PubMed

FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis.

Paik JH, Ding Z, Narurkar R, Ramkissoon S, Muller F, Kamoun WS, Chae SS, Zheng H, Ying H, Mahoney J, Hiller D, Jiang S, Protopopov A, Wong WH, Chin L, Ligon KL, DePinho RA.

Cell Stem Cell. 2009 Nov 6;5(5):540-53.PMID: 19896444 [PubMed - in process]Related articles

Telomeres and telomerase in cancer.

Artandi SE, Depinho RA.

Carcinogenesis. 2009 Nov 3. [Epub ahead of print] No abstract available. PMID: 19887512 [PubMed - as supplied by publisher]Related articles

PI3 kinase signals BCR-dependent mature B cell survival.

Srinivasan L, Sasaki Y, Calado DP, Zhang B, Paik JH, DePinho RA, Kutok JL, Kearney JF, Otipoby KL, Rajewsky K.

Cell. 2009 Oct 30;139(3):573-86.PMID: 19879843 [PubMed - in process]Related articles

Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras.

Gidekel Friedlander SY, Chu GC, Snyder EL, Girnius N, Dibelius G, Crowley D, Vasile E, DePinho RA, Jacks T.

Cancer Cell. 2009 Nov 6;16(5):379-89.PMID: 19878870 [PubMed - in process]Related articles

Foxo1 integrates insulin signaling with mitochondrial function in the liver.

Cheng Z, Guo S, Copps K, Dong X, Kollipara R, Rodgers JT, Depinho RA, Puigserver P, White MF.

Nat Med. 2009 Nov;15(11):1307-11. Epub 2009 Oct 18.PMID: 19838201 [PubMed - in process]Related articles

The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake.

Plum L, Lin HV, Dutia R, Tanaka J, Aizawa KS, Matsumoto M, Kim AJ, Cawley NX, Paik JH, Loh YP, DePinho RA, Wardlaw SL, Accili D.

Nat Med. 2009 Oct;15(10):1195-201. Epub 2009 Sep 20.PMID: 19767734 [PubMed - indexed for MEDLINE]Related articles

Brain metastasis: opportunities in basic and translational research.

Maher EA, Mietz J, Arteaga CL, DePinho RA, Mohla S.

Cancer Res. 2009 Aug 1;69(15):6015-20. Epub 2009 Jul 28. No abstract available. PMID: 19638593 [PubMed - indexed for MEDLINE]Related articles

Foxo1 links hyperglycemia to LDL oxidation and endothelial nitric oxide synthase dysfunction in vascular endothelial cells.

Tanaka J, Qiang L, Banks AS, Welch CL, Matsumoto M, Kitamura T, Ido-Kitamura Y, DePinho RA, Accili D.

Diabetes. 2009 Oct;58(10):2344-54. Epub 2009 Jul 7.PMID: 19584310 [PubMed - indexed for MEDLINE]Related articles

FoxO4 inhibits NF-kappaB and protects mice against colonic injury and inflammation.

Zhou W, Cao Q, Peng Y, Zhang QJ, Castrillon DH, DePinho RA, Liu ZP.

Gastroenterology. 2009 Oct;137(4):1403-14. Epub 2009 Jun 26.PMID: 19560465 [PubMed - indexed for MEDLINE]Related articles

Regulation of pancreatic juxtaductal endocrine cell formation by FoxO1.

Kitamura T, Kitamura YI, Kobayashi M, Kikuchi O, Sasaki T, Depinho RA, Accili D.

Mol Cell Biol. 2009 Aug;29(16):4417-30. Epub 2009 Jun 8.PMID: 19506018 [PubMed - indexed for MEDLINE]Related articles

HDAC2 negatively regulates memory formation and synaptic plasticity.

Guan JS, Haggarty SJ, Giacometti E, Dannenberg JH, Joseph N, Gao J, Nieland TJ, Zhou Y, Wang X, Mazitschek R, Bradner JE, DePinho RA, Jaenisch R, Tsai LH.

Nature. 2009 May 7;459(7243):55-60.PMID: 19424149 [PubMed - indexed for MEDLINE]Related articles

Dissecting genetic requirements of human breast tumorigenesis in a tissue transgenic model of human breast cancer in mice.

