PubMed

Osteopontin is expressed and functional in human eosinophils.

Puxeddu I, Berkman N, Ribatti D, Bader R, Haitchi HM, Davies DE, Howarth PH, Levi-Schaffer F.

Allergy. 2009 Oct 5. [Epub ahead of print]PMID: 19804447 [PubMed - as supplied by publisher]Related articles

Leukocyte analysis and differentiation using high speed microfluidic single cell impedance cytometry.

Holmes D, Pettigrew D, Reccius CH, Gwyer JD, van Berkel C, Holloway J, Davies DE, Morgan H.

Lab Chip. 2009 Oct 21;9(20):2881-9. Epub 2009 Aug 7.PMID: 19789739 [PubMed - indexed for MEDLINE]Related articles

Rethinking the pathogenesis of asthma.

Holgate ST, Davies DE.

Immunity. 2009 Sep 18;31(3):362-7.PMID: 19766079 [PubMed - indexed for MEDLINE]Related articles

Induction of a disintegrin and metalloprotease 33 during embryonic lung development and the influence of IL-13 or maternal allergy.

Haitchi HM, Bassett DJ, Bucchieri F, Gao X, Powell RM, Hanley NA, Wilson DI, Holgate ST, Davies DE.

J Allergy Clin Immunol. 2009 Sep;124(3):590-7, 597.e1-11. Epub 2009 Aug 8.PMID: 19665773 [PubMed - indexed for MEDLINE]Related articles

Cytoplasmic tail of IL-13Ralpha2 regulates IL-4 signal transduction.

Andrews AL, Nordgren IK, Kirby I, Holloway JW, Holgate ST, Davies DE, Tavassoli A.

Biochem Soc Trans. 2009 Aug;37(Pt 4):873-6. Review.PMID: 19614610 [PubMed - indexed for MEDLINE]Related articles

Breakdown in epithelial barrier function in patients with asthma: identification of novel therapeutic approaches.

Swindle EJ, Collins JE, Davies DE.

J Allergy Clin Immunol. 2009 Jul;124(1):23-34; quiz 35-6. Review.PMID: 19560576 [PubMed - indexed for MEDLINE]Related articles

Frmd7 expression in developing mouse brain.

Self J, Haitchi HM, Griffiths H, Holgate ST, Davies DE, Lotery A.

Eye (Lond). 2009 Mar 6. [Epub ahead of print]PMID: 19265863 [PubMed - as supplied by publisher]Related articles

Contribution of bronchial fibroblasts to the antiviral response in asthma.

Bedke N, Haitchi HM, Xatzipsalti M, Holgate ST, Davies DE.

J Immunol. 2009 Mar 15;182(6):3660-7.PMID: 19265144 [PubMed - indexed for MEDLINE]Related articles

Chronological expression of Ciliated Bronchial Epithelium 1 during pulmonary development.

Haitchi HM, Yoshisue H, Ribbene A, Wilson SJ, Holloway JW, Bucchieri F, Hanley NA, Wilson DI, Zummo G, Holgate ST, Davies DE.

Eur Respir J. 2009 May;33(5):1095-104. Epub 2009 Feb 12.PMID: 19213785 [PubMed - indexed for MEDLINE]Related articles

The role of eosinophil major basic protein in angiogenesis.

Puxeddu I, Berkman N, Nissim Ben Efraim AH, Davies DE, Ribatti D, Gleich GJ, Levi-Schaffer F.

Allergy. 2009 Mar;64(3):368-74. Epub 2008 Dec 17.PMID: 19120069 [PubMed - indexed for MEDLINE]Related articles

Cellular localization of interleukin 13 receptor alpha2 in human primary bronchial epithelial cells and fibroblasts.

Konstantinidis AK, Puddicombe SM, Mochizuki A, Sheth PD, Yang IA, Yoshisue H, Wilson SJ, Davies DE, Holgate ST, Holloway JW.

