PubMed

Identification of a highly specific and versatile vitamin D receptor antibody.

Wang Y, Becklund BR, Deluca HF.

Arch Biochem Biophys. 2009 Nov 28. [Epub ahead of print]PMID: 19951695 [PubMed - as supplied by publisher]

Vitamin D and the parenteral nutrition patient.

DeLuca HF.

Gastroenterology. 2009 Nov;137(5 Suppl):S79-91.PMID: 19874954 [PubMed - in process]Related articles

Removal of the 20-methyl group from 2-methylene-19-nor-(20S)-1alpha,25-dihydroxyvitamin D(3) (2MD) selectively eliminates bone calcium mobilization activity.

Barycki R, Sicinski RR, Plum LA, Grzywacz P, Clagett-Dame M, Deluca HF.

Bioorg Med Chem. 2009 Nov 15;17(22):7658-69. Epub 2009 Sep 29.PMID: 19819702 [PubMed - in process]Related articles

The calcitonin/calcitonin gene related peptide-alpha gene is not required for 1alpha,25-dihydroxyvitamin D3-mediated suppression of experimental autoimmune encephalomyelitis.

Becklund BR, James BJ, Gagel RF, DeLuca HF.

Arch Biochem Biophys. 2009 Aug 15;488(2):105-8. Epub 2009 Jun 27.PMID: 19563774 [PubMed - indexed for MEDLINE]Related articles

New 1alpha,25-dihydroxy-19-norvitamin D(3) compounds constrained in a single A-ring conformation: synthesis of the analogues by ring-closing metathesis route and their biological evaluation.

Glebocka A, Sokolowska K, Sicinski RR, Plum LA, Deluca HF.

J Med Chem. 2009 Jun 11;52(11):3496-504.PMID: 19402630 [PubMed - indexed for MEDLINE]Related articles

Enhancement of 1,25-dihydroxyvitamin D3-mediated suppression of experimental autoimmune encephalomyelitis by calcitonin.

Becklund BR, Hansen DW Jr, Deluca HF.

Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5276-81. Epub 2009 Mar 12.PMID: 19282478 [PubMed - indexed for MEDLINE]Related articlesFree article

13-Methyl-substituted des-C,D analogs of (20S)-1alpha,25-dihydroxy-2-methylene-19-norvitamin D3 (2MD): synthesis and biological evaluation.

Plonska-Ocypa K, Sicinski RR, Plum LA, Grzywacz P, Frelek J, Clagett-Dame M, DeLuca HF.

Bioorg Med Chem. 2009 Feb 15;17(4):1747-63. Epub 2008 Dec 10.PMID: 19167893 [PubMed - indexed for MEDLINE]Related articles

TRPV6 is not required for 1alpha,25-dihydroxyvitamin D3-induced intestinal calcium absorption in vivo.

Kutuzova GD, Sundersingh F, Vaughan J, Tadi BP, Ansay SE, Christakos S, Deluca HF.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19655-9. Epub 2008 Dec 10.PMID: 19073913 [PubMed - indexed for MEDLINE]Related articlesFree article

Evolution of our understanding of vitamin D.

DeLuca HF.

Nutr Rev. 2008 Oct;66(10 Suppl 2):S73-87. Review.PMID: 18844850 [PubMed - indexed for MEDLINE]Related articles

Synthesis and biological properties of 2-methylene-19-nor-25-dehydro-1alpha-hydroxyvitamin D(3)-26,23-lactones--weak agonists.

Chiellini G, Grzywacz P, Plum LA, Barycki R, Clagett-Dame M, DeLuca HF.

Bioorg Med Chem. 2008 Sep 15;16(18):8563-73. Epub 2008 Aug 7.PMID: 18722130 [PubMed - indexed for MEDLINE]Related articles

Diaminobutane (DAB) dendrimers are potent binders of oral phosphate.

Williams KB, Barycka K, Zella JB, DeLuca HF.

