PubMed

Goals of treatment for type 2 diabetes: beta-cell preservation for glycemic control.

Marchetti P, Lupi R, Del Guerra S, Bugliani M, D'Aleo V, Occhipinti M, Boggi U, Marselli L, Masini M.

Diabetes Care. 2009 Nov;32 Suppl 2:S178-83. No abstract available. PMID: 19875548 [PubMed - in process]Related articles

G-protein-coupled receptor 40 (GPR40) expression and its regulation in human pancreatic islets: The role of type 2 diabetes and fatty acids.

Del Guerra S, Bugliani M, D'Aleo V, Del Prato S, Boggi U, Mosca F, Filipponi F, Lupi R.

Nutr Metab Cardiovasc Dis. 2009 Sep 14. [Epub ahead of print]PMID: 19758793 [PubMed - as supplied by publisher]Related articles

Effects of exposure of human islet beta-cells to normal and high glucose levels with or without gliclazide or glibenclamide.

Del Guerra S, D'Aleo V, Lupi R, Masini M, Bugliani M, Boggi U, Filipponi F, Marchetti P.

Diabetes Metab. 2009 Sep;35(4):293-8. Epub 2009 Jun 6.PMID: 19502091 [PubMed - in process]Related articles

The non-peptidyl low molecular weight radical scavenger IAC protects human pancreatic islets from lipotoxicity.

D'Aleo V, Del Guerra S, Martano M, Bonamassa B, Canistro D, Soleti A, Valgimigli L, Paolini M, Filipponi F, Boggi U, Del Prato S, Lupi R.

Mol Cell Endocrinol. 2009 Oct 15;309(1-2):63-6. Epub 2009 May 27.PMID: 19481137 [PubMed - indexed for MEDLINE]Related articles

Autophagy in human type 2 diabetes pancreatic beta cells.

Masini M, Bugliani M, Lupi R, del Guerra S, Boggi U, Filipponi F, Marselli L, Masiello P, Marchetti P.

Diabetologia. 2009 Jun;52(6):1083-6. Epub 2009 Apr 15.PMID: 19367387 [PubMed - indexed for MEDLINE]Related articles

Glucose transporter 2 gene polymorphisms and beta-cell function in isolated human pancreatic islets.

Del Guerra S, Lupi R, D'Aleo V, Filipponi F, Boggi U, Marchetti P.

Diabetes Metab. 2009 Apr;35(2):155-6. Epub 2009 Mar 9. No abstract available. PMID: 19269875 [PubMed - indexed for MEDLINE]Related articles

Beneficial effect of the nonpeptidyl low molecular weight radical scavenger IAC on cultured human islet function.

Mancarella R, Del Guerra S, Masini M, Bugliani M, Valgimigli L, Pedulli GF, Paolini M, Canistro D, Armando A, Soleti A, Filipponi F, Mosca F, Boggi U, Del Prato S, Marchetti P, Lupi R.

Cell Transplant. 2008;17(10-11):1271-6.PMID: 19181220 [PubMed - indexed for MEDLINE]Related articles

The TRIB3 Q84R polymorphism and risk of early-onset type 2 diabetes.

Prudente S, Scarpelli D, Chandalia M, Zhang YY, Morini E, Del Guerra S, Perticone F, Li R, Powers C, Andreozzi F, Marchetti P, Dallapiccola B, Abate N, Doria A, Sesti G, Trischitta V.

J Clin Endocrinol Metab. 2009 Jan;94(1):190-6. Epub 2008 Nov 4.PMID: 18984671 [PubMed - indexed for MEDLINE]Related articles

Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion.

Ling C, Del Guerra S, Lupi R, Rönn T, Granhall C, Luthman H, Masiello P, Marchetti P, Groop L, Del Prato S.

Diabetologia. 2008 Apr;51(4):615-22. Epub 2008 Feb 13.PMID: 18270681 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of exendin-4 on islets from type 2 diabetes patients.

Lupi R, Mancarella R, Del Guerra S, Bugliani M, Del Prato S, Boggi U, Mosca F, Filipponi F, Marchetti P.

Diabetes Obes Metab. 2008 Jun;10(6):515-9. Epub 2008 Jan 14.PMID: 18201204 [PubMed - indexed for MEDLINE]Related articles

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes.