Wu M, Jung L, Cooper AB, Fleet C, Chen L, Breault L, Clark K, Cai Z, Vincent S, Bottega S, Shen Q, Richardson A, Bosenburg M, Naber SP, DePinho RA, Kuperwasser C, Robinson MO.

Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7022-7. Epub 2009 Apr 15.PMID: 19369208 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells.

Dejean AS, Beisner DR, Ch'en IL, Kerdiles YM, Babour A, Arden KC, Castrillon DH, DePinho RA, Hedrick SM.

Nat Immunol. 2009 May;10(5):504-13. Epub 2009 Apr 12.PMID: 19363483 [PubMed - indexed for MEDLINE]Related articlesFree article

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer.

van Haaften G, Dalgliesh GL, Davies H, Chen L, Bignell G, Greenman C, Edkins S, Hardy C, O'Meara S, Teague J, Butler A, Hinton J, Latimer C, Andrews J, Barthorpe S, Beare D, Buck G, Campbell PJ, Cole J, Forbes S, Jia M, Jones D, Kok CY, Leroy C, Lin ML, McBride DJ, Maddison M, Maquire S, McLay K, Menzies A, Mironenko T, Mulderrig L, Mudie L, Pleasance E, Shepherd R, Smith R, Stebbings L, Stephens P, Tang G, Tarpey PS, Turner R, Turrell K, Varian J, West S, Widaa S, Wray P, Collins VP, Ichimura K, Law S, Wong J, Yuen ST, Leung SY, Tonon G, DePinho RA, Tai YT, Anderson KC, Kahnoski RJ, Massie A, Khoo SK, Teh BT, Stratton MR, Futreal PA.

Nat Genet. 2009 May;41(5):521-3. Epub 2009 Mar 29.PMID: 19330029 [PubMed - indexed for MEDLINE]Related articles

Braf(V600E) cooperates with Pten loss to induce metastatic melanoma.

Dankort D, Curley DP, Cartlidge RA, Nelson B, Karnezis AN, Damsky WE Jr, You MJ, DePinho RA, McMahon M, Bosenberg M.

Nat Genet. 2009 May;41(5):544-52. Epub 2009 Mar 12.PMID: 19282848 [PubMed - indexed for MEDLINE]Related articlesFree article

mTORC1 signaling governs hematopoietic stem cell quiescence.

Gan B, DePinho RA.

Cell Cycle. 2009 Apr 1;8(7):1003-6. Epub 2009 Apr 2.PMID: 19270523 [PubMed - indexed for MEDLINE]Related articlesFree article

Pten and p53 converge on c-Myc to control differentiation, self-renewal, and transformation of normal and neoplastic stem cells in glioblastoma.

Zheng H, Ying H, Yan H, Kimmelman AC, Hiller DJ, Chen AJ, Perry SR, Tonon G, Chu GC, Ding Z, Stommel JM, Dunn KL, Wiedemeyer R, You MJ, Brennan C, Wang YA, Ligon KL, Wong WH, Chin L, dePinho RA.

Cold Spring Harb Symp Quant Biol. 2008;73:427-37. Epub 2009 Jan 15.PMID: 19150964 [PubMed - indexed for MEDLINE]Related articles

Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor.

Kerdiles YM, Beisner DR, Tinoco R, Dejean AS, Castrillon DH, DePinho RA, Hedrick SM.

Nat Immunol. 2009 Feb;10(2):176-84. Epub 2009 Jan 11.PMID: 19136962 [PubMed - indexed for MEDLINE]Related articles

Identification of novel alternative splice isoforms of circulating proteins in a mouse model of human pancreatic cancer.

Menon R, Zhang Q, Zhang Y, Fermin D, Bardeesy N, DePinho RA, Lu C, Hanash SM, Omenn GS, States DJ.

Cancer Res. 2009 Jan 1;69(1):300-9.PMID: 19118015 [PubMed - indexed for MEDLINE]Related articles

mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization.