J Investig Allergol Clin Immunol. 2008;18(3):174-80.PMID: 18564628 [PubMed - indexed for MEDLINE]Related articlesFree article

Diesel exhaust increases EGFR and phosphorylated C-terminal Tyr 1173 in the bronchial epithelium.

Pourazar J, Blomberg A, Kelly FJ, Davies DE, Wilson SJ, Holgate ST, Sandström T.

Part Fibre Toxicol. 2008 May 6;5:8.PMID: 18460189 [PubMed - in process]Related articlesFree article

Epigenetic mechanisms silence a disintegrin and metalloprotease 33 expression in bronchial epithelial cells.

Yang Y, Haitchi HM, Cakebread J, Sammut D, Harvey A, Powell RM, Holloway JW, Howarth P, Holgate ST, Davies DE.

J Allergy Clin Immunol. 2008 Jun;121(6):1393-9, 1399.e1-14. Epub 2008 Apr 21.PMID: 18423563 [PubMed - indexed for MEDLINE]Related articles

The soluble form of a disintegrin and metalloprotease 33 promotes angiogenesis: implications for airway remodeling in asthma.

Puxeddu I, Pang YY, Harvey A, Haitchi HM, Nicholas B, Yoshisue H, Ribatti D, Clough G, Powell RM, Murphy G, Hanley NA, Wilson DI, Howarth PH, Holgate ST, Davies DE.

J Allergy Clin Immunol. 2008 Jun;121(6):1400-6, 1406.e1-4. Epub 2008 Apr 14.PMID: 18410963 [PubMed - indexed for MEDLINE]Related articles

The role of a soluble TNFalpha receptor fusion protein (etanercept) in corticosteroid refractory asthma: a double blind, randomised, placebo controlled trial.

Morjaria JB, Chauhan AJ, Babu KS, Polosa R, Davies DE, Holgate ST.

Thorax. 2008 Jul;63(7):584-91. Epub 2008 Feb 1.PMID: 18245148 [PubMed - indexed for MEDLINE]Related articles

Enhancement of neutrophil function by the bronchial epithelium stimulated by epidermal growth factor.

Uddin M, Seumois G, Lau LC, Rytila P, Davies DE, Djukanovic R.

Eur Respir J. 2008 Apr;31(4):714-24. Epub 2007 Dec 19.PMID: 18094008 [PubMed - indexed for MEDLINE]Related articlesFree article

The discovery of GSK221149A: a potent and selective oxytocin antagonist.

Liddle J, Allen MJ, Borthwick AD, Brooks DP, Davies DE, Edwards RM, Exall AM, Hamlett C, Irving WR, Mason AM, McCafferty GP, Nerozzi F, Peace S, Philp J, Pollard D, Pullen MA, Shabbir SS, Sollis SL, Westfall TD, Woollard PM, Wu C, Hickey DM.

Bioorg Med Chem Lett. 2008 Jan 1;18(1):90-4. Epub 2007 Nov 6.PMID: 18032036 [PubMed - indexed for MEDLINE]Related articles

IFN-gamma-induced protein 10 is a novel biomarker of rhinovirus-induced asthma exacerbations.

Wark PA, Bucchieri F, Johnston SL, Gibson PG, Hamilton L, Mimica J, Zummo G, Holgate ST, Attia J, Thakkinstian A, Davies DE.

J Allergy Clin Immunol. 2007 Sep;120(3):586-93. Epub 2007 Jul 12.PMID: 17628646 [PubMed - indexed for MEDLINE]Related articles

Effect of IL-13 receptor alpha2 levels on the biological activity of IL-13 variant R110Q.

Andrews AL, Bucchieri F, Arima K, Izuhara K, Holgate ST, Davies DE, Holloway JW.

J Allergy Clin Immunol. 2007 Jul;120(1):91-7. Epub 2007 Jun 8.PMID: 17560640 [PubMed - indexed for MEDLINE]Related articles

Local genetic and environmental factors in asthma disease pathogenesis: chronicity and persistence mechanisms.

