PubMed

A randomized trial of therapeutic drug monitoring of protease inhibitors in antiretroviral-experienced, HIV-1-infected patients.

Demeter LM, Jiang H, Mukherjee AL, Morse GD, DiFrancesco R, DiCenzo R, Dykes C, Sista P, Bacheler L, Klingman K, Rinehart A, Albrecht M.

AIDS. 2009 Jan 28;23(3):357-68.PMID: 19114860 [PubMed - indexed for MEDLINE]Related articles

Modeling and estimation of kinetic parameters and replicative fitness of HIV-1 from flow-cytometry-based growth competition experiments.

Miao H, Dykes C, Demeter LM, Cavenaugh J, Park SY, Perelson AS, Wu H.

Bull Math Biol. 2008 Aug;70(6):1749-71. Epub 2008 Jul 22.PMID: 18648886 [PubMed - indexed for MEDLINE]Related articles

Differential equation modeling of HIV viral fitness experiments: model identification, model selection, and multimodel inference.

Miao H, Dykes C, Demeter LM, Wu H.

Biometrics. 2009 Mar;65(1):292-300. Epub 2008 May 28.PMID: 18510656 [PubMed - indexed for MEDLINE]Related articles

The design and implementation of A5146, a prospective trial assessing the utility of therapeutic drug monitoring using an inhibitory quotient in antiretroviral-experienced HIV-infected patients.

Demeter LM, Mukherjee AL, DiFrancesco R, Jiang H, DiCenzo R, Bastow B, Rinehart AR, Morse GD, Albrecht M.

HIV Clin Trials. 2008 Jan-Feb;9(1):61-72.PMID: 18215983 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of efavirenz hypersusceptibility with virologic response in ACTG 368, a randomized trial of abacavir (ABC) in combination with efavirenz (EFV) and indinavir (IDV) in HIV-infected subjects with prior nucleoside analog experience.

Demeter LM, DeGruttola V, Lustgarten S, Bettendorf D, Fischl M, Eshleman S, Spreen W, Nguyen BY, Koval CE, Eron JJ, Hammer S, Squires K.

HIV Clin Trials. 2008 Jan-Feb;9(1):11-25.PMID: 18215978 [PubMed - indexed for MEDLINE]Related articlesFree article

Clinical significance of human immunodeficiency virus type 1 replication fitness.

Dykes C, Demeter LM.

Clin Microbiol Rev. 2007 Oct;20(4):550-78. Review.PMID: 17934074 [PubMed - indexed for MEDLINE]Related articlesFree article

Randomized open-label trial of two simplified, class-sparing regimens following a first suppressive three or four-drug regimen.

Fischl MA, Collier AC, Mukherjee AL, Feinberg JE, Demeter LM, Tebas P, Giuliano M, Dehlinger M, Garren K, Brizz B, Bassett R.

AIDS. 2007 Jan 30;21(3):325-33.PMID: 17255739 [PubMed - indexed for MEDLINE]Related articles

Prevalence of human papillomavirus genotypes and related abnormalities of cervical cytological results among HIV-1-infected women in Rochester, New York.

Luque AE, Jabeen M, Messing S, Lane CA, Demeter LM, Rose RC, Reichman RC.

J Infect Dis. 2006 Aug 15;194(4):428-34. Epub 2006 Jul 13.PMID: 16845625 [PubMed - indexed for MEDLINE]Related articles

Relative replication fitness of efavirenz-resistant mutants of HIV-1: correlation with frequency during clinical therapy and evidence of compensation for the reduced fitness of K103N + L100I by the nucleoside resistance mutation L74V.

Koval CE, Dykes C, Wang J, Demeter LM.

Virology. 2006 Sep 15;353(1):184-92. Epub 2006 Jun 21.PMID: 16797050 [PubMed - indexed for MEDLINE]Related articles

HIV-1 reverse transcriptase mutants resistant to nonnucleoside reverse transcriptase inhibitors do not adversely affect DNA synthesis: pre-steady-state and steady-state kinetic studies.

Domaoal RA, Bambara RA, Demeter LM.

J Acquir Immune Defic Syndr. 2006 Aug 1;42(4):405-11.PMID: 16763521 [PubMed - indexed for MEDLINE]Related articles

Evaluation of a multiple-cycle, recombinant virus, growth competition assay that uses flow cytometry to measure replication efficiency of human immunodeficiency virus type 1 in cell culture.

Dykes C, Wang J, Jin X, Planelles V, An DS, Tallo A, Huang Y, Wu H, Demeter LM.