J Bone Miner Res. 2009 Jan;24(1):97-101.PMID: 18715138 [PubMed - indexed for MEDLINE]Related articles

Crystal structures of rat vitamin D receptor bound to adamantyl vitamin D analogs: structural basis for vitamin D receptor antagonism and partial agonism.

Nakabayashi M, Yamada S, Yoshimoto N, Tanaka T, Igarashi M, Ikura T, Ito N, Makishima M, Tokiwa H, DeLuca HF, Shimizu M.

J Med Chem. 2008 Sep 11;51(17):5320-9. Epub 2008 Aug 19.PMID: 18710208 [PubMed - indexed for MEDLINE]Related articles

2-methylene-19-nor-20(S)-1alpha-hydroxy-bishomopregnacalciferol [20(S)-2MbisP], an analog of vitamin D3 [1,25(OH)2D3], does not stimulate intestinal phosphate absorption at levels previously shown to suppress parathyroid hormone.

Williams KB, DeLuca HF.

Steroids. 2008 Nov;73(12):1277-84. Epub 2008 Jun 21.PMID: 18616960 [PubMed - indexed for MEDLINE]Related articles

2-Substituted-16-ene-22-thia-1alpha,25-dihydroxy-26,27-dimethyl-19-norvitamin D3 analogs: Synthesis, biological evaluation, and crystal structure.

Shimizu M, Miyamoto Y, Takaku H, Matsuo M, Nakabayashi M, Masuno H, Udagawa N, DeLuca HF, Ikura T, Ito N.

Bioorg Med Chem. 2008 Jul 15;16(14):6949-64. Epub 2008 May 27.PMID: 18539034 [PubMed - indexed for MEDLINE]Related articles

Altered endocrine and autocrine metabolism of vitamin D in a mouse model of gastrointestinal inflammation.

Liu N, Nguyen L, Chun RF, Lagishetty V, Ren S, Wu S, Hollis B, DeLuca HF, Adams JS, Hewison M.

Endocrinology. 2008 Oct;149(10):4799-808. Epub 2008 Jun 5.PMID: 18535110 [PubMed - indexed for MEDLINE]Related articlesFree article

Synthesis and structure-activity relationships of 16-ene-22-thia-1alpha,25-dihydroxy-26,27-dimethyl-19-norvitamin D3 analogs having side chains of different sizes.

Takaku H, Miyamoto Y, Asami S, Shimazaki M, Yamada S, Yamamoto K, Udagawa N, DeLuca HF, Shimizu M.

Bioorg Med Chem. 2008 Feb 15;16(4):1796-815. Epub 2007 Nov 6.PMID: 18032055 [PubMed - indexed for MEDLINE]Related articles

Design, synthesis, and biological evaluation of a 1alpha,25-dihydroxy-19-norvitamin D3 analogue with a frozen A-ring conformation.

Sicinski RR, Glebocka A, Plum LA, DeLuca HF.

J Med Chem. 2007 Nov 29;50(24):6154-64. Epub 2007 Oct 26.PMID: 17960924 [PubMed - indexed for MEDLINE]Related articles

Differential recruitment of coactivators to the vitamin D receptor transcriptional complex by 1alpha,25-dihydroxyvitamin D3 analogs.

Schwinn MK, DeLuca HF.

Arch Biochem Biophys. 2007 Sep 15;465(2):443-51. Epub 2007 Jun 27.PMID: 17658451 [PubMed - indexed for MEDLINE]Related articles

Lithocholic acid can carry out in vivo functions of vitamin D.

Nehring JA, Zierold C, DeLuca HF.

Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10006-9. Epub 2007 May 29.PMID: 17535892 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of 2-methylene-19-nor-(20S)-1 alpha-hydroxy-bishomopregnacalciferol (2MbisP), an analog of vitamin D, on secondary hyperparathyroidism.

Slatopolsky E, Finch JL, Brown AJ, Ritter CS, Mizobuchi M, Plum LA, Clagett-Dame M, Sicinski RR, DeLuca HF.

