PubMed

Variation within the CLEC16A gene shows consistent disease association with both multiple sclerosis and type 1 diabetes in Sardinia.

Zoledziewska M, Costa G, Pitzalis M, Cocco E, Melis C, Moi L, Zavattari P, Murru R, Lampis R, Morelli L, Poddie F, Frongia P, Pusceddu P, Bajorek M, Marras A, Satta AM, Chessa A, Pugliatti M, Sotgiu S, Whalen MB, Rosati G, Cucca F, Marrosu MG.

Genes Immun. 2009 Jan;10(1):15-7. Epub 2008 Oct 23.PMID: 18946483 [PubMed - indexed for MEDLINE]Related articles

Genetic loci linked to type 1 diabetes and multiple sclerosis families in Sardinia.

Pitzalis M, Zavattari P, Murru R, Deidda E, Zoledziewska M, Murru D, Moi L, Motzo C, Orrù V, Costa G, Solla E, Fadda E, Schirru L, Melis MC, Lai M, Mancosu C, Tranquilli S, Cuccu S, Rolesu M, Secci MA, Corongiu D, Contu D, Lampis R, Nucaro A, Pala G, Pacifico A, Maioli M, Frongia P, Chessa M, Ricciardi R, Lostia S, Marinaro AM, Milia AF, Landis N, Zedda MA, Whalen MB, Santoni F, Marrosu MG, Devoto M, Cucca F.

BMC Med Genet. 2008 Jan 20;9:3.PMID: 18205952 [PubMed - indexed for MEDLINE]Related articlesFree article

Shared genetic data and the rights of involved people.

Sellaroli V, Cucca F, Santosuosso A.

Law Hum Genome Rev. 2007 Jan-Jun;(26):193-231.PMID: 18201042 [PubMed - indexed for MEDLINE]Related articles

Y-chromosome based evidence for pre-neolithic origin of the genetically homogeneous but diverse Sardinian population: inference for association scans.

Contu D, Morelli L, Santoni F, Foster JW, Francalacci P, Cucca F.

PLoS One. 2008 Jan 9;3(1):e1430.PMID: 18183308 [PubMed - indexed for MEDLINE]Related articlesFree article

Decline of lactase activity and c/t-13910 variant in Sardinian childhood.

Schirru E, Corona V, Usai-Satta P, Scarpa M, Cucca F, De Virgiliis S, Rossino R, Frau F, Macis MD, Jores RD, Congia M.

J Pediatr Gastroenterol Nutr. 2007 Oct;45(4):503-6.PMID: 18030226 [PubMed - indexed for MEDLINE]Related articles

Further evidence of a primary, causal association of the PTPN22 620W variant with type 1 diabetes.

Zoledziewska M, Perra C, Orrù V, Moi L, Frongia P, Congia M, Bottini N, Cucca F.

Diabetes. 2008 Jan;57(1):229-34. Epub 2007 Oct 12.PMID: 17934143 [PubMed - indexed for MEDLINE]Related articlesFree article

Relative predispositional effects of HLA class II DRB1-DQB1 haplotypes and genotypes on type 1 diabetes: a meta-analysis.

Thomson G, Valdes AM, Noble JA, Kockum I, Grote MN, Najman J, Erlich HA, Cucca F, Pugliese A, Steenkiste A, Dorman JS, Caillat-Zucman S, Hermann R, Ilonen J, Lambert AP, Bingley PJ, Gillespie KM, Lernmark A, Sanjeevi CB, Rønningen KS, Undlien DE, Thorsby E, Petrone A, Buzzetti R, Koeleman BP, Roep BO, Saruhan-Direskeneli G, Uyar FA, Günoz H, Gorodezky C, Alaez C, Boehm BO, Mlynarski W, Ikegami H, Berrino M, Fasano ME, Dametto E, Israel S, Brautbar C, Santiago-Cortes A, Frazer de Llado T, She JX, Bugawan TL, Rotter JI, Raffel L, Zeidler A, Leyva-Cobian F, Hawkins BR, Chan SH, Castano L, Pociot F, Nerup J.

