PubMed

Intravenous transfusion of BCR-activated B cells protects NOD mice from type 1 diabetes in an IL-10-dependent manner.

Hussain S, Delovitch TL.

J Immunol. 2007 Dec 1;179(11):7225-32.PMID: 18025164 [PubMed - indexed for MEDLINE]Related articlesFree article

Decreased renal ischemia-reperfusion injury by IL-16 inactivation.

Wang S, Diao H, Guan Q, Cruikshank WW, Delovitch TL, Jevnikar AM, Du C.

Kidney Int. 2008 Feb;73(3):318-26. Epub 2007 Nov 14.PMID: 18004294 [PubMed - indexed for MEDLINE]Related articles

The "End of the beginning" of the immunobiology of iNKT cells in health and disease.

Delovitch TL.

Int Rev Immunol. 2007 Jan-Apr;26(1-2):1-3. No abstract available. PMID: 17454261 [PubMed - indexed for MEDLINE]Related articles

CCL4 protects from type 1 diabetes by altering islet beta-cell-targeted inflammatory responses.

Meagher C, Arreaza G, Peters A, Strathdee CA, Gilbert PA, Mi QS, Santamaria P, Dekaban GA, Delovitch TL.

Diabetes. 2007 Mar;56(3):809-17.PMID: 17327452 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of PAF-AH Ib1 in NOD mice: PAF-AH may not be a candidate gene of the diabetes susceptibility Idd4.1 locus.

Mi QS, Zhou L, Grattan M, Wang ZZ, Sivilotti M, She JX, Delovitch TL.

Ann N Y Acad Sci. 2006 Oct;1079:147-52.PMID: 17130546 [PubMed - indexed for MEDLINE]Related articles

The autoimmune regulator (Aire) controls iNKT cell development and maturation.

Mi QS, Deng ZB, Joshi SK, Wang ZZ, Zhou L, Eckenrode S, Joshi R, Ly D, Yi B, Delovitch TL, She JX.

Nat Med. 2006 Sep;12(9):1100. No abstract available. PMID: 16960577 [PubMed - indexed for MEDLINE]Related articles

Protection from type 1 diabetes by invariant NK T cells requires the activity of CD4+CD25+ regulatory T cells.

Ly D, Mi QS, Hussain S, Delovitch TL.

J Immunol. 2006 Sep 15;177(6):3695-704.PMID: 16951329 [PubMed - indexed for MEDLINE]Related articlesFree article

The autoimmune regulator (Aire) controls iNKT cell development and maturation.

Mi QS, Deng ZB, Joshi SK, Wang ZZ, Zhou L, Eckenrode S, Joshi R, Ly D, Yi B, Delovitch TL, She JX.

Nat Med. 2006 Jun;12(6):624-6. Epub 2006 May 28. Retraction in: Mi QS, Deng ZB, Joshi SK, Wang ZZ, Zhou L, Eckenrode S, Joshi R, Ly D, Yi B, Delovitch TL, She JX. Nat Med. 2006 Sep;12(9):1100. PMID: 16732280 [PubMed - indexed for MEDLINE]Related articles

A defect in lineage fate decision during fetal thymic invariant NKT cell development may regulate susceptibility to type 1 diabetes.

Wagner MJ, Hussain S, Mehan M, Verdi JM, Delovitch TL.

J Immunol. 2005 Jun 1;174(11):6764-71.PMID: 15905517 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of regulatory invariant CD1d-restricted natural killer T-cells in protection against type 1 diabetes.

Hussain S, Wagner M, Ly D, Delovitch TL.

Immunol Res. 2005;31(3):177-88. Review.PMID: 15888910 [PubMed - indexed for MEDLINE]Related articles

Dysregulated B7-1 and B7-2 expression on nonobese diabetic mouse B cells is associated with increased T cell costimulation and the development of insulitis.

Hussain S, Delovitch TL.

J Immunol. 2005 Jan 15;174(2):680-7.PMID: 15634886 [PubMed - indexed for MEDLINE]Related articlesFree article

Perturbed homeostasis of peripheral T cells elicits decreased susceptibility to anti-CD3-induced apoptosis in prediabetic nonobese diabetic mice.

Yang W, Hussain S, Mi QS, Santamaria P, Delovitch TL.

J Immunol. 2004 Oct 1;173(7):4407-16.PMID: 15383571 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyperresponsiveness, resistance to B-cell receptor-dependent activation-induced cell death, and accumulation of hyperactivated B-cells in islets is associated with the onset of insulitis but not type 1 diabetes.

