PubMed

Plasma glucose concentration and prediction of future risk of type 2 diabetes.

Abdul-Ghani MA, DeFronzo RA.

Diabetes Care. 2009 Nov;32 Suppl 2:S194-8. No abstract available. PMID: 19875551 [PubMed - in process]Related articles

Skeletal muscle insulin resistance is the primary defect in type 2 diabetes.

DeFronzo RA, Tripathy D.

Diabetes Care. 2009 Nov;32 Suppl 2:S157-63. No abstract available. PMID: 19875544 [PubMed - in process]Related articles

Effect of Short-Term Free Fatty Acids Elevation on Mitochondrial Function in Skeletal Muscle of Healthy Individuals.

Chavez AO, Kamath S, Jani R, Sharma LK, Monroy A, Abdul-Ghani MA, Centonze VE, Sathyanarayana P, Coletta DK, Jenkinson CP, Bai Y, Folli F, Defronzo RA, Tripathy D.

J Clin Endocrinol Metab. 2009 Oct 28. [Epub ahead of print]PMID: 19864449 [PubMed - as supplied by publisher]Related articles

Pancreatic islet amyloidosis, beta-cell apoptosis, and alpha-cell proliferation are determinants of islet remodeling in type-2 diabetic baboons.

Guardado-Mendoza R, Davalli AM, Chavez AO, Hubbard GB, Dick EJ, Majluf-Cruz A, Tene-Perez CE, Goldschmidt L, Hart J, Perego C, Comuzzie AG, Tejero ME, Finzi G, Placidi C, La Rosa S, Capella C, Halff G, Gastaldelli A, DeFronzo RA, Folli F.

Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13992-7. Epub 2009 Jul 30.PMID: 19666551 [PubMed - indexed for MEDLINE]Related articlesFree article

Visceral fat dominant distribution in male type 2 diabetic patients is closely related to hepatic insulin resistance, irrespective of body type.

Miyazaki Y, DeFronzo RA.

Cardiovasc Diabetol. 2009 Aug 5;8:44.PMID: 19656356 [PubMed - indexed for MEDLINE]Related articlesFree article

Actos Now for the prevention of diabetes (ACT NOW) study.

Defronzo RA, Banerji M, Bray GA, Buchanan TA, Clement S, Henry RR, Kitabchi AE, Mudaliar S, Musi N, Ratner R, Reaven PD, Schwenke D, Stentz FB, Tripathy D.

BMC Endocr Disord. 2009 Jul 29;9:17.PMID: 19640291 [PubMed - in process]Related articlesFree article

Impaired regulation of the TNF-alpha converting enzyme/tissue inhibitor of metalloproteinase 3 proteolytic system in skeletal muscle of obese type 2 diabetic patients: a new mechanism of insulin resistance in humans.

Monroy A, Kamath S, Chavez AO, Centonze VE, Veerasamy M, Barrentine A, Wewer JJ, Coletta DK, Jenkinson C, Jhingan RM, Smokler D, Reyna S, Musi N, Khokka R, Federici M, Tripathy D, DeFronzo RA, Folli F.

Diabetologia. 2009 Oct;52(10):2169-81. Epub 2009 Jul 25.PMID: 19633828 [PubMed - in process]Related articles

Oral disposition index predicts the development of future diabetes above and beyond fasting and 2-h glucose levels: response to Utzschneider et al.

DeFronzo RA, Abdul-Ghani MA.

Diabetes Care. 2009 Jul;32(7):e86; author reply e87. No abstract available. PMID: 19564465 [PubMed - indexed for MEDLINE]Related articlesFree article

Pathophysiology of prediabetes.

Abdul-Ghani MA, DeFronzo RA.

Curr Diab Rep. 2009 Jun;9(3):193-9. Review.PMID: 19490820 [PubMed - indexed for MEDLINE]Related articles

Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance.

Chavez AO, Molina-Carrion M, Abdul-Ghani MA, Folli F, Defronzo RA, Tripathy D.