Tissue Antigens. 2007 Aug;70(2):110-27.PMID: 17610416 [PubMed - indexed for MEDLINE]Related articles

Variation of the myelin oligodendrocyte glycoprotein gene is not primarily associated with multiple sclerosis in the Sardinian population.

Marrosu MG, Murru R, Costa G, Melis MC, Rolesu M, Schirru L, Solla E, Cuccu S, Secci MA, Whalen MB, Cocco E, Pugliatti M, Sotgiu S, Rosati G, Cucca F.

BMC Genet. 2007 May 17;8:25.PMID: 17509152 [PubMed - indexed for MEDLINE]Related articlesFree article

High frequency of the TCRBV20S1 null allele in the Sardinian population.

Bonfigli S, Fozza C, Contini S, Buzzetti R, Cucca F, Longinotti M.

Hum Immunol. 2007 May;68(5):426-9. Epub 2007 Feb 15.PMID: 17462510 [PubMed - indexed for MEDLINE]Related articles

Genetic testing improves the diagnosis of adult type hypolactasia in the Mediterranean population of Sardinia.

Schirru E, Corona V, Usai-Satta P, Scarpa M, Oppia F, Loriga F, Cucca F, De Virgiliis S, Rossino R, Macis MD, Jores RD, Congia M.

Eur J Clin Nutr. 2007 Oct;61(10):1220-5. Epub 2007 Feb 21.PMID: 17311063 [PubMed - indexed for MEDLINE]Related articles

HLA-DQB1*0201 homozygosis predisposes to severe intestinal damage in celiac disease.

Jores RD, Frau F, Cucca F, Grazia Clemente M, Orrù S, Rais M, De Virgiliis S, Congia M.

Scand J Gastroenterol. 2007 Jan;42(1):48-53.PMID: 17190762 [PubMed - indexed for MEDLINE]Related articles

No influence of chromosome Y haplogroup variation in acute graft-versus-host disease in sardinia.

Orofino MG, Contu D, Argiolu F, Sanna MA, Gaziev J, La Nasa G, Vacca A, Cao A, Cucca F.

Transplantation. 2006 Dec 15;82(11):1529-32.PMID: 17164727 [PubMed - indexed for MEDLINE]Related articles

Role of PTPN22 in type 1 diabetes and other autoimmune diseases.

Bottini N, Vang T, Cucca F, Mustelin T.

Semin Immunol. 2006 Aug;18(4):207-13. Epub 2006 May 11. Review.PMID: 16697661 [PubMed - indexed for MEDLINE]Related articles

Zonulin upregulation is associated with increased gut permeability in subjects with type 1 diabetes and their relatives.

Sapone A, de Magistris L, Pietzak M, Clemente MG, Tripathi A, Cucca F, Lampis R, Kryszak D, Cartenì M, Generoso M, Iafusco D, Prisco F, Laghi F, Riegler G, Carratu R, Counts D, Fasano A.

Diabetes. 2006 May;55(5):1443-9.PMID: 16644703 [PubMed - indexed for MEDLINE]Related articlesFree article

Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant.

Vang T, Congia M, Macis MD, Musumeci L, Orrú V, Zavattari P, Nika K, Tautz L, Taskén K, Cucca F, Mustelin T, Bottini N.

Nat Genet. 2005 Dec;37(12):1317-9. Epub 2005 Nov 6.PMID: 16273109 [PubMed - indexed for MEDLINE]Related articles

Heterogeneity in the magnitude of the insulin gene effect on HLA risk in type 1 diabetes.

Motzo C, Contu D, Cordell HJ, Lampis R, Congia M, Marrosu MG, Todd JA, Devoto M, Cucca F.

Diabetes. 2004 Dec;53(12):3286-91.PMID: 15561961 [PubMed - indexed for MEDLINE]Related articlesFree article

The co-inheritance of type 1 diabetes and multiple sclerosis in Sardinia cannot be explained by genotype variation in the HLA region alone.

Marrosu MG, Motzo C, Murru R, Lampis R, Costa G, Zavattari P, Contu D, Fadda E, Cocco E, Cucca F.

Hum Mol Genet. 2004 Dec 1;13(23):2919-24. Epub 2004 Oct 7.PMID: 15471889 [PubMed - indexed for MEDLINE]Related articlesFree article

No association between variation of the FOXP3 gene and common type 1 diabetes in the Sardinian population.

