beck S, Schreiter K, Pfister F, Hoffmann S, Wagner P, Seeliger M, Molema G, Deutsch U, Hammes HP.

Thromb Haemost. 2009 Jul;102(1):120-30.PMID: 19572076 [PubMed - indexed for MEDLINE]Related articles

Decreased hypoxia-induced neovascularization in angiopoietin-2 heterozygous knockout mouse through reduced MMP activity.

Feng Y, Wang Y, Pfister F, Hillebrands JL, Deutsch U, Hammes HP.

Cell Physiol Biochem. 2009;23(4-6):277-84. Epub 2009 May 6.PMID: 19471095 [PubMed - indexed for MEDLINE]Related articles

VE-PTP controls blood vessel development by balancing Tie-2 activity.

Winderlich M, Keller L, Cagna G, Broermann A, Kamenyeva O, Kiefer F, Deutsch U, Nottebaum AF, Vestweber D.

J Cell Biol. 2009 May 18;185(4):657-71.PMID: 19451274 [PubMed - indexed for MEDLINE]Related articlesFree article

Agrin defines polarized distribution of orthogonal arrays of particles in astrocytes.

Noell S, Fallier-Becker P, Deutsch U, Mack AF, Wolburg H.

Cell Tissue Res. 2009 Aug;337(2):185-95. Epub 2009 May 16.PMID: 19449033 [PubMed - indexed for MEDLINE]Related articles

Myc regulates embryonic vascular permeability and remodeling.

Kokai E, Voss F, Fleischer F, Kempe S, Marinkovic D, Wolburg H, Leithäuser F, Schmidt V, Deutsch U, Wirth T.

Circ Res. 2009 May 22;104(10):1151-9. Epub 2009 Apr 30.PMID: 19407242 [PubMed - indexed for MEDLINE]Related articles

Retinal overexpression of angiopoietin-2 mimics diabetic retinopathy and enhances vascular damages in hyperglycemia.

Pfister F, Wang Y, Schreiter K, Vom Hagen F, Altvater K, Hoffmann S, Deutsch U, Hammes HP, Feng Y.

Acta Diabetol. 2009 Feb 24. [Epub ahead of print]PMID: 19238311 [PubMed - as supplied by publisher]Related articles

Switching of vascular phenotypes within a murine breast cancer model induced by angiopoietin-2.

Reiss Y, Knedla A, Tal AO, Schmidt MH, Jugold M, Kiessling F, Burger AM, Wolburg H, Deutsch U, Plate KH.

J Pathol. 2009 Mar;217(4):571-80.PMID: 19116989 [PubMed - indexed for MEDLINE]Related articles

VEGF-A stimulates ADAM17-dependent shedding of VEGFR2 and crosstalk between VEGFR2 and ERK signaling.

Swendeman S, Mendelson K, Weskamp G, Horiuchi K, Deutsch U, Scherle P, Hooper A, Rafii S, Blobel CP.

Circ Res. 2008 Oct 24;103(9):916-8. Epub 2008 Sep 25.PMID: 18818406 [PubMed - indexed for MEDLINE]Related articlesFree article

Estrogen-stimulated endothelial repair requires osteopontin.

Leen LL, Filipe C, Billon A, Garmy-Susini B, Jalvy S, Robbesyn F, Daret D, Allières C, Rittling SR, Werner N, Nickenig G, Deutsch U, Duplàa C, Dufourcq P, Lenfant F, Desgranges C, Arnal JF, Gadeau AP.

Arterioscler Thromb Vasc Biol. 2008 Dec;28(12):2131-6. Epub 2008 Sep 4.PMID: 18772499 [PubMed - indexed for MEDLINE]Related articles

Pericyte migration: a novel mechanism of pericyte loss in experimental diabetic retinopathy.

Pfister F, Feng Y, vom Hagen F, Hoffmann S, Molema G, Hillebrands JL, Shani M, Deutsch U, Hammes HP.

Diabetes. 2008 Sep;57(9):2495-502. Epub 2008 Jun 16.PMID: 18559662 [PubMed - indexed for MEDLINE]Related articlesFree article

Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts.

Saharinen P, Eklund L, Miettinen J, Wirkkala R, Anisimov A, Winderlich M, Nottebaum A, Vestweber D, Deutsch U, Koh GY, Olsen BR, Alitalo K.

Nat Cell Biol. 2008 May;10(5):527-37. Epub 2008 Apr 20.PMID: 18425119 [PubMed - indexed for MEDLINE]Related articles

Inducible endothelial cell-specific gene expression in transgenic mouse embryos and adult mice.