Holgate ST, Davies DE, Powell RM, Howarth PH, Haitchi HM, Holloway JW.

Eur Respir J. 2007 Apr;29(4):793-803. Review.PMID: 17400878 [PubMed - indexed for MEDLINE]Related articlesFree article

Cysteinyl leukotrienes synergize with growth factors to induce proliferation of human bronchial fibroblasts.

Yoshisue H, Kirkham-Brown J, Healy E, Holgate ST, Sampson AP, Davies DE.

J Allergy Clin Immunol. 2007 Jan;119(1):132-40. Epub 2006 Nov 7.PMID: 17208594 [PubMed - indexed for MEDLINE]Related articles

Expression of genes involved in oxidative stress responses in airway epithelial cells of smokers with chronic obstructive pulmonary disease.

Pierrou S, Broberg P, O'Donnell RA, Pawłowski K, Virtala R, Lindqvist E, Richter A, Wilson SJ, Angco G, Möller S, Bergstrand H, Koopmann W, Wieslander E, Strömstedt PE, Holgate ST, Davies DE, Lund J, Djukanovic R.

Am J Respir Crit Care Med. 2007 Mar 15;175(6):577-86. Epub 2006 Dec 7.PMID: 17158281 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeting the networks that underpin contiguous immunity in asthma and chronic obstructive pulmonary disease.

Sabroe I, Parker LC, Dockrell DH, Davies DE, Dower SK, Whyte MK.

Am J Respir Crit Care Med. 2007 Feb 15;175(4):306-11. Epub 2006 Nov 30. Review.PMID: 17138954 [PubMed - indexed for MEDLINE]Related articlesFree article

IL-13 receptor alpha 2: a regulator of IL-13 and IL-4 signal transduction in primary human fibroblasts.

Andrews AL, Nasir T, Bucchieri F, Holloway JW, Holgate ST, Davies DE.

J Allergy Clin Immunol. 2006 Oct;118(4):858-65. Epub 2006 Sep 8.PMID: 17030238 [PubMed - indexed for MEDLINE]Related articles

Role of deficient type III interferon-lambda production in asthma exacerbations.

Contoli M, Message SD, Laza-Stanca V, Edwards MR, Wark PA, Bartlett NW, Kebadze T, Mallia P, Stanciu LA, Parker HL, Slater L, Lewis-Antes A, Kon OM, Holgate ST, Davies DE, Kotenko SV, Papi A, Johnston SL.

Nat Med. 2006 Sep;12(9):1023-6. Epub 2006 Aug 13.PMID: 16906156 [PubMed - indexed for MEDLINE]Related articles

2,5-diketopiperazines as potent, selective, and orally bioavailable oxytocin antagonists. 3. Synthesis, pharmacokinetics, and in vivo potency.

Borthwick AD, Davies DE, Exall AM, Hatley RJ, Hughes JA, Irving WR, Livermore DG, Sollis SL, Nerozzi F, Valko KL, Allen MJ, Perren M, Shabbir SS, Woollard PM, Price MA.

J Med Chem. 2006 Jul 13;49(14):4159-70.PMID: 16821776 [PubMed - indexed for MEDLINE]Related articles

Shotgun proteomic analysis of human-induced sputum.

Nicholas B, Skipp P, Mould R, Rennard S, Davies DE, O'Connor CD, Djukanović R.

Proteomics. 2006 Aug;6(15):4390-401.PMID: 16819730 [PubMed - indexed for MEDLINE]Related articles

The genetics of asthma: ADAM33 as an example of a susceptibility gene.

Holgate ST, Yang Y, Haitchi HM, Powell RM, Holloway JW, Yoshisue H, Pang YY, Cakebread J, Davies DE.

Proc Am Thorac Soc. 2006 Jul;3(5):440-3. Review.PMID: 16799089 [PubMed - indexed for MEDLINE]Related articlesFree article

IL-4 receptor alpha is an important modulator of IL-4 and IL-13 receptor binding: implications for the development of therapeutic targets.