Zavattari P, Deidda E, Pitzalis M, Zoa B, Moi L, Lampis R, Contu D, Motzo C, Frongia P, Angius E, Maioli M, Todd JA, Cucca F.

Diabetes. 2004 Jul;53(7):1911-4.PMID: 15220219 [PubMed - indexed for MEDLINE]Related articlesFree article

Genotype effects and epistasis in type 1 diabetes and HLA-DQ trans dimer associations with disease.

Koeleman BP, Lie BA, Undlien DE, Dudbridge F, Thorsby E, de Vries RR, Cucca F, Roep BO, Giphart MJ, Todd JA.

Genes Immun. 2004 Aug;5(5):381-8.PMID: 15164102 [PubMed - indexed for MEDLINE]Related articles

Testing the possible negative association of type 1 diabetes and atopic disease by analysis of the interleukin 4 receptor gene.

Maier LM, Twells RC, Howson JM, Lam AC, Clayton DG, Smyth DJ, Savage D, Carson D, Patterson CC, Smink LJ, Walker NM, Burren OS, Nutland S, Rance H, Tuomilehto-Wolf E, Tuomilehto J, Guja C, Ionescu-Tirgoviste C, Undlien DE, Rønningen KS, Cucca F, Todd JA.

Genes Immun. 2003 Oct;4(7):469-75.PMID: 14551599 [PubMed - indexed for MEDLINE]Related articles

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease.

Ueda H, Howson JM, Esposito L, Heward J, Snook H, Chamberlain G, Rainbow DB, Hunter KM, Smith AN, Di Genova G, Herr MH, Dahlman I, Payne F, Smyth D, Lowe C, Twells RC, Howlett S, Healy B, Nutland S, Rance HE, Everett V, Smink LJ, Lam AC, Cordell HJ, Walker NM, Bordin C, Hulme J, Motzo C, Cucca F, Hess JF, Metzker ML, Rogers J, Gregory S, Allahabadia A, Nithiyananthan R, Tuomilehto-Wolf E, Tuomilehto J, Bingley P, Gillespie KM, Undlien DE, Rønningen KS, Guja C, Ionescu-Tîrgovişte C, Savage DA, Maxwell AP, Carson DJ, Patterson CC, Franklyn JA, Clayton DG, Peterson LB, Wicker LS, Todd JA, Gough SC.

Nature. 2003 May 29;423(6939):506-11. Epub 2003 Apr 30.PMID: 12724780 [PubMed - indexed for MEDLINE]Related articles

[Correlation between major histocompatibility complex (MHC)-class II and type 1 diabetes]

Cucca F, Contu D, Zavattari P, Murru D.

Minerva Endocrinol. 2003 Jun;28(2):111-22. Review. Italian. PMID: 12717342 [PubMed - indexed for MEDLINE]Related articles

Sex-related bias and exclusion mapping of the nonrecombinant portion of chromosome Y in human type 1 diabetes in the isolated founder population of Sardinia.

Contu D, Morelli L, Zavattari P, Lampis R, Angius E, Frongia P, Murru D, Maioli M, Francalacci P, Todd JA, Cucca F.

Diabetes. 2002 Dec;51(12):3573-6.PMID: 12453916 [PubMed - indexed for MEDLINE]Related articlesFree article

The distribution of DQ genes in the Saharawi population provides only a partial explanation for the high celiac disease prevalence.

Catassi C, Doloretta Macis M, Rätsch IM, De Virgiliis S, Cucca F.

Tissue Antigens. 2001 Dec;58(6):402-6.PMID: 11929591 [PubMed - indexed for MEDLINE]Related articles

Parameters for reliable results in genetic association studies in common disease.

Dahlman I, Eaves IA, Kosoy R, Morrison VA, Heward J, Gough SC, Allahabadia A, Franklyn JA, Tuomilehto J, Tuomilehto-Wolf E, Cucca F, Guja C, Ionescu-Tirgoviste C, Stevens H, Carr P, Nutland S, McKinney P, Shield JP, Wang W, Cordell HJ, Walker N, Todd JA, Concannon P.