Deutsch U, Schlaeger TM, Dehouck B, Döring A, Tauber S, Risau W, Engelhardt B.

Exp Cell Res. 2008 Apr 1;314(6):1202-16. Epub 2008 Jan 15.PMID: 18272150 [PubMed - indexed for MEDLINE]Related articles

Angiopoietin-2 deficiency decelerates age-dependent vascular changes in the mouse retina.

Feng Y, Pfister F, Schreiter K, Wang Y, Stock O, Vom Hagen F, Wolburg H, Hoffmann S, Deutsch U, Hammes HP.

Cell Physiol Biochem. 2008;21(1-3):129-36. Epub 2008 Jan 16.PMID: 18209480 [PubMed - indexed for MEDLINE]Related articles

Regulation of endothelial cell cytoskeletal reorganization by a secreted frizzled-related protein-1 and frizzled 4- and frizzled 7-dependent pathway: role in neovessel formation.

Dufourcq P, Leroux L, Ezan J, Descamps B, Lamazière JM, Costet P, Basoni C, Moreau C, Deutsch U, Couffinhal T, Duplàa C.

Am J Pathol. 2008 Jan;172(1):37-49. Epub 2007 Dec 21.PMID: 18156211 [PubMed - indexed for MEDLINE]Related articlesFree article

E- and P-selectin are not required for the development of experimental autoimmune encephalomyelitis in C57BL/6 and SJL mice.

Döring A, Wild M, Vestweber D, Deutsch U, Engelhardt B.

J Immunol. 2007 Dec 15;179(12):8470-9.PMID: 18056394 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of the orphan endothelial receptor Tie1 modifies Tie2-mediated intracellular signaling and cell survival.

Yuan HT, Venkatesha S, Chan B, Deutsch U, Mammoto T, Sukhatme VP, Woolf AS, Karumanchi SA.

FASEB J. 2007 Oct;21(12):3171-83. Epub 2007 May 15.PMID: 17504972 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired pericyte recruitment and abnormal retinal angiogenesis as a result of angiopoietin-2 overexpression.

Feng Y, vom Hagen F, Pfister F, Djokic S, Hoffmann S, Back W, Wagner P, Lin J, Deutsch U, Hammes HP.

Thromb Haemost. 2007 Jan;97(1):99-108.PMID: 17200776 [PubMed - indexed for MEDLINE]Related articles

Vascular endothelial cell-specific phosphotyrosine phosphatase (VE-PTP) activity is required for blood vessel development.

Bäumer S, Keller L, Holtmann A, Funke R, August B, Gamp A, Wolburg H, Wolburg-Buchholz K, Deutsch U, Vestweber D.

Blood. 2006 Jun 15;107(12):4754-62. Epub 2006 Mar 2.PMID: 16514057 [PubMed - indexed for MEDLINE]Related articlesFree article

Early loss of arteriolar smooth muscle cells: more than just a pericyte loss in diabetic retinopathy.

vom Hagen F, Feng Y, Hillenbrand A, Hoffmann S, Shani M, Deutsch U, Hammes HP.

Exp Clin Endocrinol Diabetes. 2005 Dec;113(10):573-6.PMID: 16320154 [PubMed - indexed for MEDLINE]Related articles

Endothelial survival factors and spatial completion, but not pericyte coverage of retinal capillaries determine vessel plasticity.

Hoffmann J, Feng Y, vom Hagen F, Hillenbrand A, Lin J, Erber R, Vajkoczy P, Gourzoulidou E, Waldmann H, Giannis A, Wolburg H, Shani M, Jaeger V, Weich HA, Preissner KT, Hoffmann S, Deutsch U, Hammes HP.

FASEB J. 2005 Dec;19(14):2035-6. Epub 2005 Oct 7.PMID: 16215210 [PubMed - indexed for MEDLINE]Related articlesFree article

Establishment of murine cell lines by constitutive and conditional immortalization.

May T, Mueller PP, Weich H, Froese N, Deutsch U, Wirth D, Kröger A, Hauser H.

J Biotechnol. 2005 Oct 17;120(1):99-110. Epub 2005 Jul 18.PMID: 16026879 [PubMed - indexed for MEDLINE]Related articles

Dietary supplementation with the tribomechanically activated zeolite clinoptilolite in immunodeficiency: effects on the immune system.

Ivkovic S, Deutsch U, Silberbach A, Walraph E, Mannel M.

Adv Ther. 2004 Mar-Apr;21(2):135-47.PMID: 15310086 [PubMed - indexed for MEDLINE]Related articles

Semaphorins guide PerPlexeD endothelial cells.

Deutsch U.