Gan B, Sahin E, Jiang S, Sanchez-Aguilera A, Scott KL, Chin L, Williams DA, Kwiatkowski DJ, DePinho RA.

Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19384-9. Epub 2008 Dec 3.PMID: 19052232 [PubMed - indexed for MEDLINE]Related articlesFree article

Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer.

Kimmelman AC, Hezel AF, Aguirre AJ, Zheng H, Paik JH, Ying H, Chu GC, Zhang JX, Sahin E, Yeo G, Ponugoti A, Nabioullin R, Deroo S, Yang S, Wang X, McGrath JP, Protopopova M, Ivanova E, Zhang J, Feng B, Tsao MS, Redston M, Protopopov A, Xiao Y, Futreal PA, Hahn WC, Klimstra DS, Chin L, DePinho RA.

Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19372-7. Epub 2008 Dec 2.PMID: 19050074 [PubMed - indexed for MEDLINE]Related articlesFree article

Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation.

Dengler HS, Baracho GV, Omori SA, Bruckner S, Arden KC, Castrillon DH, DePinho RA, Rickert RC.

Nat Immunol. 2008 Dec;9(12):1388-98. Epub 2008 Nov 2.PMID: 18978794 [PubMed - indexed for MEDLINE]Related articlesFree article

p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation.

Zheng H, Ying H, Yan H, Kimmelman AC, Hiller DJ, Chen AJ, Perry SR, Tonon G, Chu GC, Ding Z, Stommel JM, Dunn KL, Wiedemeyer R, You MJ, Brennan C, Wang YA, Ligon KL, Wong WH, Chin L, DePinho RA.

Nature. 2008 Oct 23;455(7216):1129-33.PMID: 18948956 [PubMed - indexed for MEDLINE]Related articles

Codependent activators direct myoblast-specific MyoD transcription.

Hu P, Geles KG, Paik JH, DePinho RA, Tjian R.

Dev Cell. 2008 Oct;15(4):534-46.PMID: 18854138 [PubMed - indexed for MEDLINE]Related articlesFree article

Forkhead box, class O transcription factors in brain: regulation and behavioral manifestation.

Polter A, Yang S, Zmijewska AA, van Groen T, Paik JH, Depinho RA, Peng SL, Jope RS, Li X.

Biol Psychiatry. 2009 Jan 15;65(2):150-9. Epub 2008 Sep 27.PMID: 18823877 [PubMed - indexed for MEDLINE]Related articles

What drives intense apoptosis resistance and propensity for necrosis in glioblastoma? A role for Bcl2L12 as a multifunctional cell death regulator.

Stegh AH, Chin L, Louis DN, DePinho RA.

Cell Cycle. 2008 Sep 15;7(18):2833-9. Epub 2008 Sep 11.PMID: 18769159 [PubMed - indexed for MEDLINE]Related articles

Forkhead transcription factors (FoxOs) promote apoptosis of insulin-resistant macrophages during cholesterol-induced endoplasmic reticulum stress.

Senokuchi T, Liang CP, Seimon TA, Han S, Matsumoto M, Banks AS, Paik JH, DePinho RA, Accili D, Tabas I, Tall AR.

Diabetes. 2008 Nov;57(11):2967-76. Epub 2008 Aug 26.PMID: 18728232 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signaling.

Jeon HM, Jin X, Lee JS, Oh SY, Sohn YW, Park HJ, Joo KM, Park WY, Nam DH, DePinho RA, Chin L, Kim H.

Genes Dev. 2008 Aug 1;22(15):2028-33.PMID: 18676808 [PubMed - indexed for MEDLINE]Related articlesFree article

Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma.

Stegh AH, Kesari S, Mahoney JE, Jenq HT, Forloney KL, Protopopov A, Louis DN, Chin L, DePinho RA.

Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10703-8. Epub 2008 Jul 31.PMID: 18669646 [PubMed - indexed for MEDLINE]Related articlesFree article

Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation.

Dong XC, Copps KD, Guo S, Li Y, Kollipara R, DePinho RA, White MF.

Cell Metab. 2008 Jul;8(1):65-76.PMID: 18590693 [PubMed - indexed for MEDLINE]Related articles

A mouse to human search for plasma proteome changes associated with pancreatic tumor development.