Nat Genet. 2002 Feb;30(2):149-50. Epub 2002 Jan 22.PMID: 11799396 [PubMed - indexed for MEDLINE]Related articles

Dissection of the HLA association with multiple sclerosis in the founder isolated population of Sardinia.

Marrosu MG, Murru R, Murru MR, Costa G, Zavattari P, Whalen M, Cocco E, Mancosu C, Schirru L, Solla E, Fadda E, Melis C, Porru I, Rolesu M, Cucca F.

Hum Mol Genet. 2001 Dec 1;10(25):2907-16.PMID: 11741834 [PubMed - indexed for MEDLINE]Related articlesFree article

A correlation between the relative predisposition of MHC class II alleles to type 1 diabetes and the structure of their proteins.

Cucca F, Lampis R, Congia M, Angius E, Nutland S, Bain SC, Barnett AH, Todd JA.

Hum Mol Genet. 2001 Sep 15;10(19):2025-37.PMID: 11590120 [PubMed - indexed for MEDLINE]Related articlesFree article

No evidence for SEL1L as a candidate gene for IDDM11-conferred susceptibility.

Pociot F, Larsen ZM, Zavattari P, Deidda E, Nerup J, Cattaneo M, Chiaramonte R, Comi P, Sabbadini M, Zollo M, Biunno I, Cucca F.

Diabetes Metab Res Rev. 2001 Jul-Aug;17(4):292-5.PMID: 11544613 [PubMed - indexed for MEDLINE]Related articles

The HLA-DPB1--associated component of the IDDM1 and its relationship to the major loci HLA-DQB1, -DQA1, and -DRB1.

Cucca F, Dudbridge F, Loddo M, Mulargia AP, Lampis R, Angius E, De Virgiliis S, Koeleman BP, Bain SC, Barnett AH, Gilchrist F, Cordell H, Welsh K, Todd JA.

Diabetes. 2001 May;50(5):1200-5.PMID: 11334427 [PubMed - indexed for MEDLINE]Related articlesFree article

Conditional linkage disequilibrium analysis of a complex disease superlocus, IDDM1 in the HLA region, reveals the presence of independent modifying gene effects influencing the type 1 diabetes risk encoded by the major HLA-DQB1, -DRB1 disease loci.

Zavattari P, Lampis R, Motzo C, Loddo M, Mulargia A, Whalen M, Maioli M, Angius E, Todd JA, Cucca F.

Hum Mol Genet. 2001 Apr 1;10(8):881-9.PMID: 11285254 [PubMed - indexed for MEDLINE]Related articlesFree article

Conditional ETDT analysis of the human leukocyte antigen region in type 1 diabetes.

Koeleman BP, Herr MH, Zavattari P, Dudbridge F, March R, Campbell D, Barnett AH, Bain SC, Mulargia AP, Loddo M, Amos W, Cucca F, Todd JA.

Ann Hum Genet. 2000 May;64(Pt 3):215-21.PMID: 11246473 [PubMed - indexed for MEDLINE]Related articles

The distribution of HLA class II haplotypes reveals that the Sardinian population is genetically differentiated from the other Caucasian populations.

Lampis R, Morelli L, De Virgiliis S, Congia M, Cucca F.

Tissue Antigens. 2000 Dec;56(6):515-21.PMID: 11169241 [PubMed - indexed for MEDLINE]Related articles

Suggestive evidence for association of human chromosome 18q12-q21 and its orthologue on rat and mouse chromosome 18 with several autoimmune diseases.

Merriman TR, Cordell HJ, Eaves IA, Danoy PA, Coraddu F, Barber R, Cucca F, Broadley S, Sawcer S, Compston A, Wordsworth P, Shatford J, Laval S, Jirholt J, Holmdahl R, Theofilopoulos AN, Kono DH, Tuomilehto J, Tuomilehto-Wolf E, Buzzetti R, Marrosu MG, Undlien DE, Rønningen KS, Ionesco-Tirgoviste C, Shield JP, Pociot F, Nerup J, Jacob CO, Polychronakos C, Bain SC, Todd JA.

