PubMed

An assessment of the carcinogenic potential of ezetimibe using nonclinical data in a weight-of-evidence approach.

Halleck M, Davis HR, Kirschmeier P, Levitan D, Snyder RD, Treinen K, Macdonald JS.

Toxicology. 2009 Apr 28;258(2-3):116-30. Epub 2009 Jan 22.PMID: 19428931 [PubMed - indexed for MEDLINE]Related articles

Niemann-Pick C1 Like 1 (NPC1L1) an intestinal sterol transporter.

Davis HR Jr, Altmann SW.

Biochim Biophys Acta. 2009 Jul;1791(7):679-83. Epub 2009 Jan 19. Review.PMID: 19272334 [PubMed - indexed for MEDLINE]Related articles

Lack of FFAR1/GPR40 does not protect mice from high-fat diet-induced metabolic disease.

Lan H, Hoos LM, Liu L, Tetzloff G, Hu W, Abbondanzo SJ, Vassileva G, Gustafson EL, Hedrick JA, Davis HR.

Diabetes. 2008 Nov;57(11):2999-3006. Epub 2008 Aug 4.PMID: 18678612 [PubMed - indexed for MEDLINE]Related articlesFree article

Simvastatin with or without ezetimibe in familial hypercholesterolemia.

Davis HR Jr, Murgolo NJ, Graziano MP.

N Engl J Med. 2008 Jul 31;359(5):531; author reply 532-3. No abstract available. PMID: 18677799 [PubMed - indexed for MEDLINE]Related articles

Cholesterol homeostasis by the intestine: lessons from Niemann-Pick C1 Like 1 [NPC1L1).

Davis HR Jr, Basso F, Hoos LM, Tetzloff G, Lally SM, Altmann SW.

Atheroscler Suppl. 2008 Sep;9(2):77-81. Epub 2008 Jun 27. Review.PMID: 18585981 [PubMed - indexed for MEDLINE]Related articles

Zetia: inhibition of Niemann-Pick C1 Like 1 (NPC1L1) to reduce intestinal cholesterol absorption and treat hyperlipidemia.

Davis HR, Veltri EP.

J Atheroscler Thromb. 2007 Jun;14(3):99-108. Review.PMID: 17587760 [PubMed - indexed for MEDLINE]Related articlesFree article

Tryton I, First-In-Man (FIM) Study: acute and 30 day outcome.A preliminary report.

Kaplan AV, Ramcharitar S, Louvard Y, Müller R, Davis HR, Morice MC, Serruys PW, Grube E.

EuroIntervention. 2007 May;3(1):54-9.PMID: 19737685 [PubMed - in process]Related articles

Deficiency of Niemann-Pick C1 Like 1 prevents atherosclerosis in ApoE-/- mice.

Davis HR Jr, Hoos LM, Tetzloff G, Maguire M, Zhu LJ, Graziano MP, Altmann SW.

Arterioscler Thromb Vasc Biol. 2007 Apr;27(4):841-9. Epub 2007 Jan 11.PMID: 17218600 [PubMed - indexed for MEDLINE]Related articlesFree article

In vivo responsiveness to ezetimibe correlates with niemann-pick C1 like-1 (NPC1L1) binding affinity: Comparison of multiple species NPC1L1 orthologs.

Hawes BE, O'neill KA, Yao X, Crona JH, Davis HR Jr, Graziano MP, Altmann SW.

Mol Pharmacol. 2007 Jan;71(1):19-29. Epub 2006 Sep 27.PMID: 17005902 [PubMed - indexed for MEDLINE]Related articlesFree article

Tryton side-branch stent.

Kaplan AV, Davis HR.

EuroIntervention. 2006 Aug;2(2):270-1. No abstract available. PMID: 19755273 [PubMed - in process]Related articles

Targeted deletion of Gpbar1 protects mice from cholesterol gallstone formation.

Vassileva G, Golovko A, Markowitz L, Abbondanzo SJ, Zeng M, Yang S, Hoos L, Tetzloff G, Levitan D, Murgolo NJ, Keane K, Davis HR Jr, Hedrick J, Gustafson EL.