Faca VM, Song KS, Wang H, Zhang Q, Krasnoselsky AL, Newcomb LF, Plentz RR, Gurumurthy S, Redston MS, Pitteri SJ, Pereira-Faca SR, Ireton RC, Katayama H, Glukhova V, Phanstiel D, Brenner DE, Anderson MA, Misek D, Scholler N, Urban ND, Barnett MJ, Edelstein C, Goodman GE, Thornquist MD, McIntosh MW, DePinho RA, Bardeesy N, Hanash SM.

PLoS Med. 2008 Jun 10;5(6):e123.PMID: 18547137 [PubMed - indexed for MEDLINE]Related articlesFree article

A mouse plasma peptide atlas as a resource for disease proteomics.

Zhang Q, Menon R, Deutsch EW, Pitteri SJ, Faca VM, Wang H, Newcomb LF, Depinho RA, Bardeesy N, Dinulescu D, Hung KE, Kucherlapati R, Jacks T, Politi K, Aebersold R, Omenn GS, States DJ, Hanash SM.

Genome Biol. 2008;9(6):R93. Epub 2008 Jun 3.PMID: 18522751 [PubMed - indexed for MEDLINE]Related articlesFree article

SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway.

Herzog S, Hug E, Meixlsperger S, Paik JH, DePinho RA, Reth M, Jumaa H.

Nat Immunol. 2008 Jun;9(6):623-31.PMID: 18488031 [PubMed - indexed for MEDLINE]Related articles

Targeted nanoparticles for imaging incipient pancreatic ductal adenocarcinoma.

Kelly KA, Bardeesy N, Anbazhagan R, Gurumurthy S, Berger J, Alencar H, Depinho RA, Mahmood U, Weissleder R.

PLoS Med. 2008 Apr 15;5(4):e85.PMID: 18416599 [PubMed - indexed for MEDLINE]Related articlesFree article

Oncolytic herpes virus with defective ICP6 specifically replicates in quiescent cells with homozygous genetic mutations in p16.

Aghi M, Visted T, Depinho RA, Chiocca EA.

Oncogene. 2008 Jul 10;27(30):4249-54. Epub 2008 Mar 17.PMID: 18345032 [PubMed - indexed for MEDLINE]Related articles

Specific requirement of the chromatin modifier mSin3B in cell cycle exit and cellular differentiation.

David G, Grandinetti KB, Finnerty PM, Simpson N, Chu GC, Depinho RA.

Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4168-72. Epub 2008 Mar 10.PMID: 18332431 [PubMed - indexed for MEDLINE]Related articlesFree article

LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis.

Katajisto P, Vaahtomeri K, Ekman N, Ventelä E, Ristimäki A, Bardeesy N, Feil R, DePinho RA, Mäkelä TP.

Nat Genet. 2008 Apr;40(4):455-9. Epub 2008 Mar 2.PMID: 18311138 [PubMed - indexed for MEDLINE]Related articles

Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer.

Perera SA, Maser RS, Xia H, McNamara K, Protopopov A, Chen L, Hezel AF, Kim CF, Bronson RT, Castrillon DH, Chin L, Bardeesy N, Depinho RA, Wong KK.

Carcinogenesis. 2008 Apr;29(4):747-53. Epub 2008 Feb 17.PMID: 18283039 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway.

de la Iglesia N, Konopka G, Puram SV, Chan JA, Bachoo RM, You MJ, Levy DE, Depinho RA, Bonni A.

Genes Dev. 2008 Feb 15;22(4):449-62. Epub 2008 Feb 7.PMID: 18258752 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms.

Hezel AF, Gurumurthy S, Granot Z, Swisa A, Chu GC, Bailey G, Dor Y, Bardeesy N, Depinho RA.

Mol Cell Biol. 2008 Apr;28(7):2414-25. Epub 2008 Jan 28.PMID: 18227155 [PubMed - indexed for MEDLINE]Related articlesFree article

Alu elements mediate MYB gene tandem duplication in human T-ALL.

