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Study of physico-chemical properties of novel highly sulfated, aromatic, mimetics of heparin and heparan sulfate.

Liang A, Thakkar JN, Desai UR.

J Pharm Sci. 2009 Aug 26. [Epub ahead of print]PMID: 19711446 [PubMed - as supplied by publisher]Related articles

First steps in the direction of synthetic, allosteric, direct inhibitors of thrombin and factor Xa.

Verghese J, Liang A, Sidhu PP, Hindle M, Zhou Q, Desai UR.

Bioorg Med Chem Lett. 2009 Aug 1;19(15):4126-9. Epub 2009 Jun 6.PMID: 19540113 [PubMed - in process]Related articles

Interaction of antithrombin with sulfated, low molecular weight lignins: opportunities for potent, selective modulation of antithrombin function.

Henry BL, Connell J, Liang A, Krishnasamy C, Desai UR.

J Biol Chem. 2009 Jul 31;284(31):20897-908. Epub 2009 Jun 4.PMID: 19497853 [PubMed - indexed for MEDLINE]Related articles

Capillary electrophoretic study of small, highly sulfated, non-sugar molecules interacting with antithrombin.

Liang A, Raghuraman A, Desai UR.

Electrophoresis. 2009 May;30(9):1544-51.PMID: 19425011 [PubMed - indexed for MEDLINE]Related articlesFree article

Application of molecular connectivity and electro-topological indices in quantitative structure-activity analysis of pyrazole derivatives as inhibitors of factor Xa and thrombin.

Krishnasamy C, Raghuraman A, Kier LB, Desai UR.

Chem Biodivers. 2008 Dec;5(12):2609-20.PMID: 19089820 [PubMed - indexed for MEDLINE]Related articles

On designing non-saccharide, allosteric activators of antithrombin.

Raghuraman A, Liang A, Krishnasamy C, Lauck T, Gunnarsson GT, Desai UR.

Eur J Med Chem. 2009 Jun;44(6):2626-31. Epub 2008 Oct 9.PMID: 18996625 [PubMed - indexed for MEDLINE]Related articles

Recent research developments in the direct inhibition of coagulation proteinases--inhibitors of the initiation phase.

Henry BL, Desai UR.

Cardiovasc Hematol Agents Med Chem. 2008 Oct;6(4):323-36. Review.PMID: 18855645 [PubMed - indexed for MEDLINE]Related articles

Rapid and efficient microwave-assisted synthesis of highly sulfated organic scaffolds.

Raghuraman A, Riaz M, Hindle M, Desai UR.

Tetrahedron Lett. 2007 Sep 17;48(38):6754-6758.PMID: 18797498 [PubMed]Related articlesFree article

A capillary electrophoretic method for fingerprinting low molecular weight heparins.

King JT, Desai UR.

Anal Biochem. 2008 Sep 15;380(2):229-34. Epub 2008 Jun 4.PMID: 18572011 [PubMed - indexed for MEDLINE]Related articles

Sharp dissection of the Weiss ring to induce a posterior vitreous detachment.

Desai UR, Bhatti RA, Khan KA, Rubowitz A.

Br J Ophthalmol. 2008 Mar;92(3):420-2.PMID: 18303164 [PubMed - indexed for MEDLINE]Related articles

Synthesis of biologically relevant biflavanoids--a review.

Rahman M, Riaz M, Desai UR.

Chem Biodivers. 2007 Nov;4(11):2495-527. Review.PMID: 18027351 [PubMed - indexed for MEDLINE]Related articles

A novel allosteric pathway of thrombin inhibition: Exosite II mediated potent inhibition of thrombin by chemo-enzymatic, sulfated dehydropolymers of 4-hydroxycinnamic acids.

Henry BL, Monien BH, Bock PE, Desai UR.

J Biol Chem. 2007 Nov 2;282(44):31891-9. Epub 2007 Sep 5.PMID: 17804413 [PubMed - indexed for MEDLINE]Related articlesFree article

Viral inhibition studies on sulfated lignin, a chemically modified biopolymer and a potential mimic of heparan sulfate.