Hussain S, Salojin KV, Delovitch TL.

Diabetes. 2004 Aug;53(8):2003-11.PMID: 15277379 [PubMed - indexed for MEDLINE]Related articlesFree article

Interleukin-4 but not interleukin-10 protects against spontaneous and recurrent type 1 diabetes by activated CD1d-restricted invariant natural killer T-cells.

Mi QS, Ly D, Zucker P, McGarry M, Delovitch TL.

Diabetes. 2004 May;53(5):1303-10.PMID: 15111500 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-like growth factor (IGF)-I/IGF-binding protein-3 complex: therapeutic efficacy and mechanism of protection against type 1 diabetes.

Chen W, Salojin KV, Mi QS, Grattan M, Meagher TC, Zucker P, Delovitch TL.

Endocrinology. 2004 Feb;145(2):627-38. Epub 2003 Nov 14.PMID: 14617576 [PubMed - indexed for MEDLINE]Related articlesFree article

CD1d-restricted NKT regulatory cells: functional genomic analyses provide new insights into the mechanisms of protection against Type 1 diabetes.

Mi QS, Meagher C, Delovitch TL.

Novartis Found Symp. 2003;252:146-60; discussion 160-4, 203-10. Review.PMID: 14609217 [PubMed - indexed for MEDLINE]Related articles

Blockade of tumor necrosis factor-related apoptosis-inducing ligand exacerbates type 1 diabetes in NOD mice.

Mi QS, Ly D, Lamhamedi-Cherradi SE, Salojin KV, Zhou L, Grattan M, Meagher C, Zucker P, Chen YH, Nagle J, Taub D, Delovitch TL.

Diabetes. 2003 Aug;52(8):1967-75.PMID: 12882912 [PubMed - indexed for MEDLINE]Related articlesFree article

Deficient activation and resistance to activation-induced apoptosis of CD8+ T cells is associated with defective peripheral tolerance in nonobese diabetic mice.

Arreaza G, Salojin K, Yang W, Zhang J, Gill B, Mi QS, Gao JX, Meagher C, Cameron M, Delovitch TL.

Clin Immunol. 2003 May;107(2):103-15.PMID: 12763479 [PubMed - indexed for MEDLINE]Related articles

Janus-like role of regulatory iNKT cells in autoimmune disease and tumour immunity.

Wilson SB, Delovitch TL.

Nat Rev Immunol. 2003 Mar;3(3):211-22. Review.PMID: 12658269 [PubMed - indexed for MEDLINE]Related articles

Cytokines and chemokines in the pathogenesis of murine type 1 diabetes.

Meagher C, Sharif S, Hussain S, Cameron MJ, Arreaza GA, Delovitch TL.

Adv Exp Med Biol. 2003;520:133-58. Review. No abstract available. PMID: 12613577 [PubMed - indexed for MEDLINE]Related articles

Regulation of autoimmune disease by natural killer T cells.

Sharif S, Arreaza GA, Zucker P, Mi QS, Delovitch TL.

J Mol Med. 2002 May;80(5):290-300. Epub 2002 Apr 11. Review.PMID: 12021841 [PubMed - indexed for MEDLINE]Related articles

Regulatory natural killer T cells protect against spontaneous and recurrent type 1 diabetes.

Sharif S, Arreaza GA, Zucker P, Delovitch TL.

Ann N Y Acad Sci. 2002 Apr;958:77-88. Review.PMID: 12021086 [PubMed - indexed for MEDLINE]Related articles

Congenic mapping of the diabetogenic locus Idd4 to a 5.2-cM region of chromosome 11 in NOD mice: identification of two potential candidate subloci.

Grattan M, Mi QS, Meagher C, Delovitch TL.

Diabetes. 2002 Jan;51(1):215-23.PMID: 11756344 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence that a peptide spanning the B-C junction of proinsulin is an early Autoantigen epitope in the pathogenesis of type 1 diabetes.

Chen W, Bergerot I, Elliott JF, Harrison LC, Abiru N, Eisenbarth GS, Delovitch TL.

J Immunol. 2001 Nov 1;167(9):4926-35.PMID: 11673498 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of immune responses by natural killer T cells.

Sharif S, Delovitch TL.

Arch Immunol Ther Exp (Warsz). 2001;49 Suppl 1:S23-31. Review.PMID: 11603866 [PubMed - indexed for MEDLINE]Related articles

Role of regulatory T cells in the pathogenesis of autoimmune diabetes.

Arreaza GA, Sharif S, Cameron MJ, Chen W, Delovitch TL.