Diabetes. 2001 Jan;50(1):184-94.PMID: 11147786 [PubMed - indexed for MEDLINE]Related articlesFree article

Confirmation of the DRB1-DQB1 loci as the major component of IDDM1 in the isolated founder population of Sardinia.

Zavattari P, Lampis R, Mulargia A, Loddo M, Angius E, Todd JA, Cucca F.

Hum Mol Genet. 2000 Dec 12;9(20):2967-72.PMID: 11115840 [PubMed - indexed for MEDLINE]Related articlesFree article

The inter-regional distribution of HLA class II haplotypes indicates the suitability of the Sardinian population for case-control association studies in complex diseases.

Lampis R, Morelli L, Congia M, Macis MD, Mulargia A, Loddo M, De Virgiliis S, Marrosu MG, Todd JA, Cucca F.

Hum Mol Genet. 2000 Dec 12;9(20):2959-65.PMID: 11115839 [PubMed - indexed for MEDLINE]Related articlesFree article

Major factors influencing linkage disequilibrium by analysis of different chromosome regions in distinct populations: demography, chromosome recombination frequency and selection.

Zavattari P, Deidda E, Whalen M, Lampis R, Mulargia A, Loddo M, Eaves I, Mastio G, Todd JA, Cucca F.

Hum Mol Genet. 2000 Dec 12;9(20):2947-57.PMID: 11115838 [PubMed - indexed for MEDLINE]Related articlesFree article

ICAM-1 gene is not associated with multiple sclerosis in sardinian patients.

Marrosu MG, Schirru L, Fadda E, Mancosu C, Lai M, Cocco E, Cucca F.

J Neurol. 2000 Sep;247(9):677-80.PMID: 11081805 [PubMed - indexed for MEDLINE]Related articles

The genetically isolated populations of Finland and sardinia may not be a panacea for linkage disequilibrium mapping of common disease genes.

Eaves IA, Merriman TR, Barber RA, Nutland S, Tuomilehto-Wolf E, Tuomilehto J, Cucca F, Todd JA.

Nat Genet. 2000 Jul;25(3):320-3.PMID: 10888882 [PubMed - indexed for MEDLINE]Related articles

Nutritional factors and worldwide incidence of childhood type 1 diabetes.

Muntoni S, Cocco P, Aru G, Cucca F.

Am J Clin Nutr. 2000 Jun;71(6):1525-9.PMID: 10837294 [PubMed - indexed for MEDLINE]Related articlesFree article

Evaluation of fine mapping strategies for a multifactorial disease locus: systematic linkage and association analysis of IDDM1 in the HLA region on chromosome 6p21.

Herr M, Dudbridge F, Zavattari P, Cucca F, Guja C, March R, Campbell RD, Barnett AH, Bain SC, Todd JA, Koeleman BP.

Hum Mol Genet. 2000 May 22;9(9):1291-301.PMID: 10814711 [PubMed - indexed for MEDLINE]Related articlesFree article

Transmission-ratio distortion at Xp11.4-p21.1 in type 1 diabetes.

Zavattari P, Esposito L, Nutland S, Todd JA, Cucca F.

Am J Hum Genet. 2000 Jan;66(1):330-2. No abstract available. PMID: 10631163 [PubMed - indexed for MEDLINE]Related articlesFree article

Linkage analysis of multiple sclerosis with candidate region markers in Sardinian and Continental Italian families.

D'Alfonso S, Nisticò L, Zavattari P, Marrosu MG, Murru R, Lai M, Massacesi L, Ballerini C, Gestri D, Salvetti M, Ristori G, Bomprezzi R, Trojano M, Liguori M, Gambi D, Quattrone A, Fruci D, Cucca F, Richiardi PM, Tosi R.

Eur J Hum Genet. 1999 Apr;7(3):377-85.PMID: 10234515 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic analysis of chromosome 2 in type 1 diabetes: analysis of putative loci IDDM7, IDDM12, and IDDM13 and candidate genes NRAMP1 and IA-2 and the interleukin-1 gene cluster. IMDIAB Group.