Raghuraman A, Tiwari V, Zhao Q, Shukla D, Debnath AK, Desai UR.

Biomacromolecules. 2007 May;8(5):1759-63. Epub 2007 Apr 17. No abstract available. PMID: 17439173 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel chemo-enzymatic oligomers of cinnamic acids as direct and indirect inhibitors of coagulation proteinases.

Monien BH, Henry BL, Raghuraman A, Hindle M, Desai UR.

Bioorg Med Chem. 2006 Dec 1;14(23):7988-98. Epub 2006 Aug 17.PMID: 16914317 [PubMed - indexed for MEDLINE]Related articles

Finding a needle in a haystack: development of a combinatorial virtual screening approach for identifying high specificity heparin/heparan sulfate sequence(s).

Raghuraman A, Mosier PD, Desai UR.

J Med Chem. 2006 Jun 15;49(12):3553-62.PMID: 16759098 [PubMed - indexed for MEDLINE]Related articlesFree article

Does postoperative near visual acuity predict macular hole closure?

Dhalla MS, Desai UR, Gandolfo C.

Ophthalmic Surg Lasers Imaging. 2006 May-Jun;37(3):244-6.PMID: 16749264 [PubMed - indexed for MEDLINE]Related articles

Pigmentary maculopathy in a patient with Wolfram syndrome.

Dhalla MS, Desai UR, Zuckerbrod DS.

Can J Ophthalmol. 2006 Feb;41(1):38-40.PMID: 16462870 [PubMed - indexed for MEDLINE]Related articlesFree article

Structural characterization of a serendipitously discovered bioactive macromolecule, lignin sulfate.

Raghuraman A, Tiwari V, Thakkar JN, Gunnarsson GT, Shukla D, Hindle M, Desai UR.

Biomacromolecules. 2005 Sep-Oct;6(5):2822-32.PMID: 16153124 [PubMed - indexed for MEDLINE]Related articles

Importance of tryptophan 49 of antithrombin in heparin binding and conformational activation.

Monien BH, Krishnasamy C, Olson ST, Desai UR.

Biochemistry. 2005 Sep 6;44(35):11660-8.PMID: 16128566 [PubMed - indexed for MEDLINE]Related articles

Mechanism of poly(acrylic acid) acceleration of antithrombin inhibition of thrombin: implications for the design of novel heparin mimics.

Monien BH, Cheang KI, Desai UR.

J Med Chem. 2005 Aug 11;48(16):5360-8.PMID: 16078853 [PubMed - indexed for MEDLINE]Related articles

Antithrombin activation by nonsulfated, non-polysaccharide organic polymer.

Monien BH, Desai UR.

J Med Chem. 2005 Feb 24;48(4):1269-73.PMID: 15715496 [PubMed - indexed for MEDLINE]Related articles

Synthesis of per-sulfated flavonoids using 2,2,2-trichloro ethyl protecting group and their factor Xa inhibition potential.

Gunnarsson GT, Riaz M, Adams J, Desai UR.

Bioorg Med Chem. 2005 Mar 1;13(5):1783-9.PMID: 15698795 [PubMed - indexed for MEDLINE]Related articles

Comparison of a digital retinal imaging system and seven-field stereo color fundus photography to detect diabetic retinopathy in the primary care environment.

Schiffman RM, Jacobsen G, Nussbaum JJ, Desai UR, Carey JD, Glasser D, Zimmer-Galler IE, Zeimer R, Goldberg MF.

Ophthalmic Surg Lasers Imaging. 2005 Jan-Feb;36(1):46-56.PMID: 15688971 [PubMed - indexed for MEDLINE]Related articles

Capillary electrophoresis of highly sulfated flavanoids and flavonoids.

Dantuluri M, Gunnarsson GT, Riaz M, Nguyen H, Desai UR.