Curr Dir Autoimmun. 2001;4:308-32. Review. No abstract available. PMID: 11569408 [PubMed - indexed for MEDLINE]Related articles

Activation of natural killer T cells by alpha-galactosylceramide treatment prevents the onset and recurrence of autoimmune Type 1 diabetes.

Sharif S, Arreaza GA, Zucker P, Mi QS, Sondhi J, Naidenko OV, Kronenberg M, Koezuka Y, Delovitch TL, Gombert JM, Leite-De-Moraes M, Gouarin C, Zhu R, Hameg A, Nakayama T, Taniguchi M, Lepault F, Lehuen A, Bach JF, Herbelin A.

Nat Med. 2001 Sep;7(9):1057-62.PMID: 11533711 [PubMed - indexed for MEDLINE]Related articles

CD28 co-stimulation restores T cell responsiveness in NOD mice by overcoming deficiencies in Rac-1/p38 mitogen-activated protein kinase signaling and IL-2 and IL-4 gene transcription.

Zhang J, Salojin KV, Delovitch TL.

Int Immunol. 2001 Mar;13(3):377-84.PMID: 11222507 [PubMed - indexed for MEDLINE]Related articlesFree article

Immune mechanisms that regulate susceptibility to autoimmune type I diabetes.

Singh B, Delovitch TL.

Clin Rev Allergy Immunol. 2000 Dec;19(3):247-64. Review. No abstract available. PMID: 11138408 [PubMed - indexed for MEDLINE]Related articles

Immunotherapy of spontaneous type 1 diabetes in nonobese diabetic mice by systemic interleukin-4 treatment employing adenovirus vector-mediated gene transfer.

Cameron MJ, Arreaza GA, Waldhauser L, Gauldie J, Delovitch TL.

Gene Ther. 2000 Nov;7(21):1840-6.PMID: 11110416 [PubMed - indexed for MEDLINE]Related articlesFree article

Biolistic-mediated interleukin 4 gene transfer prevents the onset of type 1 diabetes.

Cameron MJ, Strathdee CA, Holmes KD, Arreaza GA, Dekaban GA, Delovitch TL.

Hum Gene Ther. 2000 Aug 10;11(12):1647-56.PMID: 10954899 [PubMed - indexed for MEDLINE]Related articles

Differential expression of CC chemokines and the CCR5 receptor in the pancreas is associated with progression to type I diabetes.

Cameron MJ, Arreaza GA, Grattan M, Meagher C, Sharif S, Burdick MD, Strieter RM, Cook DN, Delovitch TL.

J Immunol. 2000 Jul 15;165(2):1102-10.PMID: 10878389 [PubMed - indexed for MEDLINE]Related articlesFree article

Preferential proliferation and differentiation of double-positive thymocytes into CD8(+) single-positive thymocytes in a novel cell culture medium.

Gao JX, Zhang J, Awaraji C, Bhatia M, Jevnikar A, Singh B, Bell D, Delovitch TL.

Cell Immunol. 2000 May 25;202(1):41-53.PMID: 10873305 [PubMed - indexed for MEDLINE]Related articles

Regulation of fas ligand expression during activation-induced cell death in T cells by p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase.

Zhang J, Gao JX, Salojin K, Shao Q, Grattan M, Meagher C, Laird DW, Delovitch TL.

J Exp Med. 2000 Mar 20;191(6):1017-30.PMID: 10727463 [PubMed - indexed for MEDLINE]Related articlesFree article

ZAP-70 is essential for the T cell antigen receptor-induced plasma membrane targeting of SOS and Vav in T cells.

Salojin KV, Zhang J, Meagher C, Delovitch TL.

J Biol Chem. 2000 Feb 25;275(8):5966-75.PMID: 10681590 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin B-chain reactive CD4+ regulatory T-cells induced by oral insulin treatment protect from type 1 diabetes by blocking the cytokine secretion and pancreatic infiltration of diabetogenic effector T-cells.

Bergerot I, Arreaza GA, Cameron MJ, Burdick MD, Strieter RM, Chensue SW, Chakrabarti S, Delovitch TL.

Diabetes. 1999 Sep;48(9):1720-9.PMID: 10480600 [PubMed - indexed for MEDLINE]Related articlesFree article

TCR and CD28 are coupled via ZAP-70 to the activation of the Vav/Rac-1-/PAK-1/p38 MAPK signaling pathway.

Salojin KV, Zhang J, Delovitch TL.