O'Neil J, Tchinda J, Gutierrez A, Moreau L, Maser RS, Wong KK, Li W, McKenna K, Liu XS, Feng B, Neuberg D, Silverman L, DeAngelo DJ, Kutok JL, Rothstein R, DePinho RA, Chin L, Lee C, Look AT.

J Exp Med. 2007 Dec 24;204(13):3059-66. Epub 2007 Dec 10.PMID: 18070937 [PubMed - indexed for MEDLINE]Related articlesFree article

Direct transcriptional activation of promyelocytic leukemia protein by IFN regulatory factor 3 induces the p53-dependent growth inhibition of cancer cells.

Kim TK, Lee JS, Oh SY, Jin X, Choi YJ, Lee TH, Lee E, Choi YK, You S, Chung YG, Lee JB, DePinho RA, Chin L, Kim H.

Cancer Res. 2007 Dec 1;67(23):11133-40.PMID: 18056437 [PubMed - indexed for MEDLINE]Related articlesFree article

Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types.

Martin ES, Tonon G, Sinha R, Xiao Y, Feng B, Kimmelman AC, Protopopov A, Ivanova E, Brennan C, Montgomery K, Kucherlapati R, Bailey G, Redston M, Chin L, DePinho RA.

Cancer Res. 2007 Nov 15;67(22):10736-43.PMID: 18006816 [PubMed - indexed for MEDLINE]Related articlesFree article

Malignant astrocytic glioma: genetics, biology, and paths to treatment.

Furnari FB, Fenton T, Bachoo RM, Mukasa A, Stommel JM, Stegh A, Hahn WC, Ligon KL, Louis DN, Brennan C, Chin L, DePinho RA, Cavenee WK.

Genes Dev. 2007 Nov 1;21(21):2683-710. Review.PMID: 17974913 [PubMed - indexed for MEDLINE]Related articlesFree article

Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies.

Stommel JM, Kimmelman AC, Ying H, Nabioullin R, Ponugoti AH, Wiedemeyer R, Stegh AH, Bradner JE, Ligon KL, Brennan C, Chin L, DePinho RA.

Science. 2007 Oct 12;318(5848):287-90. Epub 2007 Sep 13.PMID: 17872411 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver.

Matsumoto M, Pocai A, Rossetti L, Depinho RA, Accili D.

Cell Metab. 2007 Sep;6(3):208-16.PMID: 17767907 [PubMed - indexed for MEDLINE]Related articles

A Foxo/Notch pathway controls myogenic differentiation and fiber type specification.

Kitamura T, Kitamura YI, Funahashi Y, Shawber CJ, Castrillon DH, Kollipara R, DePinho RA, Kitajewski J, Accili D.

J Clin Invest. 2007 Sep;117(9):2477-85.PMID: 17717603 [PubMed - indexed for MEDLINE]Related articlesFree article

How stem cells age and why this makes us grow old.

Sharpless NE, DePinho RA.

Nat Rev Mol Cell Biol. 2007 Sep;8(9):703-13. Review.PMID: 17717515 [PubMed - indexed for MEDLINE]Related articles

ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence.

Ha L, Ichikawa T, Anver M, Dickins R, Lowe S, Sharpless NE, Krimpenfort P, Depinho RA, Bennett DC, Sviderskaya EV, Merlino G.

Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):10968-73. Epub 2007 Jun 19.PMID: 17576930 [PubMed - indexed for MEDLINE]Related articlesFree article

Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers.

Maser RS, Choudhury B, Campbell PJ, Feng B, Wong KK, Protopopov A, O'Neil J, Gutierrez A, Ivanova E, Perna I, Lin E, Mani V, Jiang S, McNamara K, Zaghlul S, Edkins S, Stevens C, Brennan C, Martin ES, Wiedemeyer R, Kabbarah O, Nogueira C, Histen G, Aster J, Mansour M, Duke V, Foroni L, Fielding AK, Goldstone AH, Rowe JM, Wang YA, Look AT, Stratton MR, Chin L, Futreal PA, DePinho RA.

Nature. 2007 Jun 21;447(7147):966-71. Epub 2007 May 21.PMID: 17515920 [PubMed - indexed for MEDLINE]Related articlesFree article