Biochem J. 2006 Sep 15;398(3):423-30.PMID: 16724960 [PubMed - indexed for MEDLINE]Related articlesFree article

The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1).

Garcia-Calvo M, Lisnock J, Bull HG, Hawes BE, Burnett DA, Braun MP, Crona JH, Davis HR Jr, Dean DC, Detmers PA, Graziano MP, Hughes M, Macintyre DE, Ogawa A, O'neill KA, Iyer SP, Shevell DE, Smith MM, Tang YS, Makarewicz AM, Ujjainwalla F, Altmann SW, Chapman KT, Thornberry NA.

Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8132-7. Epub 2005 May 31.PMID: 15928087 [PubMed - indexed for MEDLINE]Related articlesFree article

Endothelial progenitor cell capture by stents coated with antibody against CD34: the HEALING-FIM (Healthy Endothelial Accelerated Lining Inhibits Neointimal Growth-First In Man) Registry.

Aoki J, Serruys PW, van Beusekom H, Ong AT, McFadden EP, Sianos G, van der Giessen WJ, Regar E, de Feyter PJ, Davis HR, Rowland S, Kutryk MJ.

J Am Coll Cardiol. 2005 May 17;45(10):1574-9.PMID: 15893169 [PubMed - indexed for MEDLINE]Related articles

Characterization of the putative native and recombinant rat sterol transporter Niemann-Pick C1 Like 1 (NPC1L1) protein.

Iyer SP, Yao X, Crona JH, Hoos LM, Tetzloff G, Davis HR Jr, Graziano MP, Altmann SW.

Biochim Biophys Acta. 2005 Apr 15;1722(3):282-92.PMID: 15777641 [PubMed - indexed for MEDLINE]Related articles

Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis.

Davis HR Jr, Zhu LJ, Hoos LM, Tetzloff G, Maguire M, Liu J, Yao X, Iyer SP, Lam MH, Lund EG, Detmers PA, Graziano MP, Altmann SW.

J Biol Chem. 2004 Aug 6;279(32):33586-92. Epub 2004 Jun 1.PMID: 15173162 [PubMed - indexed for MEDLINE]Related articlesFree article

Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption.

Altmann SW, Davis HR Jr, Zhu LJ, Yao X, Hoos LM, Tetzloff G, Iyer SP, Maguire M, Golovko A, Zeng M, Wang L, Murgolo N, Graziano MP.

Science. 2004 Feb 20;303(5661):1201-4.PMID: 14976318 [PubMed - indexed for MEDLINE]Related articlesFree article

Ezetimibe potently inhibits cholesterol absorption but does not affect acute hepatic or intestinal cholesterol synthesis in rats.

van Heek M, Farley C, Compton DS, Hoos LM, Smith-Torhan A, Davis HR.

Br J Pharmacol. 2003 Apr;138(8):1459-64.PMID: 12721101 [PubMed - indexed for MEDLINE]Related articlesFree article

Human RPE cell lysis of extracellular matrix: functional urokinase plasminogen activator receptor (uPAR), collagenase and elastase.

Elner SG, Elner VM, Kindzelskii AL, Horino K, Davis HR, Todd RF 3rd, Glagov S, Petty HR.

Exp Eye Res. 2003 May;76(5):585-95.PMID: 12697422 [PubMed - indexed for MEDLINE]Related articles

Low rates of clinical restenosis with the new flexible stainless steel tube intracoronary stent: the R Stent. A six-month safety and feasibility study.

Knook AH, Wardeh AJ, Rensing BJ, Foley DP, Van Der Giessen WJ, Van Den Brand M, De Feyter PJ, Davis HR, Becker GJ, Serruys PW.

Int J Cardiovasc Intervent. 2000 Jun;3(2):91-95.PMID: 12470375 [PubMed - as supplied by publisher]Related articles

The identification of intestinal scavenger receptor class B, type I (SR-BI) by expression cloning and its role in cholesterol absorption.