Lyssenko V, Lupi R, Marchetti P, Del Guerra S, Orho-Melander M, Almgren P, Sjögren M, Ling C, Eriksson KF, Lethagen AL, Mancarella R, Berglund G, Tuomi T, Nilsson P, Del Prato S, Groop L.

J Clin Invest. 2007 Aug;117(8):2155-63.PMID: 17671651 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin secretion defects of human type 2 diabetic islets are corrected in vitro by a new reactive oxygen species scavenger.

Lupi R, Del Guerra S, Mancarella R, Novelli M, Valgimigli L, Pedulli GF, Paolini M, Soleti A, Filipponi F, Mosca F, Boggi U, Del Prato S, Masiello P, Marchetti P.

Diabetes Metab. 2007 Nov;33(5):340-5. Epub 2007 Jul 9.PMID: 17616474 [PubMed - indexed for MEDLINE]Related articlesFree article

Multilayer nanoencapsulation. New approach for immune protection of human pancreatic islets.

Krol S, del Guerra S, Grupillo M, Diaspro A, Gliozzi A, Marchetti P.

Nano Lett. 2006 Sep;6(9):1933-9.PMID: 16968004 [PubMed - indexed for MEDLINE]Related articles

Gliclazide protects human islet beta-cells from apoptosis induced by intermittent high glucose.

Del Guerra S, Grupillo M, Masini M, Lupi R, Bugliani M, Torri S, Boggi U, Del Chiaro M, Vistoli F, Mosca F, Del Prato S, Marchetti P.

Diabetes Metab Res Rev. 2007 Mar;23(3):234-8.PMID: 16952202 [PubMed - indexed for MEDLINE]Related articles

Transcription factors of beta-cell differentiation and maturation in isolated human islets: effects of high glucose, high free fatty acids and type 2 diabetes.

Lupi R, Bugliani M, Del Guerra S, Del Prato S, Marchetti P, Boggi U, Filipponi F, Mosca F.

Nutr Metab Cardiovasc Dis. 2006 Sep;16(6):e7-8. Epub 2006 Mar 31. No abstract available. PMID: 16935697 [PubMed - indexed for MEDLINE]Related articles

Effects of C-peptide on isolated human pancreatic islet cells.

Bugliani M, Torri S, Lupi R, Del Guerra S, Grupillo M, Del Chiaro M, Mosca F, Boggi U, Del Prato S, Marchetti P.

Diabetes Metab Res Rev. 2007 Mar;23(3):215-9.PMID: 16874846 [PubMed - indexed for MEDLINE]Related articles

The E23K variant of KCNJ11 encoding the pancreatic beta-cell adenosine 5'-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes.

Sesti G, Laratta E, Cardellini M, Andreozzi F, Del Guerra S, Irace C, Gnasso A, Grupillo M, Lauro R, Hribal ML, Perticone F, Marchetti P.

J Clin Endocrinol Metab. 2006 Jun;91(6):2334-9. Epub 2006 Apr 4.PMID: 16595597 [PubMed - indexed for MEDLINE]Related articlesFree article

The pancreatic beta-cell in human Type 2 diabetes.

Marchetti P, Del Prato S, Lupi R, Del Guerra S.

Nutr Metab Cardiovasc Dis. 2006 Mar;16 Suppl 1:S3-6. Epub 2006 Feb 9. Review.PMID: 16530127 [PubMed - indexed for MEDLINE]Related articles

The direct effects of the angiotensin-converting enzyme inhibitors, zofenoprilat and enalaprilat, on isolated human pancreatic islets.

Lupi R, Del Guerra S, Bugliani M, Boggi U, Mosca F, Torri S, Del Prato S, Marchetti P.

Eur J Endocrinol. 2006 Feb;154(2):355-61.PMID: 16452552 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatitis C virus infection and human pancreatic beta-cell dysfunction.

Masini M, Campani D, Boggi U, Menicagli M, Funel N, Pollera M, Lupi R, Del Guerra S, Bugliani M, Torri S, Del Prato S, Mosca F, Filipponi F, Marchetti P.