J Bone Miner Res. 2007 May;22(5):686-94.PMID: 17444814 [PubMed - indexed for MEDLINE]Related articles

Characterization of intestinal phosphate absorption using a novel in vivo method.

Williams KB, DeLuca HF.

Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1917-21. Epub 2007 Feb 13.PMID: 17299082 [PubMed - indexed for MEDLINE]Related articlesFree article

22-Alkyl-20-epi-1alpha,25-dihydroxyvitamin D3 compounds of superagonistic activity: syntheses, biological activities and interaction with the receptor.

Yamamoto K, Inaba Y, Yoshimoto N, Choi M, DeLuca HF, Yamada S.

J Med Chem. 2007 Mar 8;50(5):932-9. Epub 2007 Feb 14.PMID: 17298045 [PubMed - indexed for MEDLINE]Related articles

2-Methylene-19-nor-1alpha-hydroxyvitamin D3 analogs inhibit adipocyte differentiation and PPARgamma2 gene transcription.

Thomson B, Ahrens JM, Ntambi JM, DeLuca HF, Clagett-Dame M.

Arch Biochem Biophys. 2007 Apr 15;460(2):192-201. Epub 2007 Jan 8.PMID: 17257576 [PubMed - indexed for MEDLINE]Related articles

Selective analogs of 1alpha,25-dihydroxyvitamin D3 for the study of specific functions of Vitamin D.

DeLuca HF, Plum LA, Clagett-Dame M.

J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):263-8. Epub 2007 Jan 22.PMID: 17241781 [PubMed - indexed for MEDLINE]Related articles

New analogs of 2-methylene-19-nor-(20S)-1,25-dihydroxyvitamin D3 with conformationally restricted side chains: evaluation of biological activity and structural determination of VDR-bound conformations.

Vanhooke JL, Tadi BP, Benning MM, Plum LA, DeLuca HF.

Arch Biochem Biophys. 2007 Apr 15;460(2):161-5. Epub 2006 Dec 12.PMID: 17227670 [PubMed - indexed for MEDLINE]Related articles

Calbindin D9k is not required for 1,25-dihydroxyvitamin D3-mediated Ca2+ absorption in small intestine.

Akhter S, Kutuzova GD, Christakos S, DeLuca HF.

Arch Biochem Biophys. 2007 Apr 15;460(2):227-32. Epub 2006 Dec 12.PMID: 17224126 [PubMed - indexed for MEDLINE]Related articles

Nuclear receptor 4A2 and C/EBPbeta regulate the parathyroid hormone-mediated transcriptional regulation of the 25-hydroxyvitamin D3-1alpha-hydroxylase.

Zierold C, Nehring JA, DeLuca HF.

Arch Biochem Biophys. 2007 Apr 15;460(2):233-9. Epub 2006 Dec 12.PMID: 17224121 [PubMed - indexed for MEDLINE]Related articles

An analog of 1alpha,25-dihydroxy-19-norvitamin D3 with the 1alpha-hydroxy group fixed in the axial position lacks biological activity in vitro.

Sicinski RR, Glebocka A, Plum LA, DeLuca HF.

J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):293-7. Epub 2007 Jan 12.PMID: 17223547 [PubMed - indexed for MEDLINE]Related articles

Synthesis and biological evaluation of a des-C,D-analog of 2-methylene-19-nor-1alpha,25-(OH)2D3.

Plonska-Ocypa K, Grzywacz P, Sicinski RR, Plum LA, DeLuca HF.

J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):298-304. Epub 2007 Jan 16.PMID: 17223343 [PubMed - indexed for MEDLINE]Related articles

2-(3'-Hydroxypropylidene)-1alpha-hydroxy-19-norvitamin D compounds with truncated side chains.

Glebocka A, Sicinski RR, Plum LA, DeLuca HF.