Altmann SW, Davis HR Jr, Yao X, Laverty M, Compton DS, Zhu LJ, Crona JH, Caplen MA, Hoos LM, Tetzloff G, Priestley T, Burnett DA, Strader CD, Graziano MP.

Biochim Biophys Acta. 2002 Jan 30;1580(1):77-93.PMID: 11923102 [PubMed - indexed for MEDLINE]Related articles

Synthesis of fluorescent biochemical tools related to the 2-azetidinone class of cholesterol absorption inhibitors.

Burnett DA, Caplen MA, Browne ME, Zhau H, Altmann SW, Davis HR, Clader JW.

Bioorg Med Chem Lett. 2002 Feb 11;12(3):315-8.PMID: 11814786 [PubMed - indexed for MEDLINE]Related articles

Synthesis of iodinated biochemical tools related to the 2-azetidinone class of cholesterol absorption inhibitors.

Burnett DA, Caplen MA, Domalski MS, Browne ME, Davis HR Jr, Clader JW.

Bioorg Med Chem Lett. 2002 Feb 11;12(3):311-4.PMID: 11814785 [PubMed - indexed for MEDLINE]Related articles

Ezetimibe, a potent cholesterol absorption inhibitor, inhibits the development of atherosclerosis in ApoE knockout mice.

Davis HR Jr, Compton DS, Hoos L, Tetzloff G.

Arterioscler Thromb Vasc Biol. 2001 Dec;21(12):2032-8.PMID: 11742881 [PubMed - indexed for MEDLINE]Related articlesFree article

The synergistic hypocholesterolemic activity of the potent cholesterol absorption inhibitor, ezetimibe, in combination with 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors in dogs.

Davis HR Jr, Pula KK, Alton KB, Burrier RE, Watkins RW.

Metabolism. 2001 Oct;50(10):1234-41.PMID: 11586500 [PubMed - indexed for MEDLINE]Related articles

Ezetimibe selectively inhibits intestinal cholesterol absorption in rodents in the presence and absence of exocrine pancreatic function.

van Heek M, Farley C, Compton DS, Hoos L, Davis HR.

Br J Pharmacol. 2001 Sep;134(2):409-17.PMID: 11564660 [PubMed - indexed for MEDLINE]Related articlesFree article

Unusual brain growth patterns in early life in patients with autistic disorder: an MRI study.

Courchesne E, Karns CM, Davis HR, Ziccardi R, Carper RA, Tigue ZD, Chisum HJ, Moses P, Pierce K, Lord C, Lincoln AJ, Pizzo S, Schreibman L, Haas RH, Akshoomoff NA, Courchesne RY.

Neurology. 2001 Jul 24;57(2):245-54.PMID: 11468308 [PubMed - indexed for MEDLINE]Related articles

Ezetimibe, a potent cholesterol absorption inhibitor, normalizes combined dyslipidemia in obese hyperinsulinemic hamsters.

van Heek M, Austin TM, Farley C, Cook JA, Tetzloff GG, Davis HR.

Diabetes. 2001 Jun;50(6):1330-5.PMID: 11375333 [PubMed - indexed for MEDLINE]Related articlesFree article

The cholesterol absorption inhibitor, ezetimibe, decreases diet-induced hypercholesterolemia in monkeys.

van Heek M, Compton DS, Davis HR.

Eur J Pharmacol. 2001 Mar 9;415(1):79-84.PMID: 11245855 [PubMed - indexed for MEDLINE]Related articles

Comparison of the activity and disposition of the novel cholesterol absorption inhibitor, SCH58235, and its glucuronide, SCH60663.

van Heek M, Farley C, Compton DS, Hoos L, Alton KB, Sybertz EJ, Davis HR Jr.

Br J Pharmacol. 2000 Apr;129(8):1748-54.PMID: 10780982 [PubMed - indexed for MEDLINE]Related articlesFree article

Carboxy-substituted 2-azetidinones as cholesterol absorption inhibitors.