J Immunol. 1999 Jul 15;163(2):844-53.PMID: 10395678 [PubMed - indexed for MEDLINE]Related articlesFree article

p38 mitogen-activated protein kinase mediates signal integration of TCR/CD28 costimulation in primary murine T cells.

Zhang J, Salojin KV, Gao JX, Cameron MJ, Bergerot I, Delovitch TL.

J Immunol. 1999 Apr 1;162(7):3819-29.PMID: 10201899 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-like growth factors prevent cytokine-mediated cell death in isolated islets of Langerhans from pre-diabetic non-obese diabetic mice.

Hill DJ, Petrik J, Arany E, McDonald TJ, Delovitch TL.

J Endocrinol. 1999 Apr;161(1):153-65.PMID: 10194539 [PubMed - indexed for MEDLINE]Related articlesFree article

T-cell anergy and altered T-cell receptor signaling: effects on autoimmune disease.

Salojin KV, Zhang J, Madrenas J, Delovitch TL.

Immunol Today. 1998 Oct;19(10):468-73.PMID: 9785671 [PubMed - indexed for MEDLINE]Related articles

TCR alpha beta chains associate with the plasma membrane independently of CD3 and TCR zeta chains in murine primary T cells.

Zhang J, Salojin K, Gao JX, Cameron M, Geisler C, Delovitch TL.

J Immunol. 1998 Sep 15;161(6):2930-7.PMID: 9743355 [PubMed - indexed for MEDLINE]Related articlesFree article

Failure in immune regulation begets IDDM in NOD mice.

Cameron MJ, Meagher C, Delovitch TL.

Diabetes Metab Rev. 1998 Jun;14(2):177-85. Review.PMID: 9679670 [PubMed - indexed for MEDLINE]Related articles

Sequestration of CD4-associated Lck from the TCR complex may elicit T cell hyporesponsiveness in nonobese diabetic mice.

Zhang J, Salojin K, Delovitch TL.

J Immunol. 1998 Feb 1;160(3):1148-57.PMID: 9570528 [PubMed - indexed for MEDLINE]Related articlesFree article

The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD.

Delovitch TL, Singh B.

Immunity. 1997 Dec;7(6):727-38. Review. No abstract available. Erratum in: Immunity 1998 Apr;8(4):531. PMID: 9430219 [PubMed - indexed for MEDLINE]Related articles

Neonatal activation of CD28 signaling overcomes T cell anergy and prevents autoimmune diabetes by an IL-4-dependent mechanism.

Arreaza GA, Cameron MJ, Jaramillo A, Gill BM, Hardy D, Laupland KB, Rapoport MJ, Zucker P, Chakrabarti S, Chensue SW, Qin HY, Singh B, Delovitch TL.

J Clin Invest. 1997 Nov 1;100(9):2243-53.PMID: 9410902 [PubMed - indexed for MEDLINE]Related articlesFree article

IL-4 prevents insulitis and insulin-dependent diabetes mellitus in nonobese diabetic mice by potentiation of regulatory T helper-2 cell function.

Cameron MJ, Arreaza GA, Zucker P, Chensue SW, Strieter RM, Chakrabarti S, Delovitch TL.

J Immunol. 1997 Nov 15;159(10):4686-92.PMID: 9366391 [PubMed - indexed for MEDLINE]Related articles

Impaired plasma membrane targeting of Grb2-murine son of sevenless (mSOS) complex and differential activation of the Fyn-T cell receptor (TCR)-zeta-Cbl pathway mediate T cell hyporesponsiveness in autoimmune nonobese diabetic mice.

Salojin K, Zhang J, Cameron M, Gill B, Arreaza G, Ochi A, Delovitch TL.

J Exp Med. 1997 Sep 15;186(6):887-97.PMID: 9294143 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of T-cell anergy and suppression in susceptibility to IDDM.

Bergerot I, Arreaza G, Cameron M, Chou H, Delovitch TL.

Res Immunol. 1997 Jun;148(5):348-58. Review. No abstract available. PMID: 9352600 [PubMed - indexed for MEDLINE]Related articles

Cytokine- and costimulation-mediated therapy of IDDM.

Cameron MJ, Arreaza GA, Delovitch TL.

Crit Rev Immunol. 1997;17(5-6):537-44. Review.PMID: 9419441 [PubMed - indexed for MEDLINE]Related articles

Major histocompatibility complex class II molecules function as a template for the processing of a partially processed insulin peptide into a T-cell epitope.

Lang Y, Forquet F, Speck E, Blum J, Delovitch TL.

Diabetes. 1996 Dec;45(12):1711-9.PMID: 8922356 [PubMed - indexed for MEDLINE]Related articles