PubMed

Bis- and tris(pyridyl)amine-oxidovanadium complexes: characteristics and insulin-mimetic potential.

Nilsson J, Degerman E, Haukka M, Lisensky GC, Garribba E, Yoshikawa Y, Sakurai H, Enyedy EA, Kiss T, Esbak H, Rehder D, Nordlander E.

Dalton Trans. 2009 Oct 14;(38):7902-11. Epub 2009 Aug 5.PMID: 19771353 [PubMed - in process]Related articles

Differential regulation of adipocyte PDE3B in distinct membrane compartments by insulin and the beta3-adrenergic receptor agonist CL316243: effects of caveolin-1 knockdown on formation/maintenance of macromolecular signalling complexes.

Ahmad F, Lindh R, Tang Y, Ruishalme I, Ost A, Sahachartsiri B, Strålfors P, Degerman E, Manganiello VC.

Biochem J. 2009 Dec 10;424(3):399-410.PMID: 19747167 [PubMed - in process]Related articlesFree article

Phosphodiesterase 3B is localized in caveolae and smooth ER in mouse hepatocytes and is important in the regulation of glucose and lipid metabolism.

Berger K, Lindh R, Wierup N, Zmuda-Trzebiatowska E, Lindqvist A, Manganiello VC, Degerman E.

PLoS One. 2009;4(3):e4671. Epub 2009 Mar 5.PMID: 19262749 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of AMP-activated protein kinase by cAMP in adipocytes: roles for phosphodiesterases, protein kinase B, protein kinase A, Epac and lipolysis.

Omar B, Zmuda-Trzebiatowska E, Manganiello V, Göransson O, Degerman E.

Cell Signal. 2009 May;21(5):760-6. Epub 2009 Jan 8.PMID: 19167487 [PubMed - indexed for MEDLINE]Related articles

Protein kinase B activity is required for the effects of insulin on lipid metabolism in adipocytes.

Berggreen C, Gormand A, Omar B, Degerman E, Göransson O.

Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E635-46. Epub 2009 Jan 21.PMID: 19158325 [PubMed - indexed for MEDLINE]Related articles

Increased cAMP signaling can ameliorate the hypertensive condition in spontaneously hypertensive rats.

Berg T, Degerman E, Tasken K.

J Vasc Res. 2009;46(1):25-35. Epub 2008 May 31.PMID: 18515972 [PubMed - indexed for MEDLINE]Related articles

Macroporous gel particles as robust macroporous matrices for cell immobilization.

Plieva FM, Oknianska A, Degerman E, Mattiasson B.

Biotechnol J. 2008 Mar;3(3):410-7.PMID: 18022855 [PubMed - indexed for MEDLINE]Related articles

Perilipin and adipophilin expression in lipid loaded macrophages.

Persson J, Degerman E, Nilsson J, Lindholm MW.

Biochem Biophys Res Commun. 2007 Nov 30;363(4):1020-6. Epub 2007 Sep 29.PMID: 17927964 [PubMed - indexed for MEDLINE]Related articles

Beta-cell PDE3B regulates Ca2+-stimulated exocytosis of insulin.

Walz HA, Wierup N, Vikman J, Manganiello VC, Degerman E, Eliasson L, Holst LS.

Cell Signal. 2007 Jul;19(7):1505-13. Epub 2007 Feb 12.PMID: 17368848 [PubMed - indexed for MEDLINE]Related articles

Insulin-induced formation of macromolecular complexes involved in activation of cyclic nucleotide phosphodiesterase 3B (PDE3B) and its interaction with PKB.

Ahmad F, Lindh R, Tang Y, Weston M, Degerman E, Manganiello VC.

Biochem J. 2007 Jun 1;404(2):257-68.PMID: 17324123 [PubMed - indexed for MEDLINE]Related articlesFree article

Multisite phosphorylation of adipocyte and hepatocyte phosphodiesterase 3B.

Lindh R, Ahmad F, Resjö S, James P, Yang JS, Fales HM, Manganiello V, Degerman E.

Biochim Biophys Acta. 2007 Apr;1773(4):584-92. Epub 2007 Jan 27.PMID: 17320989 [PubMed - indexed for MEDLINE]Related articles

Re-discovering PDE3 inhibitors--new opportunities for a long neglected target.

Thompson PE, Manganiello V, Degerman E.

Curr Top Med Chem. 2007;7(4):421-36. Review.PMID: 17305583 [PubMed - indexed for MEDLINE]Related articles

Long-term regulation of cyclic nucleotide phosphodiesterase type 3B and 4 in 3T3-L1 adipocytes.

Oknianska A, Zmuda-Trzebiatowska E, Manganiello V, Degerman E.

