PubMed

Role of insulin resistance and lipotoxicity in non-alcoholic steatohepatitis.

Cusi K.

Clin Liver Dis. 2009 Nov;13(4):545-63.PMID: 19818304 [PubMed - in process]Related articles

Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with nonalcoholic steatohepatitis.

Gastaldelli A, Harrison SA, Belfort-Aguilar R, Hardies LJ, Balas B, Schenker S, Cusi K.

Hepatology. 2009 Oct;50(4):1087-93.PMID: 19670459 [PubMed - indexed for MEDLINE]Related articles

Lessons learned from studying families genetically predisposed to type 2 diabetes mellitus.

Cusi K.

Curr Diab Rep. 2009 Jun;9(3):200-7. Review.PMID: 19490821 [PubMed - indexed for MEDLINE]Related articles

Thiazolidinediones in NASH. An odd couple meant to be?

Cusi K.

J Clin Gastroenterol. 2009 Jul;43(6):503-5. No abstract available. PMID: 19384246 [PubMed - indexed for MEDLINE]Related articles

New diagnostic and treatment approaches in non-alcoholic fatty liver disease (NAFLD).

Ali R, Cusi K.

Ann Med. 2009;41(4):265-78. Review.PMID: 19353360 [PubMed - indexed for MEDLINE]Related articles

Nonalcoholic fatty liver disease in type 2 diabetes mellitus.

Cusi K.

Curr Opin Endocrinol Diabetes Obes. 2009 Apr;16(2):141-9. Review.PMID: 19262374 [PubMed - indexed for MEDLINE]Related articles

Allergic skin reaction to insulin detemir: resolution with continued use.

Balas B, Wang S, Cusi K.

Endocr Pract. 2008 Sep;14(6):796-7. No abstract available. PMID: 18996804 [PubMed - indexed for MEDLINE]Related articles

Chronic low-dose lipid infusion in healthy patients induces markers of endothelial activation independent of its metabolic effects.

Kashyap SR, Belfort R, Cersosimo E, Lee S, Cusi K.

J Cardiometab Syndr. 2008 Summer;3(3):141-6.PMID: 18983329 [PubMed - indexed for MEDLINE]Related articles

Automatic correction of intensity inhomogeneities improves unsupervised assessment of abdominal fat by MRI.

Positano V, Cusi K, Santarelli MF, Sironi A, Petz R, Defronzo R, Landini L, Gastaldelli A.

J Magn Reson Imaging. 2008 Aug;28(2):403-10.PMID: 18666138 [PubMed - indexed for MEDLINE]Related articles

Thyroid function testing in psychiatric illness: Usefulness and limitations.

Arem R, Cusi K.

Trends Endocrinol Metab. 1997 Sep;8(7):282-7.PMID: 18406817 [PubMed - in process]Related articles

Insulin-resistant muscle is exercise resistant: evidence for reduced response of nuclear-encoded mitochondrial genes to exercise.

De Filippis E, Alvarez G, Berria R, Cusi K, Everman S, Meyer C, Mandarino LJ.

Am J Physiol Endocrinol Metab. 2008 Mar;294(3):E607-14. Epub 2008 Jan 8.PMID: 18182465 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of fenofibrate in clinical practice.

Zambon A, Cusi K.

Diab Vasc Dis Res. 2007 Sep;4 Suppl 3:S15-20.PMID: 17935056 [PubMed - indexed for MEDLINE]Related articles

Addition of pioglitazone and ramipril to intensive insulin therapy in type 2 diabetic patients improves vascular dysfunction by different mechanisms.

Fernandez M, Triplitt C, Wajcberg E, Sriwijilkamol AA, Musi N, Cusi K, DeFronzo R, Cersosimo E.

Diabetes Care. 2008 Jan;31(1):121-7. Epub 2007 Oct 1.PMID: 17909084 [PubMed - indexed for MEDLINE]Related articlesFree article

Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects.

Gastaldelli A, Cusi K, Pettiti M, Hardies J, Miyazaki Y, Berria R, Buzzigoli E, Sironi AM, Cersosimo E, Ferrannini E, Defronzo RA.

Gastroenterology. 2007 Aug;133(2):496-506. Epub 2007 May 1.PMID: 17681171 [PubMed - indexed for MEDLINE]Related articles

Pioglitazone treatment increases whole body fat but not total body water in patients with non-alcoholic steatohepatitis.

Balas B, Belfort R, Harrison SA, Darland C, Finch J, Schenker S, Gastaldelli A, Cusi K.

