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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1985 1
1986 1
1987 2
1988 3
1989 2
1990 1
1991 1
1992 1
1994 1
1996 1
1997 1
1998 4
2000 1
2002 1
2003 1
2004 2
2005 4
2006 3
2007 1
2008 8
2009 1
2010 5
2011 3
2012 8
2013 8
2014 7
2015 4
2016 9
2017 6
2018 5
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2020 10
2021 12
2022 13
2023 17
2024 10

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145 results

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Page 1
COX5A Alleviates Doxorubicin-Induced Cardiotoxicity by Suppressing Oxidative Stress, Mitochondrial Dysfunction and Cardiomyocyte Apoptosis.
Zhang P, Lu H, Wu Y, Lu D, Li C, Yang X, Chen Z, Qian J, Ge J. Zhang P, et al. Int J Mol Sci. 2023 Jun 20;24(12):10400. doi: 10.3390/ijms241210400. Int J Mol Sci. 2023. PMID: 37373547 Free PMC article.
We investigate the roles of COX5A in DOX-induced cardiomyopathy and explore the underlying mechanisms. C57BL/6J mice and H9c2 cardiomyoblasts were treated with DOX, and the COX5A expression was assessed. An adeno-associated virus serum type 9 (AAV9) and lenti-virus …
We investigate the roles of COX5A in DOX-induced cardiomyopathy and explore the underlying mechanisms. C57BL/6J mice and H9c2 cardiom …
Overexpression of COX5A protects H9c2 cells against doxorubicin-induced cardiotoxicity.
Zhang P, Chen Z, Lu D, Wu Y, Fan M, Qian J, Ge J. Zhang P, et al. Biochem Biophys Res Commun. 2020 Mar 26;524(1):43-49. doi: 10.1016/j.bbrc.2020.01.013. Epub 2020 Jan 22. Biochem Biophys Res Commun. 2020. PMID: 31980176
Although COX5A appears to play a key role in modulating the physiological activity of COX and involve in energy metabolism, the involvement of COX5A in DOX-induced cardiotoxicity remains unclear. ...Overexpression of COX5A in H9c2 cells effectively attenuated …
Although COX5A appears to play a key role in modulating the physiological activity of COX and involve in energy metabolism, the invol …
COX5A as a potential biomarker for disease activity and organ damage in lupus.
Cai M, Qin Y, Wan A, Jin H, Tang J, Chen Z. Cai M, et al. Clin Exp Med. 2023 Dec;23(8):4745-4756. doi: 10.1007/s10238-023-01215-w. Epub 2023 Oct 27. Clin Exp Med. 2023. PMID: 37891386
Single-cell RNA sequencing data from the skin and kidney were used to determine the association of COX5A expression with organ damage. The associations of COX5A with SLE phenotypes were further evaluated in two independent cohorts, and receiver operating characteris …
Single-cell RNA sequencing data from the skin and kidney were used to determine the association of COX5A expression with organ damage …
COX5A over-expression protects cortical neurons from hypoxic ischemic injury in neonatal rats associated with TPI up-regulation.
Jiang Y, Bai X, Li TT, Al-Hawwas M, Jin Y, Zou Y, Hu Y, Liu LY, Zhang Y, Liu Q, Yang H, Ma J, Wang TH, Liu J, Xiong LL. Jiang Y, et al. BMC Neurosci. 2020 Apr 29;21(1):18. doi: 10.1186/s12868-020-00565-5. BMC Neurosci. 2020. PMID: 32349668 Free PMC article.
Moreover, HSV-mediated COX5A over-expression virus was transducted into OGD neurons to explore the role of COX5A in vitro, and the underlying mechanism was predicted by GeneMANIA, then verified by WB and qRT-PCR. ...Moreover, Triosephosephate isomerase (TPI) was pre …
Moreover, HSV-mediated COX5A over-expression virus was transducted into OGD neurons to explore the role of COX5A in vitro, and …
COX5A Plays a Vital Role in Memory Impairment Associated With Brain Aging via the BDNF/ERK1/2 Signaling Pathway.
Xiyang YB, Liu R, Wang XY, Li S, Zhao Y, Lu BT, Xiao ZC, Zhang LF, Wang TH, Zhang J. Xiyang YB, et al. Front Aging Neurosci. 2020 Jul 10;12:215. doi: 10.3389/fnagi.2020.00215. eCollection 2020. Front Aging Neurosci. 2020. PMID: 32754029 Free PMC article.