Diabetes Care. 2005 Apr;28(4):940-1. No abstract available. PMID: 15793203 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional and molecular defects of pancreatic islets in human type 2 diabetes.

Del Guerra S, Lupi R, Marselli L, Masini M, Bugliani M, Sbrana S, Torri S, Pollera M, Boggi U, Mosca F, Del Prato S, Marchetti P.

Diabetes. 2005 Mar;54(3):727-35.PMID: 15734849 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of prolonged in vitro exposure to sulphonylureas on the function and survival of human islets.

Del Guerra S, Marselli L, Lupi R, Boggi U, Mosca F, Benzi L, Del Prato S, Marchetti P.

J Diabetes Complications. 2005 Jan-Feb;19(1):60-4.PMID: 15642492 [PubMed - indexed for MEDLINE]Related articles

Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin.

Marchetti P, Del Guerra S, Marselli L, Lupi R, Masini M, Pollera M, Bugliani M, Boggi U, Vistoli F, Mosca F, Del Prato S.

J Clin Endocrinol Metab. 2004 Nov;89(11):5535-41.PMID: 15531508 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of peripheral benzodiazepine receptors on the function and survival of isolated human pancreatic islets.

Marselli L, Trincavelli L, Santangelo C, Lupi R, Del Guerra S, Boggi U, Falleni A, Gremigni V, Mosca F, Martini C, Dotta F, Di Mario U, Del Prato S, Marchetti P.

Eur J Endocrinol. 2004 Aug;151(2):207-14.PMID: 15296476 [PubMed - indexed for MEDLINE]Related articlesFree article

Improved insulin secretory function and reduced chemotactic properties after tissue culture of islets from type 1 diabetic patients.

Lupi R, Marselli L, Dionisi S, Del Guerra S, Boggi U, Del Chiaro M, Lencioni C, Bugliani M, Mosca F, Di Mario U, Del Prato S, Dotta F, Marchetti P.

Diabetes Metab Res Rev. 2004 May-Jun;20(3):246-51.PMID: 15133757 [PubMed - indexed for MEDLINE]Related articles

An alternative and simple method to consistently prepare viable isolated human islets for clinical transplantation.

Bugliani M, Lupi R, Del Guerra S, Boggi U, Marselli L, Sbrana S, Vistoli F, Torri S, Del Chiaro M, Signori S, Filipponi F, Del Prato S, Campa M, Corsini V, Campatelli A, Di Candio F, Mosca F, Marchetti P.

Transplant Proc. 2004 Apr;36(3):605-6.PMID: 15110608 [PubMed - indexed for MEDLINE]Related articles

Increased O-glycosylation of insulin signaling proteins results in their impaired activation and enhanced susceptibility to apoptosis in pancreatic beta-cells.

D'Alessandris C, Andreozzi F, Federici M, Cardellini M, Brunetti A, Ranalli M, Del Guerra S, Lauro D, Del Prato S, Marchetti P, Lauro R, Sesti G.

FASEB J. 2004 Jun;18(9):959-61. Epub 2004 Apr 1.PMID: 15059979 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic beta-cells.

Andreozzi F, D'Alessandris C, Federici M, Laratta E, Del Guerra S, Del Prato S, Marchetti P, Lauro R, Perticone F, Sesti G.

Endocrinology. 2004 Jun;145(6):2845-57. Epub 2004 Mar 4.PMID: 15001544 [PubMed - indexed for MEDLINE]Related articlesFree article

Rosiglitazone prevents the impairment of human islet function induced by fatty acids: evidence for a role of PPARgamma2 in the modulation of insulin secretion.

Lupi R, Del Guerra S, Marselli L, Bugliani M, Boggi U, Mosca F, Marchetti P, Del Prato S.

Am J Physiol Endocrinol Metab. 2004 Apr;286(4):E560-7. Epub 2003 Nov 18.PMID: 14625208 [PubMed - indexed for MEDLINE]Related articlesFree article

A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects.

Sesti G, Cardellini M, Marini MA, Frontoni S, D'Adamo M, Del Guerra S, Lauro D, De Nicolais P, Sbraccia P, Del Prato S, Gambardella S, Federici M, Marchetti P, Lauro R.