J Clin Microbiol. 2006 Jun;44(6):1930-43. Erratum in: J Clin Microbiol. 2007 Jun;45(6):2102. PMID: 16757582 [PubMed - indexed for MEDLINE]Related articlesFree article

The HIV-1 reverse transcriptase mutants G190S and G190A, which confer resistance to non-nucleoside reverse transcriptase inhibitors, demonstrate reductions in RNase H activity and DNA synthesis from tRNA(Lys, 3) that correlate with reductions in replication efficiency.

Wang J, Dykes C, Domaoal RA, Koval CE, Bambara RA, Demeter LM.

Virology. 2006 May 10;348(2):462-74. Epub 2006 Feb 28.PMID: 16504235 [PubMed - indexed for MEDLINE]Related articles

Modeling and estimation of replication fitness of human immunodeficiency virus type 1 in vitro experiments by using a growth competition assay.

Wu H, Huang Y, Dykes C, Liu D, Ma J, Perelson AS, Demeter LM.

J Virol. 2006 Mar;80(5):2380-9.PMID: 16474144 [PubMed - indexed for MEDLINE]Related articlesFree article

HIV-specific cytotoxic cell frequencies measured directly ex vivo by the Lysispot assay can be higher or lower than the frequencies of IFN-gamma-secreting cells: anti-HIV cytotoxicity is not generally impaired relative to other chronic virus responses.

Snyder-Cappione JE, Divekar AA, Maupin GM, Jin X, Demeter LM, Mosmann TR.

J Immunol. 2006 Feb 15;176(4):2662-8.PMID: 16456029 [PubMed - indexed for MEDLINE]Related articlesFree article

Update of the drug resistance mutations in HIV-1: 2004.

Johnson VA, Brun-Vézinet F, Clotet B, Conway B, D'Aquila RT, Demeter LM, Kuritzkes DR, Pillay D, Schapiro JM, Telenti A, Richman DD.

Top HIV Med. 2004 Oct-Nov;12(4):119-24. Review. No abstract available. PMID: 15516709 [PubMed - indexed for MEDLINE]Related articlesFree article

HIV-1 drug resistance in subjects with advanced HIV-1 infection in whom antiretroviral combination therapy is failing: a substudy of AIDS Clinical Trials Group Protocol 388.

Demeter LM, Ribaudo HJ, Erice A, Eshleman SH, Hammer SM, Hellmann NS, Fischl MA; AIDS Clinical Trials Group Protocol 388.

Clin Infect Dis. 2004 Aug 15;39(4):552-8. Epub 2004 Jul 30.PMID: 15356820 [PubMed - indexed for MEDLINE]Related articles

Identification of a preferred region for recombination and mutation in HIV-1 gag.

Dykes C, Balakrishnan M, Planelles V, Zhu Y, Bambara RA, Demeter LM.

Virology. 2004 Sep 1;326(2):262-79. Erratum in: Virology. 2004 Nov 24;329(2):513. PMID: 15302212 [PubMed - indexed for MEDLINE]Related articles

Comparison of versions 1.0 AND 1.5 of the UltraSensitive AMPLICOR HIV-1 MONITOR test for subjects with low viral load.

Jackson JB, Piwowar-Manning E, Johnson-Lewis L, Bassett R, Demeter LM, Brambilla D.

J Clin Microbiol. 2004 Jun;42(6):2774-6.PMID: 15184467 [PubMed - indexed for MEDLINE]Related articlesFree article

Structural and biochemical effects of human immunodeficiency virus mutants resistant to non-nucleoside reverse transcriptase inhibitors.

Domaoal RA, Demeter LM.

Int J Biochem Cell Biol. 2004 Sep;36(9):1735-51. Review.PMID: 15183341 [PubMed - indexed for MEDLINE]Related articles

Detection of drug-resistant minority variants of HIV-1 during virologic failure of indinavir, lamivudine, and zidovudine.

Dykes C, Najjar J, Bosch RJ, Wantman M, Furtado M, Hart S, Hammer SM, Demeter LM.

J Infect Dis. 2004 Mar 15;189(6):1091-6. Epub 2004 Mar 1.PMID: 14999613 [PubMed - indexed for MEDLINE]Related articles

A randomized trial of nelfinavir and abacavir in combination with efavirenz and adefovir dipivoxil in HIV-1-infected persons with virological failure receiving indinavir.

Hammer SM, Bassett R, Squires KE, Fischl MA, Demeter LM, Currier JS, Mellors JW, Morse GD, Eron JJ, Santana JL, DeGruttola V; ACTG 372B/D Study Team.