J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):310-5. Epub 2007 Jan 16.PMID: 17223340 [PubMed - indexed for MEDLINE]Related articles

Identification of a highly potent vitamin D receptor antagonist: (25S)-26-adamantyl-25-hydroxy-2-methylene-22,23-didehydro-19,27-dinor-20-epi-vitamin D3 (ADMI3).

Igarashi M, Yoshimoto N, Yamamoto K, Shimizu M, Ishizawa M, Makishima M, DeLuca HF, Yamada S.

Arch Biochem Biophys. 2007 Apr 15;460(2):240-53. Epub 2006 Dec 12.PMID: 17214957 [PubMed - indexed for MEDLINE]Related articles

1,25-Dihydroxyvitamin D3 regulates genes responsible for detoxification in intestine.

Kutuzova GD, DeLuca HF.

Toxicol Appl Pharmacol. 2007 Jan 1;218(1):37-44. Epub 2006 Oct 13.PMID: 17123563 [PubMed - indexed for MEDLINE]Related articles

Structure-activity relationships of 19-norvitamin D analogs having a fluoroethylidene group at the C-2 position.

Kobayashi E, Shimazaki M, Miyamoto Y, Masuno H, Yamamoto K, DeLuca HF, Yamada S, Shimizu M.

Bioorg Med Chem. 2007 Feb 1;15(3):1475-82. Epub 2006 Nov 3.PMID: 17110116 [PubMed - indexed for MEDLINE]Related articles

Methyl substitution of the 25-hydroxy group on 2-methylene-19-nor-1alpha,25-dihydroxyvitamin D3 (2MD) reduces potency but allows bone selectivity.

Grzywacz P, Plum LA, Sicinski RR, Clagett-Dame M, DeLuca HF.

Arch Biochem Biophys. 2007 Apr 15;460(2):274-84. Epub 2006 Oct 16.PMID: 17094936 [PubMed - indexed for MEDLINE]Related articles

New 19-nor-(20S)-1alpha,25-dihydroxyvitamin D3 analogs strongly stimulate osteoclast formation both in vivo and in vitro.

Sato M, Nakamichi Y, Nakamura M, Sato N, Ninomiya T, Muto A, Nakamura H, Ozawa H, Iwasaki Y, Kobayashi E, Shimizu M, DeLuca HF, Takahashi N, Udagawa N.

Bone. 2007 Feb;40(2):293-304. Epub 2006 Oct 25.PMID: 17070129 [PubMed - indexed for MEDLINE]Related articles

Calbindin D(9k) knockout mice are indistinguishable from wild-type mice in phenotype and serum calcium level.

Kutuzova GD, Akhter S, Christakos S, Vanhooke J, Kimmel-Jehan C, Deluca HF.

Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12377-81. Epub 2006 Aug 8.PMID: 16895982 [PubMed - indexed for MEDLINE]Related articlesFree article

New 2-alkylidene 1alpha,25-dihydroxy-19-norvitamin D3 analogues of high intestinal activity: synthesis and biological evaluation of 2-(3'-alkoxypropylidene) and 2-(3'-hydroxypropylidene) derivatives.

Glebocka A, Sicinski RR, Plum LA, Clagett-Dame M, DeLuca HF.

J Med Chem. 2006 May 18;49(10):2909-20.PMID: 16686534 [PubMed - indexed for MEDLINE]Related articles

2MD, a new anabolic agent for osteoporosis treatment.

Plum LA, Fitzpatrick LA, Ma X, Binkley NC, Zella JB, Clagett-Dame M, DeLuca HF.

Osteoporos Int. 2006;17(5):704-15. Epub 2006 Feb 21.PMID: 16491322 [PubMed - indexed for MEDLINE]Related articles

19nor-1,25-dihydroxyvitamin D2 specifically induces CYP3A9 in rat intestine more strongly than 1,25-dihydroxyvitamin D3 in vivo and in vitro.

Zierold C, Mings JA, Deluca HF.

Mol Pharmacol. 2006 May;69(5):1740-7. Epub 2006 Feb 16.PMID: 16484501 [PubMed - indexed for MEDLINE]Related articlesFree article

CYP27B1 null mice with LacZreporter gene display no 25-hydroxyvitamin D3-1alpha-hydroxylase promoter activity in the skin.