J Hepatol. 2007 Oct;47(4):565-70. Epub 2007 May 24.PMID: 17560678 [PubMed - indexed for MEDLINE]Related articles

Contrast-enhanced first-pass myocardial perfusion magnetic resonance imaging with parallel acquisition at 3.0 Tesla.

Ruan C, Yang SH, Cusi K, Gao F, Clarke GD.

Invest Radiol. 2007 Jun;42(6):352-60.PMID: 17507805 [PubMed - indexed for MEDLINE]Related articles

Reduction in hematocrit and hemoglobin following pioglitazone treatment is not hemodilutional in Type II diabetes mellitus.

Berria R, Glass L, Mahankali A, Miyazaki Y, Monroy A, De Filippis E, Cusi K, Cersosimo E, Defronzo RA, Gastaldelli A.

Clin Pharmacol Ther. 2007 Sep;82(3):275-81. Epub 2007 Mar 14.PMID: 17361126 [PubMed - indexed for MEDLINE]Related articles

Effects on insulin secretion and insulin action of a 48-h reduction of plasma free fatty acids with acipimox in nondiabetic subjects genetically predisposed to type 2 diabetes.

Cusi K, Kashyap S, Gastaldelli A, Bajaj M, Cersosimo E.

Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1775-81. Epub 2007 Feb 13.PMID: 17299078 [PubMed - indexed for MEDLINE]Related articlesFree article

The dipeptidyl peptidase IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single-dose administration in type 2 diabetic patients.

Balas B, Baig MR, Watson C, Dunning BE, Ligueros-Saylan M, Wang Y, He YL, Darland C, Holst JJ, Deacon CF, Cusi K, Mari A, Foley JE, DeFronzo RA.

J Clin Endocrinol Metab. 2007 Apr;92(4):1249-55. Epub 2007 Jan 23.PMID: 17244786 [PubMed - indexed for MEDLINE]Related articlesFree article

A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis.

Belfort R, Harrison SA, Brown K, Darland C, Finch J, Hardies J, Balas B, Gastaldelli A, Tio F, Pulcini J, Berria R, Ma JZ, Dwivedi S, Havranek R, Fincke C, DeFronzo R, Bannayan GA, Schenker S, Cusi K.

N Engl J Med. 2006 Nov 30;355(22):2297-307.PMID: 17135584 [PubMed - indexed for MEDLINE]Related articlesFree article

Exercise-induced improvement in vasodilatory function accompanies increased insulin sensitivity in obesity and type 2 diabetes mellitus.

De Filippis E, Cusi K, Ocampo G, Berria R, Buck S, Consoli A, Mandarino LJ.

J Clin Endocrinol Metab. 2006 Dec;91(12):4903-10. Epub 2006 Oct 3.PMID: 17018657 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduction in hematocrit level after pioglitazone treatment is correlated with decreased plasma free testosterone level, not hemodilution, in women with polycystic ovary syndrome.

Berria R, Gastaldelli A, Lucidi S, Belfort R, De Filippis E, Easton C, Brytzki R, Cusi K, Jovanovic L, DeFronzo R.

Clin Pharmacol Ther. 2006 Aug;80(2):105-14. Epub 2006 Jun 30.PMID: 16890572 [PubMed - indexed for MEDLINE]Related articles

First-pass contrast-enhanced myocardial perfusion MRI using a maximum up-slope parametric map.

Ruan C, Yang S, Clarke GD, Amurao MR, Partyka SR, Bradley YC, Cusi K.

IEEE Trans Inf Technol Biomed. 2006 Jul;10(3):574-80.PMID: 16871727 [PubMed - indexed for MEDLINE]Related articles

Detection and identification of significant ANAs in previously determined ANA negative samples.

Kidd K, Cusi K, Mueller R, Goodner M, Boyes B, Hoy E.

Clin Lab. 2005;51(9-10):517-21.PMID: 16285474 [PubMed - indexed for MEDLINE]Related articles

Dose-response effect of elevated plasma free fatty acid on insulin signaling.

Belfort R, Mandarino L, Kashyap S, Wirfel K, Pratipanawatr T, Berria R, Defronzo RA, Cusi K.

Diabetes. 2005 Jun;54(6):1640-8.PMID: 15919784 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipid infusion decreases the expression of nuclear encoded mitochondrial genes and increases the expression of extracellular matrix genes in human skeletal muscle.

Richardson DK, Kashyap S, Bajaj M, Cusi K, Mandarino SJ, Finlayson J, DeFronzo RA, Jenkinson CP, Mandarino LJ.