Antivir Ther. 2003 Dec;8(6):507-18. No abstract available. PMID: 14760884 [PubMed - indexed for MEDLINE]Related articles

Drug resistance mutations in HIV-1.

Johnson VA, Brun-Vézinet F, Clotet B, Conway B, D'Aquila RT, Demeter LM, Kuritzkes DR, Pillay D, Schapiro JM, Telenti A, Richman DD; International AIDS Society-USA Drug Resistance Mutations Group.

Top HIV Med. 2003 Nov-Dec;11(6):215-21. Review.PMID: 14724329 [PubMed - indexed for MEDLINE]Related articlesFree article

A randomized trial of 2 different 4-drug antiretroviral regimens versus a 3-drug regimen, in advanced human immunodeficiency virus disease.

Fischl MA, Ribaudo HJ, Collier AC, Erice A, Giuliano M, Dehlinger M, Eron JJ Jr, Saag MS, Hammer SM, Vella S, Morse GD, Feinberg JE, Demeter LM, Eshleman SH; Adult AIDS Clinical Trials Group 388 Study Team.

J Infect Dis. 2003 Sep 1;188(5):625-34. Epub 2003 Aug 15. Erratum in: J Infect Dis. 2003 Oct 1;188(7):1083. PMID: 12934177 [PubMed - indexed for MEDLINE]Related articles

Questions to and answers from the International AIDS Society-USA Resistance Testing Guidelines Panel.

Hirsch MS, Brun-Vézinet F, Clotet B, Conway B, Kuritzkes DR, D'Aquila RT, Demeter LM, Hammer SM, Johnson VA, Loveday C, Mellors JW, Richman DD; International AIDS Society-USA Resistance Testing Guidelines Panel.

Top HIV Med. 2003 Jul-Aug;11(4):150-4.PMID: 12876334 [PubMed - indexed for MEDLINE]Related articlesFree article

Drug resistance mutations in HIV-1.

D'Aquila RT, Schapiro JM, Brun-Vézinet F, Clotet B, Conway B, Demeter LM, Grant RM, Johnson VA, Kuritzkes DR, Loveday C, Shafer RW, Richman DD.

Top HIV Med. 2003 May-Jun;11(3):92-6. No abstract available. PMID: 12837968 [PubMed - indexed for MEDLINE]Related articlesFree article

Antiretroviral drug resistance testing in adults infected with human immunodeficiency virus type 1: 2003 recommendations of an International AIDS Society-USA Panel.

Hirsch MS, Brun-Vézinet F, Clotet B, Conway B, Kuritzkes DR, D'Aquila RT, Demeter LM, Hammer SM, Johnson VA, Loveday C, Mellors JW, Jacobsen DM, Richman DD.

Clin Infect Dis. 2003 Jul 1;37(1):113-28. Epub 2003 Jun 23.PMID: 12830416 [PubMed - indexed for MEDLINE]Related articles

Drug Resistance Mutations in HIV-1.

D'Aquila RT; International AIDS Society-USA, Schapiro JM, Brun-Vézinet F, Clotet B, Conway B, Demeter LM, Grant RM, Johnson VA, Kuritzkes DR, Loveday C, Shafer RW, Richman DD.

Top HIV Med. 2002 Nov;10(5):21-25. No abstract available. PMID: 12717052 [PubMed - as supplied by publisher]Related articlesFree article

Immune reconstitution syndrome after successful treatment of Pneumocystis carinii pneumonia in a man with human immunodeficiency virus type 1 infection.

Koval CE, Gigliotti F, Nevins D, Demeter LM.

Clin Infect Dis. 2002 Aug 15;35(4):491-3. Epub 2002 Jul 24.PMID: 12145736 [PubMed - indexed for MEDLINE]Related articles

Detection of replication-competent human immunodeficiency virus type 1 (HIV-1) in cultures from patients with levels of HIV-1 RNA in plasma suppressed to less than 500 or 50 copies per milliliter.

Demeter LM, Bosch RJ, Coombs RW, Fiscus S, Bremer J, Johnson VA, Erice A, Jackson JB, Spector SA, Squires KM, Fischl MA, Hughes MD, Hammer SM.

J Clin Microbiol. 2002 Jun;40(6):2089-94.PMID: 12037070 [PubMed - indexed for MEDLINE]Related articlesFree article

Predictors of virologic and clinical outcomes in HIV-1-infected patients receiving concurrent treatment with indinavir, zidovudine, and lamivudine. AIDS Clinical Trials Group Protocol 320.