Anal Biochem. 2005 Jan 15;336(2):316-22.PMID: 15620899 [PubMed - indexed for MEDLINE]Related articles

Familial HLA-A2- and HLA-B7-associated anterior uveitis.

Khaimi MA, Samuel MA, Desai UR, Imami NR, Schiffman RM.

Can J Ophthalmol. 2004 Oct;39(6):664-6. No abstract available. PMID: 15559654 [PubMed - indexed for MEDLINE]Related articles

1,2-dithiole-3-ones as potent inhibitors of the bacterial 3-ketoacyl acyl carrier protein synthase III (FabH).

He X, Reeve AM, Desai UR, Kellogg GE, Reynolds KA.

Antimicrob Agents Chemother. 2004 Aug;48(8):3093-102.PMID: 15273125 [PubMed - indexed for MEDLINE]Related articlesFree article

Visual prognosis in patients with traumatic choroidal rupture.

Raman SV, Desai UR, Anderson S, Samuel MA.

Can J Ophthalmol. 2004 Apr;39(3):260-6.PMID: 15180143 [PubMed - indexed for MEDLINE]Related articles

Hydropathic interaction analyses of small organic activators binding to antithrombin.

Gunnarsson GT, Desai UR.

Bioorg Med Chem. 2004 Feb 1;12(3):633-40.PMID: 14738974 [PubMed - indexed for MEDLINE]Related articles

Roles of N-terminal region residues Lys11, Arg13, and Arg24 of antithrombin in heparin recognition and in promotion and stabilization of the heparin-induced conformational change.

Schedin-Weiss S, Desai UR, Bock SC, Olson ST, Björk I.

Biochemistry. 2004 Jan 27;43(3):675-83.PMID: 14730971 [PubMed - indexed for MEDLINE]Related articles

New antithrombin-based anticoagulants.

Desai UR.

Med Res Rev. 2004 Mar;24(2):151-81. Review.PMID: 14705167 [PubMed - indexed for MEDLINE]Related articles

Intraocular irrigating solutions. A clinical study of BSS Plus and dextrose bicarbonate fortified BSS as an infusate during pars plana vitrectomy.

Samuel MA, Desai UR, Strassman I, Abusamak M.

Indian J Ophthalmol. 2003 Sep;51(3):237-42.PMID: 14601849 [PubMed - indexed for MEDLINE]Related articlesFree article

Peripapillary retinal detachment after radial optic neurotomy for central retinal vein occlusion.

Samuel MA, Desai UR, Gandolfo CB.

Retina. 2003 Aug;23(4):580-3. No abstract available. PMID: 12972785 [PubMed - indexed for MEDLINE]Related articles

Central serous chorioretinopathy in African Americans.

Desai UR, Alhalel AA, Campen TJ, Schiffman RM, Edwards PA, Jacobsen GR.

J Natl Med Assoc. 2003 Jul;95(7):553-9.PMID: 12911253 [PubMed - indexed for MEDLINE]Related articlesFree article

Exploring new non-sugar sulfated molecules as activators of antithrombin.

Gunnarsson GT, Desai UR.

Bioorg Med Chem Lett. 2003 Feb 24;13(4):679-83.PMID: 12639557 [PubMed - indexed for MEDLINE]Related articles

Incidence of ocular injuries in motor vehicle crash victims with concomitant air bag deployment.

Anderson SK, Desai UR, Raman SV.

Ophthalmology. 2002 Dec;109(12):2356-8.PMID: 12466184 [PubMed - indexed for MEDLINE]Related articles

Cytotoxic cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin.

Raja SM, Wang B, Dantuluri M, Desai UR, Demeler B, Spiegel K, Metkar SS, Froelich CJ.

J Biol Chem. 2002 Dec 20;277(51):49523-30. Epub 2002 Oct 17.PMID: 12388539 [PubMed - indexed for MEDLINE]Related articlesFree article

Interaction of designed sulfated flavanoids with antithrombin: lessons on the design of organic activators.

Gunnarsson GT, Desai UR.