Esposito L, Hill NJ, Pritchard LE, Cucca F, Muxworthy C, Merriman ME, Wilson A, Julier C, Delepine M, Tuomilehto J, Tuomilehto-Wolf E, Ionesco-Tirgoviste C, Nistico' L, Buzzetti R, Pozzilli P, Ferrari M, Bosi E, Pociot F, Nerup J, Bain SC, Todd JA.

Diabetes. 1998 Nov;47(11):1797-9. No abstract available. PMID: 9792551 [PubMed - indexed for MEDLINE]Related articlesFree article

Investigation of linkage of chromosome 8 to type 1 diabetes: multipoint analysis and exclusion mapping of human chromosome 8 in 593 affected sib-pair families from the U.K. and U.S.

Cucca F, Esposito L, Goy JV, Merriman ME, Wilson AJ, Reed PW, Bain SC, Todd JA.

Diabetes. 1998 Sep;47(9):1525-7. No abstract available. PMID: 9726245 [PubMed - indexed for MEDLINE]Related articlesFree article

Fine mapping of the diabetes-susceptibility locus, IDDM4, on chromosome 11q13.

Nakagawa Y, Kawaguchi Y, Twells RC, Muxworthy C, Hunter KM, Wilson A, Merriman ME, Cox RD, Merriman T, Cucca F, McKinney PA, Shield JP, Tuomilehto J, Tuomilehto-Wolf E, Ionesco-Tirgoviste C, Nisticò L, Buzzetti R, Pozzilli P, Joner G, Thorsby E, Undlien DE, Pociot F, Nerup J, Rönningen KS, Bain SC, Todd JA; Bart's-Oxford Family Study Group.

Am J Hum Genet. 1998 Aug;63(2):547-56.PMID: 9683605 [PubMed - indexed for MEDLINE]Related articlesFree article

DRB1-DQA1-DQB1 loci and multiple sclerosis predisposition in the Sardinian population.

Marrosu MG, Murru MR, Costa G, Murru R, Muntoni F, Cucca F.

Hum Mol Genet. 1998 Aug;7(8):1235-7.PMID: 9668164 [PubMed - indexed for MEDLINE]Related articlesFree article

A male-female bias in type 1 diabetes and linkage to chromosome Xp in MHC HLA-DR3-positive patients.

Cucca F, Goy JV, Kawaguchi Y, Esposito L, Merriman ME, Wilson AJ, Cordell HJ, Bain SC, Todd JA.

Nat Genet. 1998 Jul;19(3):301-2.PMID: 9662410 [PubMed - indexed for MEDLINE]Related articles

A search for type 1 diabetes susceptibility genes in families from the United Kingdom.

Mein CA, Esposito L, Dunn MG, Johnson GC, Timms AE, Goy JV, Smith AN, Sebag-Montefiore L, Merriman ME, Wilson AJ, Pritchard LE, Cucca F, Barnett AH, Bain SC, Todd JA.

Nat Genet. 1998 Jul;19(3):297-300.PMID: 9662409 [PubMed - indexed for MEDLINE]Related articles

Transmission of haplotypes of microsatellite markers rather than single marker alleles in the mapping of a putative type 1 diabetes susceptibility gene (IDDM6).

Merriman TR, Eaves IA, Twells RC, Merriman ME, Danoy PA, Muxworthy CE, Hunter KM, Cox RD, Cucca F, McKinney PA, Shield JP, Baum JD, Tuomilehto J, Tuomilehto-Wolf E, Ionesco-Tirgoviste C, Joner G, Thorsby E, Undlien DE, Pociot F, Nerup J, Ronningen KS, Bain SC, Todd JA.

Hum Mol Genet. 1998 Mar;7(3):517-24.PMID: 9467012 [PubMed - indexed for MEDLINE]Related articlesFree article

Evaluation of IgA deficiency in Sardinians indicates a susceptibility gene is encoded within the HLA class III region.

Cucca F, Zhu ZB, Khanna A, Cossu F, Congia M, Badiali M, Lampis R, Frau F, De Virgiliis S, Cao A, Arnone M, Piras P, Campbell RD, Cooper MD, Volanakis JE, Powis SH.

Clin Exp Immunol. 1998 Jan;111(1):76-80.PMID: 9472664 [PubMed - indexed for MEDLINE]Related articlesFree article