Demeter LM, Hughes MD, Coombs RW, Jackson JB, Grimes JM, Bosch RJ, Fiscus SA, Spector SA, Squires KE, Fischl MA, Hammer SM.

Ann Intern Med. 2001 Dec 4;135(11):954-64.PMID: 11730396 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutation of the methylated tRNA(Lys)(3) residue A58 disrupts reverse transcription and inhibits replication of human immunodeficiency virus type 1.

Renda MJ, Rosenblatt JD, Klimatcheva E, Demeter LM, Bambara RA, Planelles V.

J Virol. 2001 Oct;75(20):9671-8.PMID: 11559799 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact of clinical reverse transcriptase sequences on the replication capacity of HIV-1 drug-resistant mutants.

Dykes C, Fox K, Lloyd A, Chiulli M, Morse E, Demeter LM.

Virology. 2001 Jul 5;285(2):193-203.PMID: 11437654 [PubMed - indexed for MEDLINE]Related articles

The Y181C mutant of HIV-1 reverse transcriptase resistant to nonnucleoside reverse transcriptase inhibitors alters the size distribution of RNase H cleavages.

Archer RH, Wisniewski M, Bambara RA, Demeter LM.

Biochemistry. 2001 Apr 3;40(13):4087-95.PMID: 11300789 [PubMed - indexed for MEDLINE]Related articles

Mutants of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase resistant to nonnucleoside reverse transcriptase inhibitors demonstrate altered rates of RNase H cleavage that correlate with HIV-1 replication fitness in cell culture.

Archer RH, Dykes C, Gerondelis P, Lloyd A, Fay P, Reichman RC, Bambara RA, Demeter LM.

J Virol. 2000 Sep;74(18):8390-401.PMID: 10954539 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of env sequence evolution in human immunodeficiency virus-infected patients receiving therapy with nonnucleoside reverse-transcriptase inhibitors.

Dykes C, Mootsikapun P, Dexter A, Berrios L, Chiulli M, Reichman RC, Demeter LM.

J Infect Dis. 2000 Jul;182(1):316-20. Epub 2000 Jul 6.PMID: 10882615 [PubMed - indexed for MEDLINE]Related articles

Antiretroviral drug resistance testing in adult HIV-1 infection: recommendations of an International AIDS Society-USA Panel.

Hirsch MS, Brun-Vézinet F, D'Aquila RT, Hammer SM, Johnson VA, Kuritzkes DR, Loveday C, Mellors JW, Clotet B, Conway B, Demeter LM, Vella S, Jacobsen DM, Richman DD.

JAMA. 2000 May 10;283(18):2417-26.PMID: 10815085 [PubMed - indexed for MEDLINE]Related articles

Concentration-targeted phase I trials of atevirdine mesylate in patients with HIV infection: dosage requirements and pharmacokinetic studies. The ACTG 187 and 199 study teams.

Morse GD, Reichman RC, Fischl MA, Para M, Leedom J, Powderly W, Demeter LM, Resnick L, Bassiakos Y, Timpone J, Cox S, Batts D.

Antiviral Res. 2000 Jan;45(1):47-58.PMID: 10774589 [PubMed - indexed for MEDLINE]Related articles

Delavirdine susceptibilities and associated reverse transcriptase mutations in human immunodeficiency virus type 1 isolates from patients in a phase I/II trial of delavirdine monotherapy (ACTG 260).

Demeter LM, Shafer RW, Meehan PM, Holden-Wiltse J, Fischl MA, Freimuth WW, Para MF, Reichman RC.

Antimicrob Agents Chemother. 2000 Mar;44(3):794-7.PMID: 10681363 [PubMed - indexed for MEDLINE]Related articlesFree article

The P236L delavirdine-resistant human immunodeficiency virus type 1 mutant is replication defective and demonstrates alterations in both RNA 5'-end- and DNA 3'-end-directed RNase H activities.

Gerondelis P, Archer RH, Palaniappan C, Reichman RC, Fay PJ, Bambara RA, Demeter LM.

J Virol. 1999 Jul;73(7):5803-13.PMID: 10364332 [PubMed - indexed for MEDLINE]Related articlesFree article

ACTG 260: a randomized, phase I-II, dose-ranging trial of the anti-human immunodeficiency virus activity of delavirdine monotherapy. The AIDS Clinical Trials Group Protocol 260 Team.

Para MF, Meehan P, Holden-Wiltse J, Fischl M, Morse G, Shafer R, Demeter LM, Wood K, Nevin T, Virani-Ketter N, Freimuth WW.