Diabetes. 2003 May;52(5):1280-3.PMID: 12716765 [PubMed - indexed for MEDLINE]Related articlesFree article

Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.

Lupi R, Dotta F, Marselli L, Del Guerra S, Masini M, Santangelo C, Patané G, Boggi U, Piro S, Anello M, Bergamini E, Mosca F, Di Mario U, Del Prato S, Marchetti P.

Diabetes. 2002 May;51(5):1437-42.PMID: 11978640 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin secretory function is impaired in isolated human islets carrying the Gly(972)-->Arg IRS-1 polymorphism.

Marchetti P, Lupi R, Federici M, Marselli L, Masini M, Boggi U, Del Guerra S, Patanè G, Piro S, Anello M, Bergamini E, Purrello F, Lauro R, Mosca F, Sesti G, Del Prato S.

Diabetes. 2002 May;51(5):1419-24.PMID: 11978638 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipotoxicity in human pancreatic islets and the protective effect of metformin.

Lupi R, Del Guerra S, Fierabracci V, Marselli L, Novelli M, Patanè G, Boggi U, Mosca F, Piro S, Del Prato S, Marchetti P.

Diabetes. 2002 Feb;51 Suppl 1:S134-7.PMID: 11815472 [PubMed - indexed for MEDLINE]Related articlesFree article

Entrapment of dispersed pancreatic islet cells in CultiSpher-S macroporous gelatin microcarriers: Preparation, in vitro characterization, and microencapsulation.

Del Guerra S, Bracci C, Nilsson K, Belcourt A, Kessler L, Lupi R, Marselli L, De Vos P, Marchetti P.

Biotechnol Bioeng. 2001 Dec 20;75(6):741-4.PMID: 11745153 [PubMed - indexed for MEDLINE]Related articles

Th2 cytokines have a partial, direct protective effect on the function and survival of isolated human islets exposed to combined proinflammatory and Th1 cytokines.

Marselli L, Dotta F, Piro S, Santangelo C, Masini M, Lupi R, Realacci M, del Guerra S, Mosca F, Boggi U, Purrello F, Navalesi R, Marchetti P.

J Clin Endocrinol Metab. 2001 Oct;86(10):4974-8.PMID: 11600573 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin release form isolated, human islets after acute or prolonged exposure to glimepiride.

Del Guerra S, Parentini C, Bracci C, Lupi R, Marselli L, Aragona M, Navalesi R, Marchetti P.

Acta Diabetol. 2000;37(3):139-41. No abstract available. PMID: 11277315 [PubMed - indexed for MEDLINE]Related articles

Bovine islets are less susceptible than human islets to damage by human cytokines.

Piro S, Lupi R, Dotta F, Patanè G, Rabuazzo MA, Marselli L, Santangelo C, Realacci M, Del Guerra S, Purrello F, Marchetti P.

Transplantation. 2001 Jan 15;71(1):21-6.PMID: 11211190 [PubMed - indexed for MEDLINE]Related articles

Effects of prolonged exposure to pancreatic glucagon on the function, antigenicity and survival of isolated human islets.

Del Guerra S, Lupi R, Dotta F, Marselli L, Lencioni C, Santangelo C, Realacci M, Carmellini M, Mosca F, Navalesi R, Marchetti P.

Diabetes Metab Res Rev. 2000 Jul-Aug;16(4):281-6.PMID: 10934457 [PubMed - indexed for MEDLINE]Related articles

Lymphokine release from human lymphomononuclear cells after co-culture with isolated pancreatic islets: effects of islet species, long-term culture, and monocyte-macrophage cell removal.

Marselli L, Marchetti P, Tellini C, Giannarelli R, Lencioni C, Del Guerra S, Lupi R, Carmellini M, Mosca F, Navalesi R.

Cytokine. 2000 May;12(5):503-5.PMID: 10857768 [PubMed - indexed for MEDLINE]Related articles

Function of pancreatic islets isolated from a type 1 diabetic patient.

Marchetti P, Dotta F, Ling Z, Lupi R, Del Guerra S, Santangelo C, Realacci M, Marselli L, Di Mario U, Navalesi R.

Diabetes Care. 2000 May;23(5):701-3. No abstract available. PMID: 10834434 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of acute or prolonged exposure to human leptin on isolated human islet function.