Dev Cell. 2004 Jul;7(1):1-2. Review.PMID: 15239945 [PubMed - indexed for MEDLINE]Related articles

Angiopoietin-2 causes pericyte dropout in the normal retina: evidence for involvement in diabetic retinopathy.

Hammes HP, Lin J, Wagner P, Feng Y, Vom Hagen F, Krzizok T, Renner O, Breier G, Brownlee M, Deutsch U.

Diabetes. 2004 Apr;53(4):1104-10.PMID: 15047628 [PubMed - indexed for MEDLINE]Related articlesFree article

Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats.

Fiedler U, Krissl T, Koidl S, Weiss C, Koblizek T, Deutsch U, Martiny-Baron G, Marmé D, Augustin HG.

J Biol Chem. 2003 Jan 17;278(3):1721-7. Epub 2002 Nov 9.PMID: 12427764 [PubMed - indexed for MEDLINE]Related articlesFree article

Pericytes and the pathogenesis of diabetic retinopathy.

Hammes HP, Lin J, Renner O, Shani M, Lundqvist A, Betsholtz C, Brownlee M, Deutsch U.

Diabetes. 2002 Oct;51(10):3107-12.PMID: 12351455 [PubMed - indexed for MEDLINE]Related articlesFree article

VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts.

Nawroth R, Poell G, Ranft A, Kloep S, Samulowitz U, Fachinger G, Golding M, Shima DT, Deutsch U, Vestweber D.

EMBO J. 2002 Sep 16;21(18):4885-95. Erratum in: EMBO J. 2005 Sep 7;24(17):3158. PMID: 12234928 [PubMed - indexed for MEDLINE]Related articlesFree article

Structural and functional diversity of connexin genes in the mouse and human genome.

Willecke K, Eiberger J, Degen J, Eckardt D, Romualdi A, Güldenagel M, Deutsch U, Söhl G.

Biol Chem. 2002 May;383(5):725-37. Review.PMID: 12108537 [PubMed - indexed for MEDLINE]Related articles

Connexin genes in the mouse and human genome.

Eiberger J, Degen J, Romualdi A, Deutsch U, Willecke K, Söhl G.

Cell Commun Adhes. 2001;8(4-6):163-5.PMID: 12064582 [PubMed - indexed for MEDLINE]Related articles

EphrinB phosphorylation and reverse signaling: regulation by Src kinases and PTP-BL phosphatase.

Palmer A, Zimmer M, Erdmann KS, Eulenburg V, Porthin A, Heumann R, Deutsch U, Klein R.

Mol Cell. 2002 Apr;9(4):725-37.PMID: 11983165 [PubMed - indexed for MEDLINE]Related articles

The cytoplasmic domain of the ligand ephrinB2 is required for vascular morphogenesis but not cranial neural crest migration.

Adams RH, Diella F, Hennig S, Helmbacher F, Deutsch U, Klein R.

Cell. 2001 Jan 12;104(1):57-69.PMID: 11163240 [PubMed - indexed for MEDLINE]Related articles

Endothelium-specific replacement of the connexin43 coding region by a lacZ reporter gene.

Theis M, de Wit C, Schlaeger TM, Eckardt D, Krüger O, Döring B, Risau W, Deutsch U, Pohl U, Willecke K.

Genesis. 2001 Jan;29(1):1-13.PMID: 11135457 [PubMed - indexed for MEDLINE]Related articles

Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2.

Fachinger G, Deutsch U, Risau W.

Oncogene. 1999 Oct 21;18(43):5948-53.PMID: 10557082 [PubMed - indexed for MEDLINE]Related articlesFree article

Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis.

Adams RH, Wilkinson GA, Weiss C, Diella F, Gale NW, Deutsch U, Risau W, Klein R.

Genes Dev. 1999 Feb 1;13(3):295-306.PMID: 9990854 [PubMed - indexed for MEDLINE]Related articlesFree article

T cell interaction with ICAM-1-deficient endothelium in vitro: essential role for ICAM-1 and ICAM-2 in transendothelial migration of T cells.

Reiss Y, Hoch G, Deutsch U, Engelhardt B.

Eur J Immunol. 1998 Oct;28(10):3086-99.PMID: 9808177 [PubMed - indexed for MEDLINE]Related articles

Regulation of endothelial monocyte-activating polypeptide II release by apoptosis.

Knies UE, Behrensdorf HA, Mitchell CA, Deutsch U, Risau W, Drexler HC, Clauss M.

Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12322-7.PMID: 9770485 [PubMed - indexed for MEDLINE]Related articlesFree article

Angiopoietin-1 induces sprouting angiogenesis in vitro.