Antimicrob Agents Chemother. 1999 Jun;43(6):1373-8.PMID: 10348755 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of human papillomavirus infection and disease with magnitude of human immunodeficiency virus type 1 (HIV-1) RNA plasma level among women with HIV-1 infection.

Luque AE, Demeter LM, Reichman RC.

J Infect Dis. 1999 Jun;179(6):1405-9.PMID: 10228061 [PubMed - indexed for MEDLINE]Related articles

Interlaboratory concordance of DNA sequence analysis to detect reverse transcriptase mutations in HIV-1 proviral DNA. ACTG Sequencing Working Group. AIDS Clinical Trials Group.

Demeter LM, D'Aquila R, Weislow O, Lorenzo E, Erice A, Fitzgibbon J, Shafer R, Richman D, Howard TM, Zhao Y, Fisher E, Huang D, Mayers D, Sylvester S, Arens M, Sannerud K, Rasheed S, Johnson V, Kuritzkes D, Reichelderfer P, Japour A.

J Virol Methods. 1998 Nov;75(1):93-104.PMID: 9820578 [PubMed - indexed for MEDLINE]Related articles

Phase I study of atevirdine mesylate (U-87201E) monotherapy in HIV-1-infected patients.

Demeter LM, Meehan PM, Morse G, Fischl MA, Para M, Powderly W, Leedom J, Holden-Wiltse J, Greisberger C, Wood K, Timpone J Jr, Wathen LK, Nevin T, Resnick L, Batts DH, Reichman RC.

J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Oct 1;19(2):135-44.PMID: 9768622 [PubMed - indexed for MEDLINE]Related articles

Antiretroviral drug resistance testing in adults with HIV infection: implications for clinical management. International AIDS Society--USA Panel.

Hirsch MS, Conway B, D'Aquila RT, Johnson VA, Brun-Vézinet F, Clotet B, Demeter LM, Hammer SM, Jacobsen DM, Kuritzkes DR, Loveday C, Mellors JW, Vella S, Richman DD.

JAMA. 1998 Jun 24;279(24):1984-91. Review.PMID: 9643863 [PubMed - indexed for MEDLINE]Related articles

A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team.

Hammer SM, Squires KE, Hughes MD, Grimes JM, Demeter LM, Currier JS, Eron JJ Jr, Feinberg JE, Balfour HH Jr, Deyton LR, Chodakewitz JA, Fischl MA.

N Engl J Med. 1997 Sep 11;337(11):725-33.PMID: 9287227 [PubMed - indexed for MEDLINE]Related articlesFree article

HIV-1 drug susceptibilities and reverse transcriptase mutations in patients receiving combination therapy with didanosine and delavirdine.

Demeter LM, Meehan PM, Morse G, Gerondelis P, Dexter A, Berrios L, Cox S, Freimuth W, Reichman RC.

J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Feb 1;14(2):136-44.PMID: 9052722 [PubMed - indexed for MEDLINE]Related articles

Therapeutic efficacy and complications of excisional biopsy of condyloma acuminatum.

Bonnez W, Oakes D, Choi A, d'Arcy SJ, Pappas PG, Corey L, Stoler MH, Demeter LM, Reichman RC.

Sex Transm Dis. 1996 Jul-Aug;23(4):273-6.PMID: 8836019 [PubMed - indexed for MEDLINE]Related articles

Development of zidovudine resistance mutations in patients receiving prolonged didanosine monotherapy.

Demeter LM, Nawaz T, Morse G, Dolin R, Dexter A, Gerondelis P, Reichman RC.

J Infect Dis. 1995 Dec;172(6):1480-5.PMID: 7594706 [PubMed - indexed for MEDLINE]Related articles

Effects of zidovudine use during pregnancy on resistance and vertical transmission of human immunodeficiency virus type 1.

Frenkel LM, Wagner LE 2nd, Demeter LM, Dewhurst S, Coombs RW, Murante BL, Reichman RC.

Clin Infect Dis. 1995 May;20(5):1321-6.PMID: 7620018 [PubMed - indexed for MEDLINE]Related articles

Phase I study of atevirdine, a nonnucleoside reverse transcriptase inhibitor, in combination with zidovudine for human immunodeficiency virus type 1 infection. ACTG 199 Study Team.

Reichman RC, Morse GD, Demeter LM, Resnick L, Bassiakos Y, Fischl M, Para M, Powderly W, Leedom J, Greisberger C, et al.

J Infect Dis. 1995 Feb;171(2):297-304.PMID: 7531207 [PubMed - indexed for MEDLINE]Related articles