PubMed

Adherence to antiretroviral therapy, virological response, and time to resistance in the Dakar cohort.

Tournoud M, Etard JF, Ecochard R, Degruttola V.

Stat Med. 2009 Nov 25. [Epub ahead of print]PMID: 19941299 [PubMed - as supplied by publisher]Related articles

Development of a didanosine genotypic resistance interpretation system based on large derivation and validation datasets.

Assoumou L, Cozzi-Lepri A, Brun-Vézinet F, Degruttola V, Kuritzkes DR, Phillips A, Zolopa A, Miller V, Flandre P, Costagliola D; on behalf of the Standardization, Clinical Relevance of HIV Drug Resistance Testing Project from the Forum for Collaborative HIV Research.

AIDS. 2009 Oct 27. [Epub ahead of print]PMID: 19864933 [PubMed - as supplied by publisher]Related articles

A phylogenetic and Markov model approach for the reconstruction of mutational pathways of drug resistance.

Buendia P, Cadwallader B, DeGruttola V.

Bioinformatics. 2009 Oct 1;25(19):2522-9. Epub 2009 Aug 3.PMID: 19654117 [PubMed - in process]Related articles

Demographic variations in HIV testing history among emergency department patients: implications for HIV screening in US emergency departments.

Merchant RC, Catanzaro BM, Seage GR 3rd, Mayer KH, Clark MA, Degruttola VG, Becker BM.

J Med Screen. 2009;16(2):60-6.PMID: 19564517 [PubMed - indexed for MEDLINE]Related articles

HIV DNA and cognition in a Thai longitudinal HAART initiation cohort: the SEARCH 001 Cohort Study.

Valcour VG, Shiramizu BT, Sithinamsuwan P, Nidhinandana S, Ratto-Kim S, Ananworanich J, Siangphoe U, Kim JH, de Souza M, Degruttola V, Paul RH, Shikuma CM; Southeast Asia Research Collaboration with the University of Hawaii 001 protocol team.

Neurology. 2009 Mar 17;72(11):992-8.PMID: 19289739 [PubMed - indexed for MEDLINE]Related articlesFree article

Emergency department patient perceptions and preferences on opt-in rapid HIV screening program components.

Merchant RC, Clark MA, Seage GR 3rd, Mayer KH, Degruttola VG, Becker BM.

AIDS Care. 2009 Apr;21(4):490-500.PMID: 19283644 [PubMed - indexed for MEDLINE]Related articles

Response to zidovudine/didanosine-containing combination antiretroviral therapy among HIV-1 subtype C-infected adults in Botswana: two-year outcomes from a randomized clinical trial.

Bussmann H, Wester CW, Thomas A, Novitsky V, Okezie R, Muzenda T, Gaolathe T, Ndwapi N, Mawoko N, Widenfelt E, Moyo S, Musonda R, Mine M, Makhema J, Moffat H, Essex M, Degruttola V, Marlink RG.

J Acquir Immune Defic Syndr. 2009 May 1;51(1):37-46.PMID: 19282782 [PubMed - indexed for MEDLINE]Related articles

Emergency department patient acceptance of opt-in, universal, rapid HIV screening.

Merchant RC, Seage GR, Mayer KH, Clark MA, DeGruttola VG, Becker BM.

Public Health Rep. 2008 Nov-Dec;123 Suppl 3:27-40.PMID: 19172704 [PubMed - indexed for MEDLINE]Related articles

Video as an effective method to deliver pretest information for rapid human immunodeficiency testing.

Merchant RC, Clark MA, Mayer KH, Seage Iii GR, DeGruttola VG, Becker BM.

Acad Emerg Med. 2009 Feb;16(2):124-35. Epub 2008 Dec 18.PMID: 19120050 [PubMed - indexed for MEDLINE]Related articles

Controlling the HIV epidemic, without a vaccine!

DeGruttola V, Little S, Schooley R.

AIDS. 2008 Nov 30;22(18):2554-5. No abstract available. PMID: 19005285 [PubMed - indexed for MEDLINE]Related articles

Five-year outcomes of initial patients treated in Botswana's National Antiretroviral Treatment Program.