Andrews AL, Holloway JW, Holgate ST, Davies DE.

J Immunol. 2006 Jun 15;176(12):7456-61.PMID: 16751391 [PubMed - indexed for MEDLINE]Related articlesFree article

CD40 ligation protects bronchial epithelium against oxidant-induced caspase-independent cell death.

Merendino AM, Bucchieri F, Gagliardo R, Daryadel A, Pompeo F, Chiappara G, Santagata R, Bellia V, David S, Farina F, Davies DE, Simon HU, Vignola AM.

Am J Respir Cell Mol Biol. 2006 Aug;35(2):155-64. Epub 2006 Mar 16.PMID: 16543604 [PubMed - indexed for MEDLINE]Related articlesFree article

Parental suicide after the expected death of a child at home.

Davies DE.

BMJ. 2006 Mar 18;332(7542):647-8. Review. No abstract available. PMID: 16543334 [PubMed - indexed for MEDLINE]Related articlesFree article

Understanding the pathophysiology of severe asthma to generate new therapeutic opportunities.

Holgate ST, Holloway J, Wilson S, Howarth PH, Haitchi HM, Babu S, Davies DE.

J Allergy Clin Immunol. 2006 Mar;117(3):496-506; quiz 507. Review.PMID: 16522446 [PubMed - indexed for MEDLINE]Related articles

Enhanced upregulation of smooth muscle related transcripts by TGF beta2 in asthmatic (myo) fibroblasts.

Wicks J, Haitchi HM, Holgate ST, Davies DE, Powell RM.

Thorax. 2006 Apr;61(4):313-9. Epub 2006 Jan 31.PMID: 16449267 [PubMed - indexed for MEDLINE]Related articlesFree article

The contribution of transforming growth factor-beta and epidermal growth factor signalling to airway remodelling in chronic asthma.

Boxall C, Holgate ST, Davies DE.

Eur Respir J. 2006 Jan;27(1):208-29. Review.PMID: 16387953 [PubMed - indexed for MEDLINE]Related articlesFree article

ADAM33: a newly identified gene in the pathogenesis of asthma.

Holgate ST, Davies DE, Powell RM, Holloway JW.

Immunol Allergy Clin North Am. 2005 Nov;25(4):655-68.PMID: 16257631 [PubMed - indexed for MEDLINE]Related articles

2,5-diketopiperazines as potent, selective, and orally bioavailable oxytocin antagonists. 2. Synthesis, chirality, and pharmacokinetics.

Borthwick AD, Davies DE, Exall AM, Livermore DG, Sollis SL, Nerozzi F, Allen MJ, Perren M, Shabbir SS, Woollard PM, Wyatt PG.

J Med Chem. 2005 Nov 3;48(22):6956-69.PMID: 16250654 [PubMed - indexed for MEDLINE]Related articles

Tumour necrosis factor (TNFalpha) as a novel therapeutic target in symptomatic corticosteroid dependent asthma.

Howarth PH, Babu KS, Arshad HS, Lau L, Buckley M, McConnell W, Beckett P, Al Ali M, Chauhan A, Wilson SJ, Reynolds A, Davies DE, Holgate ST.

Thorax. 2005 Dec;60(12):1012-8. Epub 2005 Sep 15.PMID: 16166100 [PubMed - indexed for MEDLINE]Related articlesFree article

Epithelial-mesenchymal communication in the pathogenesis of chronic asthma.

Holgate ST, Holloway J, Wilson S, Bucchieri F, Puddicombe S, Davies DE.

Proc Am Thorac Soc. 2004;1(2):93-8. Review.PMID: 16113419 [PubMed - indexed for MEDLINE]Related articlesFree article

ADAM33: a newly identified protease involved in airway remodelling.

Holgate ST, Davies DE, Powell RM, Holloway JW.