J Biol Chem. 2005 Mar 18;280(11):10290-7. Epub 2004 Dec 14.PMID: 15598661 [PubMed - indexed for MEDLINE]Related articlesFree article

Sustained reduction in plasma free fatty acid concentration improves insulin action without altering plasma adipocytokine levels in subjects with strong family history of type 2 diabetes.

Bajaj M, Suraamornkul S, Kashyap S, Cusi K, Mandarino L, DeFronzo RA.

J Clin Endocrinol Metab. 2004 Sep;89(9):4649-55.PMID: 15356076 [PubMed - indexed for MEDLINE]Related articlesFree article

Discordant effects of a chronic physiological increase in plasma FFA on insulin signaling in healthy subjects with or without a family history of type 2 diabetes.

Kashyap SR, Belfort R, Berria R, Suraamornkul S, Pratipranawatr T, Finlayson J, Barrentine A, Bajaj M, Mandarino L, DeFronzo R, Cusi K.

Am J Physiol Endocrinol Metab. 2004 Sep;287(3):E537-46. Epub 2004 May 4.PMID: 15126243 [PubMed - indexed for MEDLINE]Related articlesFree article

Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes.

Civitarese AE, Jenkinson CP, Richardson D, Bajaj M, Cusi K, Kashyap S, Berria R, Belfort R, DeFronzo RA, Mandarino LJ, Ravussin E.

Diabetologia. 2004 May;47(5):816-20. Epub 2004 Apr 23.PMID: 15105989 [PubMed - indexed for MEDLINE]Related articles

A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes.

Kashyap S, Belfort R, Gastaldelli A, Pratipanawatr T, Berria R, Pratipanawatr W, Bajaj M, Mandarino L, DeFronzo R, Cusi K.

Diabetes. 2003 Oct;52(10):2461-74.PMID: 14514628 [PubMed - indexed for MEDLINE]Related articlesFree article

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1.

Patti ME, Butte AJ, Crunkhorn S, Cusi K, Berria R, Kashyap S, Miyazaki Y, Kohane I, Costello M, Saccone R, Landaker EJ, Goldfine AB, Mun E, DeFronzo R, Finlayson J, Kahn CR, Mandarino LJ.

Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8466-71. Epub 2003 Jun 27.PMID: 12832613 [PubMed - indexed for MEDLINE]Related articlesFree article

Free fatty acids reduce splanchnic and peripheral glucose uptake in patients with type 2 diabetes.

Bajaj M, Pratipanawatr T, Berria R, Pratipanawatr W, Kashyap S, Cusi K, Mandarino L, DeFronzo RA.

Diabetes. 2002 Oct;51(10):3043-8.PMID: 12351445 [PubMed - indexed for MEDLINE]Related articlesFree article

Free fatty acid-induced peripheral insulin resistance augments splanchnic glucose uptake in healthy humans.

Bajaj M, Berria R, Pratipanawatr T, Kashyap S, Pratipanawatr W, Belfort R, Cusi K, Mandarino L, DeFronzo RA.

Am J Physiol Endocrinol Metab. 2002 Aug;283(2):E346-52.PMID: 12110541 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of pioglitazone on abdominal fat distribution and insulin sensitivity in type 2 diabetic patients.

Miyazaki Y, Mahankali A, Matsuda M, Mahankali S, Hardies J, Cusi K, Mandarino LJ, DeFronzo RA.

J Clin Endocrinol Metab. 2002 Jun;87(6):2784-91.PMID: 12050251 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of IGF-I on FFA and glucose metabolism in control and type 2 diabetic subjects.

Pratipanawatr T, Pratipanawatr W, Rosen C, Berria R, Bajaj M, Cusi K, Mandarino L, Kashyap S, Belfort R, DeFronzo RA.

Am J Physiol Endocrinol Metab. 2002 Jun;282(6):E1360-8.PMID: 12006367 [PubMed - indexed for MEDLINE]Related articlesFree article

Normalization of plasma glucose concentration by insulin therapy improves insulin-stimulated glycogen synthesis in type 2 diabetes.

Pratipanawatr T, Cusi K, Ngo P, Pratipanawatr W, Mandarino LJ, DeFronzo RA.

Diabetes. 2002 Feb;51(2):462-8.PMID: 11812756 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of rosiglitazone on glucose and non-esterified fatty acid metabolism in Type II diabetic patients.

Miyazaki Y, Glass L, Triplitt C, Matsuda M, Cusi K, Mahankali A, Mahankali S, Mandarino LJ, DeFronzo RA.