Koblizek TI, Weiss C, Yancopoulos GD, Deutsch U, Risau W.

Curr Biol. 1998 Apr 23;8(9):529-32.PMID: 9560344 [PubMed - indexed for MEDLINE]Related articles

Fritz: a secreted frizzled-related protein that inhibits Wnt activity.

Mayr T, Deutsch U, Kühl M, Drexler HC, Lottspeich F, Deutzmann R, Wedlich D, Risau W.

Mech Dev. 1997 Apr;63(1):109-25.PMID: 9178261 [PubMed - indexed for MEDLINE]Related articles

Uniform vascular-endothelial-cell-specific gene expression in both embryonic and adult transgenic mice.

Schlaeger TM, Bartunkova S, Lawitts JA, Teichmann G, Risau W, Deutsch U, Sato TN.

Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3058-63.PMID: 9096345 [PubMed - indexed for MEDLINE]Related articlesFree article

Tie2 receptor expression and phosphorylation in cultured cells and mouse tissues.

Koblizek TI, Runting AS, Stacker SA, Wilks AF, Risau W, Deutsch U.

Eur J Biochem. 1997 Mar 15;244(3):774-9.PMID: 9108247 [PubMed - indexed for MEDLINE]Related articlesFree article

The mouse gene for vascular endothelial growth factor. Genomic structure, definition of the transcriptional unit, and characterization of transcriptional and post-transcriptional regulatory sequences.

Shima DT, Kuroki M, Deutsch U, Ng YS, Adamis AP, D'Amore PA.

J Biol Chem. 1996 Feb 16;271(7):3877-83.PMID: 8632007 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypoxic induction of vascular endothelial growth factor (VEGF) in human epithelial cells is mediated by increases in mRNA stability.

Shima DT, Deutsch U, D'Amore PA.

FEBS Lett. 1995 Aug 21;370(3):203-8.PMID: 7656977 [PubMed - indexed for MEDLINE]Related articles

Induction of heparin-binding EGF-like growth factor expression during myogenesis. Activation of the gene by MyoD and localization of the transmembrane form of the protein on the myotube surface.

Chen X, Raab G, Deutsch U, Zhang J, Ezzell RM, Klagsbrun M.

J Biol Chem. 1995 Aug 4;270(31):18285-94.PMID: 7629148 [PubMed - indexed for MEDLINE]Related articlesFree article

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation.

Sato TN, Tozawa Y, Deutsch U, Wolburg-Buchholz K, Fujiwara Y, Gendron-Maguire M, Gridley T, Wolburg H, Risau W, Qin Y.

Nature. 1995 Jul 6;376(6535):70-4.PMID: 7596437 [PubMed - indexed for MEDLINE]Related articles

[Reduction of thyroid volume following radioiodine therapy for functional autonomy]

Luster M, Jacob M, Thelen MH, Michalowski U, Deutsch U, Reiners C.

Nuklearmedizin. 1995 Apr;34(2):57-60. German. PMID: 7761274 [PubMed - indexed for MEDLINE]Related articles

Pax1, a member of the paired box-containing class of developmental control genes, is mapped to human chromosome 20p11.2 by in situ hybridization (ISH and FISH).

Schnittger S, Rao VV, Deutsch U, Gruss P, Balling R, Hansmann I.

Genomics. 1992 Nov;14(3):740-4.PMID: 1358810 [PubMed - indexed for MEDLINE]Related articles

Pax: a murine multigene family of paired box-containing genes.

Walther C, Guenet JL, Simon D, Deutsch U, Jostes B, Goulding MD, Plachov D, Balling R, Gruss P.

Genomics. 1991 Oct;11(2):424-34.PMID: 1685142 [PubMed - indexed for MEDLINE]Related articles

The molecular basis of the undulated/Pax-1 mutation.

Chalepakis G, Fritsch R, Fickenscher H, Deutsch U, Goulding M, Gruss P.

Cell. 1991 Sep 6;66(5):873-84.PMID: 1889089 [PubMed - indexed for MEDLINE]Related articles

Pax-3, a novel murine DNA binding protein expressed during early neurogenesis.

Goulding MD, Chalepakis G, Deutsch U, Erselius JR, Gruss P.

EMBO J. 1991 May;10(5):1135-47.PMID: 2022185 [PubMed - indexed for MEDLINE]Related articlesFree article

Spatially and temporally restricted expression of Pax2 during murine neurogenesis.

Nornes HO, Dressler GR, Knapik EW, Deutsch U, Gruss P.

Development. 1990 Aug;109(4):797-809.PMID: 1977575 [PubMed - indexed for MEDLINE]Related articlesFree article