Biochem Biophys Res Commun. 2007 Feb 23;353(4):1080-5. Epub 2006 Dec 28.PMID: 17198676 [PubMed - indexed for MEDLINE]Related articles

Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B-null mice.

Choi YH, Park S, Hockman S, Zmuda-Trzebiatowska E, Svennelid F, Haluzik M, Gavrilova O, Ahmad F, Pepin L, Napolitano M, Taira M, Sundler F, Stenson Holst L, Degerman E, Manganiello VC.

J Clin Invest. 2006 Dec;116(12):3240-51.PMID: 17143332 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel mechanisms of the regulation of protein kinase B in adipocytes; implications for protein kinase A, Epac, phosphodiesterases 3 and 4.

Zmuda-Trzebiatowska E, Manganiello V, Degerman E.

Cell Signal. 2007 Jan;19(1):81-6. Epub 2006 Jun 7.PMID: 16839743 [PubMed - indexed for MEDLINE]Related articles

Early and rapid development of insulin resistance, islet dysfunction and glucose intolerance after high-fat feeding in mice overexpressing phosphodiesterase 3B.

Walz HA, Härndahl L, Wierup N, Zmuda-Trzebiatowska E, Svennelid F, Manganiello VC, Ploug T, Sundler F, Degerman E, Ahrén B, Holst LS.

J Endocrinol. 2006 Jun;189(3):629-41.PMID: 16731793 [PubMed - indexed for MEDLINE]Related articlesFree article

Importance of cAMP-response element-binding protein in regulation of expression of the murine cyclic nucleotide phosphodiesterase 3B (Pde3b) gene in differentiating 3T3-L1 preadipocytes.

Liu H, Tang JR, Choi YH, Napolitano M, Hockman S, Taira M, Degerman E, Manganiello VC.

J Biol Chem. 2006 Jul 28;281(30):21096-113. Epub 2006 May 15.PMID: 16702214 [PubMed - indexed for MEDLINE]Related articlesFree article

Plasma membrane cyclic nucleotide phosphodiesterase 3B (PDE3B) is associated with caveolae in primary adipocytes.

Nilsson R, Ahmad F, Swärd K, Andersson U, Weston M, Manganiello V, Degerman E.

Cell Signal. 2006 Oct;18(10):1713-21. Epub 2006 Feb 28.PMID: 16503395 [PubMed - indexed for MEDLINE]Related articles

Chemical derivatization of phosphoserine and phosphothreonine containing peptides to increase sensitivity for MALDI-based analysis and for selectivity of MS/MS analysis.

Arrigoni G, Resjö S, Levander F, Nilsson R, Degerman E, Quadroni M, Pinna LA, James P.

Proteomics. 2006 Feb;6(3):757-66.PMID: 16372258 [PubMed - indexed for MEDLINE]Related articles

Identification of promoter elements in 5'-flanking region of murine cyclic nucleotide phosphodiesterase 3B gene.

Liu H, Tang JR, Degerman E, Manganiello VC.

Methods Mol Biol. 2005;307:109-24.PMID: 15988059 [PubMed - indexed for MEDLINE]Related articles

Role of PDE3B in insulin-induced glucose uptake, GLUT-4 translocation and lipogenesis in primary rat adipocytes.

Zmuda-Trzebiatowska E, Oknianska A, Manganiello V, Degerman E.

Cell Signal. 2006 Mar;18(3):382-90. Epub 2005 Jun 14.PMID: 15961276 [PubMed - indexed for MEDLINE]Related articles

VPAC2-R mediates the lipolytic effects of pituitary adenylate cyclase-activating polypeptide/vasoactive intestinal polypeptide in primary rat adipocytes.

Akesson L, Ahrén B, Edgren G, Degerman E.

Endocrinology. 2005 Feb;146(2):744-50. Epub 2004 Oct 28.PMID: 15514088 [PubMed - indexed for MEDLINE]Related articlesFree article

Milrinone efficiently potentiates insulin secretion induced by orally but not intravenously administered glucose in C57BL6J mice.

Degerman E, Manganiello V, Holst JJ, Ahrén B.

Eur J Pharmacol. 2004 Sep 13;498(1-3):319-23.PMID: 15364011 [PubMed - indexed for MEDLINE]Related articles

Dimethylaminopurine inhibits metabolic effects of insulin in primary adipocytes.

Göransson O, Rydén M, Nilsson R, Arner P, Degerman E.

J Nutr Biochem. 2004 May;15(5):303-12.PMID: 15135155 [PubMed - indexed for MEDLINE]Related articles

Beta-cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance, and deranged islet morphology.

Härndahl L, Wierup N, Enerbäck S, Mulder H, Manganiello VC, Sundler F, Degerman E, Ahrén B, Holst LS.