Pulm Pharmacol Ther. 2006;19(1):3-11. Epub 2005 Jun 13. Review.PMID: 15953744 [PubMed - indexed for MEDLINE]Related articles

Altered protein tyrosine phosphorylation in asthmatic bronchial epithelium.

Hamilton LM, Puddicombe SM, Dearman RJ, Kimber I, Sandström T, Wallin A, Howarth PH, Holgate ST, Wilson SJ, Davies DE.

Eur Respir J. 2005 Jun;25(6):978-85.PMID: 15929951 [PubMed - indexed for MEDLINE]Related articlesFree article

2,5-Diketopiperazines as potent and selective oxytocin antagonists 1: Identification, stereochemistry and initial SAR.

Wyatt PG, Allen MJ, Borthwick AD, Davies DE, Exall AM, Hatley RJ, Irving WR, Livermore DG, Miller ND, Nerozzi F, Sollis SL, Szardenings AK.

Bioorg Med Chem Lett. 2005 May 16;15(10):2579-82.PMID: 15863320 [PubMed - indexed for MEDLINE]Related articles

Epithelial stress and structural remodelling in childhood asthma.

Fedorov IA, Wilson SJ, Davies DE, Holgate ST.

Thorax. 2005 May;60(5):389-94.PMID: 15860714 [PubMed - indexed for MEDLINE]Related articlesFree article

Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus.

Wark PA, Johnston SL, Bucchieri F, Powell R, Puddicombe S, Laza-Stanca V, Holgate ST, Davies DE.

J Exp Med. 2005 Mar 21;201(6):937-47.PMID: 15781584 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-catenin/T-cell factor-mediated transcription is modulated by cell density in human bronchial epithelial cells.

Steel MD, Puddicombe SM, Hamilton LM, Powell RM, Holloway JW, Holgate ST, Davies DE, Collins JE.

Int J Biochem Cell Biol. 2005 Jun;37(6):1281-95. Epub 2005 Jan 18.PMID: 15778091 [PubMed - indexed for MEDLINE]Related articles

ADAM33 expression in asthmatic airways and human embryonic lungs.

Haitchi HM, Powell RM, Shaw TJ, Howarth PH, Wilson SJ, Wilson DI, Holgate ST, Davies DE.

Am J Respir Crit Care Med. 2005 May 1;171(9):958-65. Epub 2005 Feb 11.PMID: 15709049 [PubMed - indexed for MEDLINE]Related articlesFree article

Talking about death with dying children.

Davies DE.

N Engl J Med. 2005 Jan 6;352(1):91-2; author reply 91-2. No abstract available. PMID: 15635120 [PubMed - indexed for MEDLINE]Related articles

Expression of ErbB receptors and mucins in the airways of long term current smokers.

O'Donnell RA, Richter A, Ward J, Angco G, Mehta A, Rousseau K, Swallow DM, Holgate ST, Djukanovic R, Davies DE, Wilson SJ.

Thorax. 2004 Dec;59(12):1032-40.PMID: 15563701 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of tumor necrosis factor alpha in asthma.

Babu KS, Davies DE, Holgate ST.

Immunol Allergy Clin North Am. 2004 Nov;24(4):583-97, v-vi. Review.PMID: 15474860 [PubMed - indexed for MEDLINE]Related articles

Relationship between peripheral airway dysfunction, airway obstruction, and neutrophilic inflammation in COPD.

O'Donnell RA, Peebles C, Ward JA, Daraker A, Angco G, Broberg P, Pierrou S, Lund J, Holgate ST, Davies DE, Delany DJ, Wilson SJ, Djukanovic R.

Thorax. 2004 Oct;59(10):837-42.PMID: 15454648 [PubMed - indexed for MEDLINE]Related articlesFree article

The discovery and role of ADAM33, a new candidate gene for asthma.

Holloway JW, Davies DE, Powell R, Haitchi HM, Keith TP, Holgate ST.

Expert Rev Mol Med. 2004 Aug 3;6(17):1-12. Review.PMID: 15387895 [PubMed - indexed for MEDLINE]Related articles