Vanhooke JL, Prahl JM, Kimmel-Jehan C, Mendelsohn M, Danielson EW, Healy KD, DeLuca HF.

Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):75-80. Epub 2005 Dec 21.PMID: 16371465 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypercalcemia produced by parathyroid hormone suppresses experimental autoimmune encephalomyelitis in female but not male mice.

Meehan TF, Vanhooke J, Prahl J, Deluca HF.

Arch Biochem Biophys. 2005 Oct 15;442(2):214-21. Epub 2005 Sep 2.PMID: 16183034 [PubMed - indexed for MEDLINE]Related articles

A new vitamin D analog, 2MD, restores trabecular and cortical bone mass and strength in ovariectomized rats with established osteopenia.

Ke HZ, Qi H, Crawford DT, Simmons HA, Xu G, Li M, Plum L, Clagett-Dame M, DeLuca HF, Thompson DD, Brown TA.

J Bone Miner Res. 2005 Oct;20(10):1742-55. Epub 2005 Jun 13.PMID: 16160732 [PubMed - indexed for MEDLINE]Related articles

NMR assignments of tryptophan residue in apo and holo LBD-rVDR.

Sicinska W, Westler WM, DeLuca HF.

Proteins. 2005 Nov 15;61(3):461-7.PMID: 16130132 [PubMed - indexed for MEDLINE]Related articles

Responsiveness of human retinoblastoma and neuroblastoma models to a non-calcemic 19-nor Vitamin D analog.

Albert DM, Plum LA, Yang W, Marcet M, Lindstrom MJ, Clagett-Dame M, DeLuca HF.

J Steroid Biochem Mol Biol. 2005 Oct;97(1-2):165-72. Epub 2005 Aug 1.PMID: 16055326 [PubMed - indexed for MEDLINE]Related articles

All-trans retinoic acid antagonizes the action of calciferol and its active metabolite, 1,25-dihydroxycholecalciferol, in rats.

Rohde CM, DeLuca HF.

J Nutr. 2005 Jul;135(7):1647-52.PMID: 15987844 [PubMed - indexed for MEDLINE]Related articlesFree article

Parathyroid hormone decreases renal vitamin D receptor expression in vivo.

Healy KD, Vanhooke JL, Prahl JM, DeLuca HF.

Proc Natl Acad Sci U S A. 2005 Mar 29;102(13):4724-8. Epub 2005 Mar 15.PMID: 15769857 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanism and function of high vitamin D receptor levels in genetic hypercalciuric stone-forming rats.

Karnauskas AJ, van Leeuwen JP, van den Bemd GJ, Kathpalia PP, DeLuca HF, Bushinsky DA, Favus MJ.

J Bone Miner Res. 2005 Mar;20(3):447-54. Epub 2004 Nov 29.PMID: 15746989 [PubMed - indexed for MEDLINE]Related articles

Overview of general physiologic features and functions of vitamin D.

DeLuca HF.

Am J Clin Nutr. 2004 Dec;80(6 Suppl):1689S-96S. Review.PMID: 15585789 [PubMed - indexed for MEDLINE]Related articlesFree article

1,25-Dihydroxyvitamin D3 up-regulates the renal vitamin D receptor through indirect gene activation and receptor stabilization.

Healy KD, Frahm MA, DeLuca HF.

Arch Biochem Biophys. 2005 Jan 15;433(2):466-73.PMID: 15581603 [PubMed - indexed for MEDLINE]Related articles

Gene expression profiles in rat intestine identify pathways for 1,25-dihydroxyvitamin D(3) stimulated calcium absorption and clarify its immunomodulatory properties.

Kutuzova GD, Deluca HF.

Arch Biochem Biophys. 2004 Dec 15;432(2):152-66.PMID: 15542054 [PubMed - indexed for MEDLINE]Related articles