J Biol Chem. 2004 Apr 9;279(15):15214-22. Epub 2004 Jan 20.PMID: 14736883 [PubMed - indexed for MEDLINE]Related articlesFree article

Dual effects of pituitary adenylate cyclase-activating polypeptide and isoproterenol on lipid metabolism and signaling in primary rat adipocytes.

Akesson L, Ahrén B, Manganiello VC, Holst LS, Edgren G, Degerman E.

Endocrinology. 2003 Dec;144(12):5293-9. Epub 2003 Aug 28.PMID: 12960103 [PubMed - indexed for MEDLINE]Related articlesFree article

Important role of phosphodiesterase 3B for the stimulatory action of cAMP on pancreatic beta-cell exocytosis and release of insulin.

Härndahl L, Jing XJ, Ivarsson R, Degerman E, Ahrén B, Manganiello VC, Renström E, Holst LS.

J Biol Chem. 2002 Oct 4;277(40):37446-55. Epub 2002 Aug 6.PMID: 12169692 [PubMed - indexed for MEDLINE]Related articlesFree article

Recruitment of pelagic fish in an unstable climate: studies in Sweden's four largest lakes.

Nyberg P, Bergstrand E, Degerman E, Enderlein O.

Ambio. 2001 Dec;30(8):559-64.PMID: 11878031 [PubMed - indexed for MEDLINE]Related articles

Human impact on the fish diversity in the four largest lakes of Sweden.

Degerman E, Hammar J, Nyberg P, Svärdson G.

Ambio. 2001 Dec;30(8):522-8.PMID: 11878026 [PubMed - indexed for MEDLINE]Related articles

C(2)-ceramide influences the expression and insulin-mediated regulation of cyclic nucleotide phosphodiesterase 3B and lipolysis in 3T3-L1 adipocytes.

Mei J, Holst LS, Landström TR, Holm C, Brindley D, Manganiello V, Degerman E.

Diabetes. 2002 Mar;51(3):631-7.PMID: 11872660 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein phosphatase 2A is the main phosphatase involved in the regulation of protein kinase B in rat adipocytes.

Resjö S, Göransson O, Härndahl L, Zolnierowicz S, Manganiello V, Degerman E.

Cell Signal. 2002 Mar;14(3):231-8.PMID: 11812651 [PubMed - indexed for MEDLINE]Related articles

Ser-474 is the major target of insulin-mediated phosphorylation of protein kinase B beta in primary rat adipocytes.

Göransson O, Resjö S, Rönnstrand L, Manganiello V, Degerman E.

Cell Signal. 2002 Feb;14(2):175-82.PMID: 11781143 [PubMed - indexed for MEDLINE]Related articles

Methods to study phosphorylation and activation of the hormone-sensitive adipocyte phosphodiesterase type 3B in rat adipocytes.

Degerman E, Resjö S, Landström TR, Manganiello V.

Methods Mol Biol. 2001;155:167-80. Review. No abstract available. PMID: 11293069 [PubMed - indexed for MEDLINE]Related articles

Identification of a novel isoform of the cyclic-nucleotide phosphodiesterase PDE3A expressed in vascular smooth-muscle myocytes.

Choi YH, Ekholm D, Krall J, Ahmad F, Degerman E, Manganiello VC, Movsesian MA.

Biochem J. 2001 Jan 1;353(Pt 1):41-50.PMID: 11115397 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation and function of the cyclic nucleotide phosphodiesterase (PDE3) gene family.

Shakur Y, Holst LS, Landstrom TR, Movsesian M, Degerman E, Manganiello V.

Prog Nucleic Acid Res Mol Biol. 2001;66:241-77. Review. No abstract available. PMID: 11051766 [PubMed - indexed for MEDLINE]Related articles

Membrane localization of cyclic nucleotide phosphodiesterase 3 (PDE3). Two N-terminal domains are required for the efficient targeting to, and association of, PDE3 with endoplasmic reticulum.

Shakur Y, Takeda K, Kenan Y, Yu ZX, Rena G, Brandt D, Houslay MD, Degerman E, Ferrans VJ, Manganiello VC.

J Biol Chem. 2000 Dec 8;275(49):38749-61.PMID: 10952971 [PubMed - indexed for MEDLINE]Related articlesFree article

Airborne cell analysis.

Santesson S, Andersson M, Degerman E, Johansson T, Nilsson J, Nilsson S.

Anal Chem. 2000 Aug 1;72(15):3412-8.PMID: 10952520 [PubMed - indexed for MEDLINE]Related articles

Substrates of semicarbazide-sensitive amine oxidase co-operate with vanadate to stimulate tyrosine phosphorylation of insulin-receptor-substrate proteins, phosphoinositide 3-kinase activity and GLUT4 translocation in adipose cells.

Enrique-Tarancón G, Castan I, Morin N, Marti L, Abella A, Camps M, Casamitjana R, Palacín M, Testar X, Degerman E, Carpéné C, Zorzano A.