Diabetes Care. 2009 Aug;32(8):1542-6. Epub 2009 Jun 1.PMID: 19487637 [PubMed - indexed for MEDLINE]Related articlesFree article

The efficacy and safety of saxagliptin when added to metformin therapy in patients with inadequately controlled type 2 diabetes with metformin alone.

DeFronzo RA, Hissa MN, Garber AJ, Luiz Gross J, Yuyan Duan R, Ravichandran S, Chen RS; Saxagliptin 014 Study Group.

Diabetes Care. 2009 Sep;32(9):1649-55. Epub 2009 May 28.PMID: 19478198 [PubMed - indexed for MEDLINE]Related articles

Predictive models of insulin resistance derived from simple morphometric and biochemical indices related to obesity and the metabolic syndrome in baboons.

Chavez AO, Gastaldelli A, Guardado-Mendoza R, Lopez-Alvarenga JC, Leland MM, Tejero ME, Sorice G, Casiraghi F, Davalli A, Bastarrachea RA, Comuzzie AG, DeFronzo RA, Folli F.

Cardiovasc Diabetol. 2009 Apr 23;8:22.PMID: 19389241 [PubMed - in process]Related articlesFree article

Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus.

Defronzo RA.

Diabetes. 2009 Apr;58(4):773-95. No abstract available. PMID: 19336687 [PubMed - indexed for MEDLINE]Related articlesFree article

Whole body overexpression of PGC-1alpha has opposite effects on hepatic and muscle insulin sensitivity.

Liang H, Balas B, Tantiwong P, Dube J, Goodpaster BH, O'Doherty RM, DeFronzo RA, Richardson A, Musi N, Ward WF.

Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E945-54. Epub 2009 Feb 10.PMID: 19208857 [PubMed - indexed for MEDLINE]Related articles

Retinol-binding protein 4 is associated with impaired glucose tolerance but not with whole body or hepatic insulin resistance in Mexican Americans.

Chavez AO, Coletta DK, Kamath S, Cromack DT, Monroy A, Folli F, DeFronzo RA, Tripathy D.

Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E758-64. Epub 2009 Feb 3.PMID: 19190263 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial reactive oxygen species generation in obese non-diabetic and type 2 diabetic participants.

Abdul-Ghani MA, Jani R, Chavez A, Molina-Carrion M, Tripathy D, Defronzo RA.

Diabetologia. 2009 Apr;52(4):574-82. Epub 2009 Jan 30.PMID: 19183935 [PubMed - indexed for MEDLINE]Related articles

Pioglitazone stimulates AMP-activated protein kinase signalling and increases the expression of genes involved in adiponectin signalling, mitochondrial function and fat oxidation in human skeletal muscle in vivo: a randomised trial.

Coletta DK, Sriwijitkamol A, Wajcberg E, Tantiwong P, Li M, Prentki M, Madiraju M, Jenkinson CP, Cersosimo E, Musi N, Defronzo RA.

Diabetologia. 2009 Apr;52(4):723-32. Epub 2009 Jan 24.PMID: 19169664 [PubMed - indexed for MEDLINE]Related articles

Strong association between insulin resistance in liver and skeletal muscle in non-diabetic subjects.

Abdul-Ghani MA, Matsuda M, DeFronzo RA.

Diabet Med. 2008 Nov;25(11):1289-94.PMID: 19046218 [PubMed - indexed for MEDLINE]Related articles

Fasting versus postload plasma glucose concentration and the risk for future type 2 diabetes: results from the Botnia Study.

Abdul-Ghani MA, Lyssenko V, Tuomi T, DeFronzo RA, Groop L.

Diabetes Care. 2009 Feb;32(2):281-6. Epub 2008 Nov 18.PMID: 19017778 [PubMed - indexed for MEDLINE]Related articlesFree article

Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance.

Haus JM, Kashyap SR, Kasumov T, Zhang R, Kelly KR, Defronzo RA, Kirwan JP.