Vaccaro WD, Sher R, Davis HR Jr.

Bioorg Med Chem Lett. 1998 Feb 3;8(3):319-22.PMID: 9871677 [PubMed - indexed for MEDLINE]Related articles

Sugar-substituted 2-azetidinone cholesterol absorption inhibitors: enhanced potency by modification of the sugar.

Vaccaro WD, Davis HR Jr.

Bioorg Med Chem Lett. 1998 Feb 3;8(3):313-8.PMID: 9871676 [PubMed - indexed for MEDLINE]Related articles

Sugar-substituted 2-azetidinones as cholesterol absorption inhibitors.

Vaccaro WD, Sher R, Davis HR Jr.

Bioorg Med Chem Lett. 1998 Jan 6;8(1):35-40.PMID: 9871624 [PubMed - indexed for MEDLINE]Related articles

2-Azetidinone cholesterol absorption inhibitors: increased potency by substitution of the C-4 phenyl ring.

Vaccaro WD, Sher R, Davis HR Jr.

Bioorg Med Chem. 1998 Sep;6(9):1429-37.PMID: 9801814 [PubMed - indexed for MEDLINE]Related articles

Effect of chronic central administration of glucagon-like peptide-1 (7-36) amide on food consumption and body weight in normal and obese rats.

Davis HR Jr, Mullins DE, Pines JM, Hoos LM, France CF, Compton DS, Graziano MP, Sybertz EJ, Strader CD, Van Heek M.

Obes Res. 1998 Mar;6(2):147-56.PMID: 9545022 [PubMed - indexed for MEDLINE]Related articles

Discovery of 1-(4-fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)-hydroxypropyl]-(4S)-(4 -hydroxyphenyl)-2-azetidinone (SCH 58235): a designed, potent, orally active inhibitor of cholesterol absorption.

Rosenblum SB, Huynh T, Afonso A, Davis HR Jr, Yumibe N, Clader JW, Burnett DA.

J Med Chem. 1998 Mar 12;41(6):973-80.PMID: 9526571 [PubMed - indexed for MEDLINE]Related articles

In vivo metabolism-based discovery of a potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active metabolites of SCH48461.

Van Heek M, France CF, Compton DS, McLeod RL, Yumibe NP, Alton KB, Sybertz EJ, Davis HR Jr.

J Pharmacol Exp Ther. 1997 Oct;283(1):157-63.PMID: 9336320 [PubMed - indexed for MEDLINE]Related articlesFree article

Diet-induced obese mice develop peripheral, but not central, resistance to leptin.

Van Heek M, Compton DS, France CF, Tedesco RP, Fawzi AB, Graziano MP, Sybertz EJ, Strader CD, Davis HR Jr.

J Clin Invest. 1997 Feb 1;99(3):385-90.PMID: 9022070 [PubMed - indexed for MEDLINE]Related articlesFree article

The relationship of tissue localization, distribution and turnover to feeding after intraperitoneal 125I-leptin administration to ob/ob and db/db mice.

Van Heek M, Mullins DE, Wirth MA, Graziano MP, Fawzi AB, Compton DS, France CF, Hoos LM, Casale RL, Sybertz EJ, Strader CD, Davis HR Jr.

Horm Metab Res. 1996 Dec;28(12):653-8.PMID: 9013736 [PubMed - indexed for MEDLINE]Related articles

Recent legislation on genetics and insurance.

Davis HR, Mitrius JV.

Jurimetrics. 1996 Fall;37(1):69-82. No abstract available. PMID: 11658097 [PubMed - indexed for MEDLINE]Related articles

2-Azetidinone cholesterol absorption inhibitors: structure-activity relationships on the heterocyclic nucleus.

Clader JW, Burnett DA, Caplen MA, Domalski MS, Dugar S, Vaccaro W, Sher R, Browne ME, Zhao H, Burrier RE, Salisbury B, Davis HR Jr.