Bussmann H, Wester CW, Ndwapi N, Grundmann N, Gaolathe T, Puvimanasinghe J, Avalos A, Mine M, Seipone K, Essex M, Degruttola V, Marlink RG.

AIDS. 2008 Nov 12;22(17):2303-11.PMID: 18981769 [PubMed - indexed for MEDLINE]Related articles

Initiatives for developing and comparing genotype interpretation systems: external validation of existing systems for didanosine against virological response.

Assoumou L, Brun-Vézinet F, Cozzi-Lepri A, Kuritzkes D, Phillips A, Zolopa A, Degruttola V, Miller V, Costagliola D; Standardization and Clinical Relevance of HIV Drug Resistance Testing Project of the Forum for Collaborative HIV Research.

J Infect Dis. 2008 Aug 15;198(4):470-80.PMID: 18598191 [PubMed - indexed for MEDLINE]Related articles

Accommodating uncertainty in a tree set for function estimation.

Healy BC, DeGruttola VG, Hu C.

Stat Appl Genet Mol Biol. 2008;7(1):Article5. Epub 2008 Feb 19.PMID: 18312210 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of efavirenz hypersusceptibility with virologic response in ACTG 368, a randomized trial of abacavir (ABC) in combination with efavirenz (EFV) and indinavir (IDV) in HIV-infected subjects with prior nucleoside analog experience.

Demeter LM, DeGruttola V, Lustgarten S, Bettendorf D, Fischl M, Eshleman S, Spreen W, Nguyen BY, Koval CE, Eron JJ, Hammer S, Squires K.

HIV Clin Trials. 2008 Jan-Feb;9(1):11-25.PMID: 18215978 [PubMed - indexed for MEDLINE]Related articlesFree article

Resampling-based analyses of the effects of combinations of HIV genetic mutations on drug susceptibility.

Schumi J, Degruttola V.

Stat Med. 2008 Oct 15;27(23):4740-57.PMID: 18186529 [PubMed - indexed for MEDLINE]Related articles

Higher-than-expected rates of lactic acidosis among highly active antiretroviral therapy-treated women in Botswana: preliminary results from a large randomized clinical trial.

Wester CW, Okezie OA, Thomas AM, Bussmann H, Moyo S, Muzenda T, Makhema J, van Widenfelt E, Musonda R, Novitsky V, Gaolathe T, Ndwapi N, Essex M, Kuritzkes DR, DeGruttola V, Marlink RG.

J Acquir Immune Defic Syndr. 2007 Nov 1;46(3):318-22.PMID: 18090299 [PubMed - indexed for MEDLINE]Related articles

Resampling-based multiple testing methods with covariate adjustment: application to investigation of antiretroviral drug susceptibility.

Yang Y, Degruttola V.

Biometrics. 2008 Jun;64(2):329-36. Epub 2007 Sep 26.PMID: 17900313 [PubMed - indexed for MEDLINE]Related articles

Comparison of patient comprehension of rapid HIV pre-test fundamentals by information delivery format in an emergency department setting.

Merchant RC, Gee EM, Clark MA, Mayer KH, Seage GR 3rd, Degruttola VG.

BMC Public Health. 2007 Sep 12;7:238.PMID: 17850670 [PubMed - indexed for MEDLINE]Related articlesFree article

Efficient Hybrid EM for Linear and Nonlinear Mixed Effects Models with Censored Response.

Vaida F, Fitzgerald AP, Degruttola V.

Comput Stat Data Anal. 2007 Aug 15;51(12):5718-5730.PMID: 19578533 [PubMed]Related articlesFree article

The reverse transcriptase 67N 70R 215Y genotype is the predominant TAM pathway associated with virologic failure among HIV type 1C-infected adults treated with ZDV/ddI-containing HAART in southern Africa.

Novitsky V, Wester CW, DeGruttola V, Bussmann H, Gaseitsiwe S, Thomas A, Moyo S, Musonda R, Van Widenfelt E, Marlink RG, Essex M.