Diabetes. 2009 Feb;58(2):337-43. Epub 2008 Nov 13.PMID: 19008343 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of renal glucose reabsorption: a novel strategy for achieving glucose control in type 2 diabetes mellitus.

Abdul-Ghani MA, DeFronzo RA.

Endocr Pract. 2008 Sep;14(6):782-90. Review.PMID: 18996802 [PubMed - indexed for MEDLINE]Related articles

Differences in insulin action and secretion, plasma lipids and blood pressure levels between impaired fasting glucose and impaired glucose tolerance in Japanese subjects.

Miyazaki Y, Akasaka H, Ohnishi H, Saitoh S, DeFronzo RA, Shimamoto K.

Hypertens Res. 2008 Jul;31(7):1357-63.PMID: 18957806 [PubMed - indexed for MEDLINE]Related articles

Genome-wide linkage scan for genes influencing plasma triglyceride levels in the Veterans Administration Genetic Epidemiology Study.

Coletta DK, Schneider J, Hu SL, Dyer TD, Puppala S, Farook VS, Arya R, Lehman DM, Blangero J, DeFronzo RA, Duggirala R, Jenkinson CP.

Diabetes. 2009 Jan;58(1):279-84. Epub 2008 Oct 17.PMID: 18931038 [PubMed - indexed for MEDLINE]Related articlesFree article

Elevated concentrations of liver enzymes and ferritin identify a new phenotype of insulin resistance: effect of weight loss after gastric banding.

Gastaldelli A, Perego L, Paganelli M, Sesti G, Hribal M, Chavez AO, Defronzo RA, Pontiroli A, Folli F.

Obes Surg. 2009 Jan;19(1):80-6. Epub 2008 Sep 24.PMID: 18820980 [PubMed - indexed for MEDLINE]Related articles

Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes and inadequate glycemic control: a randomized, double-blind, placebo-controlled study.

DeFronzo RA, Fleck PR, Wilson CA, Mekki Q; Alogliptin Study 010 Group.

Diabetes Care. 2008 Dec;31(12):2315-7. Epub 2008 Sep 22.PMID: 18809631 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of exenatide versus sitagliptin on postprandial glucose, insulin and glucagon secretion, gastric emptying, and caloric intake: a randomized, cross-over study.

DeFronzo RA, Okerson T, Viswanathan P, Guan X, Holcombe JH, MacConell L.

Curr Med Res Opin. 2008 Oct;24(10):2943-52. Epub 2008 Sep 10.PMID: 18786299 [PubMed - indexed for MEDLINE]Related articles

Efficacy and safety of Technosphere inhaled insulin compared with Technosphere powder placebo in insulin-naive type 2 diabetes suboptimally controlled with oral agents.

Rosenstock J, Bergenstal R, Defronzo RA, Hirsch IB, Klonoff D, Boss AH, Kramer D, Petrucci R, Yu W, Levy B; 0008 Study Group.

Diabetes Care. 2008 Nov;31(11):2177-82. Epub 2008 Aug 4.PMID: 18678610 [PubMed - indexed for MEDLINE]Related articlesFree article

Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects.

Reyna SM, Ghosh S, Tantiwong P, Meka CS, Eagan P, Jenkinson CP, Cersosimo E, Defronzo RA, Coletta DK, Sriwijitkamol A, Musi N.

Diabetes. 2008 Oct;57(10):2595-602. Epub 2008 Jul 15.PMID: 18633101 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial dysfunction, insulin resistance, and type 2 diabetes mellitus.

Abdul-Ghani MA, DeFronzo RA.

Curr Diab Rep. 2008 Jun;8(3):173-8. Review.PMID: 18625112 [PubMed - indexed for MEDLINE]Related articles

Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance.

Abdul-Ghani MA, Muller FL, Liu Y, Chavez AO, Balas B, Zuo P, Chang Z, Tripathy D, Jani R, Molina-Carrion M, Monroy A, Folli F, Van Remmen H, DeFronzo RA.