J Med Chem. 2002 Sep 26;45(20):4460-70.PMID: 12238925 [PubMed - indexed for MEDLINE]Related articles

Importance of lysine 125 for heparin binding and activation of antithrombin.

Schedin-Weiss S, Desai UR, Bock SC, Gettins PG, Olson ST, Björk I.

Biochemistry. 2002 Apr 16;41(15):4779-88.PMID: 11939772 [PubMed - indexed for MEDLINE]Related articles

Designing small, nonsugar activators of antithrombin using hydropathic interaction analyses.

Gunnarsson GT, Desai UR.

J Med Chem. 2002 Mar 14;45(6):1233-43.PMID: 11881992 [PubMed - indexed for MEDLINE]Related articles

Probing reactive center loop insertion in serpins: a simple method for ovalbumin.

Desai UR, Johns JL, Lahaye L, Wright HT.

Anal Biochem. 2002 Mar 1;302(1):81-7.PMID: 11846379 [PubMed - indexed for MEDLINE]Related articles

Choroidal granulomas in systemic sarcoidosis.

Desai UR, Tawansy KA, Joondeph BC, Schiffman RM.

Retina. 2001;21(1):40-7.PMID: 11217928 [PubMed - indexed for MEDLINE]Related articles

Unilateral retinoschisis in fetal alcohol syndrome.

Desai UR, Raman VR, Dennehy P.

Retina. 2000;20(6):676-8. No abstract available. PMID: 11131427 [PubMed - indexed for MEDLINE]Related articles

Mechanism of heparin activation of antithrombin: evidence for an induced-fit model of allosteric activation involving two interaction subsites.

Desai UR, Petitou M, Björk I, Olson ST.

Biochemistry. 1998 Sep 15;37(37):13033-41.PMID: 9737884 [PubMed - indexed for MEDLINE]Related articles

Mechanism of heparin activation of antithrombin. Role of individual residues of the pentasaccharide activating sequence in the recognition of native and activated states of antithrombin.

Desai UR, Petitou M, Björk I, Olson ST.

J Biol Chem. 1998 Mar 27;273(13):7478-87.PMID: 9516447 [PubMed - indexed for MEDLINE]Related articlesFree article

Combined pars plana vitrectomy and scleral buckling for pseudophakic and aphakic retinal detachments in which a break is not seen preoperatively.

Desai UR, Strassman IB.

Ophthalmic Surg Lasers. 1997 Sep;28(9):718-22.PMID: 9304632 [PubMed - indexed for MEDLINE]Related articles

Intraocular pressure elevation after simple pars plana vitrectomy.

Desai UR, Alhalel AA, Schiffman RM, Campen TJ, Sundar G, Muhich A.

Ophthalmology. 1997 May;104(5):781-6.PMID: 9160023 [PubMed - indexed for MEDLINE]Related articles

Prepapillary vascular loop and a recurrent vitreous hemorrhage.

Strassman IB, Desai UR.

Retina. 1997;17(2):166-7. No abstract available. PMID: 9143049 [PubMed - indexed for MEDLINE]Related articles

Differential behavior of (25R)-5,6-epoxyspirostan-22 alpha-O-3 beta-ol and (25R)-5,6-epoxyspirostan-22 alpha-O-3 beta, 4 beta-diol toward Dowex.

Korde SS, Baig MH, Desai UR, Trivedi GK.

Steroids. 1996 May;61(5):290-5.PMID: 8738833 [PubMed - indexed for MEDLINE]Related articles

Vitrectomy and juvenile epiretinal membrane.

Desai UR, Blinder KJ, Dennehy PJ.

Ophthalmic Surg Lasers. 1996 Feb;27(2):137-9.PMID: 8640437 [PubMed - indexed for MEDLINE]Related articles

Strategy for the sequence analysis of heparin.

Liu J, Desai UR, Han XJ, Toida T, Linhardt RJ.

Glycobiology. 1995 Dec;5(8):765-74.PMID: 8720074 [PubMed - indexed for MEDLINE]Related articles