AIDS Res Hum Retroviruses. 2007 Jul;23(7):868-78.PMID: 17678469 [PubMed - indexed for MEDLINE]Related articles

Nonparametric tests for two-group comparisons of dependent observations obtained at varying time points.

May S, Degruttola V.

Biometrics. 2007 Mar;63(1):194-200.PMID: 17447945 [PubMed - indexed for MEDLINE]Related articles

Host immune status and incidence of hepatocellular carcinoma among subjects infected with hepatitis C virus: a nested case-control study in Japan.

Suruki RY, Mueller N, Hayashi K, Harn D, DeGruttola V, Raker CA, Tsubouchi H, Stuver SO.

Cancer Epidemiol Biomarkers Prev. 2006 Dec;15(12):2521-5.PMID: 17164379 [PubMed - indexed for MEDLINE]Related articlesFree article

Hidden Markov models for settings with interval-censored transition times and uncertain time origin: application to HIV genetic analyses.

Healy B, Degruttola V.

Biostatistics. 2007 Apr;8(2):438-52. Epub 2006 Aug 28.PMID: 16940036 [PubMed - indexed for MEDLINE]Related articlesFree article

Longitudinal analysis of clinical markers following antiretroviral therapy initiated during acute or early HIV type 1 infection.

Kassutto S, Maghsoudi K, Johnston MN, Robbins GK, Burgett NC, Sax PE, Cohen D, Pae E, Davis B, Zachary K, Basgoz N, D'agata EM, DeGruttola V, Walker BD, Rosenberg ES.

Clin Infect Dis. 2006 Apr 1;42(7):1024-31. Epub 2006 Feb 27.PMID: 16511771 [PubMed - indexed for MEDLINE]Related articles

A flexible B-spline model for multiple longitudinal biomarkers and survival.

Brown ER, Ibrahim JG, DeGruttola V.

Biometrics. 2005 Mar;61(1):64-73.PMID: 15737079 [PubMed - indexed for MEDLINE]Related articles

Clinically validated genotype analysis: guiding principles and statistical concerns.

Brun-Vézinet F, Costagliola D, Khaled MA, Calvez V, Clavel F, Clotet B, Haubrich R, Kempf D, King M, Kuritzkes D, Lanier R, Miller M, Miller V, Phillips A, Pillay D, Schapiro J, Scott J, Shafer R, Zazzi M, Zolopa A, DeGruttola V.

Antivir Ther. 2004 Aug;9(4):465-78. Review.PMID: 15456077 [PubMed - indexed for MEDLINE]Related articles

Immunophenotypic markers and antiretroviral therapy (IMART): T cell activation and maturation help predict treatment response.

Mildvan D, Bosch RJ, Kim RS, Spritzler J, Haas DW, Kuritzkes D, Kagan J, Nokta M, DeGruttola V, Moreno M, Landay A.

J Infect Dis. 2004 May 15;189(10):1811-20. Epub 2004 Apr 29.PMID: 15122517 [PubMed - indexed for MEDLINE]Related articles

A randomized trial of nelfinavir and abacavir in combination with efavirenz and adefovir dipivoxil in HIV-1-infected persons with virological failure receiving indinavir.

Hammer SM, Bassett R, Squires KE, Fischl MA, Demeter LM, Currier JS, Mellors JW, Morse GD, Eron JJ, Santana JL, DeGruttola V; ACTG 372B/D Study Team.

Antivir Ther. 2003 Dec;8(6):507-18. No abstract available. PMID: 14760884 [PubMed - indexed for MEDLINE]Related articles

Assessing resistance costs of antiretroviral therapies via measures of future drug options.

Jiang H, Deeks SG, Kuritzkes DR, Lallemant M, Katzenstein D, Albrecht M, DeGruttola V.

J Infect Dis. 2003 Oct 1;188(7):1001-8. Epub 2003 Sep 23.PMID: 14513420 [PubMed - indexed for MEDLINE]Related articles

Non-parametric methods to predict HIV drug susceptibility phenotype from genotype.

DiRienzo AG, DeGruttola V, Larder B, Hertogs K.

Stat Med. 2003 Sep 15;22(17):2785-98.PMID: 12939786 [PubMed - indexed for MEDLINE]Related articles

Characterizing classes of antiretroviral drugs by genotype.