Am J Physiol Endocrinol Metab. 2008 Sep;295(3):E678-85. Epub 2008 Jul 1.PMID: 18593850 [PubMed - indexed for MEDLINE]Related articlesFree article

The relationship between fasting hyperglycemia and insulin secretion in subjects with normal or impaired glucose tolerance.

Abdul-Ghani MA, Matsuda M, Jani R, Jenkinson CP, Coletta DK, Kaku K, DeFronzo RA.

Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E401-6. Epub 2008 May 20.PMID: 18492770 [PubMed - indexed for MEDLINE]Related articlesFree article

One-hour plasma glucose concentration and the metabolic syndrome identify subjects at high risk for future type 2 diabetes.

Abdul-Ghani MA, Abdul-Ghani T, Ali N, Defronzo RA.

Diabetes Care. 2008 Aug;31(8):1650-5. Epub 2008 May 16.PMID: 18487478 [PubMed - indexed for MEDLINE]Related articlesFree article

Rosiglitazone and pioglitazone similarly improve insulin sensitivity and secretion, glucose tolerance and adipocytokines in type 2 diabetic patients.

Miyazaki Y, DeFronzo RA.

Diabetes Obes Metab. 2008 Dec;10(12):1204-11. Epub 2008 May 12.PMID: 18476983 [PubMed - indexed for MEDLINE]Related articles

Association of genetic variation in ENPP1 with obesity-related phenotypes.

Jenkinson CP, Coletta DK, Flechtner-Mors M, Hu SL, Fourcaudot MJ, Rodriguez LM, Schneider J, Arya R, Stern MP, Blangero J, Duggirala R, DeFronzo RA.

Obesity (Silver Spring). 2008 Jul;16(7):1708-13. Epub 2008 May 8.PMID: 18464750 [PubMed - indexed for MEDLINE]Related articles

PROactive: time for a critical appraisal.

Betteridge DJ, DeFronzo RA, Chilton RJ.

Eur Heart J. 2008 Apr;29(8):969-83. Epub 2008 Mar 28. Review.PMID: 18375395 [PubMed - indexed for MEDLINE]Related articlesFree article

Adipocytes in subjects with impaired fasting glucose and impaired glucose tolerance are resistant to the anti-lipolytic effect of insulin.

Abdul-Ghani MA, Molina-Carrion M, Jani R, Jenkinson C, Defronzo RA.

Acta Diabetol. 2008 Sep;45(3):147-50. Epub 2008 Mar 21.PMID: 18357404 [PubMed - indexed for MEDLINE]Related articles

Mechanism of action of exenatide to reduce postprandial hyperglycemia in type 2 diabetes.

Cervera A, Wajcberg E, Sriwijitkamol A, Fernandez M, Zuo P, Triplitt C, Musi N, DeFronzo RA, Cersosimo E.

Am J Physiol Endocrinol Metab. 2008 May;294(5):E846-52. Epub 2008 Mar 11.PMID: 18334612 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of acute physiological hyperinsulinemia on gene expression in human skeletal muscle in vivo.

Coletta DK, Balas B, Chavez AO, Baig M, Abdul-Ghani M, Kashyap SR, Folli F, Tripathy D, Mandarino LJ, Cornell JE, Defronzo RA, Jenkinson CP.

Am J Physiol Endocrinol Metab. 2008 May;294(5):E910-7. Epub 2008 Mar 11.PMID: 18334611 [PubMed - indexed for MEDLINE]Related articlesFree article

Physiological and molecular determinants of insulin action in the baboon.

Chavez AO, Lopez-Alvarenga JC, Tejero ME, Triplitt C, Bastarrachea RA, Sriwijitkamol A, Tantiwong P, Voruganti VS, Musi N, Comuzzie AG, DeFronzo RA, Folli F.

Diabetes. 2008 Apr;57(4):899-908. Epub 2008 Jan 3.PMID: 18174524 [PubMed - indexed for MEDLINE]Related articlesFree article

Decreased non-insulin-dependent glucose clearance contributes to the rise in fasting plasma glucose in the nondiabetic range.