Diabetologia. 2001 Dec;44(12):2210-9.PMID: 11793023 [PubMed - indexed for MEDLINE]Related articles

Skeletal muscle insulin resistance in normoglycemic subjects with a strong family history of type 2 diabetes is associated with decreased insulin-stimulated insulin receptor substrate-1 tyrosine phosphorylation.

Pratipanawatr W, Pratipanawatr T, Cusi K, Berria R, Adams JM, Jenkinson CP, Maezono K, DeFronzo RA, Mandarino LJ.

Diabetes. 2001 Nov;50(11):2572-8.PMID: 11679436 [PubMed - indexed for MEDLINE]Related articlesFree article

Exercise increases hexokinase II mRNA, but not activity in obesity and type 2 diabetes.

Cusi KJ, Pratipanawatr T, Koval J, Printz R, Ardehali H, Granner DK, Defronzo RA, Mandarino LJ.

Metabolism. 2001 May;50(5):602-6.PMID: 11319725 [PubMed - indexed for MEDLINE]Related articles

Improved glycemic control and enhanced insulin sensitivity in type 2 diabetic subjects treated with pioglitazone.

Miyazaki Y, Mahankali A, Matsuda M, Glass L, Mahankali S, Ferrannini E, Cusi K, Mandarino LJ, DeFronzo RA.

Diabetes Care. 2001 Apr;24(4):710-9.PMID: 11315836 [PubMed - indexed for MEDLINE]Related articlesFree article

Physiological hyperinsulinemia impairs insulin-stimulated glycogen synthase activity and glycogen synthesis.

Iozzo P, Pratipanawatr T, Pijl H, Vogt C, Kumar V, Pipek R, Matsuda M, Mandarino LJ, Cusi KJ, DeFronzo RA.

Am J Physiol Endocrinol Metab. 2001 May;280(5):E712-9.PMID: 11287353 [PubMed - indexed for MEDLINE]Related articlesFree article

Vanadyl sulfate improves hepatic and muscle insulin sensitivity in type 2 diabetes.

Cusi K, Cukier S, DeFronzo RA, Torres M, Puchulu FM, Redondo JC.

J Clin Endocrinol Metab. 2001 Mar;86(3):1410-7.PMID: 11238540 [PubMed - indexed for MEDLINE]Related articlesFree article

Recombinant human insulin-like growth factor I treatment for 1 week improves metabolic control in type 2 diabetes by ameliorating hepatic and muscle insulin resistance.

Cusi K, DeFronzo R.

J Clin Endocrinol Metab. 2000 Sep;85(9):3077-84.PMID: 10999789 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of MAP kinase pathway activity in vivo in human skeletal muscle.

Osman AA, Pendergrass M, Koval J, Maezono K, Cusi K, Pratipanawatr T, Mandarino LJ.

Am J Physiol Endocrinol Metab. 2000 Jun;278(6):E992-9.PMID: 10827000 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle.

Cusi K, Maezono K, Osman A, Pendergrass M, Patti ME, Pratipanawatr T, DeFronzo RA, Kahn CR, Mandarino LJ.

J Clin Invest. 2000 Feb;105(3):311-20.PMID: 10675357 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus.

Cusi K, Consoli A, DeFronzo RA.

J Clin Endocrinol Metab. 1996 Nov;81(11):4059-67.PMID: 8923861 [PubMed - indexed for MEDLINE]Related articles

Regulation of hexokinase II and glycogen synthase mRNA, protein, and activity in human muscle.

Mandarino LJ, Printz RL, Cusi KA, Kinchington P, O'Doherty RM, Osawa H, Sewell C, Consoli A, Granner DK, DeFronzo RA.

Am J Physiol. 1995 Oct;269(4 Pt 1):E701-8. Erratum in: Am J Physiol 1996 Jan;270(1 Pt 1):section E followi. PMID: 7485484 [PubMed - indexed for MEDLINE]Related articles

Safety and efficacy of normalizing fasting glucose with bedtime NPH insulin alone in NIDDM.

Cusi K, Cunningham GR, Comstock JP.

Diabetes Care. 1995 Jun;18(6):843-51.PMID: 7555511 [PubMed - indexed for MEDLINE]Related articles

Value of sensitive thyrotropin measurement in ambulatory and hospitalized patients.

Arem R, Cusi K, Kiefe C.

Clin Invest Med. 1990 Jun;13(3):132-8.PMID: 2364588 [PubMed - indexed for MEDLINE]Related articles