Foulkes AS, DeGruttola V.

Stat Med. 2003 Aug 30;22(16):2637-55.PMID: 12898549 [PubMed - indexed for MEDLINE]Related articles

What constitutes efficacy for a human immunodeficiency virus vaccine that ameliorates viremia: issues involving surrogate end points in phase 3 trials.

Gilbert PB, DeGruttola VG, Hudgens MG, Self SG, Hammer SM, Corey L.

J Infect Dis. 2003 Jul 15;188(2):179-93. Epub 2003 Jul 1.PMID: 12854072 [PubMed - indexed for MEDLINE]Related articles

Design and analysis of clinical trials with a bivariate failure time endpoint, with application to AIDS Clinical Trials Group Study A5142.

DiRienzo AG, DeGruttola V.

Control Clin Trials. 2003 Apr;24(2):122-34.PMID: 12689734 [PubMed - indexed for MEDLINE]Related articles

Baseline predictors of CD4 T-lymphocyte recovery with combination antiretroviral therapy.

Bennett KK, DeGruttola VG, Marschner IC, Havlir DV, Richman DD.

J Acquir Immune Defic Syndr. 2002 Sep 1;31(1):20-6.PMID: 12352146 [PubMed - indexed for MEDLINE]Related articles

Modelling HIV viral rebound using non-linear mixed effects models.

Fitzgerald AP, DeGruttola VG, Vaida F.

Stat Med. 2002 Jul 30;21(14):2093-108.PMID: 12111889 [PubMed - indexed for MEDLINE]Related articles

Dual vs single protease inhibitor therapy following antiretroviral treatment failure: a randomized trial.

Hammer SM, Vaida F, Bennett KK, Holohan MK, Sheiner L, Eron JJ, Wheat LJ, Mitsuyasu RT, Gulick RM, Valentine FT, Aberg JA, Rogers MD, Karol CN, Saah AJ, Lewis RH, Bessen LJ, Brosgart C, DeGruttola V, Mellors JW; AIDS Clinical Trials Group 398 Study Team.

JAMA. 2002 Jul 10;288(2):169-80.PMID: 12095381 [PubMed - indexed for MEDLINE]Related articlesFree article

ACTG (AIDS Clinical Trials Group) 384: a strategy trial comparing consecutive treatments for HIV-1.

Smeaton LM, DeGruttola V, Robbins GK, Shafer RW.

Control Clin Trials. 2001 Apr;22(2):142-59.PMID: 11306153 [PubMed - indexed for MEDLINE]Related articles

Virologic and regimen termination surrogate end points in AIDS clinical trials.

Gilbert PB, DeGruttola V, Hammer SM, Kuritzkes DR.

JAMA. 2001 Feb 14;285(6):777-84.PMID: 11176916 [PubMed - indexed for MEDLINE]Related articles

Beta-blockade for patients undergoing vascular surgery.

Litwack RS, Gilligan DM, DeGruttola V.

N Engl J Med. 2000 Apr 6;342(14):1052; author reply 1052-3. No abstract available. PMID: 10755897 [PubMed - indexed for MEDLINE]Related articles

Two double-blinded, randomized, comparative trials of 4 human immunodeficiency virus type 1 (HIV-1) envelope vaccines in HIV-1-infected individuals across a spectrum of disease severity: AIDS Clinical Trials Groups 209 and 214.

Schooley RT, Spino C, Kuritzkes D, Walker BD, Valentine FA, Hirsch MS, Cooney E, Friedland G, Kundu S, Merigan TC Jr, McElrath MJ, Collier A, Plaeger S, Mitsuyasu R, Kahn J, Haslett P, Uherova P, deGruttola V, Chiu S, Zhang B, Jones G, Bell D, Ketter N, Twadell T, Chernoff D, Rosandich M.

J Infect Dis. 2000 Nov;182(5):1357-64. Epub 2000 Oct 9.PMID: 11023459 [PubMed - indexed for MEDLINE]Related articles

Methods for investigation of the relationship between drug-susceptibility phenotype and human immunodeficiency virus type 1 genotype with applications to AIDS clinical trials group 333.