Cytochrome c oxidase subunit Va (COX5A) is involved in maintaining normal mitochondrial function. ...In vitro studies supported that COX5A affected neuronal growth via BDNF. In summary, this study was the first to show that COX5A in the hippocampus plays a vi …
Cytochrome c oxidase subunit Va (COX5A) is involved in maintaining normal mitochondrial function. ...In vitro studies supported that …
miR-204/COX5A axis contributes to invasion and chemotherapy resistance in estrogen receptor-positive breast cancers.
Zeng J, Li G, Xia Y, Wang F, Wang Y, Xu S, Zhou Y, Liu X, Xie X, Zhang J. Zeng J, et al. Cancer Lett. 2020 Nov 1;492:185-196. doi: 10.1016/j.canlet.2020.07.027. Epub 2020 Aug 3. Cancer Lett. 2020. PMID: 32758616
We report that miR-204 can target and inhibit the expression of COX5A, thus, reversing the functions of COX5A in ER + breast cancer cells. We found that COX5A may serve as a prognostic biomarker in ER + breast cancer....
We report that miR-204 can target and inhibit the expression of COX5A, thus, reversing the functions of COX5A in ER + breast c …
Protective Role of Cytochrome C Oxidase 5A (COX5A) against Mitochondrial Disorder and Oxidative Stress in VSMC Phenotypic Modulation and Neointima Formation.
Guan H, Sun J, Liang X, Yao W. Guan H, et al. Curr Vasc Pharmacol. 2023;21(2):128-142. doi: 10.2174/1570161121666230315142507. Curr Vasc Pharmacol. 2023. PMID: 36924093
METHODS: For in vitro assays, human aortic vascular smooth muscle cells (HA-VSMCs) were transfected with pcDNA3.1-COX5A and COX5A siRNA to overexpress and knockdown COX5A, respectively. ...These effects were reversed by overexpression of COX5A and aggr …
METHODS: For in vitro assays, human aortic vascular smooth muscle cells (HA-VSMCs) were transfected with pcDNA3.1-COX5A and COX5A …
A novel homozygous variant in COX5A causes an attenuated phenotype with failure to thrive, lactic acidosis, hypoglycemia, and short stature.
Torraco A, Morlino S, Rizza T, Di Nottia M, Bottaro G, Bisceglia L, Montanari A, Cappa M, Castori M, Bertini E, Carrozzo R. Torraco A, et al. Clin Genet. 2022 Jul;102(1):56-60. doi: 10.1111/cge.14127. Epub 2022 Mar 9. Clin Genet. 2022. PMID: 35246835
A biallelic pathogenic variant in the mitochondrial complex IV subunit COX5A was previously reported in a couple of sibs with failure to thrive, lactic acidosis and pulmonary hypertension and a lethal phenotype. ...Clinical exome revealed the homozygous missense variant c. …
A biallelic pathogenic variant in the mitochondrial complex IV subunit COX5A was previously reported in a couple of sibs with failure …
Hypermethylation of Cox5a promoter is associated with mitochondrial dysfunction in skeletal muscle of high fat diet-induced insulin resistant rats.
Gong YY, Liu YY, Li J, Su L, Yu S, Zhu XN, Cao XP, Xiao HP. Gong YY, et al. PLoS One. 2014 Dec 1;9(12):e113784. doi: 10.1371/journal.pone.0113784. eCollection 2014. PLoS One. 2014. PMID: 25436770 Free PMC article.
Using whole genome promoter methylation analysis of skeletal muscle followed by qPCR and bisulfite sequencing analysis, we identified hypermethylation of Cox5a in HFD rats. Furthermore, we found that Cox5a hypermethylation was associated with downregulation of Co …
Using whole genome promoter methylation analysis of skeletal muscle followed by qPCR and bisulfite sequencing analysis, we identified hyperm …
Gene expression of cox5a, 5b, or 6b1 and their roles in preimplantation mouse embryos.
Cui XS, Li XY, Jeong YJ, Jun JH, Kim NH. Cui XS, et al. Biol Reprod. 2006 Mar;74(3):601-10. doi: 10.1095/biolreprod.105.045633. Epub 2005 Nov 16. Biol Reprod. 2006. PMID: 16291927
Immunocytochemical studies revealed that COX5A, 5B, or 6B1 proteins were expressed in all blastomeres of the blastocyst. ...These results suggest that gene expression of the Cox subunits, Cox5a, 5b, and 6b1 is not required for embryo developmental events up to the b …
Immunocytochemical studies revealed that COX5A, 5B, or 6B1 proteins were expressed in all blastomeres of the blastocyst. ...These res …
145 results