J Med Chem. 1996 Sep 13;39(19):3684-93.PMID: 8809157 [PubMed - indexed for MEDLINE]Related articles

Amides of piperidine, morpholine and piperazine substituted 1-phenylethylamines: inhibitors of acylCoA:cholesterol acyltransferase (ACAT) activity in vitro and in vivo.

Dugar S, Davis HR Jr, Burrier RE, Salisbury BG.

Bioorg Med Chem. 1995 Sep;3(9):1231-6.PMID: 8564414 [PubMed - indexed for MEDLINE]Related articles

Substituted (1,2-diarylethyl)amide acyl-CoA:cholesterol acyltransferase inhibitors: effect of polar groups on in vitro and in vivo activity.

Clader JW, Berger JG, Burrier RE, Davis HR, Domalski M, Dugar S, Kogan TP, Salisbury B, Vaccaro W.

J Med Chem. 1995 May 12;38(10):1600-7.PMID: 7752185 [PubMed - indexed for MEDLINE]Related articles

Hypocholesterolemic activity of a novel inhibitor of cholesterol absorption, SCH 48461.

Salisbury BG, Davis HR, Burrier RE, Burnett DA, Bowkow G, Caplen MA, Clemmons AL, Compton DS, Hoos LM, McGregor DG, et al.

Atherosclerosis. 1995 May;115(1):45-63.PMID: 7669087 [PubMed - indexed for MEDLINE]Related articles

The effect of acyl CoA: cholesterol acyltransferase inhibition on the uptake, esterification and secretion of cholesterol by the hamster small intestine.

Burrier RE, Smith AA, McGregor DG, Hoos LM, Zilli DL, Davis HR Jr.

J Pharmacol Exp Ther. 1995 Jan;272(1):156-63.PMID: 7815329 [PubMed - indexed for MEDLINE]Related articles

Inhibition of PDGF receptor binding and PDGF-stimulated biological activity in vitro and of intimal lesion formation in vivo by 2-bromomethyl-5-chlorobenzene sulfonylphthalimide.

Mullins DE, Hamud F, Reim R, Davis HR.

Arterioscler Thromb. 1994 Jul;14(7):1047-55.PMID: 8018659 [PubMed - indexed for MEDLINE]Related articlesFree article

2-Azetidinones as inhibitors of cholesterol absorption.

Burnett DA, Caplen MA, Davis HR Jr, Burrier RE, Clader JW.

J Med Chem. 1994 Jun 10;37(12):1733-6. No abstract available. PMID: 8021912 [PubMed - indexed for MEDLINE]Related articles

Demonstration of a direct effect on hepatic acyl CoA: cholesterol acyl transferase (ACAT) activity by an orally administered enzyme inhibitor in the hamster.

Burrier RE, Deren S, McGregor DG, Hoos LM, Smith AA, Davis HR Jr.

Biochem Pharmacol. 1994 Apr 29;47(9):1545-51.PMID: 8185666 [PubMed - indexed for MEDLINE]Related articles

NG-nitro-L-arginine methyl ester does not affect balloon catheter-induced intimal hyperplasia in rats.

Watkins RW, Pula K, Cook J, Hoos L, McLeod R, Prioli NA, Davis HR Jr.

Biochem Biophys Res Commun. 1993 Nov 30;197(1):304-9.PMID: 7504485 [PubMed - indexed for MEDLINE]Related articles

Human and monkey corneal endothelium expression of low-density lipoprotein receptors.

Elner SG, Elner VM, Pavilack MA, Davis HR, Cornicelli JA, Yue BY.

Am J Ophthalmol. 1991 Jan 15;111(1):84-91.PMID: 1985497 [PubMed - indexed for MEDLINE]Related articles

Development of atherosclerosis in genetically hyperlipidemic rabbits during chronic fish-oil ingestion.

Rich S, Miller JF Jr, Charous S, Davis HR, Shanks P, Glagov S, Lands WE.

Arteriosclerosis. 1989 Mar-Apr;9(2):189-94.PMID: 2923575 [PubMed - indexed for MEDLINE]Related articlesFree article