Sevin AD, DeGruttola V, Nijhuis M, Schapiro JM, Foulkes AS, Para MF, Boucher CA.

J Infect Dis. 2000 Jul;182(1):59-67. Epub 2000 Jul 6.PMID: 10882582 [PubMed - indexed for MEDLINE]Related articles

The relation between baseline HIV drug resistance and response to antiretroviral therapy: re-analysis of retrospective and prospective studies using a standardized data analysis plan.

DeGruttola V, Dix L, D'Aquila R, Holder D, Phillips A, Ait-Khaled M, Baxter J, Clevenbergh P, Hammer S, Harrigan R, Katzenstein D, Lanier R, Miller M, Para M, Yerly S, Zolopa A, Murray J, Patick A, Miller V, Castillo S, Pedneault L, Mellors J.

Antivir Ther. 2000 Mar;5(1):41-8.PMID: 10846592 [PubMed - indexed for MEDLINE]Related articles

Both serum HIV type 1 RNA levels and CD4+ lymphocyte counts predict clinical outcome in HIV type 1-infected subjects with 200 to 500 CD4+ cells per cubic millimeter. AIDS Clinical Trials Group Study 175 Virology Study Team.

Kim S, Hughes MD, Hammer SM, Jackson JB, DeGruttola V, Katzenstein DA.

AIDS Res Hum Retroviruses. 2000 May 1;16(7):645-53.PMID: 10791875 [PubMed - indexed for MEDLINE]Related articles

Clinical trials using HIV-1 RNA-based primary endpoints: statistical analysis and potential biases.

Marschner IC, Betensky RA, DeGruttola V, Hammer SM, Kuritzkes DR.

J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Mar 1;20(3):220-7.PMID: 10077169 [PubMed - indexed for MEDLINE]Related articles

Treatment with amprenavir alone or amprenavir with zidovudine and lamivudine in adults with human immunodeficiency virus infection. AIDS Clinical Trials Group 347 Study Team.

Murphy RL, Gulick RM, DeGruttola V, D'Aquila RT, Eron JJ, Sommadossi JP, Currier JS, Smeaton L, Frank I, Caliendo AM, Gerber JG, Tung R, Kuritzkes DR.

J Infect Dis. 1999 Apr;179(4):808-16.PMID: 10068575 [PubMed - indexed for MEDLINE]Related articles

Predicting long-term postoperative cardiovascular outcomes.

Litwack RS, DeGruttola V.

Anesthesiology. 1998 Nov;89(5):1286-8. No abstract available. Erratum in: anesthesiology 1999 Feb;90(2):644. PMID: 9822031 [PubMed - indexed for MEDLINE]Related articlesFree article

Efficient trial designs for studying combination antiretroviral treatments in patients with various resistance profiles.

Gilbert P, DeGruttola V, Hammer S.

J Infect Dis. 1998 Aug;178(2):340-8.PMID: 9697713 [PubMed - indexed for MEDLINE]Related articles

Trial design in the era of highly effective antiviral drug combinations for HIV infection.

DeGruttola V, Hughes M, Gilbert P, Phillips A.

AIDS. 1998;12 Suppl A:S149-56. Review. No abstract available. PMID: 9632997 [PubMed - indexed for MEDLINE]Related articles

Use of changes in plasma levels of human immunodeficiency virus type 1 RNA to assess the clinical benefit of antiretroviral therapy.

Marschner IC, Collier AC, Coombs RW, D'Aquila RT, DeGruttola V, Fischl MA, Hammer SM, Hughes MD, Johnson VA, Katzenstein DA, Richman DD, Smeaton LM, Spector SA, Saag MS.

J Infect Dis. 1998 Jan;177(1):40-7.PMID: 9419168 [PubMed - indexed for MEDLINE]Related articles

Surrogate endpoints.

Fleming TR, DeGruttola V, DeMets DL.

AIDS Clin Rev. 1997-1998:129-43. Review. No abstract available. PMID: 9305447 [PubMed - indexed for MEDLINE]Related articles