Biochem J. 2000 Aug 15;350 Pt 1:171-80.PMID: 10926841 [PubMed - indexed for MEDLINE]Related articlesFree article

Cyclic nucleotide phosphodiesterase 3B is a downstream target of protein kinase B and may be involved in regulation of effects of protein kinase B on thymidine incorporation in FDCP2 cells.

Ahmad F, Cong LN, Stenson Holst L, Wang LM, Rahn Landstrom T, Pierce JH, Quon MJ, Degerman E, Manganiello VC.

J Immunol. 2000 May 1;164(9):4678-88.PMID: 10779773 [PubMed - indexed for MEDLINE]Related articlesFree article

Functions of the N-terminal region of cyclic nucleotide phosphodiesterase 3 (PDE 3) isoforms.

Kenan Y, Murata T, Shakur Y, Degerman E, Manganiello VC.

J Biol Chem. 2000 Apr 21;275(16):12331-8.PMID: 10766874 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphorylation of PDE3B by phosphatidylinositol 3-kinase associated with the insulin receptor.

Rondinone CM, Carvalho E, Rahn T, Manganiello VC, Degerman E, Smith UP.

J Biol Chem. 2000 Apr 7;275(14):10093-8.PMID: 10744689 [PubMed - indexed for MEDLINE]Related articlesFree article

Down-regulation of cyclic-nucleotide phosphodiesterase 3B in 3T3-L1 adipocytes induced by tumour necrosis factor alpha and cAMP.

Rahn Landström T, Mei J, Karlsson M, Manganiello V, Degerman E.

Biochem J. 2000 Mar 1;346 Pt 2:337-43.PMID: 10677351 [PubMed - indexed for MEDLINE]Related articlesFree article

Cyclic nucleotide phosphodiesterases (PDEs): diverse regulators of cyclic nucleotide signals and inviting molecular targets for novel therapeutic agents.

Manganiello VC, Degerman E.

Thromb Haemost. 1999 Aug;82(2):407-11. Review. No abstract available. PMID: 10605731 [PubMed - indexed for MEDLINE]Related articles

Cyclic nucleotide phosphodiesterases (PDE) 3 and 4 in normal, malignant, and HTLV-I transformed human lymphocytes.

Ekholm D, Mulloy JC, Gao G, Degerman E, Franchini G, Manganiello VC.

Biochem Pharmacol. 1999 Sep 15;58(6):935-50.PMID: 10509746 [PubMed - indexed for MEDLINE]Related articles

Phosphorylation and activation of phosphodiesterase type 3B (PDE3B) in adipocytes in response to serine/threonine phosphatase inhibitors: deactivation of PDE3B in vitro by protein phosphatase type 2A.

Resjö S, Oknianska A, Zolnierowicz S, Manganiello V, Degerman E.

Biochem J. 1999 Aug 1;341 ( Pt 3):839-45.PMID: 10417351 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms involved in the regulation of free fatty acid release from isolated human fat cells by acylation-stimulating protein and insulin.

Van Harmelen V, Reynisdottir S, Cianflone K, Degerman E, Hoffstedt J, Nilsell K, Sniderman A, Arner P.

J Biol Chem. 1999 Jun 25;274(26):18243-51.PMID: 10373426 [PubMed - indexed for MEDLINE]Related articlesFree article

IL-3 and IL-4 activate cyclic nucleotide phosphodiesterases 3 (PDE3) and 4 (PDE4) by different mechanisms in FDCP2 myeloid cells.

Ahmad F, Gao G, Wang LM, Landstrom TR, Degerman E, Pierce JH, Manganiello VC.

J Immunol. 1999 Apr 15;162(8):4864-75.PMID: 10202031 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms of inhibition of lipolysis by insulin, vanadate and peroxovanadate in rat adipocytes.

Castan I, Wijkander J, Manganiello V, Degerman E.

Biochem J. 1999 Apr 15;339 ( Pt 2):281-9.PMID: 10191258 [PubMed - indexed for MEDLINE]Related articlesFree article

Hormone-sensitive lipase, the rate-limiting enzyme in triglyceride hydrolysis, is expressed and active in beta-cells.

Mulder H, Holst LS, Svensson H, Degerman E, Sundler F, Ahrén B, Rorsman P, Holm C.

Diabetes. 1999 Jan;48(1):228-32.PMID: 9892250 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein kinase B is expressed in pancreatic beta cells and activated upon stimulation with insulin-like growth factor I.

Holst LS, Mulder H, Manganiello V, Sundler F, Ahrén B, Holm C, Degerman E.

Biochem Biophys Res Commun. 1998 Sep 8;250(1):181-6.PMID: 9735353 [PubMed - indexed for MEDLINE]Related articles