Lupi R, Marchetti P, Maffei M, Del Guerra S, Benzi L, Marselli L, Bertacca A, Navalesi R.

Biochem Biophys Res Commun. 1999 Mar 24;256(3):637-41.PMID: 10080951 [PubMed - indexed for MEDLINE]Related articles

The biguanide compound metformin prevents desensitization of human pancreatic islets induced by high glucose.

Lupi R, Del Guerra S, Tellini C, Giannarelli R, Coppelli A, Lorenzetti M, Carmellini M, Mosca F, Navalesi R, Marchetti P.

Eur J Pharmacol. 1999 Jan 8;364(2-3):205-9.PMID: 9932725 [PubMed - indexed for MEDLINE]Related articles

Transplantation of purified bovine islets into the thymus of non-immunosuppressed pigs.

Del Guerra S, Carmellini M, Giannarelli R, Marchetti P, Solari R, Coppelli A, Calabrese M, Meacci L, Tellini C, Lupi R, Cecchetti P, Mosca F, Navalesi R.

Acta Diabetol. 1998 Oct;35(3):165-6. No abstract available. PMID: 9840455 [PubMed - indexed for MEDLINE]Related articles

Characterization of sulfonylurea receptors in isolated human pancreatic islets.

Giannaccini G, Lupi R, Trincavelli ML, Navalesi R, Betti L, Marchetti P, Lucacchini A, Del Guerra S, Martini C.

J Cell Biochem. 1998 Nov 1;71(2):182-8.PMID: 9779817 [PubMed - indexed for MEDLINE]Related articles

Corticotropin-releasing hormone facilitates early survival of discordant (bovine-to-rat) islet xenografts.

Lupi R, Marchetti P, Coppelli A, Giannarelli R, Petraglia F, Luisi S, Del Guerra S, Tellini C, Florio P, Genazzani A, Viacava P, Navalesi R.

Transplant Proc. 1998 Aug;30(5):2481-3. No abstract available. PMID: 9723547 [PubMed - indexed for MEDLINE]Related articles

Xenotransplantation of bovine islets into the thymus of totally pancreatectomized pigs.

Carmellini M, Del Guerra S, Solari R, Marchetti P, Bellissima G, Meacci L, Burchielli S, Giannarelli R, Calabrese M, Navalesi R, Mosca F.

Transplant Proc. 1998 Aug;30(5):2478-80. No abstract available. PMID: 9723546 [PubMed - indexed for MEDLINE]Related articles

Similar insulinotropic effects of alpha- and beta-D-glucose anomers on isolated large mammal and human islets.

Lupi R, Marchetti P, Tellini C, Del Guerra S, Coppelli A, Lorenzetti M, Masiello P, Carmellini M, Mosca F, Navalesi R.

Transplant Proc. 1998 Mar;30(2):612. No abstract available. PMID: 9532199 [PubMed - indexed for MEDLINE]Related articles

Effects of monensin on insulin release from isolated human islets.

Lorenzetti M, Marchetti P, Cecchetti P, Tellini C, Del Guerra S, Lupi R, Giannarelli R, Lencioni C, Carmellini M, Mosca F, Navalesi R, Benzi L.

Transplant Proc. 1998 Mar;30(2):611. No abstract available. PMID: 9532198 [PubMed - indexed for MEDLINE]Related articles

Pancreatic glucagon damages isolated human islet function.

Marchetti P, Lupi R, Lorenzetti M, Giannarelli R, Del Guerra S, Tellini C, Coppelli A, Lencioni C, Marselli L, Carmellini M, Mosca F, Navalesi R.

Transplant Proc. 1998 Mar;30(2):397. No abstract available. PMID: 9532099 [PubMed - indexed for MEDLINE]Related articles

Preparation and long-term culture of isolated human pancreatic islets.

Giannarelli R, Coppelli A, Marchetti P, Tellini C, Del Guerra S, Lupi R, Lorenzetti M, Masiello P, Carmellini M, Mosca F, Lencioni C, Navalesi R.

Transplant Proc. 1998 Mar;30(2):384-5. No abstract available. PMID: 9532093 [PubMed - indexed for MEDLINE]Related articles