Jani R, Molina M, Matsuda M, Balas B, Chavez A, DeFronzo RA, Abdul-Ghani M.

Diabetes Care. 2008 Feb;31(2):311-5. Epub 2007 Nov 13.PMID: 18000182 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin reduces plasma arginase activity in type 2 diabetic patients.

Kashyap SR, Lara A, Zhang R, Park YM, DeFronzo RA.

Diabetes Care. 2008 Jan;31(1):134-9. Epub 2007 Oct 10.PMID: 17928367 [PubMed - indexed for MEDLINE]Related articlesFree article

Rosiglitazone decreases albuminuria in type 2 diabetic patients.

Miyazaki Y, Cersosimo E, Triplitt C, DeFronzo RA.

Kidney Int. 2007 Dec;72(11):1367-73. Epub 2007 Sep 5.PMID: 17805239 [PubMed - indexed for MEDLINE]Related articles

Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects.

Gastaldelli A, Cusi K, Pettiti M, Hardies J, Miyazaki Y, Berria R, Buzzigoli E, Sironi AM, Cersosimo E, Ferrannini E, Defronzo RA.

Gastroenterology. 2007 Aug;133(2):496-506. Epub 2007 May 1.PMID: 17681171 [PubMed - indexed for MEDLINE]Related articles

Peripheral disruption of the Grb10 gene enhances insulin signaling and sensitivity in vivo.

Wang L, Balas B, Christ-Roberts CY, Kim RY, Ramos FJ, Kikani CK, Li C, Deng C, Reyna S, Musi N, Dong LQ, DeFronzo RA, Liu F.

Mol Cell Biol. 2007 Sep;27(18):6497-505. Epub 2007 Jul 9.PMID: 17620412 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of peroxisome proliferator-activated receptor (PPAR)-alpha and PPAR-gamma agonists on glucose and lipid metabolism in patients with type 2 diabetes mellitus.

Bajaj M, Suraamornkul S, Hardies LJ, Glass L, Musi N, DeFronzo RA.

Diabetologia. 2007 Aug;50(8):1723-31. Epub 2007 May 23.PMID: 17520238 [PubMed - indexed for MEDLINE]Related articles

The insulin resistance syndrome: physiological considerations.

Kashyap SR, Defronzo RA.

Diab Vasc Dis Res. 2007 Mar;4(1):13-9. Review.PMID: 17469039 [PubMed - indexed for MEDLINE]Related articles

Association of neuropeptide Y receptor Y5 polymorphisms with dyslipidemia in Mexican Americans.

Coletta DK, Schneider J, Stern MP, Blangero J, DeFronzo RA, Duggirala R, Jenkinson CP.

Obesity (Silver Spring). 2007 Apr;15(4):809-15.PMID: 17426313 [PubMed - indexed for MEDLINE]Related articles

Biomedical imaging research opportunities workshop IV: a white paper.

Hendee WR, Banovac F, Carson PL, DeFronzo RA, Eckelman WC, Fullerton GD, Larson SM, McLennan G, Welch MJ.

Med Phys. 2007 Feb;34(2):673-9.PMID: 17388185 [PubMed - indexed for MEDLINE]Related articles

What is the best predictor of future type 2 diabetes?

Abdul-Ghani MA, Williams K, DeFronzo RA, Stern M.

Diabetes Care. 2007 Jun;30(6):1544-8. Epub 2007 Mar 23.PMID: 17384342 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduction in hematocrit and hemoglobin following pioglitazone treatment is not hemodilutional in Type II diabetes mellitus.

Berria R, Glass L, Mahankali A, Miyazaki Y, Monroy A, De Filippis E, Cusi K, Cersosimo E, Defronzo RA, Gastaldelli A.

Clin Pharmacol Ther. 2007 Sep;82(3):275-81. Epub 2007 Mar 14.PMID: 17361126 [PubMed - indexed